IL105193A0 - Fluorinated hydroxyalkylquinoline acids and pharmaceutical compositions containing them - Google Patents

Fluorinated hydroxyalkylquinoline acids and pharmaceutical compositions containing them

Info

Publication number
IL105193A0
IL105193A0 IL105193A IL10519393A IL105193A0 IL 105193 A0 IL105193 A0 IL 105193A0 IL 105193 A IL105193 A IL 105193A IL 10519393 A IL10519393 A IL 10519393A IL 105193 A0 IL105193 A0 IL 105193A0
Authority
IL
Israel
Prior art keywords
fluorinated
pharmaceutical compositions
compositions containing
hydroxyalkylquinoline
acids
Prior art date
Application number
IL105193A
Other languages
English (en)
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of IL105193A0 publication Critical patent/IL105193A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL105193A 1992-04-10 1993-03-29 Fluorinated hydroxyalkylquinoline acids and pharmaceutical compositions containing them IL105193A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/866,690 US5270324A (en) 1992-04-10 1992-04-10 Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
CN92105948A CN1080169A (zh) 1992-04-10 1992-06-16 含有水溶性药物的控释片

Publications (1)

Publication Number Publication Date
IL105193A0 true IL105193A0 (en) 1993-07-08

Family

ID=25742768

Family Applications (1)

Application Number Title Priority Date Filing Date
IL105193A IL105193A0 (en) 1992-04-10 1993-03-29 Fluorinated hydroxyalkylquinoline acids and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (1) US5270324A (de)
EP (1) EP0565185B1 (de)
JP (1) JP2504687B2 (de)
CN (2) CN1080169A (de)
AT (1) ATE168100T1 (de)
AU (1) AU653476B2 (de)
BG (1) BG62402B1 (de)
CA (1) CA2092896C (de)
CZ (1) CZ246394A3 (de)
DE (1) DE69319482T2 (de)
ES (1) ES2117691T3 (de)
FI (1) FI944734A0 (de)
HR (1) HRP930803A2 (de)
HU (1) HU218917B (de)
IL (1) IL105193A0 (de)
LV (1) LV12290B (de)
MX (1) MX9302033A (de)
NO (1) NO943792L (de)
SI (1) SI9300188A (de)
WO (1) WO1993021159A1 (de)
ZA (1) ZA932533B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
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US5856322A (en) * 1990-10-12 1999-01-05 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
GB9216768D0 (en) * 1992-08-07 1992-09-23 Leo Pharm Prod Ltd Chemical compounds
ES2080656B1 (es) * 1993-07-19 1996-10-16 Merck Frosst Canada Inc Acidos de hidroxialquilquinolina fluorados como antagonistas del leucotrieno.
CA2130723C (en) * 1993-09-03 2006-01-31 Wilhelm Quittmann Process for preparing y-mercaptocarboxylic acid derivatives
DE4339724C1 (de) * 1993-11-22 1995-01-19 Siemens Ag Gasarmatur
TW448160B (en) * 1993-12-28 2001-08-01 Merck & Co Inc Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
US5491077A (en) * 1994-07-20 1996-02-13 Merck & Co., Inc. Microbial method
US5427933A (en) * 1994-07-20 1995-06-27 Merck & Co., Inc. Reduction of phenylalkyl ketones to the corresponding (S)-hydroxy derivatives using mucor hiemalis IFO 5834
GB9415997D0 (en) * 1994-08-08 1994-09-28 Merck Sharp & Dohme Therapeutic agents
US5545758A (en) * 1994-08-11 1996-08-13 Merck & Co., Inc. Process for the preparation of diisopinocampheylchloroborane
US5523477A (en) * 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5558879A (en) * 1995-04-28 1996-09-24 Andrx Pharmaceuticals, Inc. Controlled release formulation for water soluble drugs in which a passageway is formed in situ
US5648448A (en) * 1995-06-06 1997-07-15 Hitachi Chemical Company, Ltd. Method of preparation of polyquinolines
US5750539A (en) * 1995-06-07 1998-05-12 Merck Frosst Canada Heteroaryl diol acids as leukotriene antagonists
NZ331160A (en) * 1996-02-08 2000-07-28 Merck & Co Inc use of loratadine and a leukotriene antagonist to treat asthma
NZ520907A (en) * 1997-12-23 2004-05-28 Schering Corp Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine
US6384038B1 (en) * 1998-04-14 2002-05-07 Sepracor Inc. Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
US6696466B1 (en) 2000-09-07 2004-02-24 Leslie Joe Dunaway Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines
CA2371048C (en) 2002-02-06 2011-01-04 Delmar Chemicals Inc. Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
DE50307710D1 (de) * 2003-08-15 2007-08-30 Abb Turbo Systems Ag Rotationsdichtung
AU2004283832B2 (en) * 2003-10-10 2011-04-07 Synthon B.V. Solid-state montelukast
US7829716B2 (en) * 2004-04-30 2010-11-09 Synthon Pharmaceuticals, Inc. Process for making montelukast and intermediates therefor
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
US20060030550A1 (en) * 2004-08-04 2006-02-09 Lithgow Theodore L Pharmaceutical formulations
MX2007004976A (es) 2004-10-25 2007-06-14 Schering Corp Antagonistas de receptor m1 y/o m3 en combinacion con otros compuestos activos para tratar trastornos respiratorios.
EP1948612A2 (de) * 2005-11-16 2008-07-30 Teva Pharmaceutical Industries Ltd Verfahren zum trocknen von montelukast-natrium durch azeotrope entfernung des lösungsmittels
AR057908A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast e intermediarios del mismo
CN101432267A (zh) * 2006-03-17 2009-05-13 斯索恩有限公司 孟鲁司特金刚烷胺盐
WO2008001213A1 (en) * 2006-06-26 2008-01-03 Aurobindo Pharma Limited An improved process for the preparation of leukotriene receptor antagonist (montelukast sodium)
RU2009104346A (ru) * 2006-07-11 2010-08-20 Шеринг Корпорейшн (US) Ксинафоатная соль замещенного 5-оксазол-2-ил-хинолинового соединения
US7271268B1 (en) 2006-12-22 2007-09-18 Formosa Laboratories Inc. Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives
PL205444B1 (pl) * 2007-05-02 2010-04-30 Zak & Lstrok Ady Farmaceutyczn Sposób wytwarzania soli sodowej kwasu 1-(((1(R)-(3-(2-(7--chloro-2- chinolinylo)-etenylo)fenylo)-3-(2-(1-hydroksy-1- metyloetylo)fenylo)propylo)sulfanylo)metylo)-cyklopropanooctowego
WO2009117381A2 (en) * 2008-03-17 2009-09-24 Dr. Reddy's Laboratories Ltd. Preparation of montelukast and its salts
WO2009130056A1 (en) * 2008-04-25 2009-10-29 Synthon B.V. Process for making montelukast intermediates
EP2443134A2 (de) 2009-06-16 2012-04-25 Schering Corporation Neue [3,2-c]heteroarylsteroide als glucocorticoidrezeptoragonisten, zusammensetzungen und verwendung
RU2605929C2 (ru) * 2011-07-26 2016-12-27 Сан Фарма Адвансед Ресёрч Компани Лтд. Производные хинолина и хиноксалина, полезные в качестве антагонистов цистеинил-лейкотриена
CN104069502B (zh) * 2013-03-29 2018-02-16 北京罗诺强施医药技术研发中心有限公司 复合骨架材料及其药物组合物
CN105085391B (zh) * 2015-06-10 2017-08-22 广东默泰同创医药科技有限公司 用作白三烯受体拮抗剂的环丙基不饱和喹啉化合物及应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK282986A (da) * 1985-06-18 1987-02-24 Merck Frosst Canada Inc Substitueret quinolin og farmaceutisk praeparat indeholdende en saadan forbindelse
US4962203A (en) * 1985-06-18 1990-10-09 Merck Frost Canada, Inc. 2-substituted quinolines useful as leukotriene antagonists
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
US4851409A (en) * 1986-02-14 1989-07-25 Merck Frosst Canada Inc. 2-substituted quinoline dioic acids and pharmaceutical compositions
EP0271287A3 (de) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Chinolindicarbonsäuren und ihre Amide
FR2617352B1 (fr) * 1987-06-26 1989-12-01 Eduvision Sa Procede de codage de donnees informatiques pour transmission aux normes video, videodisque mettant en oeuvre ledit procede et interface d'exploitation d'un tel videodisque
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
IL88433A0 (en) * 1987-11-25 1989-06-30 Merck Frosst Canada Inc Diarylstyrylquinoline diacids and pharmaceutical compositions containing them
DE3814504A1 (de) * 1988-04-29 1989-11-09 Bayer Ag (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3900261A1 (de) * 1988-05-31 1989-12-07 Bayer Ag Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
US4918081A (en) * 1988-06-20 1990-04-17 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene d4
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof
CA2053209C (en) * 1990-10-12 1998-12-08 Michel L. Belley Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
IE920499A1 (en) * 1991-02-21 1992-08-26 Merck Frosst Canada Inc Quinoline-containing ketoacids as leukotriene antagonists

Also Published As

Publication number Publication date
CN1043761C (zh) 1999-06-23
JPH0625173A (ja) 1994-02-01
HRP930803A2 (en) 1994-12-31
ATE168100T1 (de) 1998-07-15
LV12290B (en) 1999-11-20
ES2117691T3 (es) 1998-08-16
JP2504687B2 (ja) 1996-06-05
DE69319482T2 (de) 1999-02-04
EP0565185B1 (de) 1998-07-08
LV12290A (lv) 1999-06-20
FI944734A7 (fi) 1994-10-07
BG99085A (bg) 1995-06-30
BG62402B1 (bg) 1999-10-29
NO943792D0 (no) 1994-10-07
EP0565185A1 (de) 1993-10-13
CA2092896A1 (en) 1993-10-11
CN1083052A (zh) 1994-03-02
DE69319482D1 (de) 1998-08-13
AU653476B2 (en) 1994-09-29
AU3686393A (en) 1993-10-14
NO943792L (no) 1994-12-08
CZ246394A3 (en) 1996-01-17
FI944734L (fi) 1994-10-07
MX9302033A (es) 1994-07-29
SI9300188A (sl) 1993-12-31
HU9402905D0 (en) 1995-01-30
ZA932533B (en) 1993-11-04
HU218917B (hu) 2000-12-28
FI944734A0 (fi) 1994-10-07
HUT70399A (en) 1995-10-30
US5270324A (en) 1993-12-14
WO1993021159A1 (en) 1993-10-28
CA2092896C (en) 2005-12-20
CN1080169A (zh) 1994-01-05

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