IL112955A - 3-(AMINOMETHYLOXADIAZOLYL) IMIDAZO £1, 5-a| £1, 4| BENZODIAZEPIN-6-ONES AND ANALOGS THEREOF, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

3-(AMINOMETHYLOXADIAZOLYL) IMIDAZO £1, 5-a| £1, 4| BENZODIAZEPIN-6-ONES AND ANALOGS THEREOF, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
IL112955A
IL112955A IL112955A IL11295595A IL112955A IL 112955 A IL112955 A IL 112955A IL 112955 A IL112955 A IL 112955A IL 11295595 A IL11295595 A IL 11295595A IL 112955 A IL112955 A IL 112955A
Authority
IL
Israel
Prior art keywords
imidazo
dihydro
mmol
oxadiazol
benzodiazepin
Prior art date
Application number
IL112955A
Other languages
English (en)
Other versions
IL112955A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL112955A0 publication Critical patent/IL112955A0/xx
Publication of IL112955A publication Critical patent/IL112955A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
IL112955A 1994-03-16 1995-03-10 3-(AMINOMETHYLOXADIAZOLYL) IMIDAZO £1, 5-a| £1, 4| BENZODIAZEPIN-6-ONES AND ANALOGS THEREOF, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IL112955A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH78394 1994-03-16
CH1095 1995-01-03

Publications (2)

Publication Number Publication Date
IL112955A0 IL112955A0 (en) 1995-06-29
IL112955A true IL112955A (en) 1998-02-08

Family

ID=25683249

Family Applications (1)

Application Number Title Priority Date Filing Date
IL112955A IL112955A (en) 1994-03-16 1995-03-10 3-(AMINOMETHYLOXADIAZOLYL) IMIDAZO £1, 5-a| £1, 4| BENZODIAZEPIN-6-ONES AND ANALOGS THEREOF, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (27)

Country Link
US (1) US5665718A (fr)
EP (1) EP0672666B1 (fr)
JP (1) JP2690282B2 (fr)
KR (1) KR100214800B1 (fr)
CN (1) CN1036995C (fr)
AT (1) ATE203536T1 (fr)
AU (1) AU679608B2 (fr)
BG (1) BG62210B1 (fr)
CA (1) CA2143246C (fr)
CZ (1) CZ288594B6 (fr)
DE (1) DE59509432D1 (fr)
DK (1) DK0672666T3 (fr)
ES (1) ES2160646T3 (fr)
FI (1) FI112487B (fr)
GR (1) GR3037019T3 (fr)
HU (1) HU219987B (fr)
IL (1) IL112955A (fr)
IS (1) IS4273A (fr)
LV (1) LV11327B (fr)
MA (1) MA23479A1 (fr)
NO (1) NO303731B1 (fr)
NZ (1) NZ270685A (fr)
PH (1) PH31443A (fr)
PT (1) PT672666E (fr)
RO (1) RO117698B1 (fr)
RU (1) RU2139873C1 (fr)
SK (1) SK33995A3 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5905176A (en) * 1998-08-28 1999-05-18 Eastman Chemical Company Process for the production of cyclobutyl halides
BR0010495A (pt) * 1999-05-12 2002-02-13 Hoffmann La Roche Derivado da imidazodiazepina
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
RU2199309C1 (ru) * 2001-12-29 2003-02-27 Закрытое акционерное общество "Брынцалов-А" Лекарственное средство нобрассит седативного и анксиолитического действия
US20060065608A1 (en) * 2004-09-29 2006-03-30 Choate Chris E Process and apparatus for generating useful biomass from organic waste streams
EP1855679B1 (fr) * 2005-01-19 2016-06-29 Merck Sharp & Dohme Corp. Inhibiteurs de la beta-secretase d'aminomethyle dans le traitement de la maladie d'alzheimer
ATE506951T1 (de) * 2005-01-19 2011-05-15 Merck Sharp & Dohme Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer- krankheit
US7595395B2 (en) * 2005-05-16 2009-09-29 Wisys Technology Foundation Gabaergic agents to treat memory deficits
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
CN104059072B (zh) 2006-07-10 2016-06-22 Paion英国有限公司 短效苯并二氮杂*盐及其多晶型
WO2009024324A2 (fr) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Traitement des troubles du sommeil
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
CA2696703C (fr) 2007-08-20 2016-07-26 Evotec Neurosciences Gmbh Traitement de troubles du sommeil
RU2503681C2 (ru) * 2008-09-30 2014-01-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Новое конденсированное производное аминодигидротиазина
EP2450039A1 (fr) 2010-11-08 2012-05-09 PAION UK Ltd. Régime de dosage permettant la sédation avec CNS 7056 (Remimazolam)
AR092008A1 (es) 2012-05-22 2015-03-18 Paion Uk Ltd Composiciones que comprenden benzodiazepinas de accion rapida, uso y metodo de preparacion
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
EP3363790B1 (fr) 2013-09-06 2020-02-19 Aurigene Discovery Technologies Limited Dérivés 1,2,4-oxadiazole utilisés comme immunomodulateurs
LT3267984T (lt) * 2015-03-10 2022-03-25 Aurigene Discovery Technologies Limited 1,2,4-oksadiazolo ir tiadiazolo junginiai kaip imunomoduliatoriai
JP2018507894A (ja) * 2015-03-10 2018-03-22 オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ 免疫調節剤としての３−置換−１，２，４−オキサジアゾールおよびチアジアゾール化合物
ES3027652T3 (en) 2016-04-14 2025-06-16 Paion Uk Ltd Orally inhaled and nasal benzodiazepines
WO2019061324A1 (fr) 2017-09-29 2019-04-04 Curis Inc. Formes cristallines d'immunomodulateurs
KR102838640B1 (ko) 2017-10-11 2025-07-24 오리진 온콜로지 리미티드 3-치환된 1,2,4-옥사다이아졸의 결정질 형태
AU2018360386B2 (en) 2017-11-03 2023-11-09 Aurigene Oncology Limited Dual inhibitors of TIM-3 and PD-1 pathways
WO2019087092A1 (fr) 2017-11-06 2019-05-09 Aurigene Discovery Technologies Limited Thérapies conjointes à des fins d'immunomodulation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA755418B (en) * 1974-09-11 1977-06-29 Hoffmann La Roche Diazepine derivatives
SE422580B (sv) * 1975-08-07 1982-03-15 Hoffmann La Roche Analogiforfarande for framstellning av imidazo (1,5-a)(1,4)diazepin-foreningar
IL49161A (en) * 1975-08-07 1982-04-30 Sparamedica Ag Imidazo(1,5-a)(1,4)-diazepine derivatives,their manufacture and pharmaceutical compositions containing them
FI63033C (fi) * 1977-07-21 1983-04-11 Boehringer Sohn Ingelheim Foerfarande foer framstaellning av anxiolytiska tranquilliserande sedativa och/eller neuroleptiska substituerade 1-piperazinyl-4h-s-triazolo(3,4-c)tieno(2,3-e)-1,4-diazepiner
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
FI850191A7 (fi) * 1984-01-19 1985-07-20 Hoffmann La Roche Imidatsodiatsepiini-johdannaisia.
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine

Also Published As

Publication number Publication date
NO950999D0 (no) 1995-03-15
PH31443A (en) 1998-11-03
ES2160646T3 (es) 2001-11-16
FI951251A7 (fi) 1995-09-17
NZ270685A (en) 1996-05-28
FI112487B (fi) 2003-12-15
JP2690282B2 (ja) 1997-12-10
CZ66395A3 (en) 1995-10-18
KR950032199A (ko) 1995-12-20
US5665718A (en) 1997-09-09
LV11327A (lv) 1996-06-20
LV11327B (en) 1996-10-20
AU679608B2 (en) 1997-07-03
NO950999L (no) 1995-09-18
DK0672666T3 (da) 2001-11-12
CN1111632A (zh) 1995-11-15
RU95103921A (ru) 1996-12-10
NO303731B1 (no) 1998-08-24
RO117698B1 (ro) 2002-06-28
JPH07258260A (ja) 1995-10-09
PT672666E (pt) 2002-01-30
CA2143246A1 (fr) 1995-09-17
FI951251A0 (fi) 1995-03-16
BG99505A (en) 1996-01-31
GR3037019T3 (en) 2002-01-31
IS4273A (is) 1995-09-17
EP0672666A3 (fr) 1995-11-08
HUT71817A (en) 1996-02-28
AU1476095A (en) 1995-09-28
SK33995A3 (en) 1995-10-11
CA2143246C (fr) 2000-08-22
HU9500743D0 (en) 1995-04-28
RU2139873C1 (ru) 1999-10-20
BG62210B1 (bg) 1999-05-31
KR100214800B1 (ko) 1999-08-02
IL112955A0 (en) 1995-06-29
CZ288594B6 (cs) 2001-07-11
EP0672666A2 (fr) 1995-09-20
HU219987B (hu) 2001-10-28
ATE203536T1 (de) 2001-08-15
EP0672666B1 (fr) 2001-07-25
DE59509432D1 (de) 2001-08-30
MA23479A1 (fr) 1995-10-01
CN1036995C (zh) 1998-01-14

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees