IL111274A - Derivatives of 6-O-demethyl galanthamine - and pharmaceutical compositions containing them - Google Patents

Derivatives of 6-O-demethyl galanthamine - and pharmaceutical compositions containing them

Info

Publication number: IL111274A
Authority: IL; Israel
Prior art keywords: hydrogen; derivatives; pharmaceutical compositions; compositions containing; alkylaminocarbonyl
Prior art date: 1993-10-15

Application number

IL11127494A

Other languages

English (en)

Other versions

IL111274A0 (en

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-15

Filing date

1994-10-13

Publication date

2000-11-21

1994-10-13 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1994-12-29 Publication of IL111274A0 publication Critical patent/IL111274A0/xx

2000-11-21 Publication of IL111274A publication Critical patent/IL111274A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL11127494A 1993-10-15 1994-10-13 Derivatives of 6-O-demethyl galanthamine - and pharmaceutical compositions containing them IL111274A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/137,440 US6323195B1 (en)	1993-10-15	1993-10-15	Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (2)

Publication Number	Publication Date
IL111274A0 IL111274A0 (en)	1994-12-29
IL111274A true IL111274A (en)	2000-11-21

Family

ID=22477446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11127494A IL111274A (en)	1993-10-15	1994-10-13	Derivatives of 6-O-demethyl galanthamine - and pharmaceutical compositions containing them

Country Status (23)

Country	Link
US (2)	US6323195B1 (de)
EP (2)	EP1020470A3 (de)
JP (1)	JP2664344B2 (de)
KR (1)	KR0169114B1 (de)
CN (1)	CN1039911C (de)
AT (1)	ATE212348T1 (de)
AU (1)	AU696249B2 (de)
CA (1)	CA2118174C (de)
CZ (1)	CZ287071B6 (de)
DE (1)	DE69429708T2 (de)
DK (1)	DK0653427T3 (de)
EG (1)	EG20472A (de)
ES (1)	ES2171428T3 (de)
FI (1)	FI108723B (de)
IL (1)	IL111274A (de)
NO (1)	NO310415B1 (de)
NZ (1)	NZ264683A (de)
PL (1)	PL177730B1 (de)
PT (1)	PT653427E (de)
RO (1)	RO114133B1 (de)
RU (1)	RU2114850C1 (de)
TW (1)	TW363969B (de)
ZA (1)	ZA948062B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9514821D0 (en) *	1995-07-19	1995-09-20	Sod Conseils Rech Applic	Galanthamine derivatives
AT403803B (de) *	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
AU1738800A (en) *	1998-11-23	2000-06-13	Bonnie Davis	Dosage formulations for acetylcholinesterase inhibitors
AU775914B2 (en)	1998-12-24	2004-08-19	Janssen Pharmaceutica N.V.	Controlled release galantamine composition
EP1150695B1 (de) *	1999-01-11	2007-02-28	Atanas Russinov Djananov	Nahrungszusatz aus kräutern zur steigerung der muskulären kraft und ausdauer von athleten
US8603546B2 (en) *	1999-01-11	2013-12-10	Herbaceuticals Inc.	Herbal supplement for increased muscle strength and endurance for athletes
ATE254928T1 (de) *	1999-03-31	2003-12-15	Eisai Co Ltd	Stabilisierte zusammensetzung mit nootropen wirkstoffen
EP1237539B1 (de) *	1999-10-26	2005-10-19	Janssen Pharmaceutica N.V.	Orale lösung enthaltend galanthamine und ein süssungsmittel
JP2003516947A (ja)	1999-12-10	2003-05-20	デイビス、ボニー	ニコチン様物質受容体のモジュレーターとしてのガランタミンおよびリコラミンの類似物
NZ516302A (en)	2000-03-31	2004-02-27	Sanochemia Pharmazeutika Ag	Novel derivatives and analogues of galanthamin
US20030162770A1 (en) *	2002-02-22	2003-08-28	Davis Bonnie M.	Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20050143350A1 (en) *	2003-11-19	2005-06-30	Seed John C.	Combination drug therapy to treat obesity
US20050142193A1 (en) *	2003-12-31	2005-06-30	Lijuan Tang	Galantamine formulations
US20050191349A1 (en) *	2003-12-31	2005-09-01	Garth Boehm	Galantamine formulations
EP1779867A4 (de) *	2004-07-01	2009-12-02	Eisai R&D Man Co Ltd	Mittel zur förderung der nervenreveneration
ATE478659T1 (de) *	2005-05-13	2010-09-15	Alza Corp	Mehrlagiges arzneimittelausbringsystem mit sperre gegen reservoirmaterialfluss
US20080188510A1 (en) *	2005-05-23	2008-08-07	Eisai R & D Management Co., Ltd.	Novel methods using zonisamide
DE602006015338D1 (de) *	2005-09-22	2010-08-19	Galantos Pharma Gmbh	Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1777222A1 (de)	2005-09-22	2007-04-25	Galantos Pharma GmbH	Cholinesterase Inhibitoren mit erhöter Blut Hirn Schranke Permeabilität zur Behandlung von kognitiven Störungen
WO2007035941A2 (en) *	2005-09-23	2007-03-29	Alza Corporation	Transdermal galantamine delivery system
CA2721007C (en)	2008-04-14	2014-04-29	Galantos Pharma Gmbh	Derivatives of galantamine as pro-drugs for the treatment of human brain diseases
US20120184532A1 (en) *	2009-07-23	2012-07-19	Shire Llc	Galantamine amino acid and peptide prodrugs and uses thereof
WO2013160728A1 (en)	2012-04-26	2013-10-31	Alma Mater Studiorum - Universita' Di Bologna	Dual targeting compounds for the treatment of alzheimer's disease
EP3628315A1 (de)	2018-09-28	2020-04-01	Université de Caen Normandie	Kombination aus acetylcholinesterase-inhibitor und 5-ht4-rezeptoragonist als neuroprotektives mittel zur behandlung von neurodegenerativen krankheiten
CN113292420A (zh) *	2021-05-27	2021-08-24	神隆医药（常熟）有限公司	加兰他敏中间体原料2-溴-5-羟基-4-甲氧基苯甲酸回收方法
US12551491B1 (en) *	2025-07-23	2026-02-17	Alpha Cognition Inc.	Dosage regimens for benzgalantamine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL122665B1 (en)	1978-11-21	1982-08-31	Edinen Zentar Chim	Process for preparing novel dienones of narvedine type and their derivatives
US4751306A (en) *	1985-09-09	1988-06-14	E. I. Du Pont De Nemours And Company	Imide intermediates for the preparation of analgesic and/or antagonist octahydrobenzofuroisoquinolines
US4663318A (en)	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
EP0363415B1 (de) *	1987-05-04	2008-10-15	Davis, Bonnie	Mittel zur behandlung der alzheimer-krankheit
US6150354A (en) *	1987-01-15	2000-11-21	Bonnie Davis	Compounds for the treatment of Alzheimer's disease
NL8800350A (nl)	1988-02-12	1989-09-01	Stichting Biomedical Research	Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
CA1320486C (en) *	1988-06-01	1993-07-20	John J. Lafferty	.alpha. -adrenergic receptor antagonists
WO1992020327A1 (en)	1991-05-14	1992-11-26	Ernir Snorrason	Treatment of fatigue syndrome with cholinesterase inhibitors
US5153193A (en)	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5231093A (en) *	1991-10-01	1993-07-27	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

1993
- 1993-10-15 US US08/137,440 patent/US6323195B1/en not_active Expired - Lifetime
1994
- 1994-10-10 DE DE69429708T patent/DE69429708T2/de not_active Expired - Lifetime
- 1994-10-10 EP EP00107570A patent/EP1020470A3/de not_active Withdrawn
- 1994-10-10 DK DK94115959T patent/DK0653427T3/da active
- 1994-10-10 EP EP94115959A patent/EP0653427B1/de not_active Expired - Lifetime
- 1994-10-10 AT AT94115959T patent/ATE212348T1/de active
- 1994-10-10 ES ES94115959T patent/ES2171428T3/es not_active Expired - Lifetime
- 1994-10-10 PT PT94115959T patent/PT653427E/pt unknown
- 1994-10-13 FI FI944821A patent/FI108723B/fi not_active IP Right Cessation
- 1994-10-13 RU RU94036448A patent/RU2114850C1/ru active
- 1994-10-13 EG EG64194A patent/EG20472A/xx active
- 1994-10-13 IL IL11127494A patent/IL111274A/xx not_active IP Right Cessation
- 1994-10-13 NZ NZ264683A patent/NZ264683A/en not_active IP Right Cessation
- 1994-10-14 RO RO94-01669A patent/RO114133B1/ro unknown
- 1994-10-14 NO NO19943893A patent/NO310415B1/no not_active IP Right Cessation
- 1994-10-14 AU AU75814/94A patent/AU696249B2/en not_active Expired
- 1994-10-14 CA CA002118174A patent/CA2118174C/en not_active Expired - Lifetime
- 1994-10-14 CN CN94117060A patent/CN1039911C/zh not_active Expired - Lifetime
- 1994-10-14 KR KR1019940026303A patent/KR0169114B1/ko not_active Expired - Lifetime
- 1994-10-14 PL PL94305456A patent/PL177730B1/pl unknown
- 1994-10-14 CZ CZ19942546A patent/CZ287071B6/cs not_active IP Right Cessation
- 1994-10-14 TW TW083109526A patent/TW363969B/zh not_active IP Right Cessation
- 1994-10-14 ZA ZA948062A patent/ZA948062B/xx unknown
- 1994-10-17 JP JP6250778A patent/JP2664344B2/ja not_active Expired - Fee Related
1995
- 1995-05-22 US US08/445,921 patent/US5777108A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU7581494A (en)	1995-05-04
JPH07188240A (ja)	1995-07-25
RO114133B1 (ro)	1999-01-29
CZ254694A3 (en)	1995-09-13
PL305456A1 (en)	1995-04-18
CA2118174C (en)	2000-01-18
AU696249B2 (en)	1998-09-03
FI108723B (fi)	2002-03-15
DK0653427T3 (da)	2002-04-15
KR0169114B1 (ko)	1999-01-15
TW363969B (en)	1999-07-11
NO310415B1 (no)	2001-07-02
US6323195B1 (en)	2001-11-27
JP2664344B2 (ja)	1997-10-15
DE69429708T2 (de)	2002-08-29
FI944821A0 (fi)	1994-10-13
DE69429708D1 (de)	2002-03-14
RU2114850C1 (ru)	1998-07-10
CZ287071B6 (en)	2000-08-16
EP1020470A3 (de)	2000-07-26
EP1020470A2 (de)	2000-07-19
CN1111245A (zh)	1995-11-08
EG20472A (en)	1999-05-31
CN1039911C (zh)	1998-09-23
ES2171428T3 (es)	2002-09-16
EP0653427B1 (de)	2002-01-23
PT653427E (pt)	2002-06-28
NO943893L (no)	1995-04-18
EP0653427A1 (de)	1995-05-17
RU94036448A (ru)	1996-09-10
PL177730B1 (pl)	2000-01-31
ATE212348T1 (de)	2002-02-15
NO943893D0 (no)	1994-10-14
ZA948062B (en)	1995-06-06
CA2118174A1 (en)	1995-04-16
FI944821L (fi)	1995-04-16
KR950011443A (ko)	1995-05-15
IL111274A0 (en)	1994-12-29
US5777108A (en)	1998-07-07
NZ264683A (en)	1998-03-25

Legal Events

Date	Code	Title
2001-04-30	FF	Patent granted
2001-07-24	KB	Patent renewed
2002-05-23	HCA	Change of name of proprietor(s) after amalgamation
2009-05-03	FF	Patent granted
2012-10-31	KB	Patent renewed
2015-05-31	EXP	Patent expired

Publication	Publication Date	Title
IL111274A (en)	2000-11-21	Derivatives of 6-O-demethyl galanthamine - and pharmaceutical compositions containing them
GR3018212T3 (en)	1996-02-29	Naphtylalkylamines, process for their preparation and pharmaceutical compositions containing them.
HUT66660A (en)	1994-12-28	Intermediates for producing 9-[(substituted glicyl)-amido]-6-demetyl-6-deoxy-tetracyclines and pharmaceutical compositions containing them
GR3017243T3 (en)	1995-11-30	Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them.
IL111273A0 (en)	1994-12-29	Galanthamine derivatives, a process for their preparation and their use as medicaments
IL97535A0 (en)	1992-06-21	Squalene synthetase inhibitor dioxabicyclo(1,2,3)octanes,their production and pharmaceutical compositions containing them
AU1614492A (en)	1992-11-19	New peptide compound and a process for the preparation thereof
ES2103027T3 (es)	1997-08-16	Derivados de tienopiridina y composiciones farmaceuticas que los contienen.
GB9104548D0 (en)	1991-04-17	Antineoplastic modified imidazoacridines
AU5595490A (en)	1990-11-29	Antispasmodic agents
AU6582394A (en)	1994-11-21	Novel bisoxadiazolidine derivative
ES2173120T3 (es)	2002-10-16	Compuestos de cefem.
HU9502627D0 (en)	1995-11-28	Antitumor compositions and methods of treatment
MY109729A (en)	1997-05-31	Benzofuranylimidazole derivatives, a process for the preparation and therapeutical compositions containing the same
TW324719B (en)	1998-01-11	Succinamide compound, production thereof and use thereof
AU7458894A (en)	1995-02-20	1,5-benzodiazepine derivatives useful as cck or gastrin antagonists
TW254937B (en)	1995-08-21	Benzocycloheptene derivative and process for preparation thereof
IT1247921B (it)	1995-01-05	Composti ad attivita' anticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono