ATE161843T1 - Chinuclidine derivate als squalen synthase inhibitoren - Google Patents

Chinuclidine derivate als squalen synthase inhibitoren

Info

Publication number
ATE161843T1
ATE161843T1 AT93919477T AT93919477T ATE161843T1 AT E161843 T1 ATE161843 T1 AT E161843T1 AT 93919477 T AT93919477 T AT 93919477T AT 93919477 T AT93919477 T AT 93919477T AT E161843 T1 ATE161843 T1 AT E161843T1
Authority
AT
Austria
Prior art keywords
pct
hydroxy
nhch2
sch2
alkylcarbamoyl
Prior art date
Application number
AT93919477T
Other languages
German (de)
English (en)
Inventor
George Robert Brown
Keith Blakeney Mallion
Paul Robert Owen Whittamore
David Robert Brittain
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ATE161843T1 publication Critical patent/ATE161843T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT93919477T 1992-08-28 1993-08-24 Chinuclidine derivate als squalen synthase inhibitoren ATE161843T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929218334A GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ATE161843T1 true ATE161843T1 (de) 1998-01-15

Family

ID=10721113

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93919477T ATE161843T1 (de) 1992-08-28 1993-08-24 Chinuclidine derivate als squalen synthase inhibitoren

Country Status (13)

Country Link
US (1) US5714496A (2)
EP (1) EP0656897B1 (2)
JP (1) JPH08502731A (2)
AT (1) ATE161843T1 (2)
AU (1) AU4969193A (2)
CA (2) CA2143430A1 (2)
DE (1) DE69316224D1 (2)
FI (1) FI950893A0 (2)
GB (2) GB9218334D0 (2)
IL (1) IL106797A0 (2)
TW (1) TW231293B (2)
WO (1) WO1994005660A1 (2)
ZA (1) ZA936201B (2)

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ATE405840T1 (de) * 2002-12-19 2008-09-15 Scripps Research Inst Zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung
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KR20070032700A (ko) * 2004-05-20 2007-03-22 폴드알엑스 파마슈티칼스, 인크. 트랜스티레틴을 안정화하고 트랜스티레틴 미스폴딩을억제하기 위한, ２-((헤테로)아릴)-벤즈옥사졸 화합물 및유도체, 그리고 조성물 및 방법
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WO2006045010A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
CA2617213C (en) 2005-07-29 2014-01-28 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
EP2074223A4 (en) * 2006-09-15 2010-03-10 Foldrx Pharmaceuticals Inc TEST PROCEDURE FOR THE DETECTION OF PROTEINS IN THE NATIVE CONDITION AND FOR THE IDENTIFICATION OF THE STABILITY OF PROTEINS IN THE NATIVE CONDITION MODULATING COMPOUNDS
WO2008092231A1 (en) 2007-02-01 2008-08-07 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
KR101629356B1 (ko) 2008-06-26 2016-06-13 리스버로직스 코퍼레이션 퀴나졸리논 유도체의 제조방법
AU2010204106B2 (en) 2009-01-08 2014-05-08 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
NZ755378A (en) 2009-03-18 2022-07-29 Resverlogix Corp Novel quinazolinones and related compounds for use as anti-inflammatory agents
KR20190091564A (ko) 2009-04-22 2019-08-06 리스버로직스 코퍼레이션 신규한 소염제
RU2586330C2 (ru) 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
RU2640115C2 (ru) 2011-11-01 2017-12-26 Ресверлоджикс Корп. Фармацевтические композиции замещенных хиназолинонов
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US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
JO3789B1 (ar) 2015-03-13 2021-01-31 Resverlogix Corp التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة

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Also Published As

Publication number Publication date
IL106797A0 (en) 1993-12-08
GB9317153D0 (en) 1993-10-06
US5714496A (en) 1998-02-03
JPH08502731A (ja) 1996-03-26
AU4969193A (en) 1994-03-29
EP0656897A1 (en) 1995-06-14
ZA936201B (en) 1994-02-28
CA2104981A1 (en) 1994-03-01
FI950893A7 (fi) 1995-02-27
WO1994005660A1 (en) 1994-03-17
DE69316224D1 (de) 1998-02-12
EP0656897B1 (en) 1998-01-07
GB9218334D0 (en) 1992-10-14
CA2143430A1 (en) 1994-03-17
TW231293B (2) 1994-10-01
FI950893A0 (fi) 1995-02-27

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties