IL107627A - Pharmaceutical compositions containing 3-substituted-2-amino-4- (hetero) arylpyrano (iso) quinoline derivatives, some new such derivatives and their preparation - Google Patents

Pharmaceutical compositions containing 3-substituted-2-amino-4- (hetero) arylpyrano (iso) quinoline derivatives, some new such derivatives and their preparation

Info

Publication number: IL107627A
Authority: IL; Israel
Prior art keywords: phenyl; alkyl; optionally substituted; substituted; derivatives
Prior art date: 1992-11-18

Application number

IL107627A

Other languages

English (en)

Other versions

IL107627A0 (en

Original Assignee

Lilly Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-18

Filing date

1993-11-16

Publication date

1997-04-15

1992-11-18 Priority claimed from GB929224169A external-priority patent/GB9224169D0/en

1993-02-06 Priority claimed from GB939302367A external-priority patent/GB9302367D0/en

1993-11-16 Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd

1994-02-27 Publication of IL107627A0 publication Critical patent/IL107627A0/xx

1997-04-15 Publication of IL107627A publication Critical patent/IL107627A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 2
229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
125000005842 heteroatom Chemical group 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 9
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
-1 cyano, carboxy Chemical group 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
101100134927 Gallus gallus COR8 gene Proteins 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
150000001562 benzopyrans Chemical class 0.000 abstract 1
125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
125000004185 ester group Chemical group 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

IL107627A 1992-11-18 1993-11-16 Pharmaceutical compositions containing 3-substituted-2-amino-4- (hetero) arylpyrano (iso) quinoline derivatives, some new such derivatives and their preparation IL107627A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929224169A GB9224169D0 (en)	1992-11-18	1992-11-18	Pharmaceutical compounds
GB939302367A GB9302367D0 (en)	1993-02-06	1993-02-06	Pharmaceutical compounds

Publications (2)

Publication Number	Publication Date
IL107627A0 IL107627A0 (en)	1994-02-27
IL107627A true IL107627A (en)	1997-04-15

Family

ID=26301995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL107627A IL107627A (en)	1992-11-18	1993-11-16	Pharmaceutical compositions containing 3-substituted-2-amino-4- (hetero) arylpyrano (iso) quinoline derivatives, some new such derivatives and their preparation

Country Status (16)

Country	Link
US (1)	US5434160A (fr)
EP (2)	EP1004584A3 (fr)
JP (1)	JPH06199862A (fr)
KR (1)	KR940011465A (fr)
CN (1)	CN1040982C (fr)
AU (1)	AU668602B2 (fr)
CA (1)	CA2103203A1 (fr)
CO (1)	CO4130335A1 (fr)
CZ (1)	CZ243493A3 (fr)
FI (1)	FI103727B1 (fr)
HU (1)	HU9303261D0 (fr)
IL (1)	IL107627A (fr)
NO (1)	NO304890B1 (fr)
NZ (1)	NZ250195A (fr)
PL (1)	PL301059A1 (fr)
TW (1)	TW289755B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9306062D0 (en) *	1993-03-24	1993-05-12	Lilly Industries Ltd	Pharmaceutical compounds
FR2795071B1 (fr) *	1999-06-16	2001-07-27	Adir	Nouveaux derives de carboxylate de 7-oxo-2,3,7,14- tetrahydro-1h-benzo[b]pyrano[3,2,h] acridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU781986B2 (en) *	1999-11-05	2005-06-23	Cytovia, Inc.	Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1392683B1 (fr)	2001-05-16	2009-12-02	Cytovia, Inc.	4h-chromènes substitués et analogues en tant qu'activateurs de caspases et inducteurs d'apoptose, et leur utilisation comme agents anticancéreux
US6858607B1 (en)	2001-05-16	2005-02-22	Cytovia, Inc.	7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1392283A4 (fr)	2001-05-16	2004-10-20	Cytovia Inc	Coumarines et quinolines substituees utilisees comme activateurs des caspases
US7476741B2 (en)	2002-05-16	2009-01-13	Cytovia, Inc.	Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
CN100349887C (zh) *	2002-05-16	2007-11-21	西托维亚公司	取代的4－芳基－4h－吡咯并[2,3－h]色烯和类似物及其药物组合物和用途
CA2579768A1 (fr)	2004-09-09	2006-03-16	Howard Florey Institute Of Experimental Physiology And Medicine	Inhibiteurs d'enzymes et leurs utilisations
US7843312B2 (en) *	2006-12-12	2010-11-30	Honeywell International Inc.	Wireless control of security system with key-operated key fob
US8263775B2 (en)	2007-11-19	2012-09-11	Howard Florey Institute	Insulin-regulated aminopeptidase (IRAP) inhibitors and uses thereof
CN107235954A (zh)	2010-11-12	2017-10-10	德国癌症研究中心	作为Wnt通路拮抗剂的色烯衍生物及其类似物
WO2023099589A1 (fr) *	2021-12-01	2023-06-08	INSERM (Institut National de la Santé et de la Recherche Médicale)	Inhibiteurs d'irap à utiliser pour le traitement de maladies inflammatoires
CN115028643B (zh) *	2022-06-10	2024-03-22	中国药科大学	吡喃并喹啉衍生物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4243674A (en) *	1978-06-12	1981-01-06	Pfizer Inc.	9-Hydroxydibenzo[b,d]pyrans and intermediates therefore
JPS61502124A (ja) *	1984-05-09	1986-09-25	ジ　オ−ストラリアン　ナシヨナル　ユニヴア−シテイ−	免疫応答の調節方法
JP2631710B2 (ja) *	1988-08-16	1997-07-16	日本ヘキスト・マリオン・ルセル株式会社	ピラノ〔ｆ〕キノリノン誘導体及び該化合物を有効成分とする医薬組成物
US4931221A (en) *	1988-12-30	1990-06-05	Ppg Industries, Inc.	Photochromic spiropyran compounds
US5284868A (en) *	1991-10-09	1994-02-08	Eli Lilly And Company	Pharmaceutical compounds
GB9306062D0 (en) *	1993-03-24	1993-05-12	Lilly Industries Ltd	Pharmaceutical compounds

1993
- 1993-11-11 EP EP99204310A patent/EP1004584A3/fr not_active Withdrawn
- 1993-11-11 EP EP19930308999 patent/EP0599514A3/en not_active Ceased
- 1993-11-12 US US08/150,945 patent/US5434160A/en not_active Expired - Fee Related
- 1993-11-15 PL PL93301059A patent/PL301059A1/xx unknown
- 1993-11-15 TW TW082109528A patent/TW289755B/zh active
- 1993-11-15 NZ NZ250195A patent/NZ250195A/en unknown
- 1993-11-15 AU AU50671/93A patent/AU668602B2/en not_active Ceased
- 1993-11-15 CZ CZ932434A patent/CZ243493A3/cs unknown
- 1993-11-16 IL IL107627A patent/IL107627A/xx not_active IP Right Cessation
- 1993-11-16 NO NO934145A patent/NO304890B1/no not_active IP Right Cessation
- 1993-11-16 KR KR1019930024262A patent/KR940011465A/ko not_active Ceased
- 1993-11-16 FI FI935065A patent/FI103727B1/fi active
- 1993-11-16 CA CA002103203A patent/CA2103203A1/fr not_active Abandoned
- 1993-11-17 JP JP5287139A patent/JPH06199862A/ja active Pending
- 1993-11-17 CO CO93418738A patent/CO4130335A1/es unknown
- 1993-11-17 HU HU9303261A patent/HU9303261D0/hu unknown
- 1993-11-17 CN CN93115028A patent/CN1040982C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1004584A2 (fr)	2000-05-31
TW289755B (fr)	1996-11-01
EP0599514A3 (en)	1994-07-06
FI103727B (fi)	1999-08-31
NO934145D0 (no)	1993-11-16
NO304890B1 (no)	1999-03-01
AU668602B2 (en)	1996-05-09
NO934145L (no)	1994-05-19
FI103727B1 (fi)	1999-08-31
HU9303261D0 (en)	1994-03-28
CN1040982C (zh)	1998-12-02
EP0599514A2 (fr)	1994-06-01
FI935065L (fi)	1994-05-19
CA2103203A1 (fr)	1994-05-19
EP1004584A3 (fr)	2000-07-05
FI935065A0 (fi)	1993-11-16
IL107627A0 (en)	1994-02-27
JPH06199862A (ja)	1994-07-19
PL301059A1 (en)	1994-05-30
US5434160A (en)	1995-07-18
KR940011465A (ko)	1994-06-21
CZ243493A3 (en)	1994-06-15
CN1092072A (zh)	1994-09-14
NZ250195A (en)	1995-12-21
CO4130335A1 (es)	1995-02-13
AU5067193A (en)	1994-06-02

Legal Events

Date	Code	Title
1997-11-20	FF	Patent granted
1998-02-22	KB	Patent renewed
1999-06-20	HC	Change of name of proprietor(s)
2000-06-29	KB	Patent renewed
2004-07-25	RH1	Patent not in force

Publication	Publication Date	Title
CA2053253A1 (fr)	1991-08-29	Nouveaux derives d'aryl- et d'heteroarylethenylene et procede d'obtention
NO178697C (no)	1996-05-15	Analogifremgangsmåte for fremstilling av terapeutisk aktive pyrazolopyridin-forbindelser
ES8302002A1 (es)	1982-12-16	Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
CO5251463A1 (es)	2003-02-28	Compuestos heterociclicos y composicion farmaceutica que coniene dichos compuestos
IL89354A0 (en)	1989-09-10	3-alkenyl-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
NZ227436A (en)	1992-10-28	Cell proliferation inhibiting composition comprising a substituted styrene derivative
ES8306160A1 (es)	1983-05-01	"procedimiento para preparar un nuevo compuesto de cefem".
CA2072785A1 (fr)	1993-01-04	Derives de l'hydrazine pharmacologiquement actifs et procedes conduisant a leur obtention
IE861875L (en)	1987-01-16	Poly-4-aminopyrrole-2-carboxamido derivatives
IL112102A0 (en)	1995-03-15	Annelated dihydropyridinoacetic acid derivatives, their preparation and pharmaceutical compositions containing them
EP1004584A3 (fr)	2000-07-05	Dérivés de pyranoquinoléine comme inhibiteurs de la prolifération des cellules
GB1435916A (en)	1976-05-19	Pharmaceutical weight-reducing compositions
ES8800905A1 (es)	1987-12-01	Un procedimiento para la preparacion de nuevos derivados de dihidroisoquinolina
MY104540A (en)	1994-04-30	Pharmaceutical preparations.
AU562377B2 (en)	1987-06-11	1,1-diphenyl-propanol-derivatives
GB9908021D0 (en)	1999-06-02	Pharmaceutical compounds
IL106564A (en)	1997-07-13	Tetrahydronaphthalene derivatives their preparation and pharmaceutical compositions containing them
ES8205413A1 (es)	1982-06-01	Procedimiento para preparar nuevas benzotiopirano (2,3-c)pi-ridinas
IL81052A (en)	1992-03-29	6h-isoxazolo(3,4-d)pyrazolo(3,4-b)pyridines,a process for their preparation and pharmaceutical compositions containing them
YU72093A (sh)	1996-10-18	Farmaceutska jedinjenja
MX9802679A (es)	1998-12-31	Derivados de ditiolan, su preparacion y su efecto terapeutico.