IL112665A - 5-Substituted derivatives of mycophenolic acid their preparation and pharmaceutical compositions containing them - Google Patents
5-Substituted derivatives of mycophenolic acid their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL112665A IL112665A IL11266595A IL11266595A IL112665A IL 112665 A IL112665 A IL 112665A IL 11266595 A IL11266595 A IL 11266595A IL 11266595 A IL11266595 A IL 11266595A IL 112665 A IL112665 A IL 112665A
- Authority
- IL
- Israel
- Prior art keywords
- mycophenolic acid
- preparation
- pharmaceutical compositions
- compositions containing
- substituted derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12413995A IL124139A (en) | 1994-02-18 | 1995-02-16 | 5-substituted derivatives of mycophenolic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/198,749 US5493030A (en) | 1994-02-18 | 1994-02-18 | 5-substituted derivatives of mycophenolic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL112665A0 IL112665A0 (en) | 1995-05-26 |
| IL112665A true IL112665A (en) | 1999-05-09 |
Family
ID=22734662
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11266595A IL112665A (en) | 1994-02-18 | 1995-02-16 | 5-Substituted derivatives of mycophenolic acid their preparation and pharmaceutical compositions containing them |
| IL12413995A IL124139A (en) | 1994-02-18 | 1995-02-16 | 5-substituted derivatives of mycophenolic acid |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12413995A IL124139A (en) | 1994-02-18 | 1995-02-16 | 5-substituted derivatives of mycophenolic acid |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5493030A (fr) |
| EP (1) | EP0745073B1 (fr) |
| JP (1) | JPH09509174A (fr) |
| CN (1) | CN1141038A (fr) |
| AT (1) | ATE194608T1 (fr) |
| AU (1) | AU1875495A (fr) |
| BR (1) | BR9506819A (fr) |
| CA (1) | CA2183530A1 (fr) |
| CO (1) | CO4340734A1 (fr) |
| DE (1) | DE69517957T2 (fr) |
| DK (1) | DK0745073T3 (fr) |
| ES (1) | ES2149971T3 (fr) |
| FI (1) | FI963218L (fr) |
| GR (1) | GR3033864T3 (fr) |
| GT (1) | GT199500007A (fr) |
| HR (1) | HRP950070B1 (fr) |
| IL (2) | IL112665A (fr) |
| IS (1) | IS4264A (fr) |
| MX (1) | MX9603478A (fr) |
| MY (1) | MY112804A (fr) |
| PE (1) | PE22996A1 (fr) |
| PH (1) | PH31441A (fr) |
| PT (1) | PT745073E (fr) |
| SI (1) | SI0745073T1 (fr) |
| SV (1) | SV1995000007A (fr) |
| TW (1) | TW384288B (fr) |
| UY (2) | UY23910A1 (fr) |
| WO (1) | WO1995022538A1 (fr) |
| ZA (1) | ZA951299B (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514979B1 (en) | 1999-03-03 | 2003-02-04 | University Of Maryland Biotechnology Institute | Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor |
| US6811998B2 (en) | 1999-06-25 | 2004-11-02 | Roche Diagnostics Operations, Inc. | Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase |
| US7214754B2 (en) * | 1999-12-13 | 2007-05-08 | Ppg Industries Ohio, Inc. | Polymerizable polyol (allyl carbonate) compositions |
| US7179791B2 (en) * | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| AU2003261354A1 (en) * | 2002-08-02 | 2004-02-23 | The Regents Of The University Of California | New uses for inhibitors of inosine monophosphate dehydrogenase |
| US20050261237A1 (en) * | 2003-04-25 | 2005-11-24 | Boojamra Constantine G | Nucleoside phosphonate analogs |
| US7407965B2 (en) * | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7452901B2 (en) * | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| JP2006524710A (ja) * | 2003-04-25 | 2006-11-02 | ギリアード サイエンシーズ， インコーポレイテッド | キナーゼインヒビターホスホネート抱合体 |
| US7432261B2 (en) * | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| PL1628685T3 (pl) * | 2003-04-25 | 2011-05-31 | Gilead Sciences Inc | Przeciwwirusowe analogi fosfonianowe |
| WO2004096287A2 (fr) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase |
| US7470724B2 (en) * | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US7300924B2 (en) * | 2003-04-25 | 2007-11-27 | Gilead Sciences, Inc. | Anti-infective phosphonate analogs |
| CN101410120A (zh) * | 2003-04-25 | 2009-04-15 | 吉里德科学公司 | 抗炎的膦酸酯化合物 |
| US20090247488A1 (en) * | 2003-04-25 | 2009-10-01 | Carina Cannizzaro | Anti-inflammatory phosphonate compounds |
| WO2005002626A2 (fr) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Composes de phosphonate therapeutiques |
| US20050187170A1 (en) * | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
| ES2308226T3 (es) * | 2003-09-11 | 2008-12-01 | Sandoz Ag | Proceso para la produccion de micofenolato mofetil. |
| WO2005044308A1 (fr) * | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Analogues phosphonates d'antimetabolites |
| US7427624B2 (en) * | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
| BRPI0418031A (pt) * | 2003-12-22 | 2007-04-17 | Gilead Sciences Inc | inibidores de quinase fosfonato-substituìdos |
| US20050153990A1 (en) * | 2003-12-22 | 2005-07-14 | Watkins William J. | Phosphonate substituted kinase inhibitors |
| DE602004019815D1 (de) * | 2003-12-22 | 2009-04-16 | Gilead Sciences Inc | 4'-substituierte carbovir- und abacavir-derivate sowie verwandte verbindungen mit hiv- und hcv-antiviraler wirkung |
| WO2006115509A2 (fr) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence |
| EP1778251B1 (fr) | 2004-07-27 | 2011-04-13 | Gilead Sciences, Inc. | Conjugues de phosphonate nucleosidique comme agents anti-vih |
| AU2005299284A1 (en) * | 2004-10-26 | 2006-05-04 | Gilead Sciences, Inc. | Phosphonate derivatives of mycophenolic acid |
| US20080161324A1 (en) * | 2006-09-14 | 2008-07-03 | Johansen Lisa M | Compositions and methods for treatment of viral diseases |
| CN101422424B (zh) * | 2007-10-31 | 2012-10-24 | 王世亮 | 霉酚酸类药物植入剂及其制备方法和应用 |
| AU2009268681B2 (en) * | 2008-07-08 | 2014-10-02 | Gilead Sciences, Inc. | Salts of HIV inhibitor compounds |
| WO2013044028A2 (fr) * | 2011-09-21 | 2013-03-28 | Texas A&M University System | Analogues d'acide mycophénolique comme agents chimiosensibilisants anti-tumoraux |
| CN105271935B (zh) * | 2015-11-03 | 2017-06-30 | 陶祖岐 | 一种生活垃圾制成的装饰板和包装箱板 |
| US10603299B2 (en) | 2016-06-02 | 2020-03-31 | Steven Baranowitz | Prevention and treatment of viral infections |
| CA3026241A1 (fr) | 2016-06-02 | 2017-12-07 | Steven Baranowitz | Prevention et traitement d'infections virales |
| US12011429B2 (en) | 2016-06-02 | 2024-06-18 | Steven Baranowitz | Prevention and treatment of viral infections |
| EP3661937B1 (fr) | 2017-08-01 | 2021-07-28 | Gilead Sciences, Inc. | Formes crystallines d'éthyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)méthyl)(phénoxy)phosphoryl)-l-alaninate (gs-9131) pour le traitement des infections virales |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5542995B2 (fr) * | 1972-02-24 | 1980-11-04 | ||
| US3825571A (en) * | 1971-07-31 | 1974-07-23 | Chugai Pharmaceutical Co Ltd | Mycophenolic acid derivatives |
| JPS5529994B2 (fr) * | 1972-03-02 | 1980-08-07 | ||
| US4515956A (en) * | 1982-12-16 | 1985-05-07 | The Dow Chemical Company | Selective preparation of isomers and enantiomers of cyclopropane carboxylic acids |
| US4479005A (en) * | 1982-12-16 | 1984-10-23 | The Dow Chemical Company | Selective preparation of isomers and enantiomers of cyclopropane carboxylic acids |
| US4686234A (en) * | 1985-11-27 | 1987-08-11 | Syntex (U.S.A) Inc. | Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis |
| US4725622A (en) * | 1986-01-23 | 1988-02-16 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US4959387A (en) * | 1986-01-23 | 1990-09-25 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US5231179A (en) * | 1986-01-27 | 1993-07-27 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds and their production |
| US4748173A (en) * | 1987-01-30 | 1988-05-31 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions |
| US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US4861776A (en) * | 1987-01-30 | 1989-08-29 | Syntex (U.S.A) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use |
| US4727069A (en) * | 1987-01-30 | 1988-02-23 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions |
| JPH0637486B2 (ja) * | 1988-05-18 | 1994-05-18 | 三共株式会社 | 新規抗生物質フタレキシンおよびその製造法 |
| US5155228A (en) * | 1989-03-23 | 1992-10-13 | Merck & Co., Inc. | FK-506 C10-C18 process intermediates |
| US4940797A (en) * | 1989-03-23 | 1990-07-10 | Merck & Co., Inc. | Process for synthesis of FK-506 C10-C18 intermediates |
| US5068345A (en) * | 1989-10-30 | 1991-11-26 | Eastman Kodak Company | Oxazolidinone aldol adduct |
| US5247083A (en) * | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
-
1994
- 1994-02-18 US US08/198,749 patent/US5493030A/en not_active Expired - Lifetime
-
1995
- 1995-02-15 PH PH49980A patent/PH31441A/en unknown
- 1995-02-16 SV SV1995000007A patent/SV1995000007A/es not_active Application Discontinuation
- 1995-02-16 JP JP7521868A patent/JPH09509174A/ja not_active Ceased
- 1995-02-16 FI FI963218A patent/FI963218L/fi unknown
- 1995-02-16 PT PT95910984T patent/PT745073E/pt unknown
- 1995-02-16 IS IS4264A patent/IS4264A/is unknown
- 1995-02-16 IL IL11266595A patent/IL112665A/xx not_active IP Right Cessation
- 1995-02-16 CA CA002183530A patent/CA2183530A1/fr not_active Abandoned
- 1995-02-16 TW TW084101398A patent/TW384288B/zh not_active IP Right Cessation
- 1995-02-16 ES ES95910984T patent/ES2149971T3/es not_active Expired - Lifetime
- 1995-02-16 DE DE69517957T patent/DE69517957T2/de not_active Expired - Fee Related
- 1995-02-16 HR HR08/198,749 patent/HRP950070B1/xx not_active IP Right Cessation
- 1995-02-16 PE PE1995262077A patent/PE22996A1/es not_active Application Discontinuation
- 1995-02-16 WO PCT/US1995/001787 patent/WO1995022538A1/fr not_active Ceased
- 1995-02-16 AT AT95910984T patent/ATE194608T1/de not_active IP Right Cessation
- 1995-02-16 MX MX9603478A patent/MX9603478A/es unknown
- 1995-02-16 EP EP95910984A patent/EP0745073B1/fr not_active Expired - Lifetime
- 1995-02-16 CO CO95005930A patent/CO4340734A1/es unknown
- 1995-02-16 BR BR9506819A patent/BR9506819A/pt active Search and Examination
- 1995-02-16 CN CN95191654A patent/CN1141038A/zh active Pending
- 1995-02-16 AU AU18754/95A patent/AU1875495A/en not_active Abandoned
- 1995-02-16 DK DK95910984T patent/DK0745073T3/da active
- 1995-02-16 MY MYPI95000420A patent/MY112804A/en unknown
- 1995-02-16 SI SI9530434T patent/SI0745073T1/xx unknown
- 1995-02-16 IL IL12413995A patent/IL124139A/xx not_active IP Right Cessation
- 1995-02-16 UY UY23910A patent/UY23910A1/es not_active IP Right Cessation
- 1995-02-16 ZA ZA951299A patent/ZA951299B/xx unknown
- 1995-02-17 GT GT199500007A patent/GT199500007A/es unknown
- 1995-06-06 US US08/483,042 patent/US5633279A/en not_active Expired - Lifetime
-
1998
- 1998-11-23 UY UY25262A patent/UY25262A1/es not_active Application Discontinuation
-
2000
- 2000-07-13 GR GR20000401101T patent/GR3033864T3/el not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |