IL107200A - Process for producing citrate of alkali metal - Google Patents

Process for producing citrate of alkali metal

Info

Publication number: IL107200A
Authority: IL; Israel
Prior art keywords: alkali metal; set forth; aqueous solution; citric acid; citrate
Prior art date: 1992-10-07

Application number

IL10720093A

Other languages

English (en)

Hebrew (he)

Other versions

IL107200A0 (en

Original Assignee

Cerester Holding B V

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-07

Filing date

1993-10-06

Publication date

1996-10-16

1993-10-06 Application filed by Cerester Holding B V filed Critical Cerester Holding B V

1994-01-25 Publication of IL107200A0 publication Critical patent/IL107200A0/xx

1996-10-16 Publication of IL107200A publication Critical patent/IL107200A/en

Links

229910052783 alkali metal Inorganic materials 0.000 title claims abstract description 31
238000000034 method Methods 0.000 title claims abstract description 31
-1 alkali-metal citrate Chemical class 0.000 title claims abstract description 21
238000004519 manufacturing process Methods 0.000 title claims description 6
239000007864 aqueous solution Substances 0.000 claims abstract description 17
239000003463 adsorbent Substances 0.000 claims abstract description 14
239000003957 anion exchange resin Substances 0.000 claims abstract description 13
238000000855 fermentation Methods 0.000 claims abstract description 12
230000004151 fermentation Effects 0.000 claims abstract description 12
239000000243 solution Substances 0.000 claims abstract description 7
150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 80
239000001509 sodium citrate Substances 0.000 claims description 9
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical group [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 8
150000001340 alkali metals Chemical class 0.000 claims description 7
229940038773 trisodium citrate Drugs 0.000 claims description 7
235000019263 trisodium citrate Nutrition 0.000 claims description 7
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
235000011152 sodium sulphate Nutrition 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims 1
239000012266 salt solution Substances 0.000 claims 1
150000003839 salts Chemical class 0.000 abstract description 7
238000001179 sorption measurement Methods 0.000 description 6
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
229960001031 glucose Drugs 0.000 description 5
239000000047 product Substances 0.000 description 5
150000001450 anions Chemical class 0.000 description 4
238000000926 separation method Methods 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
150000001720 carbohydrates Chemical class 0.000 description 3
239000008121 dextrose Substances 0.000 description 3
239000000203 mixture Substances 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
229920001429 chelating resin Polymers 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
150000001860 citric acid derivatives Chemical class 0.000 description 2
238000003795 desorption Methods 0.000 description 2
239000008103 glucose Substances 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
235000011083 sodium citrates Nutrition 0.000 description 2
229910021653 sulphate ion Inorganic materials 0.000 description 2
OSNSWKAZFASRNG-WNFIKIDCSA-N (2s,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol;hydrate Chemical compound O.OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O OSNSWKAZFASRNG-WNFIKIDCSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000003513 alkali Substances 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
239000012043 crude product Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
239000003599 detergent Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
239000012535 impurity Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000002336 sorption--desorption measurement Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000001117 sulphuric acid Substances 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL10720093A 1992-10-07 1993-10-06 Process for producing citrate of alkali metal IL107200A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929221111A GB9221111D0 (en)	1992-10-07	1992-10-07	Process for the production of an alkali metal citrate

Publications (2)

Publication Number	Publication Date
IL107200A0 IL107200A0 (en)	1994-01-25
IL107200A true IL107200A (en)	1996-10-16

Family

ID=10723119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10720093A IL107200A (en)	1992-10-07	1993-10-06	Process for producing citrate of alkali metal

Country Status (12)

Country	Link
US (1)	US5382681A (fr)
EP (1)	EP0592123B1 (fr)
JP (1)	JPH07291894A (fr)
CN (1)	CN1035611C (fr)
AT (1)	ATE144975T1 (fr)
AU (1)	AU661200B2 (fr)
CZ (1)	CZ284996B6 (fr)
DE (1)	DE69305826T2 (fr)
GB (1)	GB9221111D0 (fr)
IL (1)	IL107200A (fr)
RU (1)	RU2124496C1 (fr)
TR (1)	TR27690A (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2920451B2 (ja) *	1993-03-29	1999-07-19	エスエス製薬株式会社	消炎鎮痛貼付剤
CN1068236C (zh) *	1994-02-15	2001-07-11	莱利工业公司	解吸方法和装置
US6146534A (en)	1996-08-19	2000-11-14	Reilly Industries, Inc.	Thermally-managed separation and dewatering processes for recovering acid products
CN1056191C (zh) *	1995-12-04	2000-09-06	中国科学院生态环境研究中心	用阴离子交换树脂制取柠檬酸三钠的方法
CN1060522C (zh) *	1996-01-30	2001-01-10	天津轻工业学院	分离提纯柠檬酸的方法
US6420439B1 (en)	1998-04-15	2002-07-16	Reilly Industries, Inc.	Crosslinked, non-swellable ampholytic base resins
US6872314B2 (en) *	2003-08-29	2005-03-29	Eastman Chemical Company	Dewatering process
US20100098782A1 (en) *	2008-10-16	2010-04-22	Johnsondiversey, Inc.	Use of sodium acid sulfate as a disinfectant
CN103012115B (zh) *	2012-12-30	2014-01-29	湖南尔康制药股份有限公司	一种药用枸橼酸钾的生产工艺
WO2024097329A1 (fr)	2022-11-02	2024-05-10	Amalgamated Research Llc	Séparateur smb pour purification d'acide organique à l'aide d'une résine cationique fortement acide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2362906A (en) *	1943-02-25	1944-11-14	Mutual Citrus Products Company	Process of recovering citric acid values from citrus products
US2697725A (en) *	1950-03-18	1954-12-21	Sharples Corp	Recovery of organic acids from aqueous solutions
JPS5231033B2 (fr) *	1972-05-03	1977-08-12
DE2727304C2 (de) *	1977-06-16	1982-12-02	Dr. Madaus & Co, 5000 Köln	Saures Alkalicitrat, dessen Herstellung und Verwendung
US5041645A (en) *	1985-05-10	1991-08-20	Haarmann & Reimer Corp.	Method for the preparation and recovery of alkali metal citrates
US4924027A (en) *	1986-12-18	1990-05-08	Uop	Separation of salts of citric acid from fermentation broth with a weakly basic anionic exchange resin adsorbent
US4720579A (en) *	1986-12-18	1988-01-19	Uop Inc.	Separation of citric acid from fermentation broth with a neutral polymeric adsorbent
ES2018707B3 (es) *	1988-01-11	1991-05-01	Uop (A New York General Partnership)	Separacion de acido citrico de caldo de fermentacion
US4994609A (en) *	1990-06-06	1991-02-19	Innova S.A.	Production of citric acid
US5237098A (en) *	1992-10-09	1993-08-17	Miles, Inc.	Production of citric acid and trisodium citrate from molasses

1992
- 1992-10-07 GB GB929221111A patent/GB9221111D0/en active Pending
1993
- 1993-09-17 US US08/122,300 patent/US5382681A/en not_active Expired - Lifetime
- 1993-09-21 DE DE69305826T patent/DE69305826T2/de not_active Expired - Fee Related
- 1993-09-21 EP EP93307466A patent/EP0592123B1/fr not_active Expired - Lifetime
- 1993-09-21 AT AT93307466T patent/ATE144975T1/de not_active IP Right Cessation
- 1993-09-30 TR TR00876/93A patent/TR27690A/xx unknown
- 1993-10-04 JP JP5248256A patent/JPH07291894A/ja not_active Withdrawn
- 1993-10-05 AU AU48834/93A patent/AU661200B2/en not_active Ceased
- 1993-10-06 RU RU93056164A patent/RU2124496C1/ru active
- 1993-10-06 IL IL10720093A patent/IL107200A/en not_active IP Right Cessation
- 1993-10-07 CZ CZ932102A patent/CZ284996B6/cs not_active IP Right Cessation
- 1993-10-07 CN CN93118695.1A patent/CN1035611C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1090264A (zh)	1994-08-03
AU661200B2 (en)	1995-07-13
DE69305826D1 (de)	1996-12-12
DE69305826T2 (de)	1997-03-13
AU4883493A (en)	1994-04-21
ATE144975T1 (de)	1996-11-15
US5382681A (en)	1995-01-17
EP0592123B1 (fr)	1996-11-06
TR27690A (tr)	1995-06-19
GB9221111D0 (en)	1992-11-18
CN1035611C (zh)	1997-08-13
EP0592123A1 (fr)	1994-04-13
RU2124496C1 (ru)	1999-01-10
CZ284996B6 (cs)	1999-04-14
IL107200A0 (en)	1994-01-25
CZ210293A3 (en)	1994-04-13
JPH07291894A (ja)	1995-11-07

Legal Events

Date	Code	Title
1997-03-18	FF	Patent granted
1997-07-13	KB	Patent renewed
2000-07-16	FF	Patent granted
2000-08-31	KB	Patent renewed
2003-12-10	KB	Patent renewed
2008-08-10	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US6013492A (en)	2000-01-11	Microbial process for producing calcium D-pantothenate
EP0575550B1 (fr)	1997-11-26	Recuperation d'acide phytique et/ou lactique et extraction directe d'inositol
KR20010041516A (ko)	2001-05-25	음이온 교환 크로마토그래피를 사용한 유기산의 정제
US5382681A (en)	1995-01-17	Process for the production of an alkali metal citrate
EP0633240B1 (fr)	1998-01-21	Récupération d'acide citrique à partir de courants du procédé par l'addition d'acides forts et de leurs sels
US5449824A (en)	1995-09-12	Recovery of organic acid salts from impure process streams by addition of bases
KR100776895B1 (ko)	2007-11-19	2-Ｏ-α-Ｄ-글루코피라노실-Ｌ-아스코르브산 고함유물의제조방법
AU658788B2 (en)	1995-04-27	Recovery of organic acid salts from impure process streams by addition of bases
US3173949A (en)	1965-03-16	Recovery of glutamic acid from a fermentation broth using cation exchange resins
JP3243891B2 (ja)	2002-01-07	ピルビン酸の精製方法
WO1997013761A1 (fr)	1997-04-17	Procede de recuperation d'acide ascorbique
SU1392902A1 (ru)	1990-05-07	Способ выделени и очистки бактериальной эндонуклеазы из культуральной жидкости SеRRатIа маRсеSсеUS
US3522296A (en)	1970-07-28	Method for producing choline salts of organic acids from choline chloride
KR800001597B1 (ko)	1980-12-29	누클레오 타이드의 정제법
KR100280374B1 (ko)	2001-02-01	약산성 양이온 교환수지를 이용한 l-오르니틴의 정제방법
JPH04183395A (ja)	1992-06-30	マンニトールの分離精製方法
JPH0662667B2 (ja)	1994-08-17	グルタチオンの精製方法
JPS5817594B2 (ja)	1983-04-08	セフアロスポリンｃノセイセイホウ
JPS597318B2 (ja)	1984-02-17	ホ−テイマイシンａの精製法
JPS648000B2 (fr)	1989-02-10