IL109889A0 - Dinucleotide analogues, intermediates therefor and oligonucleotides derived therefrom - Google Patents
Dinucleotide analogues, intermediates therefor and oligonucleotides derived therefromInfo
- Publication number
- IL109889A0 IL109889A0 IL10988994A IL10988994A IL109889A0 IL 109889 A0 IL109889 A0 IL 109889A0 IL 10988994 A IL10988994 A IL 10988994A IL 10988994 A IL10988994 A IL 10988994A IL 109889 A0 IL109889 A0 IL 109889A0
- Authority
- IL
- Israel
- Prior art keywords
- derived therefrom
- oligonucleotides derived
- intermediates therefor
- dinucleotide analogues
- dinucleotide
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5304—Acyclic saturated phosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939311682A GB9311682D0 (en) | 1993-06-05 | 1993-06-05 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL109889A0 true IL109889A0 (en) | 1994-10-07 |
Family
ID=10736736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10988994A IL109889A0 (en) | 1993-06-05 | 1994-06-03 | Dinucleotide analogues, intermediates therefor and oligonucleotides derived therefrom |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0629633A3 (fr) |
| JP (1) | JPH06345791A (fr) |
| KR (1) | KR950000727A (fr) |
| AU (1) | AU676291B2 (fr) |
| CA (1) | CA2125129A1 (fr) |
| GB (1) | GB9311682D0 (fr) |
| IL (1) | IL109889A0 (fr) |
| ZA (1) | ZA943892B (fr) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9417746D0 (en) * | 1994-09-03 | 1994-10-19 | Ciba Geigy Ag | Chemical compounds |
| GB9417938D0 (en) * | 1994-09-06 | 1994-10-26 | Ciba Geigy Ag | Compounds |
| US6166197A (en) * | 1995-03-06 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions |
| WO1996027606A1 (fr) | 1995-03-06 | 1996-09-12 | Isis Pharmaceuticals, Inc. | Procede ameliore pour la synthese des pyrimidines a substitution 2'-o et de leurs composes oligomeres |
| KR100323136B1 (ko) * | 1995-08-24 | 2002-05-13 | 구광시 | 나일론6필라멘트사의제조방법 |
| GB9612600D0 (en) | 1996-06-13 | 1996-08-21 | Ciba Geigy Ag | Chemical compounds |
| WO2008100447A2 (fr) | 2007-02-09 | 2008-08-21 | Gilead Sciences, Inc. | Analogues nucléosidiques pour traitement antiviral |
| US7820810B2 (en) | 2007-03-19 | 2010-10-26 | Isis Pharmaceuticals, Inc. | Process for the synthesis of 2′-O-substituted purine nulceosides |
| US20120059045A1 (en) * | 2008-10-24 | 2012-03-08 | Isis Pharmaceuticals, Inc. | Methods of using oligomeric compounds comprising 2'-substituted nucleosides |
| EP2447274B1 (fr) | 2008-10-24 | 2017-10-04 | Ionis Pharmaceuticals, Inc. | Composants oligomères et procédés |
| EP2601204B1 (fr) | 2010-04-28 | 2016-09-07 | Ionis Pharmaceuticals, Inc. | Nucléosides modifiés et composés oligomères préparés à partir de ceux-ci |
| WO2011139699A2 (fr) | 2010-04-28 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Nucléosides modifiés en 5' et composés oligomères préparés à partir de ceux-ci |
| NZ607996A (en) | 2010-09-22 | 2014-07-25 | Alios Biopharma Inc | Substituted nucleotide analogs |
| CA2860234A1 (fr) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Analogues de nucleotide phosphorothioate substitue |
| HK1206362A1 (zh) | 2012-03-21 | 2016-01-08 | Alios Biopharma, Inc. | 硫代氨基磷酸酯核苷酸前藥的固體形式 |
| WO2013142157A1 (fr) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Combinaisons pharmaceutiques comprenant un analogue thionucléotidique |
| HRP20200250T1 (hr) | 2013-08-08 | 2020-05-29 | The Scripps Research Institute | Metoda site-specifično enzimsko obilježavanje nukleinskih kiselina in vitro ugradnjom neprirodnih nukleotida |
| TWI638047B (zh) | 2014-04-09 | 2018-10-11 | 史基普研究協會 | 藉由核酸三磷酸酯轉運子將非天然或經修飾的核苷三磷酸酯輸入至細胞中 |
| WO2017106767A1 (fr) | 2015-12-18 | 2017-06-22 | The Scripps Research Institute | Production de nucléotides non naturels par l'utilisation d'un système crispr/cas9 |
| US20190218257A1 (en) | 2016-06-24 | 2019-07-18 | The Scripps Research Institute | Novel nucleoside triphosphate transporter and uses thereof |
| JP7325341B2 (ja) | 2017-07-11 | 2023-08-14 | シンソークス,インク. | 非天然ヌクレオチドの組み込み及びその方法 |
| WO2019014262A1 (fr) | 2017-07-11 | 2019-01-17 | The Scripps Research Institute | Incorporation de nucléotides non naturels et procédés d'utilisation in vivo de ceux-ci |
| KR20240141853A (ko) | 2017-08-03 | 2024-09-27 | 신톡스, 인크. | 자가면역 질환의 치료를 위한 사이토카인 접합체 |
| SG11202006101WA (en) | 2017-12-29 | 2020-07-29 | Scripps Research Inst | Unnatural base pair compositions and methods of use |
| CN112004547A (zh) | 2018-02-26 | 2020-11-27 | 新索思股份有限公司 | Il-15缀合物及其用途 |
| SG11202102930YA (en) | 2018-11-08 | 2021-04-29 | Synthorx Inc | Interleukin 10 conjugates and uses thereof |
| EP3923974A4 (fr) | 2019-02-06 | 2023-02-08 | Synthorx, Inc. | Conjugués d'il-2 et méthodes d'utilisation de ceux-ci |
| AU2020291535A1 (en) | 2019-06-14 | 2022-01-20 | The Scripps Research Institute | Reagents and methods for replication, transcription, and translation in semi-synthetic organisms |
| CN114555128A (zh) | 2019-08-15 | 2022-05-27 | 新索思股份有限公司 | 采用il-2缀合物的免疫肿瘤学组合疗法 |
| EP4017540A1 (fr) | 2019-08-23 | 2022-06-29 | Synthorx, Inc. | Conjugués d'il-15 et leurs utilisations |
| US12234271B2 (en) | 2019-09-10 | 2025-02-25 | Synthorx, Inc. | Il-2 conjugates and methods of use to treat autoimmune diseases |
| WO2021091986A1 (fr) | 2019-11-04 | 2021-05-14 | Synthorx, Inc. | Conjugués d'interleukine 10 et leurs utilisations |
| IL299074A (en) | 2020-06-25 | 2023-02-01 | Synthorx Inc | Immuno-oncology therapeutic combination with IL-2 and anti-AGFR antibody conjugates |
| JP2023546010A (ja) | 2020-10-09 | 2023-11-01 | シンソークス, インコーポレイテッド | Il-2コンジュゲートを用いた免疫腫瘍療法 |
| IL301611A (en) | 2020-10-09 | 2023-05-01 | Synthorx Inc | Immuno oncology combination therapy with il-2 conjugates and pembrolizumab |
| CN116761885A (zh) | 2020-10-23 | 2023-09-15 | 斯克利普斯研究所 | 包含非天然核苷酸的多核苷酸的逆转录 |
| WO2022174102A1 (fr) | 2021-02-12 | 2022-08-18 | Synthorx, Inc. | Polythérapie contre le cancer du poumon avec des conjugués d'il-2 et un anticorps anti-pd-1 ou un fragment de liaison à l'antigène de ce dernier |
| TW202245843A (zh) | 2021-02-12 | 2022-12-01 | 美商欣爍克斯公司 | Il-2接合物及西米普利單抗(cemiplimab)之皮膚癌組合療法 |
| EP4346904A1 (fr) | 2021-06-03 | 2024-04-10 | Synthorx, Inc. | Polythérapie contre le cancer de la tête et du cou comprenant un conjugué d'il-2 et du cétuximab |
| EP4452327A1 (fr) | 2021-12-20 | 2024-10-30 | Synthorx, Inc. | Polythérapie contre le cancer de la tête et du cou comprenant un conjugué d'il-2 et du pembrolizumab |
| WO2023122750A1 (fr) | 2021-12-23 | 2023-06-29 | Synthorx, Inc. | Polythérapie contre le cancer avec des conjugués d'il-2 et du cétuximab |
| WO2024136899A1 (fr) | 2022-12-21 | 2024-06-27 | Synthorx, Inc. | Thérapie anticancéreuse avec des conjugués d'il-2 et des thérapies par récepteur antigénique chimérique |
| CN121263208A (zh) | 2023-03-20 | 2026-01-02 | 新索思股份有限公司 | 使用il-2 peg缀合物的癌症疗法 |
| WO2025158385A1 (fr) | 2024-01-25 | 2025-07-31 | Genzyme Corporation | Il-2 pégylé pour supprimer une réponse immunitaire adaptative à une thérapie génique |
| WO2025207517A2 (fr) | 2024-03-25 | 2025-10-02 | Synthorx, Inc. | Synthétases d'arnt synthétiques et cellules comprenant des molécules synthétiques pour la production de polypeptides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| US5672697A (en) * | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
-
1993
- 1993-06-05 GB GB939311682A patent/GB9311682D0/en active Pending
-
1994
- 1994-05-27 EP EP94303883A patent/EP0629633A3/xx not_active Withdrawn
- 1994-06-03 CA CA002125129A patent/CA2125129A1/fr not_active Abandoned
- 1994-06-03 ZA ZA943892A patent/ZA943892B/xx unknown
- 1994-06-03 AU AU64522/94A patent/AU676291B2/en not_active Ceased
- 1994-06-03 IL IL10988994A patent/IL109889A0/xx unknown
- 1994-06-04 KR KR1019940012618A patent/KR950000727A/ko not_active Withdrawn
- 1994-06-06 JP JP6145827A patent/JPH06345791A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR950000727A (ko) | 1995-01-03 |
| EP0629633A2 (fr) | 1994-12-21 |
| CA2125129A1 (fr) | 1994-12-06 |
| AU676291B2 (en) | 1997-03-06 |
| JPH06345791A (ja) | 1994-12-20 |
| ZA943892B (en) | 1995-02-14 |
| AU6452294A (en) | 1994-12-08 |
| GB9311682D0 (en) | 1993-07-21 |
| EP0629633A3 (en) | 1995-01-11 |
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