ATE167188T1 - Technetium-99m-komplex zur untersuchung der nierenfunktion - Google Patents

Technetium-99m-komplex zur untersuchung der nierenfunktion

Info

Publication number
ATE167188T1
ATE167188T1 AT90900458T AT90900458T ATE167188T1 AT E167188 T1 ATE167188 T1 AT E167188T1 AT 90900458 T AT90900458 T AT 90900458T AT 90900458 T AT90900458 T AT 90900458T AT E167188 T1 ATE167188 T1 AT E167188T1
Authority
AT
Austria
Prior art keywords
acooh
symbols
complex
technetium
unsubstituted
Prior art date
Application number
AT90900458T
Other languages
English (en)
Inventor
Dennis L Nosco
Alfons M Verbruggen
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE167188T1 publication Critical patent/ATE167188T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90900458T 1988-11-16 1989-11-16 Technetium-99m-komplex zur untersuchung der nierenfunktion ATE167188T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/272,177 US4925650A (en) 1988-11-16 1988-11-16 Technetium -99m complex for examining the renal function

Publications (1)

Publication Number Publication Date
ATE167188T1 true ATE167188T1 (de) 1998-06-15

Family

ID=23038736

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90900458T ATE167188T1 (de) 1988-11-16 1989-11-16 Technetium-99m-komplex zur untersuchung der nierenfunktion

Country Status (9)

Country Link
US (1) US4925650A (de)
EP (1) EP0444130B1 (de)
JP (1) JP3129431B2 (de)
AT (1) ATE167188T1 (de)
AU (1) AU629880B2 (de)
CA (1) CA2002850C (de)
DE (1) DE68928705T2 (de)
IL (3) IL107560A (de)
WO (1) WO1990005733A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
US5071636A (en) * 1987-12-29 1991-12-10 Nihon Medi-Physics Co., Ltd. Chelating compounds and their use
DE69023616T2 (de) * 1989-06-16 1996-04-18 Neorx Corp Radionukleid-chelatverbindungen zur radiomarkierung von proteinen.
US5164176A (en) * 1989-06-16 1992-11-17 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
US5250666A (en) * 1989-06-16 1993-10-05 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
JP3005943B2 (ja) * 1990-04-17 2000-02-07 マリンクロッド・インコーポレイテッド テクネチウム―９９ｍ錯化合物製造のための方法及びキット
US5143713A (en) * 1990-05-30 1992-09-01 Board Of Regents, The University Of Texas System 99m Tc labeled liposomes
US5158760A (en) * 1990-05-30 1992-10-27 Board Of Regents, The University Of Texas System 99m TC labeled liposomes
US5037631A (en) * 1990-10-29 1991-08-06 Mallinckrodt Medical, Inc. Technetium-99M complex for examinating the renal function
US5104638A (en) * 1990-10-29 1992-04-14 Mallinckrodt Medical, Inc. Method of making a radiopharmaceutical complex from a kit
US5116598A (en) * 1990-10-29 1992-05-26 Mallinckrodt Medical, Inc. N4 technetium-99 m complexes for use as radiopharmaceuticals
JP2860157B2 (ja) * 1990-10-31 1999-02-24 日本メジフィジックス株式会社 腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法
US5243073A (en) * 1990-12-14 1993-09-07 Mallinckrodt Medical, Inc. Hexadentate ligands useful in radiographic imaging agents
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
AU1995392A (en) * 1991-05-08 1992-12-21 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
US5808091A (en) * 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
NZ244613A (en) * 1991-10-29 1996-05-28 Bracco International B V Subst A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand
EP0542216A1 (de) * 1991-11-13 1993-05-19 Hoechst Aktiengesellschaft Diaminomercapto (thio)ether als Komplexbildner für in der Nuklearmedizin einsetzbare Nuklide, Verfahren zur Herstellung der Komplexe, sowie Markierungskits, enthaltend diese Komplexe
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5496533A (en) * 1992-07-31 1996-03-05 Australian Nuclear Science & Technology Organisation Rhenium complexes
AU658310B2 (en) * 1992-07-31 1995-04-06 Australian Nuclear Science & Technology Organisation Rhenium complexes
US5688485A (en) * 1992-12-31 1997-11-18 The Dupont Merck Pharmaceutical Company Radiolabelled complexes of ester-substituted diaminethiols
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
CA2158249A1 (en) * 1993-03-31 1994-10-13 James W. Brodack Radiopharmaceutical formulations having non-stannous reductants
EP0618191A1 (de) * 1993-04-02 1994-10-05 AMERSHAM INTERNATIONAL plc Metall-chelatierende Verbindungen
US5464934A (en) * 1993-05-14 1995-11-07 Mallinckrodt Medical, Inc. Metal chelates as spacer compounds in biologically active peptides
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
WO1996007629A1 (en) * 1994-09-08 1996-03-14 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5986074A (en) * 1996-05-06 1999-11-16 Emory University Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5955053A (en) * 1996-05-06 1999-09-21 Emory University Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5919934A (en) * 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
IL153218A0 (en) 2000-06-02 2003-07-06 Univ Texas Ethylenedicysteine (ec) -drug conjugates
EP1486216A4 (de) * 2002-02-26 2006-08-23 Amato Pharm Prod Ltd Verfahren zur verkapselung eines metallkomplexes mit liposomen
JP2006522100A (ja) * 2003-03-10 2006-09-28 バイオジェン アイデック インク 標的化ペプチドに対するチオール媒介性薬物結合
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US7414137B2 (en) * 2006-03-23 2008-08-19 Inspire Pharmaceuticals, Inc. Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
KR102040476B1 (ko) * 2012-03-26 2019-11-06 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 촬상 및 치료를 위한 에틸렌디시스테인-당 콘쥬게이트의 효율적 합성법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2810753A (en) * 1954-05-24 1957-10-22 Dow Chemical Co Metal ion chelating agents
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4670545A (en) * 1984-05-11 1987-06-02 University Patents, Inc. Chelating agents for technetium-99M
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
ATE52516T1 (de) * 1986-05-28 1990-05-15 Mallinckrodt Inc Technetiumchelate fuer die bestimmung der nierenfunktion.
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof

Also Published As

Publication number Publication date
IL107560A (en) 1996-11-14
DE68928705T2 (de) 1998-10-15
IL92211A (en) 1995-01-24
IL92211A0 (en) 1990-07-26
IL107560A0 (en) 1994-02-27
DE68928705D1 (de) 1998-07-16
AU4648989A (en) 1990-06-12
US4925650A (en) 1990-05-15
CA2002850A1 (en) 1990-05-16
WO1990005733A1 (en) 1990-05-31
JPH04505152A (ja) 1992-09-10
EP0444130A1 (de) 1991-09-04
CA2002850C (en) 2000-01-25
EP0444130B1 (de) 1998-06-10
AU629880B2 (en) 1992-10-15
JP3129431B2 (ja) 2001-01-29

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