IL105473A - Oncoinhibin process and its preparation and pharmaceutical composition containing it - Google Patents

Oncoinhibin process and its preparation and pharmaceutical composition containing it

Info

Publication number: IL105473A
Authority: IL; Israel
Prior art keywords: oncoinhibin; cells; human; growth; cell
Prior art date: 1992-04-24

Application number

IL10547393A

Other languages

English (en)

Other versions

IL105473A0 (en

Original Assignee

Res Dev Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-24

Filing date

1993-04-21

Publication date

1998-09-24

1993-04-21 Application filed by Res Dev Foundation filed Critical Res Dev Foundation

1993-08-18 Publication of IL105473A0 publication Critical patent/IL105473A0/xx

1998-09-24 Publication of IL105473A publication Critical patent/IL105473A/en

Links

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230000007246 mechanism Effects 0.000 description 1
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239000003226 mitogen Substances 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
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238000005457 optimization Methods 0.000 description 1
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238000007254 oxidation reaction Methods 0.000 description 1
239000008188 pellet Substances 0.000 description 1
KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
210000005259 peripheral blood Anatomy 0.000 description 1
239000011886 peripheral blood Substances 0.000 description 1
230000035699 permeability Effects 0.000 description 1
150000004633 phorbol derivatives Chemical class 0.000 description 1
208000010916 pituitary tumor Diseases 0.000 description 1
238000007747 plating Methods 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
239000000047 product Substances 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
238000010926 purge Methods 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
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235000019515 salmon Nutrition 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
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VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Zoology (AREA)
Toxicology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL10547393A 1992-04-24 1993-04-21 Oncoinhibin process and its preparation and pharmaceutical composition containing it IL105473A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/874,308 US5241051A (en)	1992-04-24	1992-04-24	Oncoinhibin

Publications (2)

Publication Number	Publication Date
IL105473A0 IL105473A0 (en)	1993-08-18
IL105473A true IL105473A (en)	1998-09-24

Family

ID=25363462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10547393A IL105473A (en)	1992-04-24	1993-04-21	Oncoinhibin process and its preparation and pharmaceutical composition containing it

Country Status (18)

Country	Link
US (1)	US5241051A (de)
EP (1)	EP0637319B1 (de)
JP (1)	JP3434511B2 (de)
KR (1)	KR950701347A (de)
CN (1)	CN1068335C (de)
AT (1)	ATE209500T1 (de)
AU (1)	AU671637B2 (de)
CA (1)	CA2118498C (de)
DE (1)	DE69331231T2 (de)
FI (1)	FI112081B (de)
IL (1)	IL105473A (de)
NO (1)	NO313099B1 (de)
NZ (1)	NZ252429A (de)
RU (1)	RU2139087C1 (de)
SA (1)	SA93140393B1 (de)
TW (1)	TW372873B (de)
WO (1)	WO1993022346A1 (de)
ZA (1)	ZA932830B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5993798A (en) *	1992-04-24	1999-11-30	Research Development Foundation	Oncoinhibin and methods of pharmaceutical use
ATE374034T1 (de) *	1996-04-03	2007-10-15	Rogosin Inst	Konditioniertes medium und diffusionsfähiges biologisches material gewonnen durch inkubierung von eingeschlossenen zellen
RU2136695C1 (ru) *	1998-03-18	1999-09-10	ЗАОПП "Эндо-Фарм-А"	Сывороточный гликопротеин, обладающий биологической активностью в сверхмалых дозах
NZ727304A (en) *	2012-01-18	2018-08-31	Biosuccess Biotech Co Ltd	Compositions and methods of use of phorbol esters for the treatment of stroke
EP4628094A3 (de) *	2016-06-06	2025-12-31	City of Hope	Baff-r-antikörper und verwendungen davon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6463395A (en) *	1987-05-04	1989-03-09	Oncogen	Oncostatin m and novel composition having antitumor activity
US4874746A (en) *	1987-12-22	1989-10-17	Institute Of Molecular Biology, Inc.	Wound headling composition of TGF-alpha and PDGF
US4868902A (en) *	1988-02-03	1989-09-19	Hughes Aircraft Company	GaAs capacitive feedback transimpedance amplifier
IL112768A (en) *	1989-04-10	1998-06-15	Oncogen	Pharmaceutical compositions containing oncostatin m for inhibiting angiogenesis

1992
- 1992-04-24 US US07/874,308 patent/US5241051A/en not_active Expired - Lifetime
1993
- 1993-04-21 IL IL10547393A patent/IL105473A/en not_active IP Right Cessation
- 1993-04-22 ZA ZA932830A patent/ZA932830B/xx unknown
- 1993-04-23 CA CA002118498A patent/CA2118498C/en not_active Expired - Fee Related
- 1993-04-23 EP EP93910750A patent/EP0637319B1/de not_active Expired - Lifetime
- 1993-04-23 NZ NZ252429A patent/NZ252429A/en unknown
- 1993-04-23 AU AU41135/93A patent/AU671637B2/en not_active Ceased
- 1993-04-23 DE DE69331231T patent/DE69331231T2/de not_active Expired - Fee Related
- 1993-04-23 WO PCT/US1993/003828 patent/WO1993022346A1/en not_active Ceased
- 1993-04-23 JP JP51939593A patent/JP3434511B2/ja not_active Expired - Fee Related
- 1993-04-23 RU RU94045922A patent/RU2139087C1/ru not_active IP Right Cessation
- 1993-04-23 AT AT93910750T patent/ATE209500T1/de not_active IP Right Cessation
- 1993-04-23 TW TW082103154A patent/TW372873B/zh active
- 1993-04-24 CN CN93106355A patent/CN1068335C/zh not_active Expired - Fee Related
- 1993-11-30 SA SA93140393A patent/SA93140393B1/ar unknown
1994
- 1994-10-19 NO NO19943968A patent/NO313099B1/no unknown
- 1994-10-19 FI FI944907A patent/FI112081B/fi not_active IP Right Cessation
- 1994-10-21 KR KR1019940703739A patent/KR950701347A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
US5241051A (en)	1993-08-31
IL105473A0 (en)	1993-08-18
CN1068335C (zh)	2001-07-11
RU94045922A (ru)	1997-05-10
EP0637319A4 (de)	1997-06-11
KR950701347A (ko)	1995-03-23
FI112081B (fi)	2003-10-31
FI944907L (fi)	1994-10-19
CN1083389A (zh)	1994-03-09
DE69331231D1 (de)	2002-01-10
NO943968D0 (no)	1994-10-19
SA93140393B1 (ar)	2006-05-23
DE69331231T2 (de)	2002-08-22
JP3434511B2 (ja)	2003-08-11
ATE209500T1 (de)	2001-12-15
CA2118498C (en)	2005-06-21
CA2118498A1 (en)	1993-11-11
AU4113593A (en)	1993-11-29
AU671637B2 (en)	1996-09-05
NZ252429A (en)	1996-06-25
JPH07506364A (ja)	1995-07-13
FI944907A0 (fi)	1994-10-19
EP0637319A1 (de)	1995-02-08
ZA932830B (en)	1994-11-22
RU2139087C1 (ru)	1999-10-10
NO313099B1 (no)	2002-08-12
WO1993022346A1 (en)	1993-11-11
NO943968L (no)	1994-10-19
EP0637319B1 (de)	2001-11-28
TW372873B (en)	1999-11-01

Legal Events

Date	Code	Title
1999-01-26	FF	Patent granted
1999-12-22	KB	Patent renewed
2003-07-06	KB	Patent renewed
2008-01-06	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
Jirik et al.	1989	Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.
Cameron et al.	1986	Purification to homogeneity and amino acid sequence analysis of two anionic species of human interleukin 1.
EP0326120A2 (de)	1989-08-02	Menschliches IFN-beta2/IL-6, dessen Reinigung und Verwendungen
CA2572802A1 (en)	1991-06-23	Cytotoxic lymphocyte maturation factor and monoclonal antibodies directed thereto
Asai et al.	1992	A novel glial growth inhibitory factor, gliostatin, derived from neurofibroma
Sherr et al.	1990	Colony-stimulating factor 1 (macrophage colony-stimulating-factor)
Symons et al.	1990	A soluble binding protein specific for interleukin 1β is produced by activated mononuclear cells
Prestidge et al.	1984	Biochemical comparison of murine colony-stimulating factors secreted by a T cell lymphoma and a myelomonocytic leukemia.
CN1136043A (zh)	1996-11-20	人白细胞介素-6抑制剂
Andus et al.	1987	Discrimination of hepatocyte‐stimulating activity from human recombinant tumor necrosis factor α
EP0637319B1 (de)	2001-11-28	Ein neuartiges, antineoplastisches cytokin
Bienkowski et al.	1990	Purification and characterization of interleukin 1 receptor level antagonist proteins from THP-1 cells.
US5993798A (en)	1999-11-30	Oncoinhibin and methods of pharmaceutical use
FI91484C (fi)	1994-07-11	Menetelmä uuden solun kasvua säätelevän tekijän, onkostatiini M:n valmistamiseksi
WO1988004937A1 (en)	1988-07-14	Novel polypeptide having gamma-interferon activity
Van den Eijnden-Van Raaij et al.	1989	Purification of a growth factor related to platelet-derived growth factor and a type β transforming growth factor secreted by mouse neuroblastoma cells. A general strategy for the purification of basic polypeptide growth factors
Fresno et al.	1982	Proteins synthesized by inducer T cells: evidence for a mitogenic peptide shared by inducer molecules that stimulate different cell types
Kawade et al.	1981	Antigenic cross-reaction between the α types of human and mouse interferon
Sancéau et al.	1988	Interferon-β2 (BSF-2) mRNA is expressed in human monocytes
Van Damme et al.	1992	Human growth factor for murine interleukin (IL)‐9 responsive T cell lines: Co‐induction with IL‐6 in fibroblasts and identification as LIF/HILDA
AU651139B2 (en)	1994-07-14	Human IFN-beta 2/IL-6, its purification and use
FI98373B (fi)	1997-02-28	Uusi diagnostisesti käyttökelpoinen polypeptidi, onkostatiini M
Pestka et al.	1981	The human interferons
Taniyama et al.	1988	Demonstration of a novel tumor-killing factor secreted from human macrophage-monocyte hybridomas.
JPH03133935A (ja)	1991-06-07	ヒト天然型インターロイキン６組成物