IE883779L - Cyclosporin crystal form - Google Patents
Cyclosporin crystal formInfo
- Publication number
- IE883779L IE883779L IE883779A IE377988A IE883779L IE 883779 L IE883779 L IE 883779L IE 883779 A IE883779 A IE 883779A IE 377988 A IE377988 A IE 377988A IE 883779 L IE883779 L IE 883779L
- Authority
- IE
- Ireland
- Prior art keywords
- crystal form
- cyclosporin
- ciclosporin
- intra
- orthorhombic crystal
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 239000013078 crystal Substances 0.000 title abstract 3
- 229930105110 Cyclosporin A Natural products 0.000 title 1
- 229930182912 cyclosporin Natural products 0.000 title 1
- 230000000699 topical effect Effects 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Novel pharmaceutical compositions, in particular topical forms, e.g. for dermal or topical ophthalmic use, and injectible forms, e.g. for intra-lesional or intra-articular injection, comprising Ciclosporin as active ingredient in orthorhombic crystal form. Ciclosporin in non-solvate orthorhombic crystal form is preferred for use in the compositions of the invention, is new and also part of the invention, together with its use and processes for its production.
[CA1341396C]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13623087A | 1987-12-21 | 1987-12-21 | |
| US17261388A | 1988-03-24 | 1988-03-24 | |
| US21254888A | 1988-06-28 | 1988-06-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE883779L true IE883779L (en) | 1989-06-21 |
| IE62006B1 IE62006B1 (en) | 1994-12-14 |
Family
ID=27384838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE377988A IE62006B1 (en) | 1987-12-21 | 1988-12-19 | "Orthorhombic ciclosporin crystal form, process for its production and pharmaceutical compositions containing it" |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPH0791316B2 (en) |
| KR (1) | KR100188305B1 (en) |
| AT (1) | AT403163B (en) |
| AU (1) | AU626274B2 (en) |
| BE (1) | BE1002665A4 (en) |
| CA (1) | CA1341396C (en) |
| CH (1) | CH677926A5 (en) |
| CY (1) | CY1799A (en) |
| DE (1) | DE3843054C2 (en) |
| DK (1) | DK175220B1 (en) |
| ES (1) | ES2012580A6 (en) |
| FI (1) | FI89065C (en) |
| FR (1) | FR2624863B1 (en) |
| GB (1) | GB2211848B (en) |
| GR (1) | GR1002486B (en) |
| HK (1) | HK102894A (en) |
| HU (1) | HU203564B (en) |
| IE (1) | IE62006B1 (en) |
| IL (1) | IL88719A0 (en) |
| IT (1) | IT1235356B (en) |
| LU (1) | LU87409A1 (en) |
| MY (1) | MY103943A (en) |
| NL (1) | NL195096C (en) |
| NO (1) | NO177228C (en) |
| NZ (1) | NZ227384A (en) |
| SE (1) | SE503174C2 (en) |
| SG (1) | SG99494G (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639724A (en) | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| US7081445B2 (en) | 1989-02-20 | 2006-07-25 | Novartis Ag | Cyclosporin galenic forms |
| US5294604A (en) * | 1989-12-20 | 1994-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating ocular diseases by periocular administration of cyclosporine A or G |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| SG45449A1 (en) * | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
| DK0589843T3 (en) | 1992-09-25 | 2002-04-02 | Novartis Ag | Cyclosporin-containing pharmaceutical preparations |
| ATE218359T1 (en) | 1994-11-03 | 2002-06-15 | Novartis Erfind Verwalt Gmbh | NEW PREPARATION FORMS OF CYCLOSPORIN FOR ORAL APPLICATION WITH SIMPLE COMPOSITION AND HIGH BIOAVAILABILITY AND METHOD FOR THE PRODUCTION THEREOF |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| DE19544507B4 (en) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin containing preparations |
| US6262054B1 (en) * | 1996-02-01 | 2001-07-17 | Sloan-Kettering Institute Of Cancer Research | Combination therapy method for treating breast cancer using edatrexate |
| PT988046E (en) | 1997-01-30 | 2004-12-31 | Novartis Ag | COMPOSITIONS OF OIL-FREE OIL CONTAINING CYCLOSPORINE A |
| TW581681B (en) | 1998-02-20 | 2004-04-01 | Nektar Therapeutics | Liquid crystal forms of cyclosporin |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| EP1706095B1 (en) | 2004-01-20 | 2008-12-24 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
| CN1763084B (en) * | 2005-10-11 | 2010-04-21 | 山东新时代药业有限公司 | Preparation method of high-purity cyclosporine A |
| UA113627C2 (en) | 2011-05-27 | 2017-02-27 | CRYSTAL FORM OF CYCLOSPORIN A, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT | |
| JP6363506B2 (en) | 2011-11-15 | 2018-07-25 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | Cyclosporine A2 suspension |
| CN108714137B (en) * | 2011-11-15 | 2022-02-01 | 阿勒根公司 | Thermostatible suspension of cyclosporin A form 2 |
| CN104039813B (en) | 2011-11-15 | 2017-08-29 | 阿勒根公司 | cyclosporin A form 2 and preparation method thereof |
| KR102029513B1 (en) * | 2011-11-15 | 2019-10-07 | 알러간, 인코포레이티드 | Sustained action formulation of cyclosporin form 2 |
| US20260132169A1 (en) * | 2022-10-20 | 2026-05-14 | Chugai Seiyaku Kabushiki Kaisha | Method for producing cyclic peptide crystals |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH614931A5 (en) * | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| CH640519A5 (en) * | 1976-04-09 | 1984-01-13 | Sandoz Ag | Process for preparing a modified form of the antibiotic S 7481/F-1 |
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| DE2819094A1 (en) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING |
| CH637124A5 (en) * | 1978-10-18 | 1983-07-15 | Sandoz Ag | Antibiotic, its preparation and use |
-
1988
- 1988-12-09 HU HU886374A patent/HU203564B/en unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/en not_active Expired - Lifetime
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-19 SE SE8804570A patent/SE503174C2/en not_active IP Right Cessation
- 1988-12-19 FI FI885869A patent/FI89065C/en not_active IP Right Cessation
- 1988-12-19 DK DK198807054A patent/DK175220B1/en not_active IP Right Cessation
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 NZ NZ227384A patent/NZ227384A/en unknown
- 1988-12-19 IL IL88719A patent/IL88719A0/en unknown
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 NO NO885625A patent/NO177228C/en unknown
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-20 AT AT0309588A patent/AT403163B/en not_active IP Right Cessation
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/en not_active Expired - Lifetime
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/en not_active Expired - Lifetime
- 1988-12-20 LU LU87409A patent/LU87409A1/en unknown
- 1988-12-20 IT IT8848690A patent/IT1235356B/en active
- 1988-12-20 BE BE8801421A patent/BE1002665A4/en not_active IP Right Cessation
- 1988-12-20 GR GR880100850A patent/GR1002486B/en not_active IP Right Cessation
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 DE DE3843054A patent/DE3843054C2/en not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
- 1988-12-21 NL NL8803125A patent/NL195096C/en active Search and Examination
- 1988-12-21 ES ES8803887A patent/ES2012580A6/en not_active Expired - Lifetime
-
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/en not_active IP Right Cessation
-
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |