IL103232A0 - Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles benzo(b)thiophenes and 1,2-benzisothiazoles,a process for their preparation and their use as medicaments - Google Patents

Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles benzo(b)thiophenes and 1,2-benzisothiazoles,a process for their preparation and their use as medicaments

Info

Publication number: IL103232A0
Authority: IL; Israel
Prior art keywords: indazoles; loweralkyl; hydrogen; compounds; useful
Prior art date: 1991-09-23

Application number

IL103232A

Other languages

English (en)

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-23

Filing date

1992-09-21

Publication date

1993-02-21

1992-09-21 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1993-02-21 Publication of IL103232A0 publication Critical patent/IL103232A0/xx

Links

239000003814 drug Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical class C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000006870 function Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
-1 loweralkyl Inorganic materials 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
JULKLMOOTJHVHH-UHFFFAOYSA-N n-pyridin-2-ylindol-1-amine Chemical class C1=CC2=CC=CC=C2N1NC1=CC=CC=N1 JULKLMOOTJHVHH-UHFFFAOYSA-N 0.000 abstract 1
239000002858 neurotransmitter agent Substances 0.000 abstract 1
230000002474 noradrenergic effect Effects 0.000 abstract 1
208000022821 personality disease Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000000862 serotonergic effect Effects 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IL103232A 1991-09-23 1992-09-21 Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles benzo(b)thiophenes and 1,2-benzisothiazoles,a process for their preparation and their use as medicaments IL103232A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/764,031 US5185350A (en)	1991-09-23	1991-09-23	Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles

Publications (1)

Publication Number	Publication Date
IL103232A0 true IL103232A0 (en)	1993-02-21

Family

ID=25069502

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL103232A IL103232A0 (en)	1991-09-23	1992-09-21	Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles benzo(b)thiophenes and 1,2-benzisothiazoles,a process for their preparation and their use as medicaments

Country Status (18)

Country	Link
US (2)	US5185350A (cs)
EP (1)	EP0534343B1 (cs)
JP (1)	JP2961023B2 (cs)
KR (1)	KR930006006A (cs)
AT (1)	ATE160346T1 (cs)
AU (1)	AU653263B2 (cs)
CA (1)	CA2078814C (cs)
CZ (1)	CZ290692A3 (cs)
DE (1)	DE69223205T2 (cs)
DK (1)	DK0534343T3 (cs)
ES (1)	ES2111025T3 (cs)
FI (1)	FI924230L (cs)
GR (1)	GR3025774T3 (cs)
HU (1)	HU9203023D0 (cs)
IL (1)	IL103232A0 (cs)
MX (1)	MX9205374A (cs)
NO (1)	NO923686L (cs)
TW (1)	TW207539B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH06500551A (ja) *	1990-09-13	1994-01-20	ビーチャム・グループ・パブリック・リミテッド・カンパニー	５ｈｔ受容体アンタゴニストとしてのインドールウレア
US5356910A (en)	1993-07-19	1994-10-18	Hoechst-Roussel Pharmaceuticals Inc.	Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
JPH09507071A (ja) *	1993-12-21	1997-07-15	イーライ・リリー・アンド・カンパニー	アミロイド原性ペプチドに関連した状態を治療又は予防する方法
DE19626373A1 (de) *	1996-07-02	1998-01-08	Boehringer Ingelheim Kg	Neuartige Verwendung von Wirkstoffen, welche die Funktion von nichtneuronalem Acetylcholin beeinflussen
TW200302722A (en) *	2002-02-13	2003-08-16	Astrazeneca Ab	Therapeutic agents
US20050222123A1 (en)	2004-01-27	2005-10-06	North Shore-Long Island Jewish Research Institute	Cholinesterase inhibitors for treating inflammation
JP4857128B2 (ja)	2004-02-20	2012-01-18	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー	新規な化合物
JP4787471B2 (ja) *	2004-05-21	2011-10-05	株式会社ポッカコーポレーション	脳機能亢進剤
DE602005020280D1 (de)	2004-06-01	2010-05-12	Hoffmann La Roche	3-amino-1-arylpropyl-indole als monoamin-wiederaufnahmehemmer
EP2351737A1 (en) *	2005-11-30	2011-08-03	F. Hoffmann-La Roche AG	3-Amino-1-arylpropyl indoles and aza-substituted indoles
BRPI0619263A2 (pt)	2005-11-30	2011-09-27	Hoffmann La Roche	indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis
EP1957488B1 (en)	2005-11-30	2009-09-09	F.Hoffmann-La Roche Ag	3-amino-2-arylpropyl azaindoles and uses thereof
KR102534969B1 (ko) *	2021-08-20	2023-05-26	김수영	포켓 인슐레이터 및 이를 포함하는 단열체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3852335T2 (de) *	1987-04-24	1995-05-11	Hoechst Roussel Pharma	N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
US4970219A (en) *	1989-06-28	1990-11-13	Hoechst-Roussel Pharmaceuticals Inc.	Heteroarylamino- and heteroaryloxypyridinamine compounds which have useful utility in treating skin disorders
US4983615A (en) *	1989-06-28	1991-01-08	Hoechst-Roussel Pharmaceuticals Inc.	Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5177088A (en) *	1991-04-17	1993-01-05	Hoechst-Roussel Pharmaceuticals Incorporated	Substituted 3-(pyridinylamino)-indoles

1991
- 1991-09-23 US US07/764,031 patent/US5185350A/en not_active Expired - Fee Related
1992
- 1992-09-10 TW TW081107145A patent/TW207539B/zh active
- 1992-09-21 DK DK92116110T patent/DK0534343T3/da active
- 1992-09-21 EP EP92116110A patent/EP0534343B1/en not_active Expired - Lifetime
- 1992-09-21 DE DE69223205T patent/DE69223205T2/de not_active Expired - Fee Related
- 1992-09-21 IL IL103232A patent/IL103232A0/xx unknown
- 1992-09-21 FI FI924230A patent/FI924230L/fi unknown
- 1992-09-21 AT AT92116110T patent/ATE160346T1/de not_active IP Right Cessation
- 1992-09-21 ES ES92116110T patent/ES2111025T3/es not_active Expired - Lifetime
- 1992-09-22 MX MX9205374A patent/MX9205374A/es not_active IP Right Cessation
- 1992-09-22 HU HU9203023A patent/HU9203023D0/hu unknown
- 1992-09-22 CA CA002078814A patent/CA2078814C/en not_active Expired - Lifetime
- 1992-09-22 AU AU25297/92A patent/AU653263B2/en not_active Expired - Fee Related
- 1992-09-22 JP JP4251779A patent/JP2961023B2/ja not_active Expired - Fee Related
- 1992-09-22 CZ CS922906A patent/CZ290692A3/cs unknown
- 1992-09-22 KR KR1019920017238A patent/KR930006006A/ko not_active Withdrawn
- 1992-09-22 NO NO92923686A patent/NO923686L/no unknown
1993
- 1993-03-25 US US08/038,317 patent/US5328918A/en not_active Expired - Lifetime
1997
- 1997-12-23 GR GR970403425T patent/GR3025774T3/el unknown

Also Published As

Publication number	Publication date
KR930006006A (ko)	1993-04-20
JPH061787A (ja)	1994-01-11
DE69223205T2 (de)	1998-05-14
FI924230A0 (fi)	1992-09-21
AU653263B2 (en)	1994-09-22
ATE160346T1 (de)	1997-12-15
AU2529792A (en)	1993-03-25
NO923686D0 (no)	1992-09-22
MX9205374A (es)	1993-03-01
FI924230A7 (fi)	1993-03-24
HUT64055A (en)	1993-11-29
US5328918A (en)	1994-07-12
CZ290692A3 (en)	1993-04-14
CA2078814A1 (en)	1993-03-24
CA2078814C (en)	2003-09-09
EP0534343A1 (en)	1993-03-31
GR3025774T3 (en)	1998-03-31
DK0534343T3 (da)	1998-07-27
US5185350A (en)	1993-02-09
NO923686L (no)	1993-03-24
EP0534343B1 (en)	1997-11-19
TW207539B (cs)	1993-06-11
DE69223205D1 (de)	1998-01-02
FI924230L (fi)	1993-03-24
HU9203023D0 (en)	1993-11-29
JP2961023B2 (ja)	1999-10-12
ES2111025T3 (es)	1998-03-01

Publication	Publication Date	Title
AU639943B2 (en)	1993-08-12	N-aminocarbamates related to physostigmine, a process for their preparation and their use as medicaments
GR3025774T3 (en)	1998-03-31	Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments
EP0405425A3 (en)	1992-09-09	Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments
HU9201887D0 (en)	1992-08-28	Process for the production of //aralkyl-piperidine-4-yl/-methyl/-2a,3,4,5-tetrahydro-1-/2h/-acenaphtylene-1-on derivatives and of medical preparations containing them as active agents
HU912786D0 (en)	1992-01-28	Process for producing 4-substituted-dihydro-pyrido(4,3-d) pyrimidine derivatives as well as pharmaceutical preparatives containing said compounds
AU8148387A (en)	1988-05-26	Fused heterocyclic tetrahydroaminoquinolinols and related compounds, a process for their preparation and their use as medicaments
ATE79118T1 (de)	1992-08-15	N-pyridinyl-9h-carbazol-9-amine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
IL94854A0 (en)	1991-04-15	(1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds,a process for their preparation and their use as medicaments
AU619985B2 (en)	1992-02-06	4,5,5a,6-tetrahydro-3h-isoxazolo(5,4,3-kl)acridines derivatives, a process for their preparation and their use as medicaments