IL101074A - GnRH ANALOGS AND THEIR PREPARATION - Google Patents

GnRH ANALOGS AND THEIR PREPARATION

Info

Publication number: IL101074A
Authority: IL; Israel
Prior art keywords: unnatural amino; peptides; preparation; inhibit; synthesis
Prior art date: 1991-03-14

Application number

IL101074A

Other languages

English (en)

Other versions

IL101074A0 (en

Inventor

Carl A Hoeger

Jean Edouard Frederic Rivier

Paula Guess Theobald

John S Porter

Catherine Laure Rivier

Wylie Walker Vale Jr

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-14

Filing date

1992-02-26

Publication date

1997-09-30

1992-02-26 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1992-02-26 Priority to IL11865992A priority Critical patent/IL118659A/xx

1992-11-15 Publication of IL101074A0 publication Critical patent/IL101074A0/xx

1997-09-30 Publication of IL101074A publication Critical patent/IL101074A/xx

Links

NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical class C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 title abstract 2
150000001413 amino acids Chemical class 0.000 abstract 4
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
102000004196 processed proteins & peptides Human genes 0.000 abstract 3
230000015572 biosynthetic process Effects 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
102000006771 Gonadotropins Human genes 0.000 abstract 1
108010086677 Gonadotropins Proteins 0.000 abstract 1
206010062767 Hypophysitis Diseases 0.000 abstract 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
-1 cyanoguanidino group Chemical group 0.000 abstract 1
210000002149 gonad Anatomy 0.000 abstract 1
239000002622 gonadotropin Substances 0.000 abstract 1
229940094892 gonadotropins Drugs 0.000 abstract 1
210000003635 pituitary gland Anatomy 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Radar Systems Or Details Thereof (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Optical Radar Systems And Details Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL101074A 1991-03-14 1992-02-26 GnRH ANALOGS AND THEIR PREPARATION IL101074A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL11865992A IL118659A (en)	1991-03-14	1992-02-26	Unnatural amino acids

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US66969591A	1991-03-14	1991-03-14

Publications (2)

Publication Number	Publication Date
IL101074A0 IL101074A0 (en)	1992-11-15
IL101074A true IL101074A (en)	1997-09-30

Family

ID=24687346

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL101074A IL101074A (en)	1991-03-14	1992-02-26	GnRH ANALOGS AND THEIR PREPARATION

Country Status (14)

Country	Link
EP (1)	EP0575490B1 (de)
JP (2)	JP2522628B2 (de)
KR (1)	KR0123009B1 (de)
AT (1)	ATE182899T1 (de)
AU (1)	AU664989B2 (de)
CA (1)	CA2101316C (de)
DE (1)	DE69229722T2 (de)
ES (1)	ES2137945T3 (de)
IE (1)	IE74226B1 (de)
IL (1)	IL101074A (de)
NZ (1)	NZ241755A (de)
PT (1)	PT100246B (de)
WO (1)	WO1992017025A2 (de)
ZA (1)	ZA921559B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5352796A (en) *	1989-10-30	1994-10-04	The Salk Institute For Biological Studies	Amino acids useful in making GnRH analogs
US5502035A (en) *	1993-08-06	1996-03-26	Tap Holdings Inc.	N-terminus modified analogs of LHRH
US5413990A (en) *	1993-08-06	1995-05-09	Tap Pharmaceuticals Inc.	N-terminus modified analogs of LHRH
US5506207A (en) *	1994-03-18	1996-04-09	The Salk Institute For Biological Studies	GNRH antagonists XIII
US5843901A (en) *	1995-06-07	1998-12-01	Advanced Research & Technology Institute	LHRH antagonist peptides
DE19544212A1 (de) *	1995-11-28	1997-06-05	Asta Medica Ag	Neue LH-RH-Antagonisten mit verbesserter Wirkung
US6077840A (en) *	1996-12-18	2000-06-20	Meiji Seika Kaisha, Ltd.	Tetrahydrobenzindolone derivatives
US5821230A (en) *	1997-04-11	1998-10-13	Ferring Bv	GnRH antagonist decapeptides
US5977302A (en) *	1997-11-20	1999-11-02	Ortho-Mcneil Pharmaceutical, Inc.	Liquid phase process for the preparation of GnRH peptides
CN100500692C (zh)	2000-03-14	2009-06-17	赞塔里斯有限公司	新型lhrh拮抗剂,其制备方法和药物用途
MX2012006877A (es)	2009-12-18	2012-08-31	Idenix Pharmaceuticals Inc	Inhibidores de virus de hepatitis c de arileno o heteroarileno 5, 5 - fusionado.
US10450343B2 (en)	2013-03-21	2019-10-22	Sanofi-Aventis Deutschland Gmbh	Synthesis of cyclic imide containing peptide products
CA2907454C (en)	2013-03-21	2021-05-04	Sanofi-Aventis Deutschland Gmbh	Synthesis of hydantoin containing peptide products
DE102015200585A1 (de) *	2015-01-15	2016-07-21	Sms Group Gmbh	Verfahren und System zum Betrieb einer hüttentechnischen Anlage

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4234571A (en) *	1979-06-11	1980-11-18	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
US4667014A (en) *	1983-03-07	1987-05-19	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4677193A (en) *	1985-02-22	1987-06-30	The Salk Institute For Biological Studies	Peptides containing an aliphatic-aromatic ketone side chain
US4801577A (en) *	1987-02-05	1989-01-31	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
JPS63233963A (ja) *	1987-03-24	1988-09-29	Showa Denko Kk	フエニルアラニン誘導体および蛋白分解酵素阻害剤
US5169932A (en) *	1989-10-30	1992-12-08	The Salk Institute For Biological Studies	Gnrh analogs

1992
- 1992-02-26 IL IL101074A patent/IL101074A/xx not_active IP Right Cessation
- 1992-02-27 NZ NZ241755A patent/NZ241755A/xx unknown
- 1992-03-02 ZA ZA921559A patent/ZA921559B/xx unknown
- 1992-03-11 AT AT92908108T patent/ATE182899T1/de not_active IP Right Cessation
- 1992-03-11 AU AU15882/92A patent/AU664989B2/en not_active Ceased
- 1992-03-11 CA CA002101316A patent/CA2101316C/en not_active Expired - Fee Related
- 1992-03-11 EP EP92908108A patent/EP0575490B1/de not_active Expired - Lifetime
- 1992-03-11 KR KR1019930702730A patent/KR0123009B1/ko not_active Expired - Fee Related
- 1992-03-11 ES ES92908108T patent/ES2137945T3/es not_active Expired - Lifetime
- 1992-03-11 DE DE69229722T patent/DE69229722T2/de not_active Expired - Fee Related
- 1992-03-11 WO PCT/US1992/001921 patent/WO1992017025A2/en not_active Ceased
- 1992-03-11 JP JP4508317A patent/JP2522628B2/ja not_active Expired - Lifetime
- 1992-03-13 PT PT100246A patent/PT100246B/pt not_active IP Right Cessation
- 1992-03-13 IE IE920825A patent/IE74226B1/en not_active IP Right Cessation
1995
- 1995-12-12 JP JP32332595A patent/JP3222050B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69229722T2 (de)	2000-02-17
JPH08277253A (ja)	1996-10-22
JP3222050B2 (ja)	2001-10-22
WO1992017025A3 (en)	1992-12-10
ES2137945T3 (es)	2000-01-01
ATE182899T1 (de)	1999-08-15
IE74226B1 (en)	1997-07-16
NZ241755A (en)	1993-06-25
JP2522628B2 (ja)	1996-08-07
CA2101316C (en)	2001-02-27
ZA921559B (en)	1992-11-25
JPH06505751A (ja)	1994-06-30
AU664989B2 (en)	1995-12-14
PT100246B (pt)	1999-06-30
IL101074A0 (en)	1992-11-15
AU1588292A (en)	1992-10-21
KR0123009B1 (ko)	1997-11-24
WO1992017025A2 (en)	1992-10-01
EP0575490B1 (de)	1999-08-04
EP0575490A1 (de)	1993-12-29
CA2101316A1 (en)	1992-09-15
DE69229722D1 (de)	1999-09-09
IE920825A1 (en)	1992-09-23
PT100246A (pt)	1993-07-30

Legal Events

Date	Code	Title
1998-03-10	FF	Patent granted
1998-08-16	KB	Patent renewed
2005-07-25	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
ZA944345B (en)	1995-04-03	Amino acids useful in making GnRH analogs
IL101074A0 (en)	1992-11-15	Gnrh analogs and their preparation
ES524370A0 (es)	1985-05-16	Un metodo de preparar un peptido que inhibe la liberacion de gonadotropinas por la glandula pituitaria en mamiferos
KR970701730A (ko)	1997-04-12	GnRH 길항물질(GNRH ANTAGONISTS)
CA2014590A1 (en)	1990-10-15	Novel peptides, and antidementia agents containing the same
EP0751148A3 (de)	1997-07-02	D-Aminosäure Substituierungsanaloge von Magaininpeptiden
GR852541B (de)	1986-02-18
EP0297456A3 (de)	1990-09-26	Immunsuppressive Peptide
ATE31314T1 (de)	1987-12-15	Cyclische peptide mit somatostatin-wirkung.
SE8703855L (sv)	1989-04-08	Vasoaktiva peptider
DE3361937D1 (en)	1986-03-06	Peptides