IL106859A - Pentoxifilin metabolites and pharmaceutical preparations containing them for the treatment of VIH and similar diseases - Google Patents
Pentoxifilin metabolites and pharmaceutical preparations containing them for the treatment of VIH and similar diseasesInfo
- Publication number
- IL106859A IL106859A IL10685987A IL10685987A IL106859A IL 106859 A IL106859 A IL 106859A IL 10685987 A IL10685987 A IL 10685987A IL 10685987 A IL10685987 A IL 10685987A IL 106859 A IL106859 A IL 106859A
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- formula
- pentoxifylline
- group
- acid
- Prior art date
Links
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical class O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 title claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 11
- 201000010099 disease Diseases 0.000 title description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 84
- 230000000694 effects Effects 0.000 claims abstract description 27
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 11
- 208000014674 injury Diseases 0.000 claims description 11
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 10
- 208000027418 Wounds and injury Diseases 0.000 claims description 9
- 230000006378 damage Effects 0.000 claims description 9
- 208000030507 AIDS Diseases 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 206010006895 Cachexia Diseases 0.000 claims description 5
- 230000001413 cellular effect Effects 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical class O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 claims description 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 102000000589 Interleukin-1 Human genes 0.000 abstract description 32
- 108010002352 Interleukin-1 Proteins 0.000 abstract description 32
- 230000005764 inhibitory process Effects 0.000 abstract description 14
- 241000124008 Mammalia Species 0.000 abstract description 5
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 29
- 238000006243 chemical reaction Methods 0.000 description 26
- 210000003622 mature neutrocyte Anatomy 0.000 description 24
- -1 methylmagnesium halides Chemical class 0.000 description 23
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 20
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 13
- 150000003839 salts Chemical class 0.000 description 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
- 239000002253 acid Substances 0.000 description 12
- 125000000217 alkyl group Chemical group 0.000 description 12
- 239000002158 endotoxin Substances 0.000 description 12
- 229920006008 lipopolysaccharide Polymers 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 229960001476 pentoxifylline Drugs 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 10
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- 238000002360 preparation method Methods 0.000 description 8
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- 239000002168 alkylating agent Substances 0.000 description 7
- 229940100198 alkylating agent Drugs 0.000 description 7
- 125000004432 carbon atom Chemical group C* 0.000 description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
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- 150000002576 ketones Chemical class 0.000 description 7
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- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 4
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- 150000003512 tertiary amines Chemical class 0.000 description 4
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 3
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 150000001340 alkali metals Chemical class 0.000 description 3
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- 238000005804 alkylation reaction Methods 0.000 description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 150000002009 diols Chemical class 0.000 description 3
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 3
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- 229910052987 metal hydride Inorganic materials 0.000 description 3
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
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- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
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- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000005049 silicon tetrachloride Substances 0.000 description 1
- WKQCYNCZDDJXEK-UHFFFAOYSA-N simalikalactone C Natural products C1C(C23C)OC(=O)CC3C(C)C(=O)C(O)C2C2(C)C1C(C)C=C(OC)C2=O WKQCYNCZDDJXEK-UHFFFAOYSA-N 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000003458 sulfonic acid derivatives Chemical class 0.000 description 1
- 125000002130 sulfonic acid ester group Chemical group 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 229940102001 zinc bromide Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94790586A | 1986-12-31 | 1986-12-31 | |
| IL8493487A IL84934A (en) | 1986-12-31 | 1987-12-23 | Pharmaceutical preparations containing xanthan history to stop the activity of interleukin-1 and leukocyte-derived cytokines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL106859A true IL106859A (en) | 1996-10-16 |
Family
ID=25486973
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10685987A IL106859A (en) | 1986-12-31 | 1987-12-23 | Pentoxifilin metabolites and pharmaceutical preparations containing them for the treatment of VIH and similar diseases |
| IL8493487A IL84934A (en) | 1986-12-31 | 1987-12-23 | Pharmaceutical preparations containing xanthan history to stop the activity of interleukin-1 and leukocyte-derived cytokines |
| IL10053687A IL100536A (en) | 1986-12-31 | 1987-12-23 | Pharmaceutical preparations containing a history of xanthine Stopping an immune response and relieving adverse conditions resulting from intracellular intervention in an immune response |
| IL10685487A IL106854A (en) | 1986-12-31 | 1987-12-23 | Pantoxifilin metabolites and pharmaceutical preparations containing them to prevent an immune reaction and to reduce undesirable conditions in this regard |
| IL10686187A IL106861A (en) | 1986-12-31 | 1987-12-23 | Pentoxifylline metabolites and pharmaceutical formulations containing them for inhibiting the activity of interleukin-1 and leukocyte-derived cytokines |
| IL10053587A IL100535A (en) | 1986-12-31 | 1987-12-23 | Pharmaceutical preparations containing a history of xanthine to relieve disease states |
| IL10053387A IL100533A (en) | 1986-12-31 | 1987-12-23 | Pharmaceutical preparations containing a history of xanthine for VIH treatment and disease states |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8493487A IL84934A (en) | 1986-12-31 | 1987-12-23 | Pharmaceutical preparations containing xanthan history to stop the activity of interleukin-1 and leukocyte-derived cytokines |
| IL10053687A IL100536A (en) | 1986-12-31 | 1987-12-23 | Pharmaceutical preparations containing a history of xanthine Stopping an immune response and relieving adverse conditions resulting from intracellular intervention in an immune response |
| IL10685487A IL106854A (en) | 1986-12-31 | 1987-12-23 | Pantoxifilin metabolites and pharmaceutical preparations containing them to prevent an immune reaction and to reduce undesirable conditions in this regard |
| IL10686187A IL106861A (en) | 1986-12-31 | 1987-12-23 | Pentoxifylline metabolites and pharmaceutical formulations containing them for inhibiting the activity of interleukin-1 and leukocyte-derived cytokines |
| IL10053587A IL100535A (en) | 1986-12-31 | 1987-12-23 | Pharmaceutical preparations containing a history of xanthine to relieve disease states |
| IL10053387A IL100533A (en) | 1986-12-31 | 1987-12-23 | Pharmaceutical preparations containing a history of xanthine for VIH treatment and disease states |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0279079B1 (da) |
| JP (1) | JP2507012B2 (da) |
| KR (1) | KR960015726B1 (da) |
| AT (1) | ATE151290T1 (da) |
| AU (1) | AU668982B2 (da) |
| CA (1) | CA1313137C (da) |
| DE (1) | DE3752048T2 (da) |
| DK (1) | DK482088A (da) |
| ES (1) | ES2103255T3 (da) |
| GR (1) | GR3024054T3 (da) |
| IE (1) | IE873554L (da) |
| IL (7) | IL106859A (da) |
| WO (1) | WO1988004928A1 (da) |
| ZA (1) | ZA879754B (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196430A (en) * | 1986-12-31 | 1993-03-23 | Hoechst-Roussel Pharmaceuticals Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| US5272153A (en) * | 1986-12-31 | 1993-12-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| US5196429A (en) * | 1986-12-31 | 1993-03-23 | Hoechst-Roussel Pharmaceuticals Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| US4965271A (en) * | 1986-12-31 | 1990-10-23 | Hoechst Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| JPH04506215A (ja) * | 1989-06-13 | 1992-10-29 | スミスクライン・ビーチャム・コーポレイション | モノカイン活性干渉 |
| DD298051A5 (de) * | 1989-08-16 | 1992-02-06 | ��@���������@�������k�� | Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten |
| EP0493682A3 (en) * | 1990-11-30 | 1992-11-19 | Hoechst-Roussel Pharmaceuticals Incorporated | Use of xanthines for the preparation of a medicament effective for inhibiting the effects of allograft reaction in humans |
| EP0490181A1 (en) * | 1990-11-30 | 1992-06-17 | Hoechst-Roussel Pharmaceuticals Incorporated | Use of xanthines for preparation of a medicament having immunosuppressing activity |
| US6420374B1 (en) | 1990-11-30 | 2002-07-16 | Fred Hutchinson Cancer Research Center | Use of xanthines as immunosuppressants and to inhibit allograft reactions |
| JP3566719B2 (ja) * | 1991-05-24 | 2004-09-15 | フレッド ハッチンソン キャンサー リサーチ センター | 外来性刺激に対する細胞性応答の調整 |
| JPH05194233A (ja) * | 1991-06-10 | 1993-08-03 | Hoechst Roussel Pharmaceut Inc | マイクロペレットおよびそれらの製造方法 |
| WO1993003728A1 (en) * | 1991-08-27 | 1993-03-04 | Temple University Of The Commonwealth System Of | Xanthine suppression of antigen activation of t- or b-cells |
| WO1993008819A1 (en) * | 1991-10-31 | 1993-05-13 | The Victoria University Of Manchester | Treatment of neurological conditions by an interleukin-1 inhibiting compound |
| AU3539795A (en) * | 1994-08-25 | 1996-03-14 | Medical University Of South Carolina | Methods of treating cold symptoms using pentoxifylline |
| US5856330A (en) * | 1996-07-31 | 1999-01-05 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin |
| US5981536A (en) * | 1996-07-31 | 1999-11-09 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the modulation of apoptosis |
| JP3830115B2 (ja) * | 1997-10-06 | 2006-10-04 | シャープ株式会社 | 液晶表示素子 |
| TW561297B (en) * | 1997-11-25 | 2003-11-11 | Toshiba Corp | Electrode wiring board subjected to counter measure against static electricity and display device using the same |
| JP3019053B2 (ja) * | 1997-12-25 | 2000-03-13 | 日本電気株式会社 | 液晶表示装置及びその製造方法 |
| KR20100121527A (ko) | 2008-02-29 | 2010-11-17 | 콘서트 파마슈티컬즈, 인크. | 치환된 잔틴 유도체 |
| US8952016B2 (en) | 2009-02-27 | 2015-02-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| EP2611807A2 (en) | 2010-09-01 | 2013-07-10 | Concert Pharmaceuticals Inc. | Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purine-2,6(3h,7h)dione |
| WO2013013052A1 (en) | 2011-07-19 | 2013-01-24 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| KR20150002779A (ko) | 2012-04-13 | 2015-01-07 | 콘서트 파마슈티컬즈, 인크. | 치환된 크산틴 유도체 |
| WO2013159006A1 (en) | 2012-04-20 | 2013-10-24 | Concert Pharmaceuticals, Inc. | Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3,7-dimethyl-1h-purine-2,6(3h,7h)-dione |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0005015B1 (en) * | 1978-04-22 | 1986-10-29 | BEECHAM - WUELFING GmbH & Co. KG | Use of a xanthine derivate in the manufacture of a medicament |
| US4567183A (en) * | 1983-03-11 | 1986-01-28 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
| US4636507A (en) * | 1984-04-30 | 1987-01-13 | Hoechst-Roussel Pharmaceuticals Inc. | Host defense mechanism enhancement |
| GB8418430D0 (en) * | 1984-07-19 | 1984-08-22 | Beecham Wuelfing Gmbh & Co Kg | Treatment |
-
1987
- 1987-12-23 IL IL10685987A patent/IL106859A/en not_active IP Right Cessation
- 1987-12-23 IL IL8493487A patent/IL84934A/en not_active IP Right Cessation
- 1987-12-23 IL IL10053687A patent/IL100536A/en not_active IP Right Cessation
- 1987-12-23 IL IL10685487A patent/IL106854A/en not_active IP Right Cessation
- 1987-12-23 IL IL10686187A patent/IL106861A/xx not_active IP Right Cessation
- 1987-12-23 IL IL10053587A patent/IL100535A/en not_active IP Right Cessation
- 1987-12-23 IL IL10053387A patent/IL100533A/en not_active IP Right Cessation
- 1987-12-28 WO PCT/US1987/003479 patent/WO1988004928A1/en not_active Ceased
- 1987-12-28 JP JP63501103A patent/JP2507012B2/ja not_active Expired - Lifetime
- 1987-12-28 KR KR1019880701056A patent/KR960015726B1/ko not_active Expired - Fee Related
- 1987-12-30 AT AT87119377T patent/ATE151290T1/de not_active IP Right Cessation
- 1987-12-30 DE DE3752048T patent/DE3752048T2/de not_active Expired - Fee Related
- 1987-12-30 ZA ZA879754A patent/ZA879754B/xx unknown
- 1987-12-30 IE IE873554A patent/IE873554L/xx unknown
- 1987-12-30 CA CA000555613A patent/CA1313137C/en not_active Expired - Fee Related
- 1987-12-30 EP EP87119377A patent/EP0279079B1/en not_active Expired - Lifetime
- 1987-12-30 ES ES87119377T patent/ES2103255T3/es not_active Expired - Lifetime
-
1988
- 1988-08-30 DK DK482088A patent/DK482088A/da not_active Application Discontinuation
-
1993
- 1993-08-27 AU AU46027/93A patent/AU668982B2/en not_active Ceased
-
1997
- 1997-07-09 GR GR970401709T patent/GR3024054T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3752048D1 (de) | 1997-05-15 |
| JPH02501829A (ja) | 1990-06-21 |
| AU4602793A (en) | 1993-11-18 |
| IL106854A (en) | 1996-05-14 |
| EP0279079B1 (en) | 1997-04-09 |
| IL100535A (en) | 1994-05-30 |
| KR960015726B1 (ko) | 1996-11-20 |
| AU1150588A (en) | 1988-07-27 |
| AU637542B2 (en) | 1993-05-27 |
| WO1988004928A1 (en) | 1988-07-14 |
| IL84934A (en) | 1994-08-26 |
| ATE151290T1 (de) | 1997-04-15 |
| EP0279079A2 (en) | 1988-08-24 |
| EP0279079A3 (en) | 1990-06-13 |
| ES2103255T3 (es) | 1997-09-16 |
| AU619732B2 (en) | 1992-02-06 |
| DK482088D0 (da) | 1988-08-30 |
| IL106861A (en) | 1997-02-18 |
| JP2507012B2 (ja) | 1996-06-12 |
| CA1313137C (en) | 1993-01-26 |
| DK482088A (da) | 1988-10-28 |
| KR890700347A (ko) | 1989-04-24 |
| IL100533A (en) | 1994-05-30 |
| IL100536A (en) | 1994-05-30 |
| GR3024054T3 (en) | 1997-10-31 |
| AU1291892A (en) | 1992-05-14 |
| DE3752048T2 (de) | 1997-10-02 |
| IE873554L (en) | 1988-06-30 |
| ZA879754B (en) | 1989-07-26 |
| AU668982B2 (en) | 1996-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| HC | Change of name of proprietor(s) | ||
| NE | Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967) | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |