IL112384A - 6-aryl-hexahydropyrazino [1',2':1,6] pyrido [3,4-b] indole-1, 4-dione derivatives their preparation and pharmaceutical compositions containing them - Google Patents

6-aryl-hexahydropyrazino [1',2':1,6] pyrido [3,4-b] indole-1, 4-dione derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL112384A
IL112384A IL11238495A IL11238495A IL112384A IL 112384 A IL112384 A IL 112384A IL 11238495 A IL11238495 A IL 11238495A IL 11238495 A IL11238495 A IL 11238495A IL 112384 A IL112384 A IL 112384A
Authority
IL
Israel
Prior art keywords
dione
cis
methyl
compound
gave
Prior art date
Application number
IL11238495A
Other languages
English (en)
Other versions
IL112384A0 (en
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10749089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL112384(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corp filed Critical Icos Corp
Publication of IL112384A0 publication Critical patent/IL112384A0/xx
Publication of IL112384A publication Critical patent/IL112384A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL11238495A 1994-01-21 1995-01-19 6-aryl-hexahydropyrazino [1',2':1,6] pyrido [3,4-b] indole-1, 4-dione derivatives their preparation and pharmaceutical compositions containing them IL112384A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9401090A GB9401090D0 (en) 1994-01-21 1994-01-21 Chemical compounds

Publications (2)

Publication Number Publication Date
IL112384A0 IL112384A0 (en) 1995-03-30
IL112384A true IL112384A (en) 1998-08-16

Family

ID=10749089

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11238495A IL112384A (en) 1994-01-21 1995-01-19 6-aryl-hexahydropyrazino [1',2':1,6] pyrido [3,4-b] indole-1, 4-dione derivatives their preparation and pharmaceutical compositions containing them

Country Status (48)

Country Link
US (5) US5859006A (fr)
EP (1) EP0740668B1 (fr)
JP (3) JP3808095B2 (fr)
KR (1) KR100357411B1 (fr)
CN (2) CN1045777C (fr)
AP (1) AP556A (fr)
AT (1) ATE169018T1 (fr)
AU (2) AU689205B2 (fr)
BG (1) BG62733B1 (fr)
BR (1) BR9506559C8 (fr)
CA (1) CA2181377C (fr)
CO (1) CO4340684A1 (fr)
CZ (1) CZ286566B6 (fr)
DE (2) DE69503753T2 (fr)
DK (1) DK0740668T3 (fr)
EE (1) EE03231B1 (fr)
EG (1) EG25852A (fr)
ES (1) ES2122543T3 (fr)
FI (1) FI113176B (fr)
GB (1) GB9401090D0 (fr)
HR (1) HRP950023B1 (fr)
HU (1) HU222494B1 (fr)
IL (1) IL112384A (fr)
IN (1) IN183942B (fr)
IS (1) IS1888B (fr)
LU (1) LU91017I2 (fr)
LV (1) LV11690B (fr)
MA (1) MA23433A1 (fr)
MX (1) MX9602904A (fr)
MY (1) MY114663A (fr)
NL (1) NL300124I2 (fr)
NO (2) NO306465B1 (fr)
NZ (1) NZ279199A (fr)
OA (1) OA10584A (fr)
PE (1) PE49495A1 (fr)
PL (1) PL179744B1 (fr)
RO (1) RO117794B1 (fr)
RU (1) RU2142463C1 (fr)
SA (1) SA95150475B1 (fr)
SG (1) SG49184A1 (fr)
SI (1) SI0740668T1 (fr)
SK (1) SK280879B6 (fr)
SV (1) SV1995000002A (fr)
TN (1) TNSN95004A1 (fr)
TW (1) TW378210B (fr)
UY (1) UY23893A1 (fr)
WO (1) WO1995019978A1 (fr)
ZA (1) ZA95424B (fr)

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TW378210B (en) 2000-01-01
JP3808095B2 (ja) 2006-08-09
CN1224720A (zh) 1999-08-04
IL112384A0 (en) 1995-03-30
JP2009102386A (ja) 2009-05-14
DE10399006I1 (de) 2003-07-31
MX9602904A (es) 1997-12-31
BR9506559A (pt) 1997-10-28
HU222494B1 (hu) 2003-07-28
IS4252A (is) 1995-07-22
DE69503753T2 (de) 1999-01-21
HU9601982D0 (en) 1996-09-30
NZ279199A (en) 1998-01-26
RO117794B1 (ro) 2002-07-30
UY23893A1 (es) 1995-07-11
US6369059B1 (en) 2002-04-09
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CN1070492C (zh) 2001-09-05
TNSN95004A1 (fr) 1996-02-06
BR9506559C8 (pt) 2020-07-07
EP0740668B1 (fr) 1998-07-29
EG25852A (en) 2012-09-10
BG62733B1 (bg) 2000-06-30
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NL300124I1 (nl) 2003-07-01
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AU689205B2 (en) 1998-03-26
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US6025494A (en) 2000-02-15
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LV11690A (lv) 1997-02-20
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ZA95424B (en) 1995-09-27
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DE69503753D1 (de) 1998-09-03
NO963015L (no) 1996-09-09

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