IES20180091A2 - Blood circulation diagnosis medication o-sulfonamide benzoic acid synthesis method - Google Patents
Blood circulation diagnosis medication o-sulfonamide benzoic acid synthesis methodInfo
- Publication number
- IES20180091A2 IES20180091A2 IES20180091A IES20180091A IES20180091A2 IE S20180091 A2 IES20180091 A2 IE S20180091A2 IE S20180091 A IES20180091 A IE S20180091A IE S20180091 A IES20180091 A IE S20180091A IE S20180091 A2 IES20180091 A2 IE S20180091A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- benzoic acid
- blood circulation
- synthesis method
- washed
- Prior art date
Links
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title abstract 6
- 239000005711 Benzoic acid Substances 0.000 title abstract 3
- 235000010233 benzoic acid Nutrition 0.000 title abstract 3
- 229940124530 sulfonamide Drugs 0.000 title abstract 3
- 230000017531 blood circulation Effects 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- OCJBOOLMMGQPQU-UHFFFAOYSA-N 1,4-dichlorobenzene Chemical compound ClC1=CC=C(Cl)C=C1 OCJBOOLMMGQPQU-UHFFFAOYSA-N 0.000 abstract 1
- HCGFUIQPSOCUHI-UHFFFAOYSA-N 2-propan-2-yloxyethanol Chemical compound CC(C)OCCO HCGFUIQPSOCUHI-UHFFFAOYSA-N 0.000 abstract 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
- YHWCPXVTRSHPNY-UHFFFAOYSA-N butan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-] YHWCPXVTRSHPNY-UHFFFAOYSA-N 0.000 abstract 1
- 229940117389 dichlorobenzene Drugs 0.000 abstract 1
- WEHWNAOGRSTTBQ-UHFFFAOYSA-N dipropylamine Chemical compound CCCNCCC WEHWNAOGRSTTBQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Blood circulation diagnosis medication o-sulfonamide benzoic acid synthesis method, comprises the following steps:3 mol 2-benzene sulfonamide-6-bromo-isophenone and 4-5 mol ethylene glycol monoisopropyl ether were added to the reaction vessel, controlled the stirring speed of 130-160 rpm for 30-40 min, and then raise the temperature of the solution to 40-50 °C, 5-6 mol tetrabutyl titanate was added to the reaction vessel by 5-8 times, which was added every 20-30 min, the temperature was controlled at the 55-60 °C, itwas maintained for 130-150 min, then the temperature is reduced to 10-13 °C, the solid is precipitated, filtered and washed with the potassium bromide solution, the pH of the solution is adjusted to 4-5, then the solid is precipitated again, filtered, and washed with the dipropylamine solution, and washed with the dichlorobenzene solution, recrystallizated in ether solution, got the finished o-sulfonamide benzoic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES20180091A IES86947B2 (en) | 2018-04-03 | 2018-04-03 | Blood circulation diagnosis medication o-sulfonamide benzoic acid synthesis method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES20180091A IES86947B2 (en) | 2018-04-03 | 2018-04-03 | Blood circulation diagnosis medication o-sulfonamide benzoic acid synthesis method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES20180091A2 true IES20180091A2 (en) | 2019-01-09 |
| IES86947B2 IES86947B2 (en) | 2019-01-09 |
Family
ID=65009474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180091A IES86947B2 (en) | 2018-04-03 | 2018-04-03 | Blood circulation diagnosis medication o-sulfonamide benzoic acid synthesis method |
Country Status (1)
| Country | Link |
|---|---|
| IE (1) | IES86947B2 (en) |
-
2018
- 2018-04-03 IE IES20180091A patent/IES86947B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IES86947B2 (en) | 2019-01-09 |
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