ATE295846T1 - Pyridazino-chinolin verbindungen - Google Patents

Pyridazino-chinolin verbindungen

Info

Publication number: ATE295846T1
Authority: AT; Austria
Prior art keywords: phenyl; deriv; pyridazino; substd; opt
Prior art date: 1993-10-22

Application number

AT00101917T

Other languages

English (en)

Inventor

Thomas Michael Bare

Timothy Wayne Davenport

James Roy Empfield

Kinney Jeffrey Alan Mc

Richard Bruce Sparks

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1994-10-20

Publication date

2005-06-15

1993-10-22 Priority claimed from GB939321854A external-priority patent/GB9321854D0/en

1994-08-25 Priority claimed from GB9417171A external-priority patent/GB9417171D0/en

1994-10-20 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE295846T1 publication Critical patent/ATE295846T1/de

Links

BOYBQQBDCOIBIR-UHFFFAOYSA-N pyrido[2,3-f]cinnoline Chemical class N1=CC=C2C3=NC=CC=C3C=CC2=N1 BOYBQQBDCOIBIR-UHFFFAOYSA-N 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
125000005605 benzo group Chemical group 0.000 abstract 2
125000002541 furyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 1
241000689227 Cora <basidiomycete fungus> Species 0.000 abstract 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000005133 alkynyloxy group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
OHZYAOYVLLHTGW-UHFFFAOYSA-N pyrido[3,2-c]pyridazine Chemical class C1=CN=NC2=CC=CN=C21 OHZYAOYVLLHTGW-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT00101917T 1993-10-22 1994-10-20 Pyridazino-chinolin verbindungen ATE295846T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939321854A GB9321854D0 (en)	1993-10-22	1993-10-22	Pyridazino quinoline compounds
GB9417171A GB9417171D0 (en)	1994-08-25	1994-08-25	Pyridazino quinoline compounds

Publications (1)

Publication Number	Publication Date
ATE295846T1 true ATE295846T1 (de)	2005-06-15

Family

ID=26303731

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94930275T ATE198072T1 (de)	1993-10-22	1994-10-20	Pyridazino-chinolin verbindungen
AT00101917T ATE295846T1 (de)	1993-10-22	1994-10-20	Pyridazino-chinolin verbindungen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT94930275T ATE198072T1 (de)	1993-10-22	1994-10-20	Pyridazino-chinolin verbindungen

Country Status (29)

Country	Link
US (3)	US5744471A (de)
EP (2)	EP1004582B1 (de)
JP (1)	JP3583132B2 (de)
KR (1)	KR100261209B1 (de)
CN (1)	CN1053189C (de)
AT (2)	ATE198072T1 (de)
AU (2)	AU688393B2 (de)
CA (1)	CA2171332A1 (de)
CZ (1)	CZ292311B6 (de)
DE (2)	DE69434380T2 (de)
DK (2)	DK1004582T3 (de)
ES (2)	ES2154686T3 (de)
FI (2)	FI113865B (de)
GB (1)	GB9420590D0 (de)
GR (1)	GR3035080T3 (de)
HU (1)	HUT74161A (de)
IL (1)	IL111266A (de)
MY (2)	MY124316A (de)
NO (1)	NO306995B1 (de)
NZ (2)	NZ329303A (de)
PL (1)	PL180679B1 (de)
PT (2)	PT1004582E (de)
RU (1)	RU2168511C2 (de)
SG (2)	SG92630A1 (de)
SI (2)	SI1004582T1 (de)
SK (1)	SK282491B6 (de)
TW (1)	TW406082B (de)
UA (1)	UA60291C2 (de)
WO (1)	WO1995011244A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9420590D0 (en) *	1993-10-22	1994-11-30	Zeneca Ltd	Pyridazino quinoline compounds
US6214826B1 (en)	1994-11-12	2001-04-10	Zeneca Limited	Pyridazino quinoline compounds
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
GB9507318D0 (en)	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds
SK8802002A3 (en) *	1999-12-23	2003-06-03	Astrazeneca Ab	Use of compounds based on quinolines and compositions comprising the same
US6730675B2 (en)	1999-12-23	2004-05-04	Astrazeneca Ab	Compounds and methods for the treatment of pain
SI1244662T1 (de) *	1999-12-23	2005-08-31	Astrazeneca Ab
SK8792002A3 (en) *	1999-12-23	2003-05-02	Astrazeneca Ab	Quinoline-based compound, pharmaceutical composition containing same and use thereof
EP1244453A1 (de) *	1999-12-23	2002-10-02	AstraZeneca AB	Verfahren und zusammensetzung zur behandlung von schmerzen
US6943165B2 (en) *	1999-12-23	2005-09-13	Astrazeneca Ab	Compound and method for the treatment of pain
AU2566201A (en) *	1999-12-23	2001-07-09	Astrazeneca Ab	Compounds and methods for the treatment of pain
US20030176435A1 (en) *	2002-12-17	2003-09-18	Brown Dean Gordon	Compounds and methods for the treatment of pain
US6787547B2 (en)	1999-12-23	2004-09-07	Astrazeneca Ab	Compound and method for the treatment of pain
US20050124622A1 (en) *	1999-12-23	2005-06-09	Brown Dean G.	Compounds and methods for the treatment of pain
JP2003519145A (ja) *	1999-12-23	2003-06-17	アストラゼネカ・アクチエボラーグ	痛みの処置のための化合物および方法
WO2001047924A1 (en) *	1999-12-23	2001-07-05	Astrazeneca Ab	Methods and compositions for the treatment of pain
US6403818B1 (en)	2000-02-28	2002-06-11	Eisai Co., Ltd.	Process for producing α-hydroxy-carbonyl compound
AU2002214441A1 (en) *	2000-09-29	2002-04-08	Astrazeneca Ab	1,2,5,10-tetrahydropyridazino(4,5-b)quinoline-1,10-diones and their use for the treatment of pain
WO2002026741A1 (en) *	2000-09-29	2002-04-04	Astrazeneca Ab	1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-b]QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN
AU2001292498A1 (en) *	2000-09-29	2002-04-08	Astrazeneca Ab	1,2,5,10-tetrahydropyridazino(4,5-b)quinoline-1,10-diones and their use for the treatment of pain
EP1325003B1 (de)	2000-09-29	2006-08-02	AstraZeneca AB	7-chlor-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino¬4,5-b\|chinolin-1,10-dione und ihre verwendung zur behandlung von schmerzen
EP1390349B1 (de) *	2001-05-31	2012-07-25	Sanofi	Aminochinolin- und aminopyridinderivate und deren verwendung als adenosin a3 liganden
US8592421B2 (en)	2003-08-04	2013-11-26	Valery Khazhmuratovich Zhilov	Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon
LT2502911T (lt)	2004-06-24	2017-09-11	Vertex Pharmaceuticals Incorporated	Atp surišančios kasetės transporterių moduliatoriai
US8354427B2 (en)	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
CA2634113A1 (en) *	2005-12-24	2007-07-05	Vertex Pharmaceuticals Incorporated	Quinolin- 4 - one derivatives as modulators of abc transporters
WO2007079139A2 (en)	2005-12-28	2007-07-12	Vertex Pharmaceuticals, Inc.	Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
SI2408750T1 (sl)	2009-03-20	2015-11-30	Vertex Pharmaceuticals Incorporated	Postopek za izdelavo modulatorjev cistično-fibroznega transmembranskega regulatorja prevodnosti
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
EP2819670A1 (de)	2012-02-27	2015-01-07	Vertex Pharmaceuticals Incorporated	Pharmazeutische zusammensetzung und verabreichung davon
KR20170063954A (ko)	2014-10-07	2017-06-08	버텍스 파마슈티칼스 인코포레이티드	낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814458D0 (en) *	1988-06-17	1988-07-20	Wyeth John & Brother Ltd	Heterocyclic compounds
GB9109972D0 (en) *	1991-05-09	1991-07-03	Ici Plc	Therapeutic compounds
GB9208511D0 (en) *	1991-05-09	1992-06-03	Ici Plc	Compounds
GB9420590D0 (en) *	1993-10-22	1994-11-30	Zeneca Ltd	Pyridazino quinoline compounds
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
GB9507318D0 (en) *	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds

1994
- 1994-10-12 GB GB9420590A patent/GB9420590D0/en active Pending
- 1994-10-12 IL IL11126694A patent/IL111266A/xx not_active IP Right Cessation
- 1994-10-20 MY MYPI94002796A patent/MY124316A/en unknown
- 1994-10-20 KR KR1019960702011A patent/KR100261209B1/ko not_active Expired - Fee Related
- 1994-10-20 WO PCT/GB1994/002295 patent/WO1995011244A1/en not_active Ceased
- 1994-10-20 JP JP51152195A patent/JP3583132B2/ja not_active Expired - Fee Related
- 1994-10-20 DK DK00101917T patent/DK1004582T3/da active
- 1994-10-20 EP EP00101917A patent/EP1004582B1/de not_active Expired - Lifetime
- 1994-10-20 SG SG9900943A patent/SG92630A1/en unknown
- 1994-10-20 SG SG1996007261A patent/SG59971A1/en unknown
- 1994-10-20 SI SI9430476T patent/SI1004582T1/xx unknown
- 1994-10-20 SI SI9430314T patent/SI0724583T1/xx unknown
- 1994-10-20 MY MYPI98002508A patent/MY132875A/en unknown
- 1994-10-20 NZ NZ329303A patent/NZ329303A/xx not_active IP Right Cessation
- 1994-10-20 PT PT00101917T patent/PT1004582E/pt unknown
- 1994-10-20 RU RU96109470/04A patent/RU2168511C2/ru not_active IP Right Cessation
- 1994-10-20 US US08/637,641 patent/US5744471A/en not_active Expired - Fee Related
- 1994-10-20 DK DK94930275T patent/DK0724583T3/da active
- 1994-10-20 HU HU9600889A patent/HUT74161A/hu unknown
- 1994-10-20 PL PL94314041A patent/PL180679B1/pl not_active IP Right Cessation
- 1994-10-20 NZ NZ275472A patent/NZ275472A/en not_active IP Right Cessation
- 1994-10-20 CN CN94194578A patent/CN1053189C/zh not_active Expired - Fee Related
- 1994-10-20 DE DE69434380T patent/DE69434380T2/de not_active Expired - Fee Related
- 1994-10-20 SK SK504-96A patent/SK282491B6/sk not_active IP Right Cessation
- 1994-10-20 PT PT94930275T patent/PT724583E/pt unknown
- 1994-10-20 DE DE69426422T patent/DE69426422T2/de not_active Expired - Fee Related
- 1994-10-20 ES ES94930275T patent/ES2154686T3/es not_active Expired - Lifetime
- 1994-10-20 AT AT94930275T patent/ATE198072T1/de not_active IP Right Cessation
- 1994-10-20 ES ES00101917T patent/ES2241513T3/es not_active Expired - Lifetime
- 1994-10-20 EP EP94930275A patent/EP0724583B1/de not_active Expired - Lifetime
- 1994-10-20 CZ CZ19961138A patent/CZ292311B6/cs not_active IP Right Cessation
- 1994-10-20 CA CA002171332A patent/CA2171332A1/en not_active Abandoned
- 1994-10-20 UA UA96041567A patent/UA60291C2/uk unknown
- 1994-10-20 AU AU79440/94A patent/AU688393B2/en not_active Ceased
- 1994-10-20 AT AT00101917T patent/ATE295846T1/de not_active IP Right Cessation
- 1994-11-18 TW TW083110721A patent/TW406082B/zh not_active IP Right Cessation
1996
- 1996-04-18 FI FI961696A patent/FI113865B/fi active
- 1996-04-19 NO NO961584A patent/NO306995B1/no not_active IP Right Cessation
1997
- 1997-03-03 FI FI970907A patent/FI114916B/fi active IP Right Grant
1998
- 1998-03-19 US US09/044,109 patent/US6232313B1/en not_active Expired - Fee Related
- 1998-05-27 AU AU68999/98A patent/AU721139B2/en not_active Ceased
1999
- 1999-12-06 US US09/455,096 patent/US6103721A/en not_active Expired - Fee Related
2000
- 2000-12-14 GR GR20000402690T patent/GR3035080T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK1013997A1 (en)	1999-09-17
WO1995011244A1 (en)	1995-04-27
NO961584L (no)	1996-04-19
SI0724583T1 (en)	2001-04-30
IL111266A (en)	2002-03-10
US5744471A (en)	1998-04-28
JPH09504519A (ja)	1997-05-06
MY124316A (en)	2006-06-30
AU7944094A (en)	1995-05-08
US6232313B1 (en)	2001-05-15
PL314041A1 (en)	1996-08-05
EP0724583A1 (de)	1996-08-07
DK0724583T3 (da)	2001-03-05
ES2154686T3 (es)	2001-04-16
FI970907A0 (fi)	1997-03-03
DE69426422T2 (de)	2001-05-10
PT724583E (pt)	2001-03-30
CA2171332A1 (en)	1995-04-27
CZ113896A3 (en)	1996-09-11
KR100261209B1 (ko)	2000-09-01
IL111266A0 (en)	1994-12-29
EP1004582B1 (de)	2005-05-18
JP3583132B2 (ja)	2004-10-27
FI970907L (fi)	1997-03-03
AU688393B2 (en)	1998-03-12
HUT74161A (en)	1996-11-28
FI961696L (fi)	1996-04-18
ES2241513T3 (es)	2005-11-01
NO306995B1 (no)	2000-01-24
CN1053189C (zh)	2000-06-07
MY132875A (en)	2007-10-31
PT1004582E (pt)	2005-09-30
TW406082B (en)	2000-09-21
FI113865B (fi)	2004-06-30
CN1138332A (zh)	1996-12-18
HU9600889D0 (en)	1996-06-28
DK1004582T3 (da)	2005-08-15
SI1004582T1 (de)	2005-08-31
GR3035080T3 (en)	2001-03-30
SK50496A3 (en)	1997-03-05
EP1004582A3 (de)	2000-08-30
SK282491B6 (sk)	2002-02-05
DE69434380D1 (de)	2005-06-23
NZ275472A (en)	1998-03-25
UA60291C2 (uk)	2003-10-15
EP0724583B1 (de)	2000-12-13
SG92630A1 (en)	2002-11-19
FI114916B (fi)	2005-01-31
FI961696A0 (fi)	1996-04-18
SG59971A1 (en)	1999-02-22
RU2168511C2 (ru)	2001-06-10
US6103721A (en)	2000-08-15
GB9420590D0 (en)	1994-11-30
ATE198072T1 (de)	2000-12-15
CZ292311B6 (cs)	2003-09-17
EP1004582A2 (de)	2000-05-31
AU6899998A (en)	1998-07-30
NO961584D0 (no)	1996-04-19
AU721139B2 (en)	2000-06-22
DE69434380T2 (de)	2006-05-04
PL180679B1 (en)	2001-03-30
DE69426422D1 (de)	2001-01-18
NZ329303A (en)	2000-01-28

Legal Events

Date

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Title

Description

2006-01-15

UEP

Publication of translation of european patent specification

Ref document number: 1004582

Country of ref document: EP

2010-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE295846T1 (de)	2005-06-15	Pyridazino-chinolin verbindungen
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ATE101181T1 (de)	1994-02-15	Anti-krebs-verbindungen.
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