IL106462A - Phenylimidazolidine derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Phenylimidazolidine derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number: IL106462A
Authority: IL; Israel
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; phenylimidazolidine; derivatives
Prior art date: 1992-07-24

Application number

IL10646293A

Other languages

English (en)

Other versions

IL106462A0 (en

Original Assignee

Cassella Farbwerke Mainkur Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-24

Filing date

1993-07-23

Publication date

1997-02-18

1993-07-23 Application filed by Cassella Farbwerke Mainkur Ag filed Critical Cassella Farbwerke Mainkur Ag

1993-11-15 Publication of IL106462A0 publication Critical patent/IL106462A0/xx

1997-02-18 Publication of IL106462A publication Critical patent/IL106462A/xx

Links

TVPNGVPSNXPYLT-UHFFFAOYSA-N 1-phenylimidazolidine Chemical class C1NCCN1C1=CC=CC=C1 TVPNGVPSNXPYLT-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/40—Two or more oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL10646293A 1992-07-24 1993-07-23 Phenylimidazolidine derivatives their preparation and pharmaceutical compositions containing them IL106462A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4224414A DE4224414A1 (de)	1992-07-24	1992-07-24	Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung

Publications (2)

Publication Number	Publication Date
IL106462A0 IL106462A0 (en)	1993-11-15
IL106462A true IL106462A (en)	1997-02-18

Family

ID=6463969

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10646293A IL106462A (en)	1992-07-24	1993-07-23	Phenylimidazolidine derivatives their preparation and pharmaceutical compositions containing them

Country Status (16)

Country	Link
US (1)	US5424293A (da)
EP (1)	EP0580008B1 (da)
JP (1)	JP3775808B2 (da)
KR (1)	KR100418321B1 (da)
AT (1)	ATE168116T1 (da)
AU (1)	AU664630B2 (da)
CA (1)	CA2101179C (da)
CZ (1)	CZ289297B6 (da)
DE (2)	DE4224414A1 (da)
DK (1)	DK0580008T3 (da)
ES (1)	ES2119837T3 (da)
HU (1)	HU220767B1 (da)
IL (1)	IL106462A (da)
SK (1)	SK282517B6 (da)
TW (1)	TW306918B (da)
ZA (1)	ZA935341B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4308034A1 (de) *	1993-03-13	1994-09-15	Cassella Ag	Neue Heterocyclen, ihre Herstellung und ihre Verwendung
DE4427979A1 (de) *	1993-11-15	1996-02-15	Cassella Ag	Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
US5849736A (en) *	1993-11-24	1998-12-15	The Dupont Merck Pharmaceutical Company	Isoxazoline and isoxazole fibrinogen receptor antagonists
US5563158A (en) *	1993-12-28	1996-10-08	The Dupont Merck Pharmaceutical Company	Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
ZA963391B (en) *	1995-05-24	1997-10-29	Du Pont Merck Pharma	Isoxazoline fibrinogen receptor antagonists.
ATE212990T1 (de)	1996-03-20	2002-02-15	Hoechst Ag	Inhibitoren der knochenresorption und vitronectinrezeptor-antagonisten
DE19622489A1 (de)	1996-06-05	1997-12-11	Hoechst Ag	Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters
DE19647380A1 (de) *	1996-11-15	1998-05-20	Hoechst Ag	5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647381A1 (de)	1996-11-15	1998-05-20	Hoechst Ag	Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647382A1 (de)	1996-11-15	1998-05-20	Hoechst Ag	Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19741235A1 (de)	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) *	1997-09-23	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de)	1997-11-19	1999-05-20	Hoechst Marion Roussel De Gmbh	Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de)	1998-05-14	1999-11-18	Hoechst Marion Roussel De Gmbh	Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6163155A (en) *	1999-01-28	2000-12-19	Dresser Industries, Inc.	Electromagnetic wave resistivity tool having a tilted antenna for determining the horizontal and vertical resistivities and relative dip angle in anisotropic earth formations
DE19922462A1 (de)	1999-05-17	2000-11-23	Aventis Pharma Gmbh	Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate
CA2375229A1 (en) *	1999-06-17	2000-12-28	Source Precision Medicine, Inc.	Method and compounds for inhibiting activity of serine elastases
DE10111877A1 (de)	2001-03-10	2002-09-12	Aventis Pharma Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10137595A1 (de) *	2001-08-01	2003-02-13	Aventis Pharma Gmbh	Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
KR20090055553A (ko)	2006-07-11	2009-06-02	핼리버튼 에너지 서비시즈 인코퍼레이티드	모듈화된 지오스티어링 툴 조립체
AU2007273026B2 (en) *	2006-07-12	2010-04-08	Halliburton Energy Services, Inc.	Method and apparatus for building a tilted antenna
GB2459067B (en) *	2007-03-16	2011-11-30	Halliburton Energy Serv Inc	Robust inversion systems and methods for azimuthally sensitive resistivity logging tools
GB2472155B (en)	2008-12-16	2013-12-18	Halliburton Energy Serv Inc	Azimuthal at-bit resistivity and geosteering methods and systems
US9085959B2 (en)	2010-01-22	2015-07-21	Halliburton Energy Services, Inc.	Method and apparatus for resistivity measurements
BR112014030170A2 (pt)	2012-06-25	2017-06-27	Halliburton Energy Services Inc	método e sistema de perfilagem eletromagnética
EP3286172B1 (en)	2015-04-23	2019-06-12	Constellation Pharmaceuticals, Inc.	Lsd1 inhibitors and uses thereof
LT3532459T (lt)	2016-10-26	2023-11-10	Constellation Pharmaceuticals, Inc.	Lsd1 inhibitoriai ir jų medicininis panaudojimas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4126277A1 (de) *	1991-08-08	1993-02-11	Cassella Ag	Hydantoinderivate
DE4213634A1 (de) *	1992-04-24	1993-10-28	Cassella Ag	2,4-Dioxo-imidazolidin-Derivate

1992
- 1992-07-24 DE DE4224414A patent/DE4224414A1/de not_active Withdrawn
1993
- 1993-07-01 JP JP16304293A patent/JP3775808B2/ja not_active Expired - Fee Related
- 1993-07-06 DE DE59308732T patent/DE59308732D1/de not_active Expired - Lifetime
- 1993-07-06 EP EP93110754A patent/EP0580008B1/de not_active Expired - Lifetime
- 1993-07-06 ES ES93110754T patent/ES2119837T3/es not_active Expired - Lifetime
- 1993-07-06 DK DK93110754T patent/DK0580008T3/da active
- 1993-07-06 AT AT93110754T patent/ATE168116T1/de not_active IP Right Cessation
- 1993-07-21 SK SK769-93A patent/SK282517B6/sk unknown
- 1993-07-21 CZ CZ19931475A patent/CZ289297B6/cs not_active IP Right Cessation
- 1993-07-22 US US08/095,905 patent/US5424293A/en not_active Expired - Lifetime
- 1993-07-23 AU AU42119/93A patent/AU664630B2/en not_active Ceased
- 1993-07-23 HU HU9302138A patent/HU220767B1/hu not_active IP Right Cessation
- 1993-07-23 ZA ZA935341A patent/ZA935341B/xx unknown
- 1993-07-23 CA CA002101179A patent/CA2101179C/en not_active Expired - Fee Related
- 1993-07-23 IL IL10646293A patent/IL106462A/xx not_active IP Right Cessation
- 1993-07-23 KR KR1019930013987A patent/KR100418321B1/ko not_active Expired - Fee Related
- 1993-07-24 TW TW082105953A patent/TW306918B/zh active

Also Published As

Publication number	Publication date
EP0580008B1 (de)	1998-07-08
SK282517B6 (sk)	2002-10-08
TW306918B (da)	1997-06-01
DK0580008T3 (da)	1999-02-08
SK76993A3 (en)	1994-04-06
KR100418321B1 (ko)	2004-05-07
HUT65141A (en)	1994-04-28
HU9302138D0 (en)	1993-10-28
KR940005583A (ko)	1994-03-21
JPH0725855A (ja)	1995-01-27
ES2119837T3 (es)	1998-10-16
US5424293A (en)	1995-06-13
CA2101179C (en)	2003-10-28
ZA935341B (en)	1994-02-14
ATE168116T1 (de)	1998-07-15
AU4211993A (en)	1994-01-27
EP0580008A2 (de)	1994-01-26
JP3775808B2 (ja)	2006-05-17
AU664630B2 (en)	1995-11-23
CZ289297B6 (cs)	2001-12-12
CZ147593A3 (en)	1994-03-16
CA2101179A1 (en)	1994-01-25
DE4224414A1 (de)	1994-01-27
EP0580008A3 (de)	1995-03-15
HU220767B1 (hu)	2002-05-28
IL106462A0 (en)	1993-11-15
DE59308732D1 (de)	1998-08-13

Legal Events

Date	Code	Title
1997-08-14	FF	Patent granted
1998-01-04	KB	Patent renewed
1999-12-22	KB	Patent renewed
2003-09-17	KB	Patent renewed
2008-04-13	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL106462A0 (en)	1993-11-15	Phenylimidazolidine derivatives,their preparation and pharmaceutical compositions containing them
BG100951A (en)	1997-08-29	Novel erythromycin derivatives, method for their preparation and their use as drugs
IL76457A (en)	1989-07-31	Tetralin derivatives,their preparation and pharmaceutical compositions containing them
ZW12388A1 (en)	1989-01-04	Immunomodulatory azaspiranes
HU9401408D0 (en)	1994-08-29	Monomere bile acid derivatives, process for producing them and pharmaceutical compositions containing them
NZ236589A (en)	1993-02-25	A-nor-steroid-3-carboxylic acid derivatives and pharmaceutical compositions
ZA898436B (en)	1991-07-31	Novel 3-piperidinyl-1,2-benzisoxazoles
IL75337A0 (en)	1985-09-29	Quinone derivative,process for the preparation thereof and pharmaceutical compositions containing the same
IL103875A0 (en)	1993-04-04	Piperazinyl-and piperidinyl-cyclohexanol derivatives and pharmaceutical compositions containing the same
HUT55002A (en)	1991-04-29	Process for producing pyrimidine -4,6-dicarboxylic acid-diamides and pharmaceutical compositions containing them as active components
PH25319A (da)	1991-04-30
TW248559B (da)	1995-06-01
HUT53664A (en)	1990-11-28	Process for producing enzyme inhibiting amino acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient
AU576386B2 (en)	1988-08-25	1h-indol-3-yl containing 1,3-dimethyl-1h-purine-2,6-diones
AU579869B2 (en)	1988-12-15	4-amino-8-alkylthio-2-piperazino-pyrimido ``5,4-d`` pyrimidines
HUT46664A (en)	1988-11-28	Process for producing new dihydropyridineamide derivatives and pharmaceutical compositions comprising these compounds
ZA912618B (en)	1992-01-29	3-aminochroman derivatives,process for preparing these and pharmaceutical compositions containing them
IL85658A (en)	1992-08-18	Pharmaceutical compositions containing substituted pyridine-2,4-dicarboxylic acid derivatives,some such compounds and processes for their preparation
HUT50142A (en)	1989-12-28	Process for producing allyl-mercapto-acetyl-sidnonimine derivatives and pharmaceutical compositions containing them
ES2001389A6 (es)	1988-05-16	Procedimiento para preparar derivados de o-toluidina
HUT54653A (en)	1991-03-28	Process for producing n,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamide derivatives and pharmaceutical compositions comprising such compounds
PL314794A1 (en)	1996-09-30	Crystalline polymorphous form of (s,s,s)-n-(1-[2-carbocy-3-(n2-mezilolysilamino)propyl]-1-cyclopentylocabonyl)thyrosine
ES471507A1 (es)	1979-10-01	Procedimiento para la obtencion de piperidino-propanoles
ZA941196B (en)	1994-09-20	Angiopeptin cyclopeptide compounds process for the preparation thereof and pharmaceutical compositions containing them
HUT73562A (en)	1996-08-28	Thiocarbamoyl-pyrazole derivatives, keto-carboxylic acid ester intermediates thereof, preparations thereof, using the pyrazole derivatives and microbicide compositions containing these compounds