IL110272A - Complex pharmaceutical preparations containing SAR inhibitors and antagonist endothelin - Google Patents

Complex pharmaceutical preparations containing SAR inhibitors and antagonist endothelin

Info

Publication number: IL110272A
Authority: IL; Israel
Prior art keywords: preparation according; inhibitor; endothelin antagonist; ras inhibitor; methyl
Prior art date: 1993-07-15

Application number

IL11027294A

Other languages

English (en)

Hebrew (he)

Other versions

IL110272A0 (en

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-15

Filing date

1994-07-11

Publication date

1998-07-15

1994-07-11 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1994-10-21 Publication of IL110272A0 publication Critical patent/IL110272A0/xx

1998-07-15 Publication of IL110272A publication Critical patent/IL110272A/en

Links

229940078123 Ras inhibitor Drugs 0.000 title claims abstract description 20
239000002308 endothelin receptor antagonist Substances 0.000 title claims abstract description 19
238000002360 preparation method Methods 0.000 title claims description 14
206010019280 Heart failures Diseases 0.000 claims abstract description 11
206010020772 Hypertension Diseases 0.000 claims abstract description 11
229960005025 cilazapril Drugs 0.000 claims description 17
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239000005541 ACE inhibitor Substances 0.000 claims description 10
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 10
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
208000035475 disorder Diseases 0.000 claims description 7
239000002461 renin inhibitor Substances 0.000 claims description 7
229940086526 renin-inhibitors Drugs 0.000 claims description 7
239000002333 angiotensin II receptor antagonist Substances 0.000 claims description 5
239000000825 pharmaceutical preparation Substances 0.000 claims description 5
229940123413 Angiotensin II antagonist Drugs 0.000 claims description 3
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UZQBKCWYZBHBOW-YIPNQBBMSA-N terlakiren Chemical compound C([C@@H](C(=O)N[C@@H](CSC)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)OC(C)C)NC(=O)N1CCOCC1)C1=CC=CC=C1 UZQBKCWYZBHBOW-YIPNQBBMSA-N 0.000 description 1
108010069247 terlakiren Proteins 0.000 description 1
229950003204 terlakiren Drugs 0.000 description 1
SASWSEQJAITMKS-JJNNLWIXSA-N tert-butyl (2s)-2-[[(2s)-1-[[(2s)-1-[[(4s,5s,7s)-5-hydroxy-2,8-dimethyl-7-[[(2s,3s)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]carbamoyl]nonan-4-yl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]p Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC=1N=CC=CC=1)C(C)C)N(C)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)OC(C)(C)C)C1=CN=CN1 SASWSEQJAITMKS-JJNNLWIXSA-N 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
150000003852 triazoles Chemical class 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
229960004699 valsartan Drugs 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000006444 vascular growth Effects 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 description 1
229960002769 zofenopril Drugs 0.000 description 1
FIKYECRHLXONOX-UHFFFAOYSA-N zolasartan Chemical compound CCCCC1=NC(Cl)=C(C(O)=O)N1CC1=CC=C(OC(=C2Br)C=3C(=CC=CC=3)C3=NNN=N3)C2=C1 FIKYECRHLXONOX-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

IL11027294A 1993-07-15 1994-07-11 Complex pharmaceutical preparations containing SAR inhibitors and antagonist endothelin IL110272A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH213193		1993-07-15

Publications (2)

Publication Number	Publication Date
IL110272A0 IL110272A0 (en)	1994-10-21
IL110272A true IL110272A (en)	1998-07-15

Family

ID=4226611

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11027294A IL110272A (en)	1993-07-15	1994-07-11	Complex pharmaceutical preparations containing SAR inhibitors and antagonist endothelin

Country Status (25)

Country	Link
US (1)	US5696116A (es)
EP (1)	EP0634175B1 (es)
JP (1)	JP2746537B2 (es)
KR (1)	KR100370181B1 (es)
CN (1)	CN1105573C (es)
AT (1)	ATE198551T1 (es)
AU (1)	AU683262B2 (es)
BR (1)	BR9402815A (es)
CA (1)	CA2128142C (es)
CZ (1)	CZ285413B6 (es)
DE (1)	DE59409631D1 (es)
DK (1)	DK0634175T3 (es)
ES (1)	ES2154277T3 (es)
GR (1)	GR3035702T3 (es)
HU (1)	HU221202B1 (es)
IL (1)	IL110272A (es)
NO (1)	NO312578B1 (es)
NZ (1)	NZ260969A (es)
PL (1)	PL176445B1 (es)
PT (1)	PT634175E (es)
RU (1)	RU2146522C1 (es)
SA (1)	SA94150155B1 (es)
TW (1)	TW287949B (es)
UA (1)	UA27870C2 (es)
ZA (1)	ZA944980B (es)

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JP4917707B2 (ja) *	1997-09-26	2012-04-18	アボットゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	エンドセリン拮抗剤およびレニン−アンギオテンシン系阻害剤から成る組合せ剤
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
KR20040078140A (ko) *	1998-07-10	2004-09-08	노파르티스 아게	발사르탄 및 칼슘 채널 차단제의 항고혈압 병용 제제
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CN101011390A (zh) *	1999-01-26	2007-08-08	诺瓦提斯公司	血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用
CA2367916A1 (en)	1999-03-19	2000-09-28	Ambarish Singh	Methods for the preparation of biphenyl isoxazole sulfonamides
CA2419285C (en) *	2000-08-25	2011-08-02	Research Corporation Technologies, Inc.	New uses for amino acid anticonvulsants
US8168616B1 (en) *	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
RU2201255C1 (ru) *	2001-12-26	2003-03-27	Эпштейн Олег Ильич	Лекарственное средство и способ регуляции сосудистого тонуса
WO2004002466A1 (en) *	2002-06-28	2004-01-08	Speedel Pharma Ag	Pharmaceutical formulation comprising non-peptide renin inhibitor and surfactant
WO2005018642A1 (en) *	2003-08-22	2005-03-03	Schering Aktiengesellschaft	Chemokine inhibiting piperazine derivatives and their use to treat myocarditis
KR20080074128A (ko) *	2005-12-06	2008-08-12	산텐 세이야꾸 가부시키가이샤	각결막 장애 치료제
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1994
- 1994-06-29 ES ES94110064T patent/ES2154277T3/es not_active Expired - Lifetime
- 1994-06-29 AT AT94110064T patent/ATE198551T1/de active
- 1994-06-29 EP EP94110064A patent/EP0634175B1/de not_active Expired - Lifetime
- 1994-06-29 DK DK94110064T patent/DK0634175T3/da active
- 1994-06-29 DE DE59409631T patent/DE59409631D1/de not_active Expired - Lifetime
- 1994-06-29 PT PT94110064T patent/PT634175E/pt unknown
- 1994-07-08 NZ NZ260969A patent/NZ260969A/en not_active IP Right Cessation
- 1994-07-08 ZA ZA944980A patent/ZA944980B/xx unknown
- 1994-07-08 AU AU67357/94A patent/AU683262B2/en not_active Expired
- 1994-07-11 IL IL11027294A patent/IL110272A/en not_active IP Right Cessation
- 1994-07-11 HU HU9402064A patent/HU221202B1/hu unknown
- 1994-07-12 CZ CZ941677A patent/CZ285413B6/cs not_active IP Right Cessation
- 1994-07-12 US US08/273,663 patent/US5696116A/en not_active Expired - Lifetime
- 1994-07-12 JP JP6160010A patent/JP2746537B2/ja not_active Expired - Lifetime
- 1994-07-14 KR KR1019940016899A patent/KR100370181B1/ko not_active Expired - Lifetime
- 1994-07-14 UA UA94075635A patent/UA27870C2/uk unknown
- 1994-07-14 RU RU94026283A patent/RU2146522C1/ru active
- 1994-07-14 TW TW083106428A patent/TW287949B/zh not_active IP Right Cessation
- 1994-07-14 NO NO19942650A patent/NO312578B1/no not_active IP Right Cessation
- 1994-07-14 PL PL94304292A patent/PL176445B1/pl unknown
- 1994-07-14 BR BR9402815A patent/BR9402815A/pt not_active Application Discontinuation
- 1994-07-14 CN CN94108595A patent/CN1105573C/zh not_active Expired - Lifetime
- 1994-07-15 CA CA002128142A patent/CA2128142C/en not_active Expired - Lifetime
- 1994-08-29 SA SA94150155A patent/SA94150155B1/ar unknown
2001
- 2001-04-05 GR GR20010400550T patent/GR3035702T3/el unknown

Also Published As

Publication number	Publication date
NO942650D0 (no)	1994-07-14
CN1107364A (zh)	1995-08-30
GR3035702T3 (en)	2001-07-31
NO942650L (no)	1995-01-16
HU9402064D0 (en)	1994-09-28
KR960013371A (ko)	1996-05-22
TW287949B (es)	1996-10-11
PL176445B1 (pl)	1999-05-31
ES2154277T3 (es)	2001-04-01
AU6735794A (en)	1995-01-27
NO312578B1 (no)	2002-06-03
DE59409631D1 (de)	2001-02-15
DK0634175T3 (da)	2001-04-30
IL110272A0 (en)	1994-10-21
EP0634175B1 (de)	2001-01-10
CA2128142A1 (en)	1995-01-16
JPH0753408A (ja)	1995-02-28
NZ260969A (en)	1996-01-26
ATE198551T1 (de)	2001-01-15
RU2146522C1 (ru)	2000-03-20
PT634175E (pt)	2001-06-29
CZ167794A3 (en)	1995-01-18
PL304292A1 (en)	1995-01-23
UA27870C2 (uk)	2000-10-16
SA94150155B1 (ar)	2005-11-15
JP2746537B2 (ja)	1998-05-06
CZ285413B6 (cs)	1999-08-11
ZA944980B (en)	1995-02-06
EP0634175A1 (de)	1995-01-18
CA2128142C (en)	2007-03-06
HUT67331A (en)	1995-03-28
US5696116A (en)	1997-12-09
BR9402815A (pt)	1995-04-04
KR100370181B1 (ko)	2003-04-26
HU221202B1 (en)	2002-08-28
CN1105573C (zh)	2003-04-16
RU94026283A (ru)	1996-05-20
AU683262B2 (en)	1997-11-06

Legal Events

Date	Code	Title
2004-11-10	KB	Patent renewed
2008-11-27	KB	Patent renewed
2012-07-31	KB	Patent renewed
2015-02-26	EXP	Patent expired

Publication	Publication Date	Title
CA2128142C (en)	2007-03-06	Pharmaceutical combination containing ras inhibitor and endothelin antagonist for the treatment of cardiovascular disorders
RU2334513C2 (ru)	2008-09-27	Фармацевтические композиции, включающие валсартан и ингибиторы нейтральной эндопептидазы (nep)
US8404744B2 (en)	2013-03-26	Methods of treatment and pharmaceutical composition
KR102159601B1 (ko)	2020-09-28	심방 확장 또는 재형성을 특징으로 하는 질환을 치료하기 위한 nep 억제제
EP0498361A2 (en)	1992-08-12	Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor
JP2012046531A (ja)	2012-03-08	医薬組合せ剤
JPH11503139A (ja)	1999-03-23	ベナゼプリルまたはベナゼプリラートおよびバルサルタンを含有する組み合わせ組成物
CZ138198A3 (cs)	1998-12-16	Spojení fixní dávky inhibitoru angiotensin konvertujícího enzymu a antagonisty vápníkového kanálu, způsob pro jejich přípravu a použití v léčbě kardiovaskulárních onemocnění
US5304570A (en)	1994-04-19	Pharmaceutical composition useful for the treatment of cardiovascular diseases
RU2222328C2 (ru)	2004-01-27	Фармацевтические комбинированные препараты
CN120571025A (zh)	2025-09-02	一种含有ARNi和钙离子拮抗剂的药物组合物
HK40061914A (en)	2022-06-10	Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling
MXPA00002655A (es)	2001-05-17	Productos farmaceuticos en combinacion
EP0556204A1 (en)	1993-08-25	Pharmaceutical composition containing an ace inhibitor and an inhibitor of thromboxane a2 activity for treating nephropathies
AU2007237280A1 (en)	2007-12-20	Pharmaceutical combination of Angiotensin II antagonists and Angiotensin I converting enzyme inhibitors