IL103807A0 - Aminoalkylpyrrolidinylthio-carbapenem derivatives - Google Patents
Aminoalkylpyrrolidinylthio-carbapenem derivativesInfo
- Publication number
- IL103807A0 IL103807A0 IL103807A IL10380792A IL103807A0 IL 103807 A0 IL103807 A0 IL 103807A0 IL 103807 A IL103807 A IL 103807A IL 10380792 A IL10380792 A IL 10380792A IL 103807 A0 IL103807 A0 IL 103807A0
- Authority
- IL
- Israel
- Prior art keywords
- group
- hydrogen atom
- lower alkyl
- different
- same
- Prior art date
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000005239 aroylamino group Chemical group 0.000 abstract 1
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 125000004069 aziridinyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 sulfamoylamino group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Cephalosporin Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33588891 | 1991-11-27 | ||
| JP21561392 | 1992-07-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL103807A0 true IL103807A0 (en) | 1993-04-04 |
Family
ID=26520964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL103807A IL103807A0 (en) | 1991-11-27 | 1992-11-19 | Aminoalkylpyrrolidinylthio-carbapenem derivatives |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5550121A (fr) |
| EP (1) | EP0545290B1 (fr) |
| KR (1) | KR0175674B1 (fr) |
| CN (1) | CN1032061C (fr) |
| AT (1) | ATE195736T1 (fr) |
| AU (2) | AU651505B2 (fr) |
| BG (1) | BG97965A (fr) |
| CA (1) | CA2083980C (fr) |
| CZ (1) | CZ150193A3 (fr) |
| DE (1) | DE69231375T2 (fr) |
| FI (1) | FI933346A7 (fr) |
| HU (2) | HUT64345A (fr) |
| IL (1) | IL103807A0 (fr) |
| MX (1) | MX9206838A (fr) |
| PL (1) | PL300122A1 (fr) |
| TW (1) | TW209220B (fr) |
| WO (1) | WO1993011128A1 (fr) |
| YU (1) | YU100792A (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5317016A (en) * | 1991-08-20 | 1994-05-31 | Shionogi Seiyaku Kabushiki Kaisha | Pyrrolidylthiocarbapenem derivative |
| JP3848693B2 (ja) * | 1994-07-06 | 2006-11-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規カルバペネム誘導体 |
| US7041660B2 (en) | 1999-07-06 | 2006-05-09 | Sankyo Company, Limited | Crystalline 1-methylcarbapenem derivatives |
| TWI250160B (en) * | 1999-07-06 | 2006-03-01 | Sankyo Co | Crystalline 1-methylcarbapenem compound |
| US8093378B2 (en) * | 2006-04-28 | 2012-01-10 | Kaneka Corporation | Crystallization method for intermediates of carbapenem antibiotics |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3579888D1 (de) * | 1984-11-08 | 1990-10-31 | Sumitomo Pharma | Carbapenemverbindungen und deren herstellung. |
| FI81576C (fi) * | 1984-12-25 | 1990-11-12 | Sankyo Co | Foerfarande foer framstaellning av derivat av 6-(1-hydroxietyl)-2-(1,2-disubstituerade-4-pyrrolidinyltio)-2- karbapenem-3-karboxylsyra, vilka aer anvaendbara som laekemedel. |
| DE3780344T2 (de) * | 1986-03-27 | 1993-01-28 | Sumitomo Pharma | Beta-lactam-verbindungen und deren herstellung. |
| CA2033390A1 (fr) * | 1989-12-29 | 1991-06-30 | Susumu Nakagawa | Derives de 2-¬(2-cyclopropylpyrrolidin-4-yl)thio|carbapeneme |
| JPH05255332A (ja) * | 1991-11-27 | 1993-10-05 | Banyu Pharmaceut Co Ltd | アルキルアミノアルキルピロリジニルチオカルバペネム誘導体 |
-
1992
- 1992-11-14 TW TW081109118A patent/TW209220B/zh active
- 1992-11-19 IL IL103807A patent/IL103807A0/xx unknown
- 1992-11-24 YU YU100792A patent/YU100792A/sh unknown
- 1992-11-25 AU AU29632/92A patent/AU651505B2/en not_active Ceased
- 1992-11-26 WO PCT/JP1992/001544 patent/WO1993011128A1/fr not_active Ceased
- 1992-11-26 CZ CS931501A patent/CZ150193A3/cs unknown
- 1992-11-26 HU HU9302170A patent/HUT64345A/hu unknown
- 1992-11-26 EP EP92120226A patent/EP0545290B1/fr not_active Expired - Lifetime
- 1992-11-26 KR KR1019930702228A patent/KR0175674B1/ko not_active Expired - Fee Related
- 1992-11-26 PL PL92300122A patent/PL300122A1/xx unknown
- 1992-11-26 DE DE69231375T patent/DE69231375T2/de not_active Expired - Fee Related
- 1992-11-26 AT AT92120226T patent/ATE195736T1/de not_active IP Right Cessation
- 1992-11-27 MX MX9206838A patent/MX9206838A/es unknown
- 1992-11-27 CA CA002083980A patent/CA2083980C/fr not_active Expired - Fee Related
- 1992-11-27 CN CN92114620A patent/CN1032061C/zh not_active Expired - Fee Related
-
1993
- 1993-07-16 BG BG97965A patent/BG97965A/xx unknown
- 1993-07-26 FI FI933346A patent/FI933346A7/fi unknown
-
1994
- 1994-09-27 US US08/312,619 patent/US5550121A/en not_active Expired - Fee Related
- 1994-10-18 AU AU75894/94A patent/AU667786B2/en not_active Ceased
-
1995
- 1995-03-29 HU HU95P/P00093P patent/HU210817A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2083980C (fr) | 2003-04-29 |
| AU2963292A (en) | 1993-06-03 |
| KR0175674B1 (ko) | 1999-03-20 |
| WO1993011128A1 (fr) | 1993-06-10 |
| PL300122A1 (en) | 1994-04-18 |
| MX9206838A (es) | 1993-05-31 |
| CZ150193A3 (en) | 1994-03-16 |
| AU667786B2 (en) | 1996-04-04 |
| KR930703322A (ko) | 1993-11-29 |
| BG97965A (bg) | 1994-05-27 |
| EP0545290A1 (fr) | 1993-06-09 |
| FI933346A0 (fi) | 1993-07-26 |
| EP0545290B1 (fr) | 2000-08-23 |
| CN1073176A (zh) | 1993-06-16 |
| TW209220B (fr) | 1993-07-11 |
| AU651505B2 (en) | 1994-07-21 |
| US5550121A (en) | 1996-08-27 |
| ATE195736T1 (de) | 2000-09-15 |
| DE69231375D1 (de) | 2000-09-28 |
| HU9302170D0 (en) | 1993-10-28 |
| CN1032061C (zh) | 1996-06-19 |
| HUT64345A (en) | 1993-12-28 |
| HU210817A9 (en) | 1995-08-28 |
| YU100792A (sh) | 1995-10-24 |
| AU7589494A (en) | 1995-01-27 |
| FI933346A7 (fi) | 1993-07-26 |
| CA2083980A1 (fr) | 1993-05-28 |
| DE69231375T2 (de) | 2001-03-01 |
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