IL101660A - Pharmaceutical preparation for the treatment of the immune system - Google Patents

Pharmaceutical preparation for the treatment of the immune system

Info

Publication number: IL101660A
Authority: IL; Israel
Prior art keywords: treatment; autoimmune diseases; pharmaceutical composition; formula; compound
Prior art date: 1991-04-22

Application number

IL10166092A

Other languages

English (en)

Hebrew (he)

Original Assignee

Angelini Ricerche Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-22

Filing date

1992-04-21

Publication date

1996-08-04

1992-04-21 Application filed by Angelini Ricerche Spa filed Critical Angelini Ricerche Spa

1996-08-04 Publication of IL101660A publication Critical patent/IL101660A/en

Links

208000023275 Autoimmune disease Diseases 0.000 title claims abstract description 24
239000008194 pharmaceutical composition Substances 0.000 title claims description 18
150000001875 compounds Chemical class 0.000 claims abstract description 17
125000000217 alkyl group Chemical group 0.000 claims abstract description 8
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 8
150000003839 salts Chemical class 0.000 claims abstract description 8
239000002552 dosage form Substances 0.000 claims description 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
239000008174 sterile solution Substances 0.000 claims description 3
230000009885 systemic effect Effects 0.000 claims 1
239000003814 drug Substances 0.000 abstract description 12
-1 1-benzyl-indazol-3-yl Chemical group 0.000 abstract description 2
238000004519 manufacturing process Methods 0.000 abstract description 2
230000001225 therapeutic effect Effects 0.000 abstract description 2
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 16
230000000694 effects Effects 0.000 description 12
229940079593 drug Drugs 0.000 description 11
238000002560 therapeutic procedure Methods 0.000 description 10
229960005149 bendazac Drugs 0.000 description 8
BYFMCKSPFYVMOU-UHFFFAOYSA-N bendazac Chemical compound C12=CC=CC=C2C(OCC(=O)O)=NN1CC1=CC=CC=C1 BYFMCKSPFYVMOU-UHFFFAOYSA-N 0.000 description 8
229960000905 indomethacin Drugs 0.000 description 8
238000000540 analysis of variance Methods 0.000 description 7
210000004369 blood Anatomy 0.000 description 6
239000008280 blood Substances 0.000 description 6
201000010099 disease Diseases 0.000 description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
208000009386 Experimental Arthritis Diseases 0.000 description 5
241000700159 Rattus Species 0.000 description 5
230000002917 arthritic effect Effects 0.000 description 5
230000037396 body weight Effects 0.000 description 5
235000005911 diet Nutrition 0.000 description 5
230000037213 diet Effects 0.000 description 5
229960002895 phenylbutazone Drugs 0.000 description 5
VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 5
238000012360 testing method Methods 0.000 description 5
239000002671 adjuvant Substances 0.000 description 4
230000003110 anti-inflammatory effect Effects 0.000 description 4
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
239000010931 gold Substances 0.000 description 4
229910052737 gold Inorganic materials 0.000 description 4
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 4
206010039073 rheumatoid arthritis Diseases 0.000 description 4
102000009027 Albumins Human genes 0.000 description 3
108010088751 Albumins Proteins 0.000 description 3
206010061218 Inflammation Diseases 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
102000007562 Serum Albumin Human genes 0.000 description 3
108010071390 Serum Albumin Proteins 0.000 description 3
206010003246 arthritis Diseases 0.000 description 3
230000001363 autoimmune Effects 0.000 description 3
210000003743 erythrocyte Anatomy 0.000 description 3
239000003018 immunosuppressive agent Substances 0.000 description 3
230000004054 inflammatory process Effects 0.000 description 3
238000000034 method Methods 0.000 description 3
238000004062 sedimentation Methods 0.000 description 3
239000003826 tablet Substances 0.000 description 3
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
102000004506 Blood Proteins Human genes 0.000 description 2
108010017384 Blood Proteins Proteins 0.000 description 2
206010018364 Glomerulonephritis Diseases 0.000 description 2
208000030836 Hashimoto thyroiditis Diseases 0.000 description 2
208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 2
229960001138 acetylsalicylic acid Drugs 0.000 description 2
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 2
239000000872 buffer Substances 0.000 description 2
150000002344 gold compounds Chemical class 0.000 description 2
230000035876 healing Effects 0.000 description 2
229960000890 hydrocortisone Drugs 0.000 description 2
230000001939 inductive effect Effects 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 2
206010028417 myasthenia gravis Diseases 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
201000000596 systemic lupus erythematosus Diseases 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 1
RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 description 1
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 description 1
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 description 1
208000019838 Blood disease Diseases 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
239000004150 EU approved colour Substances 0.000 description 1
206010018691 Granuloma Diseases 0.000 description 1
208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 1
208000037319 Hepatitis infectious Diseases 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
206010030113 Oedema Diseases 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
206010037660 Pyrexia Diseases 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
241000219289 Silene Species 0.000 description 1
210000001744 T-lymphocyte Anatomy 0.000 description 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
229960000212 aminophenazone Drugs 0.000 description 1
230000000202 analgesic effect Effects 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
230000001078 anti-cholinergic effect Effects 0.000 description 1
230000001754 anti-pyretic effect Effects 0.000 description 1
230000001147 anti-toxic effect Effects 0.000 description 1
229940124347 antiarthritic drug Drugs 0.000 description 1
229940114079 arachidonic acid Drugs 0.000 description 1
235000021342 arachidonic acid Nutrition 0.000 description 1
201000000448 autoimmune hemolytic anemia Diseases 0.000 description 1
210000003719 b-lymphocyte Anatomy 0.000 description 1
210000003651 basophil Anatomy 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
238000003759 clinical diagnosis Methods 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
239000000470 constituent Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 description 1
229960001140 cyproheptadine Drugs 0.000 description 1
230000006378 damage Effects 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000002158 endotoxin Substances 0.000 description 1
HCZKYJDFEPMADG-UHFFFAOYSA-N erythro-nordihydroguaiaretic acid Natural products C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000010200 folin Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
230000037406 food intake Effects 0.000 description 1
235000012631 food intake Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
208000014951 hematologic disease Diseases 0.000 description 1
230000002949 hemolytic effect Effects 0.000 description 1
208000027700 hepatic dysfunction Diseases 0.000 description 1
208000005252 hepatitis A Diseases 0.000 description 1
230000008105 immune reaction Effects 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
208000026278 immune system disease Diseases 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
230000001861 immunosuppressant effect Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
208000027866 inflammatory disease Diseases 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
238000009533 lab test Methods 0.000 description 1
238000011005 laboratory method Methods 0.000 description 1
230000003902 lesion Effects 0.000 description 1
229920006008 lipopolysaccharide Polymers 0.000 description 1
208000019423 liver disease Diseases 0.000 description 1
230000000527 lymphocytic effect Effects 0.000 description 1
229960003951 masoprocol Drugs 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
238000002156 mixing Methods 0.000 description 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
230000007170 pathology Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
239000002831 pharmacologic agent Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000002633 protecting effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
150000003218 pyrazolidines Chemical class 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
230000007928 solubilization Effects 0.000 description 1
238000005063 solubilization Methods 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
231100000816 toxic dose Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL10166092A 1991-04-22 1992-04-21 Pharmaceutical preparation for the treatment of the immune system IL101660A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI911101A IT1253703B (it)	1991-04-22	1991-04-22	Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie

Publications (1)

Publication Number	Publication Date
IL101660A true IL101660A (en)	1996-08-04

Family

ID=11359721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10166092A IL101660A (en)	1991-04-22	1992-04-21	Pharmaceutical preparation for the treatment of the immune system

Country Status (16)

Country	Link
US (1)	US5278183A (de)
EP (1)	EP0510748B1 (de)
JP (1)	JP3056879B2 (de)
KR (1)	KR100210199B1 (de)
AT (1)	ATE135573T1 (de)
AU (1)	AU657524B2 (de)
BG (1)	BG61366B2 (de)
CA (1)	CA2066304C (de)
CZ (1)	CZ280613B6 (de)
DE (1)	DE69209128T2 (de)
DK (1)	DK0510748T3 (de)
IL (1)	IL101660A (de)
IT (1)	IT1253703B (de)
NZ (1)	NZ242392A (de)
SK (1)	SK278546B6 (de)
ZA (1)	ZA922740B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2723315B1 (fr)	1994-08-02	1996-10-25	Cird Galderma	Procede et composition pour stimuler la differenciation des cellules preadipocytaires et traitements therapeutiques associes
IT1276031B1 (it) *	1995-10-31	1997-10-24	Angelini Ricerche Spa	Composizione farmaceutica per il trattamento delle malattie autoimmuni
IT1293795B1 (it) *	1997-07-28	1999-03-10	Angelini Ricerche Spa	Farmaco attivo nel ridurre la produzione di proteina mcp-1
CN1589269A (zh) *	2001-10-26	2005-03-02	康涅狄格大学	杂1,2－二氢化茚:一类新型有效的大麻配体
ITMI20062254A1 (it)	2006-11-24	2008-05-25	Acraf	Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
EP2262778B8 (de)	2008-03-07	2020-01-01	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.	1-benzyl-3-hydroxymethylindazolderivate und ihre verwendung bei der behandlung von auf der expression von mcp-1, cx3cr1 und p40 basierten erkrankungen
US8314099B2 (en)	2008-03-07	2012-11-20	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1 and CX3CR1
PL2254870T3 (pl) *	2008-03-07	2016-07-29	Acraf	Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CX3CR1
PL2462119T3 (pl)	2009-08-03	2014-10-31	Acraf	Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich
UA108742C2 (uk) *	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US8999292B2 (en)	2012-05-01	2015-04-07	Translatum Medicus Inc.	Methods for treating and diagnosing blinding eye diseases
EP3990433A4 (de)	2019-06-25	2023-07-26	Translatum Medicus Inc.	Verfahren zur herstellung von 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropansäure und ihren derivaten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1194564B (it) *	1983-04-18	1988-09-22	Acraf	Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
DE3664036D1 (en) *	1985-02-12	1989-07-27	Acraf	(1-phenylmethyl-5-hydroxy-1h-indazol-3-yl)-oxyacetic acid and salts thereof for use as a medicament, and pharmaceutical compositions containing them
IT1230441B (it) *	1989-02-07	1991-10-23	Acraf	Eteri della serie dell'indazolo

1991
- 1991-04-22 IT ITMI911101A patent/IT1253703B/it active IP Right Grant
1992
- 1992-04-11 EP EP92201037A patent/EP0510748B1/de not_active Expired - Lifetime
- 1992-04-11 DE DE69209128T patent/DE69209128T2/de not_active Expired - Lifetime
- 1992-04-11 DK DK92201037.6T patent/DK0510748T3/da active
- 1992-04-11 AT AT92201037T patent/ATE135573T1/de active
- 1992-04-14 US US07/868,311 patent/US5278183A/en not_active Expired - Lifetime
- 1992-04-14 AU AU14883/92A patent/AU657524B2/en not_active Expired
- 1992-04-14 ZA ZA922740A patent/ZA922740B/xx unknown
- 1992-04-16 CA CA002066304A patent/CA2066304C/en not_active Expired - Lifetime
- 1992-04-16 NZ NZ242392A patent/NZ242392A/en not_active IP Right Cessation
- 1992-04-21 IL IL10166092A patent/IL101660A/en not_active IP Right Cessation
- 1992-04-22 JP JP4102849A patent/JP3056879B2/ja not_active Expired - Lifetime
- 1992-04-22 SK SK1227-92A patent/SK278546B6/sk not_active IP Right Cessation
- 1992-04-22 KR KR1019920006797A patent/KR100210199B1/ko not_active Expired - Lifetime
- 1992-04-22 CZ CS921227A patent/CZ280613B6/cs not_active IP Right Cessation
1994
- 1994-02-25 BG BG098590A patent/BG61366B2/bg unknown

Also Published As

Publication number	Publication date
SK278546B6 (en)	1997-09-10
US5278183A (en)	1994-01-11
EP0510748A1 (de)	1992-10-28
CS122792A3 (en)	1992-11-18
DE69209128D1 (de)	1996-04-25
KR920019350A (ko)	1992-11-19
AU1488392A (en)	1992-10-29
CA2066304A1 (en)	1992-10-23
JPH0640915A (ja)	1994-02-15
EP0510748B1 (de)	1996-03-20
CZ280613B6 (cs)	1996-03-13
JP3056879B2 (ja)	2000-06-26
ITMI911101A0 (it)	1991-04-22
BG61366B2 (bg)	1997-06-30
KR100210199B1 (ko)	1999-07-15
DK0510748T3 (da)	1996-07-22
ZA922740B (en)	1992-12-30
ITMI911101A1 (it)	1992-10-22
IT1253703B (it)	1995-08-23
AU657524B2 (en)	1995-03-16
CA2066304C (en)	2005-06-21
ATE135573T1 (de)	1996-04-15
DE69209128T2 (de)	1996-11-28
NZ242392A (en)	1997-06-24

Legal Events

Date	Code	Title
1997-01-10	FF	Patent granted
1997-03-18	KB	Patent renewed
1998-10-30	KB	Patent renewed
2002-06-30	KB	Patent renewed
2006-07-05	KB	Patent renewed
2010-10-31	KB	Patent renewed
2012-12-31	EXP	Patent expired

Publication	Publication Date	Title
US5278183A (en)	1994-01-11	Method for the treatment of autoimmune diseases
US6509348B1 (en)	2003-01-21	Combination of an ADP-receptor blocking antiplatelet drug and a thromboxane A2 receptor antagonist and a method for inhibiting thrombus formation employing such combination
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