IL111194A - Process for the production of medicament formulations - Google Patents

Process for the production of medicament formulations

Info

Publication number: IL111194A
Authority: IL; Israel
Prior art keywords: medicament; mould; mandrel; longitudinal axis; compact
Prior art date: 1993-10-08

Application number

IL111194A

Other languages

English (en)

Other versions

IL111194A0 (en

Original Assignee

Fisons Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-08

Filing date

1994-10-07

Publication date

1998-02-08

1993-10-08 Priority claimed from GB939320795A external-priority patent/GB9320795D0/en

1994-07-21 Priority claimed from GB9414692A external-priority patent/GB9414692D0/en

1994-10-07 Application filed by Fisons Plc filed Critical Fisons Plc

1994-12-29 Publication of IL111194A0 publication Critical patent/IL111194A0/xx

1998-02-08 Publication of IL111194A publication Critical patent/IL111194A/en

Links

239000003814 drug Substances 0.000 title claims abstract description 132
238000000034 method Methods 0.000 title claims description 39
230000008569 process Effects 0.000 title claims description 35
238000004519 manufacturing process Methods 0.000 title claims description 18
239000000203 mixture Substances 0.000 title description 6
238000009472 formulation Methods 0.000 title description 2
238000005056 compaction Methods 0.000 claims description 51
239000000843 powder Substances 0.000 claims description 30
238000007906 compression Methods 0.000 claims description 9
230000006835 compression Effects 0.000 claims description 7
239000004480 active ingredient Substances 0.000 description 17
239000002245 particle Substances 0.000 description 10
239000000796 flavoring agent Substances 0.000 description 7
235000013355 food flavoring agent Nutrition 0.000 description 7
239000004615 ingredient Substances 0.000 description 6
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
239000008101 lactose Substances 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
PDNHLCRMUIGNBV-UHFFFAOYSA-N 1-pyridin-2-ylethanamine Chemical compound CC(N)C1=CC=CC=N1 PDNHLCRMUIGNBV-UHFFFAOYSA-N 0.000 description 4
238000009826 distribution Methods 0.000 description 4
235000003599 food sweetener Nutrition 0.000 description 4
150000004676 glycans Chemical class 0.000 description 4
239000000463 material Substances 0.000 description 4
239000001525 mentha piperita l. herb oil Substances 0.000 description 4
229960002259 nedocromil sodium Drugs 0.000 description 4
235000019477 peppermint oil Nutrition 0.000 description 4
229920001282 polysaccharide Polymers 0.000 description 4
239000005017 polysaccharide Substances 0.000 description 4
239000003765 sweetening agent Substances 0.000 description 4
FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 3
-1 316 grade Substances 0.000 description 3
239000005557 antagonist Substances 0.000 description 3
229960000265 cromoglicic acid Drugs 0.000 description 3
VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 description 3
238000012856 packing Methods 0.000 description 3
229920001707 polybutylene terephthalate Polymers 0.000 description 3
229940085605 saccharin sodium Drugs 0.000 description 3
239000007787 solid Substances 0.000 description 3
229910001220 stainless steel Inorganic materials 0.000 description 3
239000010935 stainless steel Substances 0.000 description 3
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 2
XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 2
LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
229920002774 Maltodextrin Polymers 0.000 description 2
239000005913 Maltodextrin Substances 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
238000005299 abrasion Methods 0.000 description 2
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 2
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 2
229940124630 bronchodilator Drugs 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003937 drug carrier Substances 0.000 description 2
229960001022 fenoterol Drugs 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
229960001317 isoprenaline Drugs 0.000 description 2
229940035034 maltodextrin Drugs 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
229940041616 menthol Drugs 0.000 description 2
238000003801 milling Methods 0.000 description 2
229920001343 polytetrafluoroethylene Polymers 0.000 description 2
239000004810 polytetrafluoroethylene Substances 0.000 description 2
229960002720 reproterol Drugs 0.000 description 2
WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 description 2
229960002052 salbutamol Drugs 0.000 description 2
229960000195 terbutaline Drugs 0.000 description 2
229960005486 vaccine Drugs 0.000 description 2
238000005303 weighing Methods 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
108010011485 Aspartame Proteins 0.000 description 1
KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 description 1
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
229930105110 Cyclosporin A Natural products 0.000 description 1
108010036949 Cyclosporine Proteins 0.000 description 1
201000003883 Cystic fibrosis Diseases 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
229940122459 Glutamate antagonist Drugs 0.000 description 1
208000026350 Inborn Genetic disease Diseases 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
102000036770 Islet Amyloid Polypeptide Human genes 0.000 description 1
108010041872 Islet Amyloid Polypeptide Proteins 0.000 description 1
239000000867 Lipoxygenase Inhibitor Substances 0.000 description 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
208000027771 Obstructive airways disease Diseases 0.000 description 1
GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 1
229910052581 Si3N4 Inorganic materials 0.000 description 1
UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
DXEXNWDGDYUITL-FXSSSKFRSA-N Tipredane Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@@](SC)(SCC)[C@@]1(C)C[C@@H]2O DXEXNWDGDYUITL-FXSSSKFRSA-N 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
230000009471 action Effects 0.000 description 1
239000000556 agonist Substances 0.000 description 1
239000003194 amino acid receptor blocking agent Substances 0.000 description 1
229940125715 antihistaminic agent Drugs 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
229950000210 beclometasone dipropionate Drugs 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000003152 bradykinin antagonist Substances 0.000 description 1
206010006451 bronchitis Diseases 0.000 description 1
239000000168 bronchodilator agent Substances 0.000 description 1
229960004436 budesonide Drugs 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000000812 cholinergic antagonist Substances 0.000 description 1
229960001265 ciclosporin Drugs 0.000 description 1
YNNUSGIPVFPVBX-NHCUHLMSSA-N clemastine Chemical compound CN1CCC[C@@H]1CCO[C@@](C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 YNNUSGIPVFPVBX-NHCUHLMSSA-N 0.000 description 1
229960002881 clemastine Drugs 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical class OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
229930182912 cyclosporin Natural products 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000004512 die casting Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
238000001415 gene therapy Methods 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
239000008103 glucose Substances 0.000 description 1
230000005484 gravity Effects 0.000 description 1
238000000227 grinding Methods 0.000 description 1
238000001746 injection moulding Methods 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
229960001361 ipratropium bromide Drugs 0.000 description 1
KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
239000003199 leukotriene receptor blocking agent Substances 0.000 description 1
239000003120 macrolide antibiotic agent Substances 0.000 description 1
229960001855 mannitol Drugs 0.000 description 1
238000010309 melting process Methods 0.000 description 1
238000002156 mixing Methods 0.000 description 1
229960004398 nedocromil Drugs 0.000 description 1
RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 description 1
229960004448 pentamidine Drugs 0.000 description 1
239000000813 peptide hormone Substances 0.000 description 1
239000003358 phospholipase A2 inhibitor Substances 0.000 description 1
239000013612 plasmid Substances 0.000 description 1
229960001539 poliomyelitis vaccine Drugs 0.000 description 1
229920006389 polyphenyl polymer Polymers 0.000 description 1
230000002028 premature Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000000246 remedial effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
229960004017 salmeterol Drugs 0.000 description 1
238000007873 sieving Methods 0.000 description 1
HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
229960002930 sirolimus Drugs 0.000 description 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
239000000126 substance Substances 0.000 description 1
229950001669 tipredane Drugs 0.000 description 1
238000012546 transfer Methods 0.000 description 1
239000013598 vector Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/027—Particular press methods or systems
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/30—Feeding material to presses
- B30B15/302—Feeding material in particulate or plastic state to moulding presses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
- A61M2202/066—Powder made from a compacted product by abrading

Landscapes

Engineering & Computer Science (AREA)
Mechanical Engineering (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

IL111194A 1993-10-08 1994-10-07 Process for the production of medicament formulations IL111194A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939320795A GB9320795D0 (en)	1993-10-08	1993-10-08	Process the production of pharmaceutical formulations
GB9414692A GB9414692D0 (en)	1994-07-21	1994-07-21	Process for the production of pharmaceutical formulations

Publications (2)

Publication Number	Publication Date
IL111194A0 IL111194A0 (en)	1994-12-29
IL111194A true IL111194A (en)	1998-02-08

Family

ID=26303654

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL111194A IL111194A (en)	1993-10-08	1994-10-07	Process for the production of medicament formulations

Country Status (16)

Country	Link
US (1)	US5670167A (de)
EP (1)	EP0725725B1 (de)
JP (1)	JP4249803B2 (de)
KR (1)	KR100344371B1 (de)
AT (1)	ATE157930T1 (de)
AU (1)	AU678614B2 (de)
CA (1)	CA2173610C (de)
DE (1)	DE69405580T2 (de)
DK (1)	DK0725725T3 (de)
ES (1)	ES2109018T3 (de)
FI (1)	FI111331B (de)
GR (1)	GR3025339T3 (de)
IL (1)	IL111194A (de)
NO (1)	NO309371B1 (de)
NZ (1)	NZ274526A (de)
WO (1)	WO1995010407A1 (de)

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EP2721036B1 (de)	2011-06-15	2015-07-22	Takeda GmbH	Neuartige 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isochinolin-verbindungen
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1994
- 1994-10-07 IL IL111194A patent/IL111194A/en not_active IP Right Cessation
- 1994-10-10 CA CA002173610A patent/CA2173610C/en not_active Expired - Fee Related
- 1994-10-10 US US08/624,590 patent/US5670167A/en not_active Expired - Lifetime
- 1994-10-10 AT AT94929592T patent/ATE157930T1/de not_active IP Right Cessation
- 1994-10-10 DK DK94929592.7T patent/DK0725725T3/da active
- 1994-10-10 ES ES94929592T patent/ES2109018T3/es not_active Expired - Lifetime
- 1994-10-10 JP JP51145895A patent/JP4249803B2/ja not_active Expired - Fee Related
- 1994-10-10 AU AU78591/94A patent/AU678614B2/en not_active Ceased
- 1994-10-10 KR KR1019960701807A patent/KR100344371B1/ko not_active Expired - Fee Related
- 1994-10-10 EP EP94929592A patent/EP0725725B1/de not_active Expired - Lifetime
- 1994-10-10 NZ NZ274526A patent/NZ274526A/en not_active IP Right Cessation
- 1994-10-10 WO PCT/GB1994/002214 patent/WO1995010407A1/en not_active Ceased
- 1994-10-10 DE DE69405580T patent/DE69405580T2/de not_active Expired - Lifetime
1996
- 1996-04-02 NO NO961365A patent/NO309371B1/no unknown
- 1996-04-04 FI FI961521A patent/FI111331B/fi active
1997
- 1997-11-11 GR GR970402981T patent/GR3025339T3/el unknown

Also Published As

Publication number	Publication date
FI961521A0 (fi)	1996-04-04
FI961521L (fi)	1996-04-04
IL111194A0 (en)	1994-12-29
ATE157930T1 (de)	1997-09-15
NZ274526A (en)	1997-09-22
EP0725725B1 (de)	1997-09-10
CA2173610C (en)	2005-09-13
EP0725725A1 (de)	1996-08-14
DE69405580T2 (de)	1998-02-26
ES2109018T3 (es)	1998-01-01
JP4249803B2 (ja)	2009-04-08
KR960704696A (ko)	1996-10-09
NO961365D0 (no)	1996-04-02
HK1013276A1 (en)	1999-08-20
AU678614B2 (en)	1997-06-05
US5670167A (en)	1997-09-23
NO961365L (no)	1996-06-05
AU7859194A (en)	1995-05-04
JPH09511151A (ja)	1997-11-11
KR100344371B1 (ko)	2002-11-23
GR3025339T3 (en)	1998-02-27
CA2173610A1 (en)	1995-04-20
WO1995010407A1 (en)	1995-04-20
DE69405580D1 (de)	1997-10-16
NO309371B1 (no)	2001-01-22
DK0725725T3 (da)	1998-04-14
FI111331B (fi)	2003-07-15

Legal Events

Date	Code	Title
1998-07-15	FF	Patent granted
1998-12-06	KB	Patent renewed
2009-12-24	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5670167A (en)	1997-09-23	Process for the production of medicament formulations
EP0650410B1 (de)	1997-12-03	Verfahren zur herstellung von arzneiformulierungen
KR100480221B1 (ko)	2005-07-25	분말운반시스템,장치및방법
FI102874B (fi)	1999-03-15	Lääkeaineen inhalaatiolaite
BG64618B1 (bg)	2005-09-30	Метод и устройство за пълнене на прахове
US20080202630A1 (en)	2008-08-28	Feeding Chamber, an Apparatus and a Method for Production of Doses of Dry Powder, a Method for Controlling Particle Segregation in Dry Powder During Filling
MXPA02010732A (es)	2003-03-10	Metodo y aparato para transferir uan cantidad de polvo definida.
JP2007530671A (ja)	2007-11-01	事前計量されるｄｐｉのための乾燥粉末調合剤
HK1013276B (en)	2000-08-25	Process for the production of medicament formulations
HK1104270A (en)	2008-01-11	A feeding chamber, an apparatus and a method for production of doses of dry powder, a method for controlling particle segregation in dry powder during filling