IL104853A - Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them - Google Patents
Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL104853A IL104853A IL104853A IL10485393A IL104853A IL 104853 A IL104853 A IL 104853A IL 104853 A IL104853 A IL 104853A IL 10485393 A IL10485393 A IL 10485393A IL 104853 A IL104853 A IL 104853A
- Authority
- IL
- Israel
- Prior art keywords
- pct
- preparation
- benzodiazepine derivatives
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title abstract 2
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108010089448 Cholecystokinin B Receptor Proteins 0.000 abstract 2
- 102000052874 Gastrin receptors Human genes 0.000 abstract 1
- 102100036016 Gastrin/cholecystokinin type B receptor Human genes 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9204221A GB2264492B (en) | 1992-02-27 | 1992-02-27 | Benzodiazepine derivatives |
| GB929212740A GB9212740D0 (en) | 1992-02-27 | 1992-06-16 | Benzodiazephine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104853A0 IL104853A0 (en) | 1993-06-10 |
| IL104853A true IL104853A (en) | 1997-11-20 |
Family
ID=26300386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL104853A IL104853A (en) | 1992-02-27 | 1993-02-25 | Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5688943A (da) |
| EP (1) | EP0628033B1 (da) |
| JP (1) | JP2571344B2 (da) |
| CN (1) | CN1051079C (da) |
| AT (1) | ATE245632T1 (da) |
| AU (1) | AU672390B2 (da) |
| CA (1) | CA2129990C (da) |
| DE (1) | DE69333108T2 (da) |
| DK (1) | DK0628033T3 (da) |
| ES (1) | ES2203616T3 (da) |
| FI (1) | FI121234B (da) |
| HU (1) | HU224012B1 (da) |
| IL (1) | IL104853A (da) |
| NO (1) | NO311215B1 (da) |
| PT (1) | PT628033E (da) |
| RU (1) | RU2139282C1 (da) |
| TW (1) | TW438783B (da) |
| WO (1) | WO1993016999A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2119875A1 (en) * | 1991-10-24 | 1993-04-29 | Sylvie Bourrain | Benzodiazepine derivatives, compositions containing them and their use in therapy |
| GB2282594A (en) * | 1993-08-25 | 1995-04-12 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
| GB2282595A (en) * | 1993-08-25 | 1995-04-12 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
| US5556969A (en) * | 1994-12-07 | 1996-09-17 | Merck Sharp & Dohme Ltd. | Benzodiazepine derivatives |
| AUPO284396A0 (en) * | 1996-10-08 | 1996-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Benzodiazepine derivatives |
| US6100254A (en) * | 1997-10-10 | 2000-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of protein tyrosine kinases |
| GB0015601D0 (en) * | 2000-06-26 | 2000-08-16 | Ferring Bv | Novel antidiuretic agents |
| CA2445477A1 (en) * | 2001-05-11 | 2002-11-21 | Yamanouchi Pharmaceutical Co., Ltd. | Antitumor agents |
| WO2004101533A1 (en) * | 2003-05-12 | 2004-11-25 | Janssen Pharmaceutica, N.V. | 1, 3, 4-benzotriazepin-2-one salts and their use as cck receptor ligands |
| JP2009513539A (ja) * | 2003-07-11 | 2009-04-02 | ベーリンガー・インゲルハイム・フエトメデイカ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | ベンゾジアゼピンレセプターのアルファ３サブユニットに対する選択性を有する化合物を用いて中枢神経系障害を治療または予防する方法 |
| EP1627876A1 (en) * | 2004-08-20 | 2006-02-22 | Ferring B.V. | Heterocyclic condensed compounds useful as antidiuretic agents |
| EP1839662B1 (en) * | 2005-01-19 | 2010-03-24 | Zeria Pharmaceutical Co., Ltd. | Antitumor agent |
| AU2006255047B2 (en) * | 2005-06-06 | 2011-09-15 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating sleep disorders |
| RU2325154C1 (ru) * | 2007-02-05 | 2008-05-27 | Государственное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарева" | Способ лечения истерической формы подострого реактивного психоза |
| CN101669557B (zh) * | 2009-08-20 | 2012-07-25 | 杭州六易科技有限公司 | 一种清热解毒凉茶的制作方法 |
| US9062024B2 (en) | 2009-09-28 | 2015-06-23 | Nippon Soda Co., Ltd. | Nitrogen-containing heterocyclic compound and salt thereof, and a fungicide for agricultural and horticultural use |
| CA2929858C (en) | 2013-11-22 | 2022-03-29 | CL BioSciences LLC | Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis |
| GB201414116D0 (en) * | 2014-08-08 | 2014-09-24 | Trio Medicines Ltd | Benzodiazepine derivatives |
| GB201513979D0 (en) * | 2015-08-07 | 2015-09-23 | Trio Medicines Ltd | Synthesis of benzodiazepine derivatives |
| US10786580B2 (en) * | 2016-09-09 | 2020-09-29 | On Target Laboratories, LLC | Cholecystokinin 2 receptor targeted NIR imaging and use thereof |
| US10881667B2 (en) * | 2018-10-30 | 2021-01-05 | City University Of Hong Kong | Method and composition for treating epilepsy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| CA2026856A1 (en) * | 1989-10-05 | 1991-04-06 | Mark G. Bock | 3-substituted-1,4-benzodiazepines useful as oxytocin |
| CA2032226A1 (en) * | 1989-12-18 | 1991-06-19 | Mark G. Bock | Benzodiazepine analogs |
| IL96613A0 (en) * | 1989-12-18 | 1991-09-16 | Merck & Co Inc | Pharmaceutical compositions containing benzodiazepine analogs |
| CA2032427A1 (en) * | 1989-12-18 | 1991-06-19 | Mark G. Bock | Benzodiazepines analogs |
| US4994258A (en) * | 1990-03-05 | 1991-02-19 | Merck & Co., Inc. | Gamma emitting, CCK-A antagonists for pancreatic imaging |
| US5206234A (en) * | 1990-10-22 | 1993-04-27 | Merck & Co., Inc. | Benzolactam analogs as antagonists of cck |
| US5218115A (en) * | 1991-04-10 | 1993-06-08 | Merck & Co., Inc. | Cholecystokinin antagonists |
| US5218114A (en) * | 1991-04-10 | 1993-06-08 | Merck & Co., Inc. | Cholecystokinin antagonists |
-
1993
- 1993-02-25 IL IL104853A patent/IL104853A/xx not_active IP Right Cessation
- 1993-02-26 EP EP93905480A patent/EP0628033B1/en not_active Expired - Lifetime
- 1993-02-26 ES ES93905480T patent/ES2203616T3/es not_active Expired - Lifetime
- 1993-02-26 DK DK93905480T patent/DK0628033T3/da active
- 1993-02-26 US US08/284,462 patent/US5688943A/en not_active Expired - Lifetime
- 1993-02-26 RU RU94038255A patent/RU2139282C1/ru active
- 1993-02-26 DE DE69333108T patent/DE69333108T2/de not_active Expired - Fee Related
- 1993-02-26 WO PCT/GB1993/000404 patent/WO1993016999A1/en not_active Ceased
- 1993-02-26 PT PT93905480T patent/PT628033E/pt unknown
- 1993-02-26 AU AU36391/93A patent/AU672390B2/en not_active Expired
- 1993-02-26 CA CA002129990A patent/CA2129990C/en not_active Expired - Lifetime
- 1993-02-26 AT AT93905480T patent/ATE245632T1/de not_active IP Right Cessation
- 1993-02-26 JP JP5506433A patent/JP2571344B2/ja not_active Expired - Lifetime
- 1993-02-26 HU HU9402212A patent/HU224012B1/hu active IP Right Grant
- 1993-02-27 CN CN93101848A patent/CN1051079C/zh not_active Expired - Lifetime
- 1993-03-24 TW TW082102213A patent/TW438783B/zh not_active IP Right Cessation
-
1994
- 1994-08-24 NO NO19943133A patent/NO311215B1/no not_active IP Right Cessation
- 1994-08-26 FI FI943941A patent/FI121234B/fi not_active IP Right Cessation
-
1997
- 1997-06-06 US US08/867,422 patent/US5962451A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0628033B1 (en) | 2003-07-23 |
| DK0628033T3 (da) | 2003-11-10 |
| TW438783B (en) | 2001-06-07 |
| CN1075717A (zh) | 1993-09-01 |
| WO1993016999A1 (en) | 1993-09-02 |
| HU9402212D0 (en) | 1994-09-28 |
| FI943941L (fi) | 1994-10-26 |
| CN1051079C (zh) | 2000-04-05 |
| FI121234B (fi) | 2010-08-31 |
| US5962451A (en) | 1999-10-05 |
| JPH07505121A (ja) | 1995-06-08 |
| HU224012B1 (hu) | 2005-04-28 |
| PT628033E (pt) | 2003-12-31 |
| NO943133L (no) | 1994-08-24 |
| AU672390B2 (en) | 1996-10-03 |
| ATE245632T1 (de) | 2003-08-15 |
| RU94038255A (ru) | 1996-07-10 |
| CA2129990A1 (en) | 1993-09-02 |
| NO311215B1 (no) | 2001-10-29 |
| FI943941A0 (fi) | 1994-08-26 |
| HUT67963A (en) | 1995-05-29 |
| NO943133D0 (no) | 1994-08-24 |
| ES2203616T3 (es) | 2004-04-16 |
| AU3639193A (en) | 1993-09-13 |
| DE69333108D1 (de) | 2003-08-28 |
| DE69333108T2 (de) | 2004-04-15 |
| RU2139282C1 (ru) | 1999-10-10 |
| EP0628033A1 (en) | 1994-12-14 |
| JP2571344B2 (ja) | 1997-01-16 |
| US5688943A (en) | 1997-11-18 |
| IL104853A0 (en) | 1993-06-10 |
| CA2129990C (en) | 2006-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH | Patent void | ||
| KB | Patent renewed | ||
| HC | Change of name of proprietor(s) | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |