IL111266A - 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number: IL111266A
Authority: IL; Israel
Prior art keywords: phenyl; deriv; quinoline; heteroaryl; arylpyridazino
Prior art date: 1993-10-22

Application number

IL11126694A

Other languages

English (en)

Other versions

IL111266A0 (en

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1994-10-12

Publication date

2002-03-10

1993-10-22 Priority claimed from GB939321854A external-priority patent/GB9321854D0/en

1994-08-25 Priority claimed from GB9417171A external-priority patent/GB9417171D0/en

1994-10-12 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1994-12-29 Publication of IL111266A0 publication Critical patent/IL111266A0/xx

2002-03-10 Publication of IL111266A publication Critical patent/IL111266A/xx

Links

SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
125000005605 benzo group Chemical group 0.000 abstract 2
125000002541 furyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 1
241000689227 Cora <basidiomycete fungus> Species 0.000 abstract 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000005133 alkynyloxy group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
OHZYAOYVLLHTGW-UHFFFAOYSA-N pyrido[3,2-c]pyridazine Chemical class C1=CN=NC2=CC=CN=C21 OHZYAOYVLLHTGW-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Quinoline Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL11126694A 1993-10-22 1994-10-12 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IL111266A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939321854A GB9321854D0 (en)	1993-10-22	1993-10-22	Pyridazino quinoline compounds
GB9417171A GB9417171D0 (en)	1994-08-25	1994-08-25	Pyridazino quinoline compounds

Publications (2)

Publication Number	Publication Date
IL111266A0 IL111266A0 (en)	1994-12-29
IL111266A true IL111266A (en)	2002-03-10

Family

ID=26303731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11126694A IL111266A (en)	1993-10-22	1994-10-12	2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (29)

Country	Link
US (3)	US5744471A (de)
EP (2)	EP0724583B1 (de)
JP (1)	JP3583132B2 (de)
KR (1)	KR100261209B1 (de)
CN (1)	CN1053189C (de)
AT (2)	ATE198072T1 (de)
AU (2)	AU688393B2 (de)
CA (1)	CA2171332A1 (de)
CZ (1)	CZ292311B6 (de)
DE (2)	DE69434380T2 (de)
DK (2)	DK0724583T3 (de)
ES (2)	ES2241513T3 (de)
FI (2)	FI113865B (de)
GB (1)	GB9420590D0 (de)
GR (1)	GR3035080T3 (de)
HU (1)	HUT74161A (de)
IL (1)	IL111266A (de)
MY (2)	MY124316A (de)
NO (1)	NO306995B1 (de)
NZ (2)	NZ275472A (de)
PL (1)	PL180679B1 (de)
PT (2)	PT724583E (de)
RU (1)	RU2168511C2 (de)
SG (2)	SG59971A1 (de)
SI (2)	SI1004582T1 (de)
SK (1)	SK282491B6 (de)
TW (1)	TW406082B (de)
UA (1)	UA60291C2 (de)
WO (1)	WO1995011244A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9420590D0 (en) *	1993-10-22	1994-11-30	Zeneca Ltd	Pyridazino quinoline compounds
US6214826B1 (en)	1994-11-12	2001-04-10	Zeneca Limited	Pyridazino quinoline compounds
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
GB9507318D0 (en)	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds
US6943165B2 (en) *	1999-12-23	2005-09-13	Astrazeneca Ab	Compound and method for the treatment of pain
ATE321045T1 (de) *	1999-12-23	2006-04-15		Methoden und zusammensetzungen zur behandlung von schmerzen
JP2003518500A (ja) *	1999-12-23	2003-06-10	アストラゼネカ・アクチエボラーグ	痛みの処置のための方法および組成物
US20030176435A1 (en) *	2002-12-17	2003-09-18	Brown Dean Gordon	Compounds and methods for the treatment of pain
SI1244662T1 (de) *	1999-12-23	2005-08-31	Astrazeneca Ab
US6787547B2 (en)	1999-12-23	2004-09-07	Astrazeneca Ab	Compound and method for the treatment of pain
CN1434714A (zh) *	1999-12-23	2003-08-06	阿斯特拉曾尼卡有限公司	治疗疼痛的方法和组合物
WO2001047926A1 (en) *	1999-12-23	2001-07-05	Astrazeneca Ab	Compounds and methods for the treatment of pain
US6730675B2 (en)	1999-12-23	2004-05-04	Astrazeneca Ab	Compounds and methods for the treatment of pain
EP1244663B1 (de) *	1999-12-23	2004-08-25	AstraZeneca AB	Verbindungen und verfahren zur behandlung von schmerz
CA2394888A1 (en) *	1999-12-23	2001-07-05	Astrazeneca Ab	Compound and method for the treatment of pain
EP1244664A1 (de) *	1999-12-23	2002-10-02	AstraZeneca AB	Verbindungen und methoden zur behandlung von schmerzen
US6403818B1 (en)	2000-02-28	2002-06-11	Eisai Co., Ltd.	Process for producing α-hydroxy-carbonyl compound
JP2004509963A (ja) *	2000-09-29	2004-04-02	アストラゼネカ・アクチエボラーグ	１，２，５，１０−テトラヒドロピリダジノ［４，５−ｂ］キノリン−１，１０−ジオン及び疼痛治療のためのその使用
US6933297B2 (en)	2000-09-29	2005-08-23	Astrazeneca Ab	7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain
ATE327235T1 (de)	2000-09-29	2006-06-15	Astrazeneca Ab	1,2,5,10-tetrahydropyridazino 4,5-böchinolin-1, 0-dione und ihre anwendung in der behandlung von schmerzen
AU2001292500A1 (en) *	2000-09-29	2002-04-08	Astrazeneca Ab	1,2,5,10-tetrahydropyridazino(4,5-b)quinoline-1,10-diones and their use for the treatment of pain
KR100745307B1 (ko) *	2001-05-31	2007-08-01	사노피-아벤티스	아미노퀴놀린 유도체 및 아데노신 ａ３ 리간드로서의 이의 용도
WO2005012309A1 (fr) *	2003-08-04	2005-02-10	Valery Khazhmuratovich Zhilov	Bioisosteres cycliques issus d'un systeme purine et composition pharmaceutique a base desdits bioisosteres
US8354427B2 (en)	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
RS56037B1 (sr)	2004-06-24	2017-09-29	Vertex Pharma	Modulatori atp-vezujućih kasetnih transportera
EP1979367A2 (de) *	2005-12-24	2008-10-15	Vertex Pharmaceuticals Incorporated	Chinolin-4-on-derivate als modulatoren von abc-transportern
EP3219705B1 (de)	2005-12-28	2020-03-11	Vertex Pharmaceuticals Incorporated	Pharmazeutische zusammensetzungen der amorphen form von n-[2,4-bis-(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxochinolin-3-carboxamid
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
PL2408750T3 (pl)	2009-03-20	2016-02-29	Vertex Pharma	Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
JP2015511583A (ja)	2012-02-27	2015-04-20	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	薬学的組成物およびその投与
CN107250113B (zh)	2014-10-07	2019-03-29	弗特克斯药品有限公司	囊性纤维化跨膜传导调节蛋白的调节剂的共晶

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814458D0 (en) *	1988-06-17	1988-07-20	Wyeth John & Brother Ltd	Heterocyclic compounds
GB9109972D0 (en) *	1991-05-09	1991-07-03	Ici Plc	Therapeutic compounds
GB9208511D0 (en) *	1991-05-09	1992-06-03	Ici Plc	Compounds
GB9420590D0 (en) *	1993-10-22	1994-11-30	Zeneca Ltd	Pyridazino quinoline compounds
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
GB9507318D0 (en) *	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds

1994
- 1994-10-12 GB GB9420590A patent/GB9420590D0/en active Pending
- 1994-10-12 IL IL11126694A patent/IL111266A/xx not_active IP Right Cessation
- 1994-10-20 AU AU79440/94A patent/AU688393B2/en not_active Ceased
- 1994-10-20 CN CN94194578A patent/CN1053189C/zh not_active Expired - Fee Related
- 1994-10-20 SG SG1996007261A patent/SG59971A1/en unknown
- 1994-10-20 SI SI9430476T patent/SI1004582T1/xx unknown
- 1994-10-20 DE DE69434380T patent/DE69434380T2/de not_active Expired - Fee Related
- 1994-10-20 US US08/637,641 patent/US5744471A/en not_active Expired - Fee Related
- 1994-10-20 CZ CZ19961138A patent/CZ292311B6/cs not_active IP Right Cessation
- 1994-10-20 WO PCT/GB1994/002295 patent/WO1995011244A1/en not_active Ceased
- 1994-10-20 DK DK94930275T patent/DK0724583T3/da active
- 1994-10-20 RU RU96109470/04A patent/RU2168511C2/ru not_active IP Right Cessation
- 1994-10-20 MY MYPI94002796A patent/MY124316A/en unknown
- 1994-10-20 EP EP94930275A patent/EP0724583B1/de not_active Expired - Lifetime
- 1994-10-20 DK DK00101917T patent/DK1004582T3/da active
- 1994-10-20 PL PL94314041A patent/PL180679B1/pl not_active IP Right Cessation
- 1994-10-20 PT PT94930275T patent/PT724583E/pt unknown
- 1994-10-20 AT AT94930275T patent/ATE198072T1/de not_active IP Right Cessation
- 1994-10-20 SK SK504-96A patent/SK282491B6/sk not_active IP Right Cessation
- 1994-10-20 ES ES00101917T patent/ES2241513T3/es not_active Expired - Lifetime
- 1994-10-20 SI SI9430314T patent/SI0724583T1/xx unknown
- 1994-10-20 MY MYPI98002508A patent/MY132875A/en unknown
- 1994-10-20 NZ NZ275472A patent/NZ275472A/en not_active IP Right Cessation
- 1994-10-20 AT AT00101917T patent/ATE295846T1/de not_active IP Right Cessation
- 1994-10-20 DE DE69426422T patent/DE69426422T2/de not_active Expired - Fee Related
- 1994-10-20 SG SG9900943A patent/SG92630A1/en unknown
- 1994-10-20 PT PT00101917T patent/PT1004582E/pt unknown
- 1994-10-20 ES ES94930275T patent/ES2154686T3/es not_active Expired - Lifetime
- 1994-10-20 HU HU9600889A patent/HUT74161A/hu unknown
- 1994-10-20 CA CA002171332A patent/CA2171332A1/en not_active Abandoned
- 1994-10-20 NZ NZ329303A patent/NZ329303A/xx not_active IP Right Cessation
- 1994-10-20 UA UA96041567A patent/UA60291C2/uk unknown
- 1994-10-20 JP JP51152195A patent/JP3583132B2/ja not_active Expired - Fee Related
- 1994-10-20 EP EP00101917A patent/EP1004582B1/de not_active Expired - Lifetime
- 1994-10-20 KR KR1019960702011A patent/KR100261209B1/ko not_active Expired - Fee Related
- 1994-11-18 TW TW083110721A patent/TW406082B/zh not_active IP Right Cessation
1996
- 1996-04-18 FI FI961696A patent/FI113865B/fi active
- 1996-04-19 NO NO961584A patent/NO306995B1/no not_active IP Right Cessation
1997
- 1997-03-03 FI FI970907A patent/FI114916B/fi active IP Right Grant
1998
- 1998-03-19 US US09/044,109 patent/US6232313B1/en not_active Expired - Fee Related
- 1998-05-27 AU AU68999/98A patent/AU721139B2/en not_active Ceased
1999
- 1999-12-06 US US09/455,096 patent/US6103721A/en not_active Expired - Fee Related
2000
- 2000-12-14 GR GR20000402690T patent/GR3035080T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2154686T3 (es)	2001-04-16
FI970907L (fi)	1997-03-03
EP0724583A1 (de)	1996-08-07
FI961696A0 (fi)	1996-04-18
SG59971A1 (en)	1999-02-22
DE69426422T2 (de)	2001-05-10
KR100261209B1 (ko)	2000-09-01
JP3583132B2 (ja)	2004-10-27
DE69434380D1 (de)	2005-06-23
ATE198072T1 (de)	2000-12-15
US5744471A (en)	1998-04-28
CN1053189C (zh)	2000-06-07
HU9600889D0 (en)	1996-06-28
NZ329303A (en)	2000-01-28
NO961584L (no)	1996-04-19
SI0724583T1 (en)	2001-04-30
PL180679B1 (en)	2001-03-30
CN1138332A (zh)	1996-12-18
CZ113896A3 (en)	1996-09-11
AU7944094A (en)	1995-05-08
JPH09504519A (ja)	1997-05-06
EP0724583B1 (de)	2000-12-13
HK1013997A1 (en)	1999-09-17
UA60291C2 (uk)	2003-10-15
IL111266A0 (en)	1994-12-29
FI961696L (fi)	1996-04-18
CZ292311B6 (cs)	2003-09-17
SK282491B6 (sk)	2002-02-05
US6232313B1 (en)	2001-05-15
PT1004582E (pt)	2005-09-30
TW406082B (en)	2000-09-21
PT724583E (pt)	2001-03-30
SI1004582T1 (de)	2005-08-31
NZ275472A (en)	1998-03-25
DE69434380T2 (de)	2006-05-04
HUT74161A (en)	1996-11-28
EP1004582A3 (de)	2000-08-30
AU721139B2 (en)	2000-06-22
ES2241513T3 (es)	2005-11-01
GB9420590D0 (en)	1994-11-30
AU6899998A (en)	1998-07-30
FI113865B (fi)	2004-06-30
MY124316A (en)	2006-06-30
EP1004582B1 (de)	2005-05-18
ATE295846T1 (de)	2005-06-15
CA2171332A1 (en)	1995-04-27
EP1004582A2 (de)	2000-05-31
FI114916B (fi)	2005-01-31
SK50496A3 (en)	1997-03-05
FI970907A0 (fi)	1997-03-03
RU2168511C2 (ru)	2001-06-10
SG92630A1 (en)	2002-11-19
AU688393B2 (en)	1998-03-12
MY132875A (en)	2007-10-31
NO961584D0 (no)	1996-04-19
GR3035080T3 (en)	2001-03-30
WO1995011244A1 (en)	1995-04-27
DE69426422D1 (de)	2001-01-18
US6103721A (en)	2000-08-15
DK0724583T3 (da)	2001-03-05
PL314041A1 (en)	1996-08-05
DK1004582T3 (da)	2005-08-15
NO306995B1 (no)	2000-01-24

Legal Events

Date	Code	Title
2002-08-14	FF	Patent granted
2002-09-12	KB	Patent renewed
2009-05-03	FF	Patent granted
2013-05-30	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
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