IL107560A - Kit for making radiopharmaceutical preparations containing the Technium-M99 complex - Google Patents

Kit for making radiopharmaceutical preparations containing the Technium-M99 complex

Info

Publication number: IL107560A
Authority: IL; Israel
Prior art keywords: symbols; kit; technetium; complex; acooh
Prior art date: 1988-11-16

Application number

IL10756089A

Other languages

English (en)

Hebrew (he)

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-16

Filing date

1989-11-03

Publication date

1996-11-14

1989-11-03 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

1996-11-14 Publication of IL107560A publication Critical patent/IL107560A/en

Links

239000000203 mixture Substances 0.000 title claims abstract description 19
GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title claims abstract description 18
229940056501 technetium 99m Drugs 0.000 title claims abstract description 14
239000012217 radiopharmaceutical Substances 0.000 title claims abstract description 12
229940121896 radiopharmaceutical Drugs 0.000 title claims abstract description 12
230000002799 radiopharmaceutical effect Effects 0.000 title claims abstract description 12
150000001875 compounds Chemical class 0.000 claims abstract description 21
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 9
125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 8
150000003839 salts Chemical class 0.000 claims abstract description 8
125000000547 substituted alkyl group Chemical group 0.000 claims abstract description 8
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 7
125000003277 amino group Chemical group 0.000 claims abstract description 7
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 6
239000001257 hydrogen Substances 0.000 claims abstract description 6
125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 3
-1 diaminothio compound Chemical class 0.000 claims description 13
239000002738 chelating agent Substances 0.000 claims description 8
239000003638 chemical reducing agent Substances 0.000 claims description 7
239000004615 ingredient Substances 0.000 claims description 5
125000006239 protecting group Chemical group 0.000 claims description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
230000003907 kidney function Effects 0.000 abstract description 8
239000002253 acid Chemical group 0.000 description 11
210000003734 kidney Anatomy 0.000 description 11
210000000056 organ Anatomy 0.000 description 10
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
210000002381 plasma Anatomy 0.000 description 9
239000000243 solution Substances 0.000 description 9
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
238000006243 chemical reaction Methods 0.000 description 8
230000002285 radioactive effect Effects 0.000 description 8
101150052863 THY1 gene Proteins 0.000 description 7
239000003446 ligand Substances 0.000 description 7
229910052757 nitrogen Inorganic materials 0.000 description 7
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
241000282414 Homo sapiens Species 0.000 description 5
230000000694 effects Effects 0.000 description 5
238000000034 method Methods 0.000 description 5
238000002360 preparation method Methods 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
150000007513 acids Chemical class 0.000 description 4
239000013522 chelant Substances 0.000 description 4
239000000470 constituent Substances 0.000 description 4
230000002349 favourable effect Effects 0.000 description 4
230000006870 function Effects 0.000 description 4
150000002500 ions Chemical class 0.000 description 4
238000002372 labelling Methods 0.000 description 4
210000004185 liver Anatomy 0.000 description 4
240000005020 Acaciella glauca Species 0.000 description 3
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
241000699670 Mus sp. Species 0.000 description 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
VEJXYBLYLRPHPK-UHFFFAOYSA-N [Mo].[Tc] Chemical compound [Mo].[Tc] VEJXYBLYLRPHPK-UHFFFAOYSA-N 0.000 description 3
125000005157 alkyl carboxy group Chemical group 0.000 description 3
239000011668 ascorbic acid Substances 0.000 description 3
235000010323 ascorbic acid Nutrition 0.000 description 3
229960005070 ascorbic acid Drugs 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
235000015165 citric acid Nutrition 0.000 description 3
229940012017 ethylenediamine Drugs 0.000 description 3
238000004128 high performance liquid chromatography Methods 0.000 description 3
239000007788 liquid Substances 0.000 description 3
230000005855 radiation Effects 0.000 description 3
230000002829 reductive effect Effects 0.000 description 3
XYITYKDGJLHYPW-UHFFFAOYSA-M sodium 2-iodohippurate Chemical compound [Na+].[O-]C(=O)CNC(=O)C1=CC=CC=C1I XYITYKDGJLHYPW-UHFFFAOYSA-M 0.000 description 3
235000002906 tartaric acid Nutrition 0.000 description 3
239000011975 tartaric acid Substances 0.000 description 3
210000002700 urine Anatomy 0.000 description 3
WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 2
208000037273 Pathologic Processes Diseases 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
241000288906 Primates Species 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
238000009825 accumulation Methods 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
238000001514 detection method Methods 0.000 description 2
QAWTYRYXDYHQNU-UHFFFAOYSA-N diazathiane Chemical group NSN QAWTYRYXDYHQNU-UHFFFAOYSA-N 0.000 description 2
230000024924 glomerular filtration Effects 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
230000009054 pathological process Effects 0.000 description 2
WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
239000002504 physiological saline solution Substances 0.000 description 2
230000008664 renal activity Effects 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
238000000926 separation method Methods 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000007858 starting material Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
230000010248 tubular secretion Effects 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
VMQMZMRVKUZKQL-UHFFFAOYSA-N Cu+ Chemical compound [Cu+] VMQMZMRVKUZKQL-UHFFFAOYSA-N 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N Cysteine Chemical compound SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
101100260565 Dictyostelium discoideum thyA gene Proteins 0.000 description 1
PNKUSGQVOMIXLU-UHFFFAOYSA-N Formamidine Chemical compound NC=N PNKUSGQVOMIXLU-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
206010057410 Hippus Diseases 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
WTBIAPVQQBCLFP-UHFFFAOYSA-N N.N.N.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O Chemical compound N.N.N.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O WTBIAPVQQBCLFP-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
241001504519 Papio ursinus Species 0.000 description 1
206010041953 Staring Diseases 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
MPHPHYZQRGLTBO-UHFFFAOYSA-N apazone Chemical compound CC1=CC=C2N=C(N(C)C)N3C(=O)C(CCC)C(=O)N3C2=C1 MPHPHYZQRGLTBO-UHFFFAOYSA-N 0.000 description 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
230000037396 body weight Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
150000004985 diamines Chemical class 0.000 description 1
150000001991 dicarboxylic acids Chemical class 0.000 description 1
238000007865 diluting Methods 0.000 description 1
235000011180 diphosphates Nutrition 0.000 description 1
230000008034 disappearance Effects 0.000 description 1
GRWZHXKQBITJKP-UHFFFAOYSA-L dithionite(2-) Chemical compound [O-]S(=O)S([O-])=O GRWZHXKQBITJKP-UHFFFAOYSA-L 0.000 description 1
238000010828 elution Methods 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000945 filler Substances 0.000 description 1
238000011010 flushing procedure Methods 0.000 description 1
229960005219 gentisic acid Drugs 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
210000000738 kidney tubule Anatomy 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229940028444 muse Drugs 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
229960001412 pentobarbital Drugs 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
150000003018 phosphorus compounds Chemical class 0.000 description 1
XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 1
GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000012857 radioactive material Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
239000002904 solvent Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000001117 sulphuric acid Substances 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
150000003495 technetium Chemical class 0.000 description 1
229910052713 technetium Inorganic materials 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
101150068774 thyX gene Proteins 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000036325 urinary excretion Effects 0.000 description 1
238000010200 validation analysis Methods 0.000 description 1
230000002792 vascular Effects 0.000 description 1
210000001835 viscera Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Public Health (AREA)
Optics & Photonics (AREA)
Pharmacology & Pharmacy (AREA)
Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
External Artificial Organs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL10756089A 1988-11-16 1989-11-03 Kit for making radiopharmaceutical preparations containing the Technium-M99 complex IL107560A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/272,177 US4925650A (en)	1988-11-16	1988-11-16	Technetium -99m complex for examining the renal function
IL9221189A IL92211A (en)	1988-11-16	1989-11-03	Technium complex - M99, its preparation and radiopharmaceutical preparations containing it

Publications (1)

Publication Number	Publication Date
IL107560A true IL107560A (en)	1996-11-14

Family

ID=23038736

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL10756089A IL107560A (en)	1988-11-16	1989-11-03	Kit for making radiopharmaceutical preparations containing the Technium-M99 complex
IL9221189A IL92211A (en)	1988-11-16	1989-11-03	Technium complex - M99, its preparation and radiopharmaceutical preparations containing it
IL10756093A IL107560A0 (en)	1988-11-16	1993-11-10	Kit for preparing radiopharmaceutical compositions containing a technetium-99m complex

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL9221189A IL92211A (en)	1988-11-16	1989-11-03	Technium complex - M99, its preparation and radiopharmaceutical preparations containing it
IL10756093A IL107560A0 (en)	1988-11-16	1993-11-10	Kit for preparing radiopharmaceutical compositions containing a technetium-99m complex

Country Status (9)

Country	Link
US (1)	US4925650A (de)
EP (1)	EP0444130B1 (de)
JP (1)	JP3129431B2 (de)
AT (1)	ATE167188T1 (de)
AU (1)	AU629880B2 (de)
CA (1)	CA2002850C (de)
DE (1)	DE68928705T2 (de)
IL (3)	IL107560A (de)
WO (1)	WO1990005733A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4980147A (en) *	1984-06-25	1990-12-25	University Of Utah Research Foundation	Radiolabeled technetium chelates for use in renal function determinations
US5071636A (en) *	1987-12-29	1991-12-10	Nihon Medi-Physics Co., Ltd.	Chelating compounds and their use
DE69023616T2 (de) *	1989-06-16	1996-04-18	Neorx Corp	Radionukleid-chelatverbindungen zur radiomarkierung von proteinen.
US5164176A (en) *	1989-06-16	1992-11-17	Neorx Corporation	Radionuclide metal chelates for the radiolabeling of proteins
US5250666A (en) *	1989-06-16	1993-10-05	Neorx Corporation	Radionuclide metal chelates for the radiolabeling of proteins
JP3005943B2 (ja) *	1990-04-17	2000-02-07	マリンクロッド・インコーポレイテッド	テクネチウム―９９ｍ錯化合物製造のための方法及びキット
US5143713A (en) *	1990-05-30	1992-09-01	Board Of Regents, The University Of Texas System	99m Tc labeled liposomes
US5158760A (en) *	1990-05-30	1992-10-27	Board Of Regents, The University Of Texas System	99m TC labeled liposomes
US5037631A (en) *	1990-10-29	1991-08-06	Mallinckrodt Medical, Inc.	Technetium-99M complex for examinating the renal function
US5104638A (en) *	1990-10-29	1992-04-14	Mallinckrodt Medical, Inc.	Method of making a radiopharmaceutical complex from a kit
US5116598A (en) *	1990-10-29	1992-05-26	Mallinckrodt Medical, Inc.	N4 technetium-99 m complexes for use as radiopharmaceuticals
JP2860157B2 (ja) *	1990-10-31	1999-02-24	日本メジフィジックス株式会社	腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法
US5243073A (en) *	1990-12-14	1993-09-07	Mallinckrodt Medical, Inc.	Hexadentate ligands useful in radiographic imaging agents
US7238340B1 (en)	1991-11-27	2007-07-03	Cis Bio International	Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) *	1991-02-08	1998-12-15	Diatide, Inc.	Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) *	1991-11-27	1995-08-22	Diatech, Inc.	Technetium-99m labeled peptides for imaging
AU1995392A (en) *	1991-05-08	1992-12-21	Mallinckrodt Medical, Inc.	Technetium chelates to be used for determining the renal function
US5562894A (en) *	1991-08-09	1996-10-08	Regents Of The University Of California	Amino-acyl-type and catecholamine-type contrast agents for MRI
US5808091A (en) *	1991-10-29	1998-09-15	Bracco International B.V.	Rhenium and technetium complexes containing a hypoxia localizing moiety
NZ244613A (en) *	1991-10-29	1996-05-28	Bracco International B V Subst	A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand
EP0542216A1 (de) *	1991-11-13	1993-05-19	Hoechst Aktiengesellschaft	Diaminomercapto (thio)ether als Komplexbildner für in der Nuklearmedizin einsetzbare Nuklide, Verfahren zur Herstellung der Komplexe, sowie Markierungskits, enthaltend diese Komplexe
US5783170A (en) *	1991-11-27	1998-07-21	Diatide, Inc.	Peptide-metal chelate conjugates
US5496533A (en) *	1992-07-31	1996-03-05	Australian Nuclear Science & Technology Organisation	Rhenium complexes
AU658310B2 (en) *	1992-07-31	1995-04-06	Australian Nuclear Science & Technology Organisation	Rhenium complexes
US5688485A (en) *	1992-12-31	1997-11-18	The Dupont Merck Pharmaceutical Company	Radiolabelled complexes of ester-substituted diaminethiols
US5879657A (en) *	1993-03-30	1999-03-09	The Dupont Merck Pharmaceutical Company	Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
CA2158249A1 (en) *	1993-03-31	1994-10-13	James W. Brodack	Radiopharmaceutical formulations having non-stannous reductants
EP0618191A1 (de) *	1993-04-02	1994-10-05	AMERSHAM INTERNATIONAL plc	Metall-chelatierende Verbindungen
US5464934A (en) *	1993-05-14	1995-11-07	Mallinckrodt Medical, Inc.	Metal chelates as spacer compounds in biologically active peptides
US5608110A (en) *	1993-06-15	1997-03-04	Bracco International B.V.	Heteroatom-bearing ligands and metal complexes thereof
CA2190727C (en) *	1994-05-19	2006-07-18	Sudhakar Kasina	Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
WO1996007629A1 (en) *	1994-09-08	1996-03-14	Mallinckrodt Medical, Inc.	Technetium chelates to be used for determining the renal function
US5986074A (en) *	1996-05-06	1999-11-16	Emory University	Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5955053A (en) *	1996-05-06	1999-09-21	Emory University	Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5919934A (en) *	1997-02-19	1999-07-06	The George Washington University	Compounds, compositions, and methods for cancer imaging and therapy
US6005083A (en)	1997-03-28	1999-12-21	Neorx Corporation	Bridged aromatic substituted amine ligands with donor atoms
US7067111B1 (en) *	1999-10-25	2006-06-27	Board Of Regents, University Of Texas System	Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
IL153218A0 (en)	2000-06-02	2003-07-06	Univ Texas	Ethylenedicysteine (ec) -drug conjugates
EP1486216A4 (de) *	2002-02-26	2006-08-23	Amato Pharm Prod Ltd	Verfahren zur verkapselung eines metallkomplexes mit liposomen
JP2006522100A (ja) *	2003-03-10	2006-09-28	バイオジェンアイデックインク	標的化ペプチドに対するチオール媒介性薬物結合
US9050378B2 (en) *	2003-12-10	2015-06-09	Board Of Regents, The University Of Texas System	N2S2 chelate-targeting ligand conjugates
US7414137B2 (en) *	2006-03-23	2008-08-19	Inspire Pharmaceuticals, Inc.	Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones
US8758723B2 (en)	2006-04-19	2014-06-24	The Board Of Regents Of The University Of Texas System	Compositions and methods for cellular imaging and therapy
US10925977B2 (en)	2006-10-05	2021-02-23	Ceil>Point, LLC	Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
KR102040476B1 (ko) *	2012-03-26	2019-11-06	보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템	촬상 및 치료를 위한 에틸렌디시스테인-당 콘쥬게이트의 효율적 합성법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2810753A (en) *	1954-05-24	1957-10-22	Dow Chemical Co	Metal ion chelating agents
US4673562A (en) *	1983-08-19	1987-06-16	The Children's Medical Center Corporation	Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4670545A (en) *	1984-05-11	1987-06-02	University Patents, Inc.	Chelating agents for technetium-99M
ATE66469T1 (de) *	1985-01-14	1991-09-15	Neorx Corp	Metall-radionuklid markiertes protein fuer diagnose und therapie.
ATE52516T1 (de) *	1986-05-28	1990-05-15	Mallinckrodt Inc	Technetiumchelate fuer die bestimmung der nierenfunktion.
US5279811A (en) *	1987-02-18	1994-01-18	The Du Pont Merck Pharmaceutical Company	Ester-substituted diaminedithiols and radiolabeled complexes thereof

1988
- 1988-11-16 US US07/272,177 patent/US4925650A/en not_active Expired - Lifetime
1989
- 1989-11-03 IL IL10756089A patent/IL107560A/en active IP Right Grant
- 1989-11-03 IL IL9221189A patent/IL92211A/en active IP Right Grant
- 1989-11-14 CA CA002002850A patent/CA2002850C/en not_active Expired - Lifetime
- 1989-11-16 AT AT90900458T patent/ATE167188T1/de active
- 1989-11-16 EP EP90900458A patent/EP0444130B1/de not_active Expired - Lifetime
- 1989-11-16 DE DE68928705T patent/DE68928705T2/de not_active Expired - Fee Related
- 1989-11-16 WO PCT/US1989/005132 patent/WO1990005733A1/en not_active Ceased
- 1989-11-16 JP JP02500433A patent/JP3129431B2/ja not_active Expired - Fee Related
- 1989-11-16 AU AU46489/89A patent/AU629880B2/en not_active Ceased
1993
- 1993-11-10 IL IL10756093A patent/IL107560A0/xx unknown

Also Published As

Publication number	Publication date
DE68928705T2 (de)	1998-10-15
IL92211A (en)	1995-01-24
IL92211A0 (en)	1990-07-26
IL107560A0 (en)	1994-02-27
DE68928705D1 (de)	1998-07-16
AU4648989A (en)	1990-06-12
US4925650A (en)	1990-05-15
CA2002850A1 (en)	1990-05-16
WO1990005733A1 (en)	1990-05-31
JPH04505152A (ja)	1992-09-10
EP0444130A1 (de)	1991-09-04
CA2002850C (en)	2000-01-25
EP0444130B1 (de)	1998-06-10
AU629880B2 (en)	1992-10-15
ATE167188T1 (de)	1998-06-15
JP3129431B2 (ja)	2001-01-29

Legal Events

Date	Code	Title
1997-04-15	FF	Patent granted
1997-07-13	KB	Patent renewed
2000-07-16	FF	Patent granted
2000-08-31	KB	Patent renewed
2004-01-04	KB	Patent renewed
2008-01-06	KB	Patent renewed

Publication	Publication Date	Title
US4925650A (en)	1990-05-15	Technetium -99m complex for examining the renal function
EP0200492A1 (de)	1986-11-05	Radiodiagnostische Mittel
US5116598A (en)	1992-05-26	N4 technetium-99 m complexes for use as radiopharmaceuticals
US5104638A (en)	1992-04-14	Method of making a radiopharmaceutical complex from a kit
US5037631A (en)	1991-08-06	Technetium-99M complex for examinating the renal function
HUT73665A (en)	1996-09-30	Bifunctional-chelating agents braked with calcogene atoms, pharmaceutical compositions containing them , and use of these compositions in radio- diagnosis and radiotherapy
US5688485A (en)	1997-11-18	Radiolabelled complexes of ester-substituted diaminethiols
EP1173226B1 (de)	2006-08-23	Fettsaure analoge zur diagnose von kranzarterie erkrankungen
WO1989002433A1 (en)	1989-03-23	Tris(isonitrile)copper(i) adducts for preparing radionuclide complexes
US5336482A (en)	1994-08-09	Technetium-99m complexes with N-substituted 3-hydroxy-4-pyridinones
HUT73853A (en)	1996-09-30	Type s3n2 chelators for radioactive isotopes, their metal complexes and their diagnostic and therapeutical use
John et al.	1991	Preparation, radiolabeling and biodistribution of a new class of bisaminothiol (BAT) ligands as possible imaging agents
US5338864A (en)	1994-08-16	Hexadentate ligands useful in radiographic imaging agents
EP0548245A1 (de)	1993-06-30	Isonitril-liganden enthaltender metall-radionuklid komplex
Fang et al.	1999	Pharmacology study of the neutral myocardial imaging agent technetium-99m-N (NOEt) 2.
KR20210048827A (ko)	2021-05-04	전립선 암의 영상 또는 치료를 위한 동위원소 표지 화합물