IL106797A0 - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number: IL106797A0
Authority: IL; Israel
Prior art keywords: pct; hydroxy; nhch2; sch2; alkylcarbamoyl
Prior art date: 1992-08-28

Application number

IL106797A

Other languages

English (en)

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-28

Filing date

1993-08-25

Publication date

1993-12-08

1993-08-25 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1993-12-08 Publication of IL106797A0 publication Critical patent/IL106797A0/xx

Links

150000002391 heterocyclic compounds Chemical class 0.000 title 1
-1 hydroxy, amino Chemical group 0.000 abstract 4
125000005118 N-alkylcarbamoyl group Chemical group 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
108010022535 Farnesyl-Diphosphate Farnesyltransferase Proteins 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
102100037997 Squalene synthase Human genes 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Urology & Nephrology (AREA)
Pharmacology & Pharmacy (AREA)
Vascular Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL106797A 1992-08-28 1993-08-25 Heterocyclic compounds IL106797A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929218334A GB9218334D0 (en)	1992-08-28	1992-08-28	Heterocyclic compounds

Publications (1)

Publication Number	Publication Date
IL106797A0 true IL106797A0 (en)	1993-12-08

Family

ID=10721113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL106797A IL106797A0 (en)	1992-08-28	1993-08-25	Heterocyclic compounds

Country Status (13)

Country	Link
US (1)	US5714496A (2)
EP (1)	EP0656897B1 (2)
JP (1)	JPH08502731A (2)
AT (1)	ATE161843T1 (2)
AU (1)	AU4969193A (2)
CA (2)	CA2143430A1 (2)
DE (1)	DE69316224D1 (2)
FI (1)	FI950893A0 (2)
GB (2)	GB9218334D0 (2)
IL (1)	IL106797A0 (2)
TW (1)	TW231293B (2)
WO (1)	WO1994005660A1 (2)
ZA (1)	ZA936201B (2)

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US7112593B2 (en)	2001-03-27	2006-09-26	Eisai Co., Ltd.	N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient
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GB0127731D0 (en) *	2001-11-20	2002-01-09	Coin Controls	Coin handling apparatus
ATE401334T1 (de) *	2002-05-07	2008-08-15	Neurosearch As	Neue azacyclische ethinylderivate
ATE405840T1 (de) *	2002-12-19	2008-09-15	Scripps Research Inst	Zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung
NZ550534A (en)	2004-03-25	2009-07-31	Memory Pharm Corp	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
KR20070032700A (ko) *	2004-05-20	2007-03-22	폴드알엑스 파마슈티칼스, 인크.	트랜스티레틴을 안정화하고 트랜스티레틴 미스폴딩을억제하기 위한, ２-((헤테로)아릴)-벤즈옥사졸 화합물 및유도체, 그리고 조성물 및 방법
US7781478B2 (en) *	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
EP1771169A1 (en) *	2004-07-14	2007-04-11	PTC Therapeutics, Inc.	Methods for treating hepatitis c
US7772271B2 (en) *	2004-07-14	2010-08-10	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7868037B2 (en) *	2004-07-14	2011-01-11	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
JP2008507518A (ja) *	2004-07-22	2008-03-13	ピーティーシーセラピューティクス，インコーポレーテッド	Ｃ型肝炎を治療するためのチエノピリジン
WO2006045010A2 (en)	2004-10-20	2006-04-27	Resverlogix Corp.	Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
CA2617213C (en)	2005-07-29	2014-01-28	Resverlogix Corp.	Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US8106066B2 (en)	2005-09-23	2012-01-31	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
EP2074223A4 (en) *	2006-09-15	2010-03-10	Foldrx Pharmaceuticals Inc	TEST PROCEDURE FOR THE DETECTION OF PROTEINS IN THE NATIVE CONDITION AND FOR THE IDENTIFICATION OF THE STABILITY OF PROTEINS IN THE NATIVE CONDITION MODULATING COMPOUNDS
WO2008092231A1 (en)	2007-02-01	2008-08-07	Resverlogix Corp.	Compounds for the prevention and treatment of cardiovascular diseases
KR101629356B1 (ko)	2008-06-26	2016-06-13	리스버로직스 코퍼레이션	퀴나졸리논 유도체의 제조방법
AU2010204106B2 (en)	2009-01-08	2014-05-08	Resverlogix Corp.	Compounds for the prevention and treatment of cardiovascular disease
NZ755378A (en)	2009-03-18	2022-07-29	Resverlogix Corp	Novel quinazolinones and related compounds for use as anti-inflammatory agents
KR20190091564A (ko)	2009-04-22	2019-08-06	리스버로직스 코퍼레이션	신규한 소염제
RU2586330C2 (ru)	2011-09-16	2016-06-10	Пфайзер Инк.	Твердые формы ингибитора диссоциации транстиретина
RU2640115C2 (ru)	2011-11-01	2017-12-26	Ресверлоджикс Корп.	Фармацевтические композиции замещенных хиназолинонов
US8859553B2 (en) *	2012-07-30	2014-10-14	Astar Biotech Llc	Protein kinase inhibitors
US9073878B2 (en)	2012-11-21	2015-07-07	Zenith Epigenetics Corp.	Cyclic amines as bromodomain inhibitors
US9765039B2 (en)	2012-11-21	2017-09-19	Zenith Epigenetics Ltd.	Biaryl derivatives as bromodomain inhibitors
AU2013365926B9 (en)	2012-12-21	2019-01-17	Zenith Epigenetics Ltd.	Novel heterocyclic compounds as bromodomain inhibitors
JO3789B1 (ar)	2015-03-13	2021-01-31	Resverlogix Corp	التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة

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US3405134A (en) *	1965-08-17	1968-10-08	Colgate Palmolive Co	Quinuclidyl esters of aromatic acids
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GB8918061D0 (en) *	1989-08-08	1989-09-20	Merck Sharp & Dohme	Therapeutic agents
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DE4116582A1 (de) *	1990-05-19	1991-11-21	Boehringer Ingelheim Kg	Bicyclische 1-aza-cycloalkane
ZA92278B (en) *	1991-02-01	1992-10-28	Akzo Nv	3-quinuclidine derivatives
US5385912A (en) *	1991-03-08	1995-01-31	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
CA2105655A1 (en) *	1991-03-08	1992-09-09	Kent Neuenschwander	Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5135935A (en) *	1991-05-17	1992-08-04	Merck & Co., Inc.	Squalene synthetase inhibitors
GB9127279D0 (en) *	1991-12-23	1992-02-19	Ici Plc	Heterocyclic derivatives
GB9201749D0 (en) *	1992-01-28	1992-03-11	Smithkline Beecham Plc	Medicaments
GB9202443D0 (en) *	1992-02-05	1992-03-18	Fujisawa Pharmaceutical Co	A novel substituted-acetamide compound and a process for the preparation thereof
GB9211796D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Heterocyclic derivatives

1992
- 1992-08-28 GB GB929218334A patent/GB9218334D0/en active Pending
1993
- 1993-08-18 GB GB939317153A patent/GB9317153D0/en active Pending
- 1993-08-24 EP EP93919477A patent/EP0656897B1/en not_active Expired - Lifetime
- 1993-08-24 JP JP6506955A patent/JPH08502731A/ja active Pending
- 1993-08-24 DE DE69316224T patent/DE69316224D1/de not_active Expired - Lifetime
- 1993-08-24 CA CA002143430A patent/CA2143430A1/en not_active Abandoned
- 1993-08-24 AT AT93919477T patent/ATE161843T1/de not_active IP Right Cessation
- 1993-08-24 AU AU49691/93A patent/AU4969193A/en not_active Abandoned
- 1993-08-24 ZA ZA936201A patent/ZA936201B/xx unknown
- 1993-08-24 WO PCT/GB1993/001802 patent/WO1994005660A1/en not_active Ceased
- 1993-08-25 US US08/392,928 patent/US5714496A/en not_active Expired - Fee Related
- 1993-08-25 IL IL106797A patent/IL106797A0/xx unknown
- 1993-08-27 CA CA002104981A patent/CA2104981A1/en not_active Abandoned
- 1993-08-31 TW TW082107086A patent/TW231293B/zh active
1995
- 1995-02-27 FI FI950893A patent/FI950893A0/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
GB9317153D0 (en)	1993-10-06
US5714496A (en)	1998-02-03
JPH08502731A (ja)	1996-03-26
AU4969193A (en)	1994-03-29
EP0656897A1 (en)	1995-06-14
ZA936201B (en)	1994-02-28
CA2104981A1 (en)	1994-03-01
FI950893A7 (fi)	1995-02-27
ATE161843T1 (de)	1998-01-15
WO1994005660A1 (en)	1994-03-17
DE69316224D1 (de)	1998-02-12
EP0656897B1 (en)	1998-01-07
GB9218334D0 (en)	1992-10-14
CA2143430A1 (en)	1994-03-17
TW231293B (2)	1994-10-01
FI950893A0 (fi)	1995-02-27

Publication	Publication Date	Title
TW231293B (2)	1994-10-01
BG101769A (en)	1998-04-30	Indole derivatives useful in the treatment of osteoporosis
AU3620597A (en)	1998-02-02	Indole derivatives for the treatment of osteoporosis
GB2311780B (en)	1999-03-03	Pharmaceutical Piperazine Compounds
GB9211796D0 (en)	1992-07-15	Heterocyclic derivatives
TW231292B (2)	1994-10-01
GB9207961D0 (en)	1992-05-27	Heterocyclic derivatives
ZA928428B (en)	1993-05-03	Heterocyclic compounds.
AU4486796A (en)	1996-08-14	Imidazole derivatives, their preparation and their use as sadenosylmethionine decarboxylase (=samdc) inhibitors
NO950756L (no)	1995-02-27	Kinuklidinderivater som squalensyntetase-inhibitorer
GB9226577D0 (en)	1993-02-17	Heterocyclic derivatives
JO1720B1 (en)	1993-06-15	Heterocyclic derivatives