IL112738A - 5-[3-aryl-prop-2-ynyl]-5-(arylsulfonyl)- thiazolidine-2, 4-diones and 5-(3-aryl-prop-2-ynyl)-5- (arylsulfanyl) thiazolidine-2, 4-diones derivatives thereof and pharmaceutical compositions containing them - Google Patents

5-[3-aryl-prop-2-ynyl]-5-(arylsulfonyl)- thiazolidine-2, 4-diones and 5-(3-aryl-prop-2-ynyl)-5- (arylsulfanyl) thiazolidine-2, 4-diones derivatives thereof and pharmaceutical compositions containing them

Info

Publication number
IL112738A
IL112738A IL11273895A IL11273895A IL112738A IL 112738 A IL112738 A IL 112738A IL 11273895 A IL11273895 A IL 11273895A IL 11273895 A IL11273895 A IL 11273895A IL 112738 A IL112738 A IL 112738A
Authority
IL
Israel
Prior art keywords
substituted phenyl
ynyl
thiazolidine
prop
aryl
Prior art date
Application number
IL11273895A
Other languages
English (en)
Other versions
IL112738A0 (en
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of IL112738A0 publication Critical patent/IL112738A0/xx
Publication of IL112738A publication Critical patent/IL112738A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11273895A 1994-03-08 1995-02-22 5-[3-aryl-prop-2-ynyl]-5-(arylsulfonyl)- thiazolidine-2, 4-diones and 5-(3-aryl-prop-2-ynyl)-5- (arylsulfanyl) thiazolidine-2, 4-diones derivatives thereof and pharmaceutical compositions containing them IL112738A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20798094A 1994-03-08 1994-03-08

Publications (2)

Publication Number Publication Date
IL112738A0 IL112738A0 (en) 1995-05-26
IL112738A true IL112738A (en) 1999-09-22

Family

ID=22772754

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11273895A IL112738A (en) 1994-03-08 1995-02-22 5-[3-aryl-prop-2-ynyl]-5-(arylsulfonyl)- thiazolidine-2, 4-diones and 5-(3-aryl-prop-2-ynyl)-5- (arylsulfanyl) thiazolidine-2, 4-diones derivatives thereof and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (2) US5605918A (de)
EP (1) EP0749430B1 (de)
JP (1) JPH09509963A (de)
KR (1) KR100342761B1 (de)
AT (1) ATE183743T1 (de)
AU (1) AU679626B2 (de)
BR (1) BR9507014A (de)
CA (1) CA2184739A1 (de)
CZ (1) CZ284592B6 (de)
DE (1) DE69511683T2 (de)
DK (1) DK0749430T3 (de)
ES (1) ES2135711T4 (de)
FI (1) FI963467A0 (de)
GR (1) GR3031496T3 (de)
HU (1) HUT76482A (de)
IL (1) IL112738A (de)
NZ (1) NZ282143A (de)
RU (1) RU2126395C1 (de)
SG (1) SG52318A1 (de)
SK (1) SK280914B6 (de)
TW (1) TW300222B (de)
UA (1) UA45333C2 (de)
WO (1) WO1995024400A1 (de)
ZA (1) ZA951847B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508656A (ja) * 1997-03-12 2002-03-19 スミスクライン・ビーチャム・コーポレイション 抗−アルファベータ３ヒト化モノクローナル抗体
US6605628B1 (en) 2001-08-24 2003-08-12 Wyeth Holdings Corporation Method of using 5-(arysulfonyl)-, 5-(arylsulfanyl)-and 5-(arylsulfanyl)thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase
WO2003018554A1 (en) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation 3-substituted-3-(substitutedsulfonyl or sulfanyl)pyrrolidine-2,5-diones useful for inhibition of farnesyl-protein transferase
WO2003018011A1 (en) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation 5-(substituted)-5-(substitutedsulfonyl or sulfanyl)thiazolidine-2,4-diones useful for inhibition of farnesyl-protein transferase
WO2003018135A1 (en) 2001-08-24 2003-03-06 Wyeth Holdings Corporation Method of using 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase
BRPI0412236A (pt) * 2003-07-02 2006-09-12 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para o tratamento e/ou prevenção de enfermidades que são moduladas por agonistas ppar(delta) e/ou ppar(alfa), e utilização desses compostos
US9198913B2 (en) 2009-07-31 2015-12-01 Global Alliance For Tb Drug Development Nitroimidazooxazines and their uses in anti-tubercular therapy
RU2542988C2 (ru) 2009-07-31 2015-02-27 Глоубал Элаенс Фор Тб Драг Дивелопмент Нитроимидазооксазины и их применения при противотуберкулезной терапии

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451471A (en) * 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
JPS58118577A (ja) * 1982-01-07 1983-07-14 Takeda Chem Ind Ltd チアゾリジン誘導体
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US4738972A (en) * 1985-05-21 1988-04-19 Pfizer Inc. Hypoglycemic thiazolidinediones
DK4487A (da) * 1986-01-07 1987-07-08 Yamanouchi Pharma Co Ltd Heterocycliske forbindelser og farmaceutiske praeparater indeholdende disse
US4743611A (en) * 1986-07-02 1988-05-10 American Home Products Corp. Naphthalenylsulfonylimidazolidinediones and their thioxo analogs useful as aldose reductase inhibitors
US5068342A (en) * 1989-10-27 1991-11-26 American Home Products Corporation 5-[(1- and 2-naphthalenyl)thio and sulfonyl]-2,4-thiazolidinediones and derivatives thereof
US4997948A (en) * 1989-10-27 1991-03-05 American Home Products 5-[(1- and 2-naphthalenyl) sulfonyl]-2,4-thiazolidinediones and derivatives thereof
IL113112A (en) * 1994-03-28 2000-06-01 Nissan Chemical Ind Ltd Pyridine substituted thiazolidinediones and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
FI963467A7 (fi) 1996-09-04
MX9603865A (es) 1997-07-31
UA45333C2 (uk) 2002-04-15
BR9507014A (pt) 1997-09-09
SK280914B6 (sk) 2000-09-12
AU679626B2 (en) 1997-07-03
CZ259496A3 (en) 1997-07-16
US5605918A (en) 1997-02-25
ATE183743T1 (de) 1999-09-15
GR3031496T3 (en) 2000-01-31
EP0749430A1 (de) 1996-12-27
EP0749430B1 (de) 1999-08-25
IL112738A0 (en) 1995-05-26
NZ282143A (en) 1997-12-19
KR100342761B1 (ko) 2002-12-06
SG52318A1 (en) 1998-09-28
ES2135711T3 (es) 1999-11-01
SK113396A3 (en) 1997-03-05
TW300222B (de) 1997-03-11
JPH09509963A (ja) 1997-10-07
DK0749430T3 (da) 2000-02-07
AU1916895A (en) 1995-09-25
HU9602442D0 (en) 1996-11-28
FI963467L (fi) 1996-09-04
CA2184739A1 (en) 1995-09-14
KR970701704A (ko) 1997-04-12
US5574051A (en) 1996-11-12
ZA951847B (en) 1996-09-06
ES2135711T4 (es) 2000-01-01
FI963467A0 (fi) 1996-09-04
RU2126395C1 (ru) 1999-02-20
CZ284592B6 (cs) 1999-01-13
DE69511683T2 (de) 2000-03-02
WO1995024400A1 (en) 1995-09-14
DE69511683D1 (de) 1999-09-30
HUT76482A (en) 1997-09-29

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