IL101009A0 - 2-substituted quinolines,preparation and pharmaceutical compositions containing them - Google Patents

2-substituted quinolines,preparation and pharmaceutical compositions containing them

Info

Publication number
IL101009A0
IL101009A0 IL101009A IL10100992A IL101009A0 IL 101009 A0 IL101009 A0 IL 101009A0 IL 101009 A IL101009 A IL 101009A IL 10100992 A IL10100992 A IL 10100992A IL 101009 A0 IL101009 A0 IL 101009A0
Authority
IL
Israel
Prior art keywords
substituted
preparation
substituted quinolines
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL101009A
Other versions
IL101009A (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL101009A0 publication Critical patent/IL101009A0/en
Publication of IL101009A publication Critical patent/IL101009A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Electrically Operated Instructional Devices (AREA)
  • Earth Drilling (AREA)

Abstract

2-substituted quinolines of the general formula <IMAGE> The title compounds are prepared by reacting either the corresponding halomethylquinolines with substituted phenols, then optionally alkylating these and hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivatives with sulphonamides. The novel phenyl-substituted quinolines can be used as active compounds in medicaments, in particular as lipoxygenase inhibitors.
IL10100992A 1991-02-22 1992-02-19 2-substituted quinolines their preparation and pharmaceutical compositions containing them IL101009A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4105551A DE4105551A1 (en) 1991-02-22 1991-02-22 2-SUBSTITUTED CHINOLINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
IL101009A0 true IL101009A0 (en) 1992-11-15
IL101009A IL101009A (en) 1996-08-04

Family

ID=6425643

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10100992A IL101009A (en) 1991-02-22 1992-02-19 2-substituted quinolines their preparation and pharmaceutical compositions containing them

Country Status (20)

Country Link
EP (1) EP0499926B1 (en)
JP (1) JPH0592957A (en)
KR (1) KR920016424A (en)
AT (1) ATE142623T1 (en)
AU (1) AU641585B2 (en)
CZ (1) CZ282723B6 (en)
DE (2) DE4105551A1 (en)
DK (1) DK0499926T3 (en)
ES (1) ES2091958T3 (en)
FI (1) FI920732A7 (en)
GR (1) GR3021014T3 (en)
HU (1) HUT67037A (en)
IE (1) IE75728B1 (en)
IL (1) IL101009A (en)
MY (1) MY108459A (en)
NZ (1) NZ241654A (en)
PL (2) PL170726B1 (en)
RU (1) RU2077532C1 (en)
TW (1) TW200463B (en)
ZA (1) ZA921268B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304563A (en) * 1991-02-22 1994-04-19 Bayer Aktiengesellschaft 2-substituted quinolines, and their use in medicaments
DE4226649A1 (en) * 1992-08-12 1994-02-17 Bayer Ag New isobutyl-substituted methanesulfonyl-quinolylmethoxyphenyl-cycloalkylacetic acid aminols
DE4112533A1 (en) * 1991-04-17 1992-10-22 Bayer Ag METHOD FOR THE PRODUCTION OF ENANTIOMER-PURE SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL ACETIC ACIDS
US5391555A (en) * 1991-11-12 1995-02-21 Miles Inc. Methods for treating inflammatory bowel disease with leukotriene synthesis inhibitors
TW232013B (en) * 1992-04-24 1994-10-11 Takeda Pharm Industry Co Ltd
DE4219765A1 (en) * 1992-06-17 1993-12-23 Bayer Ag Substituted (benzothiazolyl and quinoxalyl-methoxy) phenylacetic acid derivatives
DE4301900A1 (en) * 1993-01-25 1994-07-28 Bayer Ag 2-oxoquinoline-1-yl-methylphenylessigsäurederivate
ES2061406B1 (en) * 1993-05-07 1995-06-01 Uriach & Cia Sa J NEW DERIVATIVES OF 2- (QUINOLINE) WITH PHARMACOLOGICAL ACTIVITY.
US5491172A (en) * 1993-05-14 1996-02-13 Warner-Lambert Company N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
IL109431A (en) * 1993-05-14 2001-01-11 Warner Lambert Co Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
EP0634169B1 (en) * 1993-06-29 2000-01-05 Takeda Chemical Industries, Ltd. Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis
DE4443892A1 (en) * 1994-12-09 1996-06-13 Bayer Ag 4- (Quinolin-2-yl-methoxy) phenyl acetic acid derivatives
DE4443891A1 (en) 1994-12-09 1996-06-13 Bayer Ag Heterocyclically substituted oxy-phenyl- (phenyl) glycinolamides
MY123337A (en) * 1998-05-11 2006-05-31 Takeda Chemical Industries Ltd Oxyiminoalkanoic acid derivatives.
GB9818641D0 (en) * 1998-08-26 1998-10-21 Rh Ne Poulenc Rorer Limited Chemical compounds
IL145922A0 (en) * 1999-04-28 2002-07-25 Aventis Pharma Gmbh Di-aryl acid derivatives as ppar receptor ligands
RU2177317C1 (en) * 2000-10-24 2001-12-27 Московский научно-исследовательский институт медицинской экологии (МНИИМЭ) Quinoline derivatives for correction of hemostasis system, pharmaceutical composition, agent for hemostasis correction
TWI309644B (en) * 2001-02-14 2009-05-11 Nissan Chemical Ind Ltd
US6867320B2 (en) 2002-02-21 2005-03-15 Asahi Kasei Pharma Corporation Substituted phenylalkanoic acid derivatives and use thereof
PE20050676A1 (en) 2003-12-12 2005-11-02 Wyeth Corp QUINOLINES REFERRED TO CARDIOVASCULAR DISEASES
MX2007004465A (en) * 2004-10-19 2007-05-07 Hoffmann La Roche Quinoline derivatives.
PT2125786E (en) * 2006-12-21 2011-04-21 Pfizer Prod Inc Succinate salt of 2-((4-(1-methyl-4-(pyridin-4-yl)-1h-pyrazol-3-yl) phenoxy)methyl)quinoline

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3814504A1 (en) * 1988-04-29 1989-11-09 Bayer Ag (ALPHA) -SUBSTITUTED 4- (CHINOLIN-2-YL-METHOXY) PHENYL ACETIC ACIDS AND SITES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICAMENTS
DE3900261A1 (en) * 1988-05-31 1989-12-07 Bayer Ag SUBSTITUTED 4- (CHINOLIN-2-YL-METHOXY) PHENYL-ACETIC ACID DERIVATIVES
DE3908298A1 (en) * 1989-03-14 1990-09-20 Bayer Ag SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL-N, N'-SULFONYL HARVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS
DE3916663A1 (en) * 1989-05-23 1990-11-29 Bayer Ag SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL-ACYL-SULPHONAMIDES AND CYANAMIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS
DE3927931A1 (en) * 1989-08-24 1991-02-28 Bayer Ag DISUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL ACETIC DERIVATIVES
DE3927930A1 (en) * 1989-08-24 1991-02-28 Bayer Ag CYCLIC SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL-VINEGAR-ACID DERIVATIVES

Also Published As

Publication number Publication date
ATE142623T1 (en) 1996-09-15
PL171026B1 (en) 1997-02-28
EP0499926A1 (en) 1992-08-26
DK0499926T3 (en) 1997-02-10
MY108459A (en) 1996-09-30
IE75728B1 (en) 1997-09-24
CZ282723B6 (en) 1997-09-17
HUT67037A (en) 1995-01-30
EP0499926B1 (en) 1996-09-11
ZA921268B (en) 1992-11-25
FI920732L (en) 1992-08-23
CS51492A3 (en) 1992-12-16
PL293534A1 (en) 1992-10-05
KR920016424A (en) 1992-09-24
DE4105551A1 (en) 1992-08-27
AU641585B2 (en) 1993-09-23
ES2091958T3 (en) 1996-11-16
NZ241654A (en) 1994-11-25
JPH0592957A (en) 1993-04-16
IE920557A1 (en) 1992-08-26
IL101009A (en) 1996-08-04
TW200463B (en) 1993-02-21
GR3021014T3 (en) 1996-12-31
PL170726B1 (en) 1997-01-31
HU9200582D0 (en) 1992-05-28
FI920732A0 (en) 1992-02-20
FI920732A7 (en) 1992-08-23
RU2077532C1 (en) 1997-04-20
DE59207074D1 (en) 1996-10-17
AU1054292A (en) 1992-08-27

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Legal Events

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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees