IL100717A - ליגנדים חנקניים מקרוציקליים, הכנתם,קומפלקסי מתכות שלהם ותכשירי איבחון ותכשירים תרופתיים המכילים קומפלקסיםכאלה - Google Patents
ליגנדים חנקניים מקרוציקליים, הכנתם,קומפלקסי מתכות שלהם ותכשירי איבחון ותכשירים תרופתיים המכילים קומפלקסיםכאלהInfo
- Publication number
- IL100717A IL100717A IL10071792A IL10071792A IL100717A IL 100717 A IL100717 A IL 100717A IL 10071792 A IL10071792 A IL 10071792A IL 10071792 A IL10071792 A IL 10071792A IL 100717 A IL100717 A IL 100717A
- Authority
- IL
- Israel
- Prior art keywords
- group
- chain
- branched
- straight
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9100811A FR2672051B1 (fr) | 1991-01-24 | 1991-01-24 | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL100717A0 IL100717A0 (en) | 1992-09-06 |
| IL100717A true IL100717A (he) | 1996-06-18 |
Family
ID=9409017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10071792A IL100717A (he) | 1991-01-24 | 1992-01-21 | ליגנדים חנקניים מקרוציקליים, הכנתם,קומפלקסי מתכות שלהם ותכשירי איבחון ותכשירים תרופתיים המכילים קומפלקסיםכאלה |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5374416A (he) |
| EP (1) | EP0499501B1 (he) |
| JP (1) | JPH0735381B2 (he) |
| KR (1) | KR960014355B1 (he) |
| AT (1) | ATE169916T1 (he) |
| AU (1) | AU650325B2 (he) |
| CA (1) | CA2078983A1 (he) |
| CZ (1) | CZ281225B6 (he) |
| DE (1) | DE69226669T2 (he) |
| FR (1) | FR2672051B1 (he) |
| HU (1) | HUT70023A (he) |
| IE (1) | IE920204A1 (he) |
| IL (1) | IL100717A (he) |
| MX (1) | MX9200319A (he) |
| NO (1) | NO923673L (he) |
| NZ (1) | NZ241356A (he) |
| WO (1) | WO1992012978A1 (he) |
| ZA (1) | ZA92470B (he) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0382583B1 (en) * | 1989-02-10 | 1996-01-17 | Celltech Therapeutics Limited | Aza macrocycles and processes for their preparation |
| US5645818A (en) * | 1989-03-24 | 1997-07-08 | Guerbet S.A. | Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions |
| GB9126677D0 (en) * | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5462725A (en) * | 1993-05-06 | 1995-10-31 | The Dow Chemical Company | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
| US6693190B1 (en) | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
| US20030017941A1 (en) * | 1997-03-07 | 2003-01-23 | The Procter & Gamble Company | Catalysts and methods for catalytic oxidation |
| ZA981883B (en) * | 1997-03-07 | 1998-09-01 | Univ Kansas | Catalysts and methods for catalytic oxidation |
| AU732147B2 (en) * | 1997-03-07 | 2001-04-12 | Procter & Gamble Company, The | Bleach compositions |
| US20050187126A1 (en) * | 2002-08-27 | 2005-08-25 | Busch Daryle H. | Catalysts and methods for catalytic oxidation |
| US20080125344A1 (en) * | 2006-11-28 | 2008-05-29 | Daryle Hadley Busch | Bleach compositions |
| US6565828B2 (en) | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
| AU2002211393B2 (en) * | 2000-09-29 | 2007-06-28 | Anormed Inc. | Process for preparation of n-1 protected n ring nitrogen containing cyclic polyamines and products thereof |
| DE10117242C1 (de) * | 2001-04-06 | 2002-05-16 | Schering Ag | Unsymmetrische dimere Metallkomplexe, Liganden für diese Metallkomplexe, Verfahren zu deren Herstellung, Arzneimittel bzw. Diagnosemittel, die die Metallkomplexe enthalten, insbesondere Kontrastmittel |
| ES2380009T3 (es) * | 2001-07-31 | 2012-05-07 | Genzyme Global S.A.R.L. | Métodos para movilizar las células madre/progenitoras |
| US20040048763A1 (en) * | 2002-08-27 | 2004-03-11 | The Procter & Gamble Co. | Bleach compositions |
| EP1637524A1 (en) * | 2004-09-20 | 2006-03-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | 10-substituted 1-, 4, 7,-tris (carboxymethyl)-1,4,7,10-tetraazacyclo-dodecane derivative for use as contrast agents |
| TWI429404B (zh) * | 2008-03-03 | 2014-03-11 | Senomyx Inc | 異山梨醇衍生物及彼等作為風味改良劑、促味劑及促味增強劑之用途 |
| JP5735791B2 (ja) * | 2010-12-07 | 2015-06-17 | 住友化学株式会社 | 金属錯体を含む素子 |
| FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
| US10918742B2 (en) | 2016-03-25 | 2021-02-16 | Nanoprobes, Inc. | Iodine-based particles |
| WO2017178301A1 (en) | 2016-04-13 | 2017-10-19 | Bracco Imaging Spa | Contrast agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53144592A (en) * | 1977-05-19 | 1978-12-15 | Tabuse Iwao | 122alkyll1*4*7*100tetrazacyclotridecane |
| US5198208A (en) * | 1987-07-16 | 1993-03-30 | Nycomed Imaging As | Aminopolycarboxylic acids and derivatives thereof |
| DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| BR8907277A (pt) * | 1988-12-22 | 1991-03-26 | Dow Chemical Co | Processo para preparar poliazamacrociclos mono-n-alquilados |
-
1991
- 1991-01-24 FR FR9100811A patent/FR2672051B1/fr not_active Expired - Fee Related
-
1992
- 1992-01-21 IL IL10071792A patent/IL100717A/he not_active IP Right Cessation
- 1992-01-22 AT AT92400174T patent/ATE169916T1/de not_active IP Right Cessation
- 1992-01-22 HU HU9203029A patent/HUT70023A/hu unknown
- 1992-01-22 KR KR1019920702286A patent/KR960014355B1/ko not_active Expired - Lifetime
- 1992-01-22 NZ NZ241356A patent/NZ241356A/en unknown
- 1992-01-22 JP JP4505010A patent/JPH0735381B2/ja not_active Expired - Lifetime
- 1992-01-22 CZ CS922909A patent/CZ281225B6/cs unknown
- 1992-01-22 WO PCT/FR1992/000057 patent/WO1992012978A1/fr not_active Ceased
- 1992-01-22 CA CA002078983A patent/CA2078983A1/fr not_active Abandoned
- 1992-01-22 AU AU12562/92A patent/AU650325B2/en not_active Ceased
- 1992-01-22 EP EP92400174A patent/EP0499501B1/fr not_active Expired - Lifetime
- 1992-01-22 US US07/924,016 patent/US5374416A/en not_active Expired - Fee Related
- 1992-01-22 DE DE69226669T patent/DE69226669T2/de not_active Expired - Fee Related
- 1992-01-23 IE IE020492A patent/IE920204A1/en unknown
- 1992-01-23 ZA ZA92470A patent/ZA92470B/xx unknown
- 1992-01-24 MX MX9200319A patent/MX9200319A/es unknown
- 1992-09-22 NO NO92923673A patent/NO923673L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0499501B1 (fr) | 1998-08-19 |
| DE69226669D1 (de) | 1998-09-24 |
| FR2672051B1 (fr) | 1993-05-21 |
| US5374416A (en) | 1994-12-20 |
| HUT70023A (en) | 1995-09-28 |
| ATE169916T1 (de) | 1998-09-15 |
| CZ290992A3 (en) | 1993-02-17 |
| HU9203029D0 (en) | 1992-12-28 |
| AU650325B2 (en) | 1994-06-16 |
| IE920204A1 (en) | 1992-07-29 |
| AU1256292A (en) | 1992-08-27 |
| EP0499501A2 (fr) | 1992-08-19 |
| CZ281225B6 (cs) | 1996-07-17 |
| NO923673D0 (no) | 1992-09-22 |
| IL100717A0 (en) | 1992-09-06 |
| JPH05504361A (ja) | 1993-07-08 |
| EP0499501A3 (fr) | 1992-08-26 |
| MX9200319A (es) | 1992-07-01 |
| NZ241356A (en) | 1995-02-24 |
| DE69226669T2 (de) | 1999-04-15 |
| JPH0735381B2 (ja) | 1995-04-19 |
| KR960014355B1 (ko) | 1996-10-15 |
| WO1992012978A1 (fr) | 1992-08-06 |
| FR2672051A1 (fr) | 1992-07-31 |
| CA2078983A1 (fr) | 1992-07-25 |
| NO923673L (no) | 1992-11-24 |
| ZA92470B (en) | 1993-07-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL100717A (he) | ליגנדים חנקניים מקרוציקליים, הכנתם,קומפלקסי מתכות שלהם ותכשירי איבחון ותכשירים תרופתיים המכילים קומפלקסיםכאלה | |
| JP4689775B2 (ja) | 低毒性の常磁性金属のキレート錯体 | |
| RU2073005C1 (ru) | Хелатное соединение металла | |
| FI109695B (fi) | Diagnostisia 1,4,7,10-tetra-atsasyklododekaanibutyylitrioleja, niiden käyttö diagnostisina aineina ja menetelmä niiden valmistamiseksi | |
| AU627451B2 (en) | Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them | |
| BR112017020484B1 (pt) | Métodos para fabricar um composto contendo nitrogênio ou sal do mesmo e um complexo metálico, compostos contendo nitrogênio, complexos dos ditos compostos e composições farmacêuticas compreendendo os ditos complexos | |
| NZ229996A (en) | Macrocyclic polyaza compounds containing 5- or 6-membered rings and use in pharmaceutical media for diagnosis or therapy | |
| US11097017B2 (en) | Gadolinium-based contrast agents for sensitive detection of Zn2+with MRI | |
| WO2010114308A1 (en) | Heterocycle-amino acid derivatives for targeting cancer tissue and radioactive or non-radioactive labeled compounds thereof | |
| JPH06504301A (ja) | キレート化剤 | |
| JP2004526671A (ja) | 診断および治療への適用において使用するための抗酸化剤の金属キレート配位子との結合体 | |
| Chaturvedi et al. | Synthesis of analogs of bacterial cell wall glycopeptides | |
| FI75175B (fi) | Process foer framstaellning av n-karboxialkylprolin innehaollande tripeptider. | |
| US20090238768A1 (en) | Multimeric magnetic resonance contrast agents | |
| KR20080043762A (ko) | 퍼플루오로알킬 함유 착물, 그의 제조 방법 및 용도 | |
| CN101321750B (zh) | 多聚体磁共振造影剂 | |
| RU2425831C2 (ru) | Мультимерные контрастные агенты для магнитного резонанса | |
| US20240199588A1 (en) | Chiral TACN/NOTA compounds/derivatives with and without metals for application | |
| WO2001052898A1 (en) | Methods for incorporating metal chelators at carboxyl-terminal site of peptides | |
| RU2720989C9 (ru) | Способ получения нового азотсодержащего соединения или его соли и получение его промежуточного соединения | |
| EP0692977A1 (en) | Novel heterocycle based nitrogen-sulfur ligands useful in radiographic imaging agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |