IL112236A - Process for minimizing degradation of activated protein c - Google Patents

Process for minimizing degradation of activated protein c

Info

Publication number
IL112236A
IL112236A IL11223695A IL11223695A IL112236A IL 112236 A IL112236 A IL 112236A IL 11223695 A IL11223695 A IL 11223695A IL 11223695 A IL11223695 A IL 11223695A IL 112236 A IL112236 A IL 112236A
Authority
IL
Israel
Prior art keywords
apc
activated protein
minimizing degradation
autodegradation
denaturant
Prior art date
Application number
IL11223695A
Other languages
English (en)
Other versions
IL112236A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22650141&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL112236(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL112236A0 publication Critical patent/IL112236A0/xx
Publication of IL112236A publication Critical patent/IL112236A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
IL11223695A 1994-01-05 1995-01-03 Process for minimizing degradation of activated protein c IL112236A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17783294A 1994-01-05 1994-01-05

Publications (2)

Publication Number Publication Date
IL112236A0 IL112236A0 (en) 1995-03-30
IL112236A true IL112236A (en) 1999-12-31

Family

ID=22650141

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11223695A IL112236A (en) 1994-01-05 1995-01-03 Process for minimizing degradation of activated protein c

Country Status (29)

Country Link
EP (2) EP1087011A3 (de)
JP (1) JP3778588B2 (de)
KR (1) KR950032287A (de)
CN (1) CN1109891A (de)
AT (1) ATE201045T1 (de)
AU (1) AU1003195A (de)
BR (1) BR9500017A (de)
CA (1) CA2139468C (de)
CO (1) CO4600680A1 (de)
CZ (1) CZ1395A3 (de)
DE (2) DE69520844T2 (de)
DK (1) DK0662513T3 (de)
ES (1) ES2156190T3 (de)
FI (1) FI115635B (de)
GR (1) GR3036277T3 (de)
HU (1) HUT70465A (de)
IL (1) IL112236A (de)
LU (2) LU90993I2 (de)
NL (1) NL300108I2 (de)
NO (2) NO320157B1 (de)
NZ (1) NZ270271A (de)
PE (1) PE43995A1 (de)
PL (1) PL180703B1 (de)
PT (1) PT662513E (de)
RU (1) RU2167936C2 (de)
SI (1) SI0662513T1 (de)
UA (1) UA39178C2 (de)
YU (1) YU295A (de)
ZA (1) ZA9514B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9809292A (pt) 1997-04-28 2000-07-04 Lilly Co Eli Métodos aperfeiçoados para o processamento de proteìna c ativada
EP1557463A1 (de) * 1997-04-28 2005-07-27 Eli Lilly & Company Verbesserte Methoden zur Verarbeitung von aktiviertem Protein C
US6630137B1 (en) 1997-04-28 2003-10-07 Eli Lilly And Company Activated protein C formulations
US7204981B2 (en) 2000-03-28 2007-04-17 Eli Lilly And Company Methods of treating diseases with activated protein C
CA2410567A1 (en) 2000-05-24 2001-11-29 Eli Lilly And Company Formulations and use of activated protein c and protein c zymogen for treating hypercoagulable states
AU2007272412B2 (en) * 2006-07-14 2013-11-07 Genentech, Inc. Refolding of recombinant proteins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950513A (en) * 1965-12-03 1976-04-13 Novo Terapeutisk Laboratorium A/S Process of stabilizing therapeutically useful plasmin solutions
US3557002A (en) * 1967-11-15 1971-01-19 Procter & Gamble Stabilized aqueous enzyme preparation
GB2105521A (en) * 1981-08-12 1983-03-23 Univ Surrey Antenna
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c

Also Published As

Publication number Publication date
NO320157B1 (no) 2005-11-07
ATE201045T1 (de) 2001-05-15
ES2156190T3 (es) 2001-06-16
LU90993I2 (fr) 2003-02-18
EP1087011A2 (de) 2001-03-28
PT662513E (pt) 2001-08-30
EP1087011A3 (de) 2002-02-06
IL112236A0 (en) 1995-03-30
JPH07206704A (ja) 1995-08-08
NO2006006I1 (no) 2006-05-15
DE10299053I2 (de) 2004-04-01
FI950044A0 (fi) 1995-01-04
HU9500021D0 (en) 1995-03-28
UA39178C2 (uk) 2001-06-15
LU90992I2 (fr) 2003-02-18
YU295A (sh) 1997-09-30
JP3778588B2 (ja) 2006-05-24
ZA9514B (en) 1996-07-03
RU95100178A (ru) 1997-03-27
CN1109891A (zh) 1995-10-11
PL180703B1 (pl) 2001-03-30
BR9500017A (pt) 1995-10-03
CA2139468A1 (en) 1995-07-06
NO950018D0 (no) 1995-01-03
AU1003195A (en) 1995-07-13
DK0662513T3 (da) 2001-05-28
NZ270271A (en) 1996-07-26
GR3036277T3 (en) 2001-10-31
SI0662513T1 (en) 2001-10-31
CZ1395A3 (en) 1995-07-12
FI950044L (fi) 1995-07-06
RU2167936C2 (ru) 2001-05-27
KR950032287A (ko) 1995-12-20
EP0662513B1 (de) 2001-05-09
NL300108I2 (nl) 2003-06-02
FI115635B (fi) 2005-06-15
CA2139468C (en) 2007-08-21
PL306671A1 (en) 1995-07-10
CO4600680A1 (es) 1998-05-08
PE43995A1 (es) 1995-12-15
DE69520844T2 (de) 2001-11-08
DE69520844D1 (de) 2001-06-13
NO950018L (no) 1995-07-06
EP0662513A1 (de) 1995-07-12
HUT70465A (en) 1995-10-30
NL300108I1 (nl) 2003-02-03
DE10299053I1 (de) 2003-05-22

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees