IL102639A - Compositions for inducing cytotoxic t lymphocyte responses - Google Patents

Compositions for inducing cytotoxic t lymphocyte responses

Info

Publication number
IL102639A
IL102639A IL102639A IL10263992A IL102639A IL 102639 A IL102639 A IL 102639A IL 102639 A IL102639 A IL 102639A IL 10263992 A IL10263992 A IL 10263992A IL 102639 A IL102639 A IL 102639A
Authority
IL
Israel
Prior art keywords
compositions
lymphocyte responses
inducing cytotoxic
antigen
oil
Prior art date
Application number
IL102639A
Other languages
English (en)
Other versions
IL102639A0 (en
Original Assignee
Idec Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24954233&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL102639(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idec Pharma Corp filed Critical Idec Pharma Corp
Publication of IL102639A0 publication Critical patent/IL102639A0/xx
Publication of IL102639A publication Critical patent/IL102639A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • A61K39/001106Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001148Regulators of development
    • A61K39/00115Apoptosis related proteins, e.g. survivin or livin
    • A61K39/001151Apoptosis related proteins, e.g. survivin or livin p53
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001154Enzymes
    • A61K39/001164GTPases, e.g. Ras or Rho
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001169Tumor associated carbohydrates
    • A61K39/00117Mucins, e.g. MUC-1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/00118Cancer antigens from embryonic or fetal origin
    • A61K39/001182Carcinoembryonic antigen [CEA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/00119Melanoma antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/002Protozoa antigens
    • A61K39/015Hemosporidia antigens, e.g. Plasmodium antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL102639A 1991-07-25 1992-07-24 Compositions for inducing cytotoxic t lymphocyte responses IL102639A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73506991A 1991-07-25 1991-07-25

Publications (2)

Publication Number Publication Date
IL102639A0 IL102639A0 (en) 1993-01-14
IL102639A true IL102639A (en) 1997-03-18

Family

ID=24954233

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102639A IL102639A (en) 1991-07-25 1992-07-24 Compositions for inducing cytotoxic t lymphocyte responses

Country Status (27)

Country Link
US (2) US5585103A (fr)
EP (1) EP0596032B2 (fr)
JP (1) JP3939746B2 (fr)
KR (1) KR100198868B1 (fr)
AT (1) ATE166578T1 (fr)
AU (1) AU666127B2 (fr)
BG (1) BG62240B1 (fr)
BR (1) BR9206310A (fr)
CA (1) CA2113720A1 (fr)
CZ (1) CZ288048B6 (fr)
DE (1) DE69225710T3 (fr)
DK (1) DK0596032T4 (fr)
ES (1) ES2117052T5 (fr)
FI (2) FI108114B (fr)
HU (2) HU220295B (fr)
IE (1) IE922436A1 (fr)
IL (1) IL102639A (fr)
MX (1) MX9204376A (fr)
NO (1) NO317203B1 (fr)
OA (1) OA09880A (fr)
PH (1) PH30906A (fr)
RO (1) RO116459B1 (fr)
RU (1) RU2129439C1 (fr)
SK (1) SK282920B6 (fr)
TW (1) TW349867B (fr)
WO (1) WO1993001831A1 (fr)
ZA (1) ZA925614B (fr)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197311B1 (en) 1991-07-25 2001-03-06 Idec Pharmaceuticals Corporation Induction of cytotoxic T-lymphocyte responses
US5709860A (en) * 1991-07-25 1998-01-20 Idec Pharmaceuticals Corporation Induction of cytotoxic T-lymphocyte responses
WO1994021287A1 (fr) * 1993-03-15 1994-09-29 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Cellules dendritiques enrobees de peptide utilisees en tant qu'immunogenes
GB9314623D0 (en) 1993-07-14 1993-08-25 Nordion Int Inc Localization and therapy with agents directed against prostate specific antigen in breast cancer
GB9326253D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
AUPM446594A0 (en) * 1994-03-16 1994-04-14 Csl Limited Cytotoxic t-cell epitopes identified within epstein-barr virus
GB9620795D0 (en) * 1996-10-05 1996-11-20 Smithkline Beecham Plc Vaccines
US5820880A (en) * 1995-06-07 1998-10-13 The United States Of America As Represented By The Secretary Of The Army Liposomal formulation
EP0991403B1 (fr) * 1997-01-30 2003-04-02 Chiron Corporation Utilisation de microparticules contenant un antigene adsorbe dans le but de stimuler les reponses immunitaires
US6884435B1 (en) * 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
EP0983086B1 (fr) * 1997-02-05 2007-08-29 Jean-Claude Bystryn Liposomes sensibles au ph et autres types de vaccins encapsules contenant des immunomodulateurs, et procedes de production et d'utilisation
AT405939B (de) 1997-02-24 1999-12-27 Immuno Ag Verfahren zur inaktivierung von lipidumhüllten viren
US6632619B1 (en) * 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
JP2002503336A (ja) * 1997-05-16 2002-01-29 アルバータ リサーチ カウンシル 微量流通システムおよびその使用方法
AU1145699A (en) * 1997-09-05 1999-03-22 Smithkline Beecham Biologicals (Sa) Oil in water emulsions containing saponins
GB9718901D0 (en) 1997-09-05 1997-11-12 Smithkline Beecham Biolog Vaccine
ZA988461B (en) * 1997-09-18 1999-03-30 Idec Pharma Corp Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis
US6858386B1 (en) 1998-05-21 2005-02-22 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating colon cancer
US6949339B1 (en) 1998-05-21 2005-09-27 Diadexus, Inc. Method of diagnosing, monitoring, and staging colon cancer
EP1131084A4 (fr) * 1998-10-30 2001-12-19 Genetics Inst Inhibition de la differentiation des lymphocytes t cytotoxiques par des antagonistes du ligand de p-selectine (psgl)
ATE351905T1 (de) * 1998-11-10 2007-02-15 Univ Emory Mitogene regulatoren
US7198920B1 (en) * 1999-01-29 2007-04-03 Corika Corporation HER-2/neu fusion proteins
US20050226890A1 (en) * 1999-08-12 2005-10-13 Cohen David I Tat-based vaccine compositions and methods of making and using same
WO2001037864A1 (fr) * 1999-11-22 2001-05-31 Diadexus, Inc. Nouvelle methode de diagnostic, de suivi, de stadification, d'imagerie et de traitement du cancer
US7238471B1 (en) * 1999-11-23 2007-07-03 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating breast cancer
US20020048777A1 (en) * 1999-12-06 2002-04-25 Shujath Ali Method of diagnosing monitoring, staging, imaging and treating prostate cancer
AU6523901A (en) * 2000-05-26 2001-12-11 Diadexus Inc Method of diagnosing, monitoring, staging, imaging and treating colon cancer
US7229623B1 (en) * 2000-08-03 2007-06-12 Corixa Corporation Her-2/neu fusion proteins
WO2005090392A1 (fr) * 2004-03-16 2005-09-29 Inist Inc. Compositions tolerogenes a base de tat et methodes de production et d'utilisation associees
WO2002038611A2 (fr) 2000-11-09 2002-05-16 Immunolex Laboratories Procede de production d'anticorps par immunisation avec des conjugues de molecules couplees a des proteines a charge modifiee
RU2303264C2 (ru) * 2001-02-19 2007-07-20 Мерк Патент Гмбх Способ идентификации эпитопов т-клеток и его применение для получения молекул со сниженной иммуногенностью
WO2003104429A2 (fr) * 2002-06-10 2003-12-18 Idec Pharmaceuticals Corporation Genes surexprimes par le cancer des ovaires et leur utilisation dans la mise au point de nouvelles therapies
JP2006516883A (ja) 2002-09-19 2006-07-13 アメリカ合衆国 P.アリアシポリペプチド、ユウガイサシチョウバエポリペプチド、および使用法
DE60327366D1 (de) 2002-10-29 2009-06-04 Fundacao Oswaldo Cruz Lutzomyia longipalpis-polypeptide und verwendungsverfahren
AU2004226591B2 (en) * 2003-04-04 2009-06-04 Zoetis Services Llc Microfluidized oil-in-water emulsions and vaccine compositions
ATE392905T1 (de) * 2003-07-24 2008-05-15 Merial Ltd Vakzin-formulierungen mit einer öl-in-wasser- emulsion
WO2005090968A1 (fr) * 2004-03-16 2005-09-29 Inist Inc. Compositions immunomoduatrices a base de tat, leur decouverte et leur utilisation
EP1942932B1 (fr) 2005-08-08 2013-05-08 Oregon Health and Science University Inactivation d'agents pathogenes avec du peroxyde d'hydrogene pour la production de vaccin
US20100130425A1 (en) 2005-09-09 2010-05-27 Oregon Health & Science University Use of toll-like receptor ligands in treating excitotoxic injury, ischemia and/or hypoxia
EP2207035B1 (fr) 2006-03-14 2013-10-16 Oregon Health and Science University Procédés pour détecter une infection de tuberculose à mycobactérie
WO2007124133A2 (fr) 2006-04-20 2007-11-01 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Incorporated Procédés et compositions à base de la protéine toxine de shiga de type 1
KR101378872B1 (ko) 2006-09-26 2014-04-11 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) 합성 애주번트를 함유하는 백신 조성물
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
TWI441648B (zh) 2007-01-03 2014-06-21 Oncotherapy Science Inc Foxp3胜肽疫苗
WO2008106551A2 (fr) 2007-02-28 2008-09-04 The Govt. Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Serv. Polypeptides brachyury et procédés d'utilisation.
US7867483B2 (en) * 2007-10-18 2011-01-11 Bn Immunotherapeutics, Inc. Use of MVA to treat prostate cancer
US9005631B2 (en) 2008-08-04 2015-04-14 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Membrane proximal region of HIV gp41 anchored to the lipid layer of a virus-like particle vaccine
WO2010099472A2 (fr) 2009-02-27 2010-09-02 The U.S.A. Of America, As Represented By The Secretary, Department Of Health And Human Services Polypeptides spanx-b et leur utilisation
AU2010230073B2 (en) 2009-03-23 2016-05-26 Pin Pharma, Inc. Treatment of cancer with immunostimulatory HIV Tat derivative polypeptides
SI2437753T1 (sl) 2009-06-05 2016-12-30 Infectious Disease Research Institute Sintetični glukopiranozil-lipidni adjuvansi in cepivni sestavki, ki jih vsebujejo
AU2010305273B2 (en) 2009-10-07 2016-09-29 Uvic Industry Partnerships Inc. Vaccines comprising heat-sensitive transgenes
US9181306B2 (en) 2009-10-16 2015-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Insertion of foreign genes in rubella virus and their stable expression in a live, attenuated viral vaccine
EP3360566B1 (fr) 2009-11-20 2019-12-25 Oregon Health&Science University Procedes destines a detecter une infection par mycrobacterium tuberculosis
WO2011112599A2 (fr) 2010-03-12 2011-09-15 The United States Of America, As Represented By The Secretary. Department Of Health & Human Services Peptides pote immunogènes et leurs procédés d'utilisation
WO2011119920A2 (fr) 2010-03-25 2011-09-29 Oregon Health & Science University Glycoprotéines du cmv et vecteurs recombinés
AU2012243039B2 (en) 2011-04-08 2017-07-13 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
SMT201800284T1 (it) 2011-06-10 2018-07-17 Univ Oregon Health & Science Glicoproteine cmv e vettori ricombinanti
PT2734544T (pt) 2011-07-18 2021-03-16 Us Health Métodos e composições para inibir a patologia associada a poliomavírus
EP2568289A3 (fr) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunosélection du virus de la stomatite vésiculaire recombinant exprimant les protéines du VIH-1 par des anticorps largement neutralisants
EP2586461A1 (fr) 2011-10-27 2013-05-01 Christopher L. Parks Particules virales dérivées d'un virus enveloppé
US9566329B2 (en) 2012-04-06 2017-02-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Live, attenuated rubella vector to express vaccine antigens
PT2850431T (pt) 2012-05-16 2018-07-23 Immune Design Corp Vacinas para hsv-2
MX2014014683A (es) 2012-06-06 2015-02-24 Bionor Immuno As Peptidos derivados de proteinas virales para usarse como inmunogenos y reactivos de dosificacion.
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
ES2752190T3 (es) 2012-09-14 2020-04-03 Us Health Proteína Brachyury, vectores adenovirales que codifican proteína Brachyury y su uso
US20150283220A1 (en) 2012-10-19 2015-10-08 Bavarian Nordic, Inc. Methods and compositions for the treatment of cancer
EP3711768A1 (fr) 2013-04-18 2020-09-23 Immune Design Corp. Monothérapie de gla destinée à être utilisée dans le traitement du cancer
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
EP2848937A1 (fr) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Procédés d'identification de nouveaux immunogènes du VIH-1
EP3052127A1 (fr) 2013-10-04 2016-08-10 PIN Pharma, Inc. Polypeptides immunostimulants dérivés du tat de vih utilisés dans le traitement du cancer
EP2873423B1 (fr) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Trimères de glycoprotéines d'enveloppe du vih -1 soluble
DK3079716T3 (da) 2013-12-13 2019-08-19 Us Health Multiepitop-tarp-peptidvaccine og anvendelser deraf.
WO2015095770A1 (fr) 2013-12-20 2015-06-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions de polyomavirus jc immunogènes et procédés d'utilisation
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP4137150A1 (fr) 2015-08-03 2023-02-22 The United States of America, as represented by the Secretary, Department of Health and Human Services Mutants de délétion de la protéine brachyury, vecteurs sans levure codant pour les mutants de délétion de la protéine brachyury, et leur utilisation
AU2017261706B2 (en) 2016-05-10 2024-10-31 Najit Technologies, Inc. Inactivating pathogens and producing highly immunogenic inactivated vaccines using a dual oxidation process
WO2019090138A2 (fr) 2017-11-04 2019-05-09 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Conjugués immunogènes et méthodes d'utilisation de ceux-ci
EP4464380A3 (fr) 2018-12-04 2025-05-07 The Rockefeller University Immunogènes vaccinaux contre le vih
EP4103587A1 (fr) 2020-02-14 2022-12-21 Immunor AS Vaccin contre le coronavirus

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3083142A (en) * 1958-02-27 1963-03-26 Glaxo Group Ltd Improved swine erysipelas vaccine
US3790665A (en) * 1968-02-23 1974-02-05 Haver Lockhart Labor Inc Injectable adjuvant,method of preparing same and compositions including such adjuvant
US3919411A (en) * 1972-01-31 1975-11-11 Bayvet Corp Injectable adjuvant and compositions including such adjuvant
US4117113A (en) * 1974-06-25 1978-09-26 National Research Development Corporation Immunological preparations
GB1502774A (en) * 1974-06-25 1978-03-01 Nat Res Dev Immunological preparations
US4772466A (en) * 1983-08-22 1988-09-20 Syntex (U.S.A.) Inc. Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4770874A (en) * 1983-08-22 1988-09-13 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
JPS6147500A (ja) * 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
US4707443A (en) * 1985-04-19 1987-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Soluble interleukin-2 receptor as a disease indicator and a method of assaying the same
DE3751772T2 (de) * 1986-10-20 1996-12-05 Chiron Corp Impfstoff zur behandlung von hsv
US4778784A (en) * 1987-01-07 1988-10-18 Baylor College Of Medicine Cyclic peptide and method of use for inducing an immunological response to hepatitis B virus
US4963354A (en) * 1987-01-21 1990-10-16 Genentech, Inc. Use of tumor necrosis factor (TNF) as an adjuvant
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
WO1990014837A1 (fr) * 1989-05-25 1990-12-13 Chiron Corporation Composition d'adjuvant comprenant une emulsion de gouttelettes d'huile d'une taille inferieure au micron
DE69021791T2 (de) * 1989-06-30 1996-05-02 American Cyanamid Co Verwendung eines phagozytise-aktievierenden Stoffes : LPS oder IL-2 zur Herstellung eines Arzneimittels zur Behandlung von Staphylococcus-aureus-Infektionen bei Kühen.
AU1025692A (en) * 1991-02-06 1992-08-13 Ciba-Geigy Ag Novel chimeric antiidiotypic monoclonal antibodies

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RU2129439C1 (ru) 1999-04-27
HU211299A9 (en) 1995-11-28
BG62240B1 (bg) 1999-06-30
BG98410A (bg) 1995-02-28
TW349867B (en) 1999-01-11
IE922436A1 (en) 1993-01-27
DE69225710T3 (de) 2004-10-14
JP3939746B2 (ja) 2007-07-04
EP0596032B2 (fr) 2004-04-07
FI109335B (fi) 2002-07-15
ES2117052T3 (es) 1998-08-01
NO317203B1 (no) 2004-09-20
JPH06509344A (ja) 1994-10-20
OA09880A (en) 1994-09-15
ATE166578T1 (de) 1998-06-15
US5585103A (en) 1996-12-17
IL102639A0 (en) 1993-01-14
SK8994A3 (en) 1994-11-09
AU2433892A (en) 1993-02-23
CZ288048B6 (cs) 2001-04-11
AU666127B2 (en) 1996-02-01
HUT69784A (en) 1995-09-28
SK282920B6 (sk) 2003-01-09
DE69225710T2 (de) 1998-09-24
NO940218L (no) 1994-03-25
FI108114B (fi) 2001-11-30
WO1993001831A1 (fr) 1993-02-04
MX9204376A (es) 1993-02-01
DE69225710D1 (de) 1998-07-02
HU9400202D0 (en) 1994-05-30
EP0596032A4 (en) 1994-08-17
FI940335L (fi) 1994-03-24
FI940335A0 (fi) 1994-01-24
FI20011187L (fi) 2001-06-05
CA2113720A1 (fr) 1993-02-04
NO940218D0 (no) 1994-01-21
US6270769B1 (en) 2001-08-07
ZA925614B (en) 1993-04-20
ES2117052T5 (es) 2004-12-01
CZ15094A3 (en) 1994-07-13
DK0596032T3 (da) 1998-10-12
EP0596032A1 (fr) 1994-05-11
HU220295B (hu) 2001-11-28
KR100198868B1 (ko) 1999-06-15
BR9206310A (pt) 1995-04-25
DK0596032T4 (da) 2004-07-26
PH30906A (en) 1997-12-23
RO116459B1 (ro) 2001-02-28
EP0596032B1 (fr) 1998-05-27

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