IL100921A - 9-Aminotetra - hydroacridinediols and related compounds process for their preparation intermediates therefor and pharmaceutical compositions containging them - Google Patents

9-Aminotetra - hydroacridinediols and related compounds process for their preparation intermediates therefor and pharmaceutical compositions containging them

Info

Publication number
IL100921A
IL100921A IL10092192A IL10092192A IL100921A IL 100921 A IL100921 A IL 100921A IL 10092192 A IL10092192 A IL 10092192A IL 10092192 A IL10092192 A IL 10092192A IL 100921 A IL100921 A IL 100921A
Authority
IL
Israel
Prior art keywords
hydrogen
compound
formula
loweralkyl
amino
Prior art date
Application number
IL10092192A
Other languages
English (en)
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Priority to IL117795A priority Critical patent/IL117795A/en
Priority to IL11779596A priority patent/IL117795A0/xx
Publication of IL100921A publication Critical patent/IL100921A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL10092192A 1991-02-13 1992-02-11 9-Aminotetra - hydroacridinediols and related compounds process for their preparation intermediates therefor and pharmaceutical compositions containging them IL100921A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL117795A IL117795A (en) 1991-02-13 1992-02-11 6, 7-dihydro-3-(2-nitrophenyl) 1, 2-benzisoxazole-4(5h)-ones and pharmaceutically acceptable addition salts thereof
IL11779596A IL117795A0 (en) 1991-02-13 1996-04-02 Dihydrobenzisoxazolines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/654,691 US5210087A (en) 1991-02-13 1991-02-13 9-aminotetrahydroacridines and related compounds

Publications (1)

Publication Number Publication Date
IL100921A true IL100921A (en) 1998-12-27

Family

ID=24625869

Family Applications (3)

Application Number Title Priority Date Filing Date
IL10092192A IL100921A (en) 1991-02-13 1992-02-11 9-Aminotetra - hydroacridinediols and related compounds process for their preparation intermediates therefor and pharmaceutical compositions containging them
IL117795A IL117795A (en) 1991-02-13 1992-02-11 6, 7-dihydro-3-(2-nitrophenyl) 1, 2-benzisoxazole-4(5h)-ones and pharmaceutically acceptable addition salts thereof
IL11779596A IL117795A0 (en) 1991-02-13 1996-04-02 Dihydrobenzisoxazolines

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL117795A IL117795A (en) 1991-02-13 1992-02-11 6, 7-dihydro-3-(2-nitrophenyl) 1, 2-benzisoxazole-4(5h)-ones and pharmaceutically acceptable addition salts thereof
IL11779596A IL117795A0 (en) 1991-02-13 1996-04-02 Dihydrobenzisoxazolines

Country Status (25)

Country Link
US (3) US5210087A (de)
EP (1) EP0499231B1 (de)
JP (1) JPH07121915B2 (de)
KR (1) KR100223132B1 (de)
AT (1) ATE153331T1 (de)
AU (1) AU664165B2 (de)
BR (1) BR9200475A (de)
CA (1) CA2061084A1 (de)
CZ (1) CZ281927B6 (de)
DE (1) DE69219801T2 (de)
DK (1) DK0499231T3 (de)
ES (1) ES2102417T3 (de)
FI (2) FI96308C (de)
GR (1) GR3024310T3 (de)
HU (1) HU219451B (de)
IE (1) IE920459A1 (de)
IL (3) IL100921A (de)
MX (1) MX9200607A (de)
NO (1) NO177933C (de)
NZ (3) NZ270647A (de)
PL (6) PL168862B1 (de)
RO (1) RO112354B1 (de)
RU (1) RU2083564C1 (de)
TW (1) TW221426B (de)
ZA (1) ZA921004B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210087A (en) * 1991-02-13 1993-05-11 Hoechst-Roussel Pharmaceuticals Inc. 9-aminotetrahydroacridines and related compounds
GB2264707A (en) * 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease
ES2059263B1 (es) * 1992-10-27 1995-10-01 Vita Invest Sa Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol.
US5434170A (en) * 1993-12-23 1995-07-18 Andrulis Pharmaceuticals Corp. Method for treating neurocognitive disorders
ES2144353B1 (es) * 1997-12-26 2001-01-01 Consejo Superior Investigacion Nuevos analogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. su procedimiento de obtencion.
DE19830105C1 (de) * 1998-07-06 2000-02-17 Gruenenthal Gmbh Acridinderivate
WO2003076419A1 (en) * 2002-03-08 2003-09-18 Japan Science And Technology Agency Isoxazole derivatives and process for producing the same
RU2616247C1 (ru) * 2016-03-28 2017-04-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Осетинский государственный университет имени Коста Левановича Хетагурова" (СОГУ) Твердая лекарственная форма, обладающая холинопозитивным действием, на основе 9-бутиламино-3,3-диметил-1,2,4-тригидроакридина

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232945A (en) * 1962-08-13 1966-02-01 S E Massengill Company 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
EP0179383B1 (de) * 1984-10-25 1991-05-29 Hoechst-Roussel Pharmaceuticals Incorporated 9-Amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte Verbindungen, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
MX13270A (es) * 1987-10-05 1993-06-01 Pfizer Procedimiento para la preparacion de derivados de 4-aminopiridina
GB8827704D0 (en) * 1988-11-28 1988-12-29 Fujisawa Pharmaceutical Co New acridine derivatives & processes for their production
US5441727A (en) * 1989-06-21 1995-08-15 The Procter & Gamble Company Diketone deodorant composition and method of deodorization
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
US5210087A (en) * 1991-02-13 1993-05-11 Hoechst-Roussel Pharmaceuticals Inc. 9-aminotetrahydroacridines and related compounds
GB2264707A (en) * 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease

Also Published As

Publication number Publication date
PL168153B1 (pl) 1996-01-31
US5382594A (en) 1995-01-17
PL293443A1 (en) 1993-03-08
AU1090392A (en) 1992-08-20
FI97056C (fi) 1996-10-10
NZ270647A (en) 1996-02-27
IE920459A1 (en) 1992-08-12
HU219451B (hu) 2001-04-28
DE69219801D1 (de) 1997-06-26
KR920016426A (ko) 1992-09-24
FI945854L (fi) 1994-12-13
NZ260694A (en) 1996-02-27
PL166939B1 (pl) 1995-07-31
IL117795A (en) 1998-01-04
RO112354B1 (ro) 1997-08-29
CS42692A3 (en) 1992-09-16
PL296320A1 (en) 1993-07-12
JPH04312578A (ja) 1992-11-04
HU9200423D0 (en) 1992-04-28
ZA921004B (en) 1992-10-28
FI96308B (fi) 1996-02-29
GR3024310T3 (en) 1997-10-31
ES2102417T3 (es) 1997-08-01
FI96308C (fi) 1996-06-10
NO920547L (no) 1992-08-14
PL168906B1 (pl) 1996-05-31
HUT67032A (en) 1995-01-30
DK0499231T3 (da) 1997-12-01
CZ281927B6 (cs) 1997-04-16
NZ241586A (en) 1996-02-27
BR9200475A (pt) 1992-10-20
US5210087A (en) 1993-05-11
FI920566A0 (fi) 1992-02-11
FI97056B (fi) 1996-06-28
FI920566L (fi) 1992-08-14
DE69219801T2 (de) 1997-11-27
KR100223132B1 (ko) 1999-10-15
PL168861B1 (pl) 1996-04-30
FI945854A0 (fi) 1994-12-13
NO177933C (no) 1995-12-20
PL169095B1 (pl) 1996-05-31
ATE153331T1 (de) 1997-06-15
NO920547D0 (no) 1992-02-12
CA2061084A1 (en) 1992-08-14
AU664165B2 (en) 1995-11-09
RU2083564C1 (ru) 1997-07-10
EP0499231A1 (de) 1992-08-19
EP0499231B1 (de) 1997-05-21
PL168862B1 (pl) 1996-04-30
MX9200607A (es) 1992-11-30
JPH07121915B2 (ja) 1995-12-25
TW221426B (de) 1994-03-01
NO177933B (no) 1995-09-11
US5502203A (en) 1996-03-26
PL296319A1 (en) 1993-07-12
IL117795A0 (en) 1996-08-04

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees