MY108459A - 2-substituted quinolines, processes for their preparation and their use in medicaments - Google Patents

2-substituted quinolines, processes for their preparation and their use in medicaments

Info

Publication number
MY108459A
MY108459A MYPI92000276A MYPI19920276A MY108459A MY 108459 A MY108459 A MY 108459A MY PI92000276 A MYPI92000276 A MY PI92000276A MY PI19920276 A MYPI19920276 A MY PI19920276A MY 108459 A MY108459 A MY 108459A
Authority
MY
Malaysia
Prior art keywords
medicaments
substituted
processes
preparation
substituted quinolines
Prior art date
Application number
MYPI92000276A
Inventor
Klaus-Helmut Mohrs Dr
Pia Theisen-Popp Dr
Michael Matzke Dr
Christian Kohlsdorfer Dr
Dr Reiner Muller-Peddinghaus Prof
Fruchtmann Romanis
Arminhatzelmann Dr
Siegfried Raddatz Dr
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MY108459A publication Critical patent/MY108459A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Electrically Operated Instructional Devices (AREA)
  • Earth Drilling (AREA)

Abstract

THE TITLE COMPOUNDS ARE PREPARED EITHER BY REACTING THE CORRESPONDING HALOGENOMETHYLQUINOLINES WITH SUBSTITUTED PHENOLS, OPTIONALLY SUBSEQUENTLY ALKYLATING THESE OR HYDROLYSING ESTERS TO ACIDS, OR BY REACTING PHENYL-SUBSTITUTED QUINOLINECARBOXYLIC ACID DERIVATIVES WITH SULPHONAMIDES. THE NEW PHENYL-SUBSTITUTED QUINOLINES ARE UTILISABLE AS ACTIVE SUBSTANCES IN MEDICAMENTS, IN PARTICULAR AS LIPOXYGENASE INHIBITORS.
MYPI92000276A 1991-02-22 1992-02-20 2-substituted quinolines, processes for their preparation and their use in medicaments MY108459A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4105551A DE4105551A1 (en) 1991-02-22 1991-02-22 2-SUBSTITUTED CHINOLINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
MY108459A true MY108459A (en) 1996-09-30

Family

ID=6425643

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI92000276A MY108459A (en) 1991-02-22 1992-02-20 2-substituted quinolines, processes for their preparation and their use in medicaments

Country Status (20)

Country Link
EP (1) EP0499926B1 (en)
JP (1) JPH0592957A (en)
KR (1) KR920016424A (en)
AT (1) ATE142623T1 (en)
AU (1) AU641585B2 (en)
CZ (1) CZ282723B6 (en)
DE (2) DE4105551A1 (en)
DK (1) DK0499926T3 (en)
ES (1) ES2091958T3 (en)
FI (1) FI920732A7 (en)
GR (1) GR3021014T3 (en)
HU (1) HUT67037A (en)
IE (1) IE75728B1 (en)
IL (1) IL101009A (en)
MY (1) MY108459A (en)
NZ (1) NZ241654A (en)
PL (2) PL170726B1 (en)
RU (1) RU2077532C1 (en)
TW (1) TW200463B (en)
ZA (1) ZA921268B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4226649A1 (en) * 1992-08-12 1994-02-17 Bayer Ag New isobutyl-substituted methanesulfonyl-quinolylmethoxyphenyl-cycloalkylacetic acid aminols
US5304563A (en) * 1991-02-22 1994-04-19 Bayer Aktiengesellschaft 2-substituted quinolines, and their use in medicaments
DE4112533A1 (en) * 1991-04-17 1992-10-22 Bayer Ag METHOD FOR THE PRODUCTION OF ENANTIOMER-PURE SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL ACETIC ACIDS
US5391555A (en) * 1991-11-12 1995-02-21 Miles Inc. Methods for treating inflammatory bowel disease with leukotriene synthesis inhibitors
TW232013B (en) * 1992-04-24 1994-10-11 Takeda Pharm Industry Co Ltd
DE4219765A1 (en) * 1992-06-17 1993-12-23 Bayer Ag Substituted (benzothiazolyl and quinoxalyl-methoxy) phenylacetic acid derivatives
DE4301900A1 (en) * 1993-01-25 1994-07-28 Bayer Ag 2-oxoquinoline-1-yl-methylphenylessigsäurederivate
ES2061406B1 (en) * 1993-05-07 1995-06-01 Uriach & Cia Sa J NEW DERIVATIVES OF 2- (QUINOLINE) WITH PHARMACOLOGICAL ACTIVITY.
US5491172A (en) * 1993-05-14 1996-02-13 Warner-Lambert Company N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
IL109431A (en) * 1993-05-14 2001-01-11 Warner Lambert Co Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
ATE188377T1 (en) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd QUINOLINES OR QUINAZOLINE DERIVATIVES AND THE USE THEREOF IN THE PRODUCTION OF A MEDICATION FOR THE TREATMENT OF OSTEOPOROSIS
DE4443891A1 (en) 1994-12-09 1996-06-13 Bayer Ag Heterocyclically substituted oxy-phenyl- (phenyl) glycinolamides
DE4443892A1 (en) * 1994-12-09 1996-06-13 Bayer Ag 4- (Quinolin-2-yl-methoxy) phenyl acetic acid derivatives
HUP0103714A3 (en) * 1998-05-11 2003-05-28 Takeda Pharmaceutical Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity, medicaments containing them and their use
GB9818641D0 (en) * 1998-08-26 1998-10-21 Rh Ne Poulenc Rorer Limited Chemical compounds
YU72201A (en) * 1999-04-28 2005-07-19 Aventis Pharma Deutschland Gmbh. Di-aryl acid derivatives as ppar receptor ligands
RU2177317C1 (en) * 2000-10-24 2001-12-27 Московский научно-исследовательский институт медицинской экологии (МНИИМЭ) Quinoline derivatives for correction of hemostasis system, pharmaceutical composition, agent for hemostasis correction
TWI309644B (en) * 2001-02-14 2009-05-11 Nissan Chemical Ind Ltd
US6867320B2 (en) 2002-02-21 2005-03-15 Asahi Kasei Pharma Corporation Substituted phenylalkanoic acid derivatives and use thereof
AU2004298486A1 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease
MX2007004465A (en) * 2004-10-19 2007-05-07 Hoffmann La Roche Quinoline derivatives.
KR20090092338A (en) * 2006-12-21 2009-08-31 화이자 프로덕츠 인크. Succinate salt of 2-((4-(1-methyl-4-(pyridin-4-yl)-1h-pyrazol-3-yl)phenoxy)methyl)quinoline

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3814504A1 (en) * 1988-04-29 1989-11-09 Bayer Ag (ALPHA) -SUBSTITUTED 4- (CHINOLIN-2-YL-METHOXY) PHENYL ACETIC ACIDS AND SITES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICAMENTS
DE3900261A1 (en) * 1988-05-31 1989-12-07 Bayer Ag SUBSTITUTED 4- (CHINOLIN-2-YL-METHOXY) PHENYL-ACETIC ACID DERIVATIVES
DE3908298A1 (en) * 1989-03-14 1990-09-20 Bayer Ag SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL-N, N'-SULFONYL HARVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS
DE3916663A1 (en) * 1989-05-23 1990-11-29 Bayer Ag SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL-ACYL-SULPHONAMIDES AND CYANAMIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS
DE3927930A1 (en) * 1989-08-24 1991-02-28 Bayer Ag CYCLIC SUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL-VINEGAR-ACID DERIVATIVES
DE3927931A1 (en) * 1989-08-24 1991-02-28 Bayer Ag DISUBSTITUTED (CHINOLIN-2-YL-METHOXY) PHENYL ACETIC DERIVATIVES

Also Published As

Publication number Publication date
AU641585B2 (en) 1993-09-23
IL101009A (en) 1996-08-04
TW200463B (en) 1993-02-21
FI920732L (en) 1992-08-23
AU1054292A (en) 1992-08-27
ATE142623T1 (en) 1996-09-15
PL171026B1 (en) 1997-02-28
ZA921268B (en) 1992-11-25
IE920557A1 (en) 1992-08-26
GR3021014T3 (en) 1996-12-31
JPH0592957A (en) 1993-04-16
CS51492A3 (en) 1992-12-16
IE75728B1 (en) 1997-09-24
FI920732A7 (en) 1992-08-23
DK0499926T3 (en) 1997-02-10
IL101009A0 (en) 1992-11-15
PL293534A1 (en) 1992-10-05
FI920732A0 (en) 1992-02-20
RU2077532C1 (en) 1997-04-20
CZ282723B6 (en) 1997-09-17
HUT67037A (en) 1995-01-30
HU9200582D0 (en) 1992-05-28
DE59207074D1 (en) 1996-10-17
EP0499926A1 (en) 1992-08-26
DE4105551A1 (en) 1992-08-27
KR920016424A (en) 1992-09-24
PL170726B1 (en) 1997-01-31
ES2091958T3 (en) 1996-11-16
NZ241654A (en) 1994-11-25
EP0499926B1 (en) 1996-09-11

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