IE800178L - Derivatives of 4-amino-2-piperidinoquinazoline - Google Patents
Derivatives of 4-amino-2-piperidinoquinazolineInfo
- Publication number
- IE800178L IE800178L IE800178A IE17880A IE800178L IE 800178 L IE800178 L IE 800178L IE 800178 A IE800178 A IE 800178A IE 17880 A IE17880 A IE 17880A IE 800178 L IE800178 L IE 800178L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- substd
- halo
- methyl
- opt
- Prior art date
Links
- MDGLKMXWHKGENE-UHFFFAOYSA-N 2-piperidin-1-ylquinazolin-4-amine Chemical class N=1C2=CC=CC=C2C(N)=NC=1N1CCCCC1 MDGLKMXWHKGENE-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Quinazoline derivs. of formula (I) and their pharmaceutically acceptable acid addition salts are new. In (I) R = 1-4 C alkyl, benzyl or (3-6C cycloalkyl)-methyl; R1=1-4C alkyl; X is CH2CH2 substd. by one phenyl and opt. by 1 or 2 methyl; R2 = H, 1-4C alkyl or is phenyl opt. substd. by 1 or 2, 1-4C alkyl or alkoxy, halo, CR3, CONR3R4 or SO2N-R3R4. R3 and R4 = H or 1-4C alkyl. (I) are prepd. e.g. from the corresp. 2-halo-quinazoline and appropriate 4-substd. piperidine. (I) are regulators of the cardiovascular system and are esp. useful for treating hypertension in animals and humans. The usual oral dose is 1-50 mg/day for a 70 kg adult and the intravenous dose is 10-20% of the oral dose.
[FR2447919A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7903398 | 1979-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IE800178L true IE800178L (en) | 1980-07-31 |
Family
ID=10502852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE800178A IE800178L (en) | 1979-01-31 | 1979-01-30 | Derivatives of 4-amino-2-piperidinoquinazoline |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS55104278A (en) |
| AR (1) | AR222208A1 (en) |
| AT (1) | AT373595B (en) |
| BE (1) | BE881448A (en) |
| CA (1) | CA1131636A (en) |
| CS (1) | CS231970B2 (en) |
| DD (1) | DD148720A5 (en) |
| DE (1) | DE3003323A1 (en) |
| DK (1) | DK540879A (en) |
| ES (1) | ES488129A0 (en) |
| FI (1) | FI63936C (en) |
| FR (1) | FR2447919A1 (en) |
| GR (1) | GR73626B (en) |
| HU (1) | HU184233B (en) |
| IE (1) | IE800178L (en) |
| IL (1) | IL59252A (en) |
| IT (1) | IT1149902B (en) |
| LU (1) | LU82115A1 (en) |
| NL (1) | NL8000571A (en) |
| NO (1) | NO800230L (en) |
| NZ (1) | NZ192744A (en) |
| PH (1) | PH15436A (en) |
| PL (1) | PL121890B1 (en) |
| PT (1) | PT70749A (en) |
| SE (1) | SE8000699L (en) |
| SU (1) | SU895291A3 (en) |
| YU (1) | YU22980A (en) |
| ZA (1) | ZA80557B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2483920A1 (en) * | 1980-06-09 | 1981-12-11 | Synthelabo | Antihypertensive piperidino quinazoline(s) - prepd. from benzyloxy piperidine and a 2:halo-4:amino 6,7-di:methoxy quinazoline |
| ES515338A0 (en) * | 1981-09-09 | 1983-11-01 | Orion Yhtymae Oy | "METHOD FOR THE PREPARATION OF SUBSTITUTED PIPERIDINYLQUINAZOLIDINES". |
| US5280032A (en) * | 1989-02-14 | 1994-01-18 | Toyama Chemical Co., Ltd. | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same |
| WO2013070852A2 (en) * | 2011-11-08 | 2013-05-16 | Emory University | Compounds and compositions used to epigenetically transform cells and methods related thereto |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1088068A (en) * | 1977-11-16 | 1980-10-21 | Simon F. Campbell | Piperidino-quinazolines |
| GB2021108B (en) * | 1978-05-18 | 1982-07-21 | Pfizer Ltd | 6,7 - di - 4 - amino - 2 - quinazolines |
-
1979
- 1979-01-30 IE IE800178A patent/IE800178L/en unknown
- 1979-12-18 DK DK540879A patent/DK540879A/en not_active Application Discontinuation
-
1980
- 1980-01-28 PH PH23559A patent/PH15436A/en unknown
- 1980-01-29 AT AT0046980A patent/AT373595B/en not_active IP Right Cessation
- 1980-01-29 SE SE8000699A patent/SE8000699L/en not_active Application Discontinuation
- 1980-01-29 IT IT19537/80A patent/IT1149902B/en active
- 1980-01-29 NZ NZ192744A patent/NZ192744A/en unknown
- 1980-01-29 FI FI800252A patent/FI63936C/en not_active IP Right Cessation
- 1980-01-29 YU YU00229/80A patent/YU22980A/en unknown
- 1980-01-29 IL IL59252A patent/IL59252A/en unknown
- 1980-01-29 CS CS80607A patent/CS231970B2/en unknown
- 1980-01-30 JP JP990580A patent/JPS55104278A/en active Granted
- 1980-01-30 AR AR279793A patent/AR222208A1/en active
- 1980-01-30 SU SU802877159A patent/SU895291A3/en active
- 1980-01-30 HU HU80202A patent/HU184233B/en unknown
- 1980-01-30 NL NL8000571A patent/NL8000571A/en not_active Application Discontinuation
- 1980-01-30 NO NO800230A patent/NO800230L/en unknown
- 1980-01-30 FR FR8002012A patent/FR2447919A1/en active Granted
- 1980-01-30 DE DE19803003323 patent/DE3003323A1/en not_active Ceased
- 1980-01-30 BE BE0/199187A patent/BE881448A/en not_active IP Right Cessation
- 1980-01-30 PL PL1980221683A patent/PL121890B1/en unknown
- 1980-01-30 CA CA344,714A patent/CA1131636A/en not_active Expired
- 1980-01-30 ZA ZA00800557A patent/ZA80557B/en unknown
- 1980-01-30 PT PT70749A patent/PT70749A/en unknown
- 1980-01-31 ES ES488129A patent/ES488129A0/en active Granted
- 1980-01-31 LU LU82115A patent/LU82115A1/en unknown
- 1980-01-31 DD DD80218769A patent/DD148720A5/en unknown
- 1980-02-11 GR GR61081A patent/GR73626B/el unknown
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