IL108111A - Phosphonooxymethyl ethers of taxane derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Phosphonooxymethyl ethers of taxane derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL108111A
IL108111A IL10811193A IL10811193A IL108111A IL 108111 A IL108111 A IL 108111A IL 10811193 A IL10811193 A IL 10811193A IL 10811193 A IL10811193 A IL 10811193A IL 108111 A IL108111 A IL 108111A
Authority
IL
Israel
Prior art keywords
hydroxy
compound
hydrogen
formula
mmol
Prior art date
Application number
IL10811193A
Other languages
English (en)
Other versions
IL108111A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL108111A0 publication Critical patent/IL108111A0/xx
Publication of IL108111A publication Critical patent/IL108111A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • HELECTRICITY
    • H10SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10WGENERIC PACKAGES, INTERCONNECTIONS, CONNECTORS OR OTHER CONSTRUCTIONAL DETAILS OF DEVICES COVERED BY CLASS H10
    • H10W70/00Package substrates; Interposers; Redistribution layers [RDL]
    • H10W70/01Manufacture or treatment
    • H10W70/04Manufacture or treatment of leadframes
    • H10W70/047Attaching leadframes to insulating supports, e.g. for tape automated bonding [TAB]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL10811193A 1992-12-24 1993-12-21 Phosphonooxymethyl ethers of taxane derivatives, their preparation and pharmaceutical compositions containing them IL108111A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99645592A 1992-12-24 1992-12-24
US10801593A 1993-08-17 1993-08-17
US15484093A 1993-11-24 1993-11-24

Publications (2)

Publication Number Publication Date
IL108111A0 IL108111A0 (en) 1994-04-12
IL108111A true IL108111A (en) 2002-09-12

Family

ID=27380404

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10811193A IL108111A (en) 1992-12-24 1993-12-21 Phosphonooxymethyl ethers of taxane derivatives, their preparation and pharmaceutical compositions containing them

Country Status (21)

Country Link
EP (1) EP0604910B1 (pl)
JP (1) JP3189140B2 (pl)
KR (2) KR100241852B1 (pl)
CN (2) CN1184219C (pl)
AT (1) ATE193891T1 (pl)
AU (1) AU660570B2 (pl)
CA (1) CA2111527C (pl)
CZ (1) CZ289871B6 (pl)
DE (1) DE69328858T2 (pl)
DK (1) DK0604910T3 (pl)
ES (1) ES2147739T3 (pl)
FI (1) FI111724B (pl)
GR (1) GR3034312T3 (pl)
HU (1) HUT65547A (pl)
IL (1) IL108111A (pl)
MX (1) MX9308012A (pl)
NO (1) NO310238B1 (pl)
NZ (1) NZ250550A (pl)
PL (1) PL175014B1 (pl)
PT (1) PT604910E (pl)
TW (1) TW410228B (pl)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1001036E (pt) * 1992-01-15 2005-01-31 Squibb & Sons Inc Processos enzimaticos para o desdobramento de misturas enantiomericas de compostos uteis como intermediarios na preparacao de taxanos
DE69333989T2 (de) * 1992-11-13 2006-08-17 Florida State University, Tallahassee Taxane mit einer alkylsubstituierten Seitenkette und sie enthaltende pharmazeutische Zusammensetzungen
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
WO1994014787A1 (en) * 1992-12-23 1994-07-07 Bristol-Myers Squibb Company Novel sidechain-bearing taxanes and intermediates thereof
US6593482B2 (en) * 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
FR2712289B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
US6201140B1 (en) * 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
US6458976B1 (en) 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
AU4133096A (en) * 1994-10-28 1996-05-23 Research Foundation Of The State University Of New York, The Taxoid derivatives, their preparation and their use as antitumor agents
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5489589A (en) * 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
US5840929A (en) * 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
TW354293B (en) * 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
US5977163A (en) 1996-03-12 1999-11-02 Pg-Txl Company, L. P. Water soluble paclitaxel prodrugs
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
CZ20013429A3 (cs) 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxany substituované v poloze C7 karbonátem jako protinádorová činidla
IL145636A0 (en) 2000-02-02 2002-06-30 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
US20020077290A1 (en) 2000-03-17 2002-06-20 Rama Bhatt Polyglutamic acid-camptothecin conjugates and methods of preparation
WO2002024178A2 (en) * 2000-09-22 2002-03-28 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
AU2001288805A1 (en) 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
PL368945A1 (pl) 2001-11-30 2005-04-04 Bristol-Myers Squibb Company Solwaty paklitakselu
US7834043B2 (en) 2003-12-11 2010-11-16 Abbott Laboratories HIV protease inhibiting compounds
HN2005000054A (es) 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
ES2402552T3 (es) 2004-07-06 2013-05-06 Abbott Laboratories Profármacos de inhibidores de proteasa de VIH
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
CA2718567A1 (en) 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
CN101648973B (zh) * 2009-09-03 2012-05-30 漆又毛 水溶性紫杉烷及制备方法
ES2802996T3 (es) 2011-08-25 2021-01-22 Bonac Corp Compuesto de tioéter para la protección del grupo 2'-hidroxi en nucleósidos que van a ser utilizados en la síntesis de oligonucleótidos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives

Also Published As

Publication number Publication date
CN1037774C (zh) 1998-03-18
IL108111A0 (en) 1994-04-12
CA2111527C (en) 2000-07-18
PL301610A1 (en) 1994-06-27
CN1174838A (zh) 1998-03-04
EP0604910A1 (en) 1994-07-06
ATE193891T1 (de) 2000-06-15
AU660570B2 (en) 1995-06-29
NZ250550A (en) 1995-02-24
HUT65547A (en) 1994-06-28
CZ289871B6 (cs) 2002-04-17
FI935821A0 (fi) 1993-12-23
DE69328858D1 (de) 2000-07-20
NO934614D0 (no) 1993-12-15
MX9308012A (es) 1994-08-31
CN1184219C (zh) 2005-01-12
KR940014375A (ko) 1994-07-18
NO310238B1 (no) 2001-06-11
PT604910E (pt) 2000-09-29
CA2111527A1 (en) 1994-06-25
GR3034312T3 (en) 2000-12-29
DK0604910T3 (da) 2000-07-31
DE69328858T2 (de) 2001-03-01
FI111724B (fi) 2003-09-15
KR100274373B1 (en) 2000-12-15
JPH072885A (ja) 1995-01-06
AU5260993A (en) 1994-07-07
EP0604910B1 (en) 2000-06-14
NO934614L (no) 1994-06-27
KR100241852B1 (ko) 2000-03-02
JP3189140B2 (ja) 2001-07-16
CZ285593A3 (en) 1994-12-15
ES2147739T3 (es) 2000-10-01
PL175014B1 (pl) 1998-10-30
FI935821L (fi) 1994-06-25
TW410228B (en) 2000-11-01
CN1093369A (zh) 1994-10-12

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Legal Events

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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees