IL115421A - Process for crystallizing alkali metal salts of diformylamide - Google Patents

Process for crystallizing alkali metal salts of diformylamide

Info

Publication number
IL115421A
IL115421A IL11542195A IL11542195A IL115421A IL 115421 A IL115421 A IL 115421A IL 11542195 A IL11542195 A IL 11542195A IL 11542195 A IL11542195 A IL 11542195A IL 115421 A IL115421 A IL 115421A
Authority
IL
Israel
Prior art keywords
diformylamide
alkali metal
metal salts
crystallizing
crystallizing alkali
Prior art date
Application number
IL11542195A
Other languages
English (en)
Other versions
IL115421A0 (en
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/315,041 external-priority patent/US5488188A/en
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of IL115421A0 publication Critical patent/IL115421A0/xx
Publication of IL115421A publication Critical patent/IL115421A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C07C233/91—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/24—Halogenated aromatic hydrocarbons with unsaturated side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11542195A 1994-09-29 1995-09-24 Process for crystallizing alkali metal salts of diformylamide IL115421A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/315,041 US5488188A (en) 1994-09-29 1994-09-29 Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof
US08/513,501 US5599986A (en) 1994-09-29 1995-08-31 Process for the preparation of alkali metal salts of diformylamide

Publications (2)

Publication Number Publication Date
IL115421A0 IL115421A0 (en) 1995-12-31
IL115421A true IL115421A (en) 2000-02-17

Family

ID=26979688

Family Applications (2)

Application Number Title Priority Date Filing Date
IL11542195A IL115421A (en) 1994-09-29 1995-09-24 Process for crystallizing alkali metal salts of diformylamide
IL12627798A IL126277A0 (en) 1994-09-29 1998-09-17 A process for preparing (e)-1-amino-2- (fluoromethylene)-4- (p-fluorophenyl) butane and pharmaceutically acceptable salts thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL12627798A IL126277A0 (en) 1994-09-29 1998-09-17 A process for preparing (e)-1-amino-2- (fluoromethylene)-4- (p-fluorophenyl) butane and pharmaceutically acceptable salts thereof

Country Status (18)

Country Link
US (1) US5599986A (da)
EP (3) EP0872465A3 (da)
JP (1) JPH10506891A (da)
KR (1) KR970706236A (da)
CN (1) CN1159179A (da)
AT (1) ATE186717T1 (da)
AU (1) AU697344B2 (da)
CA (3) CA2199009A1 (da)
DE (1) DE69513414T2 (da)
DK (1) DK0784604T3 (da)
ES (1) ES2140708T3 (da)
FI (1) FI971282A0 (da)
HU (1) HUT77742A (da)
IL (2) IL115421A (da)
MX (1) MX9702198A (da)
NO (1) NO971433D0 (da)
NZ (3) NZ293812A (da)
WO (1) WO1996010003A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244765B2 (en) * 2004-06-25 2007-07-17 Cytokine Pharmasciences, Inc Guanylhydrazone salts, compositions, processes of making and methods of using
EP2603505A1 (en) 2010-08-11 2013-06-19 Synthon BV Process for making linezolid
EP2603506A1 (en) 2010-08-11 2013-06-19 Synthon BV Process for making linezolid
KR20200004036A (ko) * 2018-07-03 2020-01-13 주식회사유한양행 (e)-(2-(클로로메틸)-3-플루오로알릴)카바메이트 유도체의 제조방법
KR20240148807A (ko) 2022-03-22 2024-10-11 옵쉐스트바 스 아그라니첸너이아트볫스트벤너스찌유 "빅-즈다로비예쥐보트니흐" 메데토미딘 및 그 유도체의 제조 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA649772A (en) * 1962-10-02 E.I. Du Pont De Nemours And Company Fluorine-containing cyclic compounds
GB834278A (en) * 1956-12-11 1960-05-04 Leuna Werke Veb Process for working up crude formamide
DE1281427B (de) * 1966-07-20 1968-10-31 Dr Eckhard Allenstein Verfahren zur Herstellung von Diformamid und seiner Salze
US3852366A (en) * 1971-08-17 1974-12-03 Du Pont A composition of isomeric trichlorodifluorobenzenes
DE3278931D1 (en) * 1981-05-12 1988-09-29 Ici Plc 1,1-diphenylalkenes and a process for their preparation
US4454159A (en) * 1981-12-28 1984-06-12 Albert Musher Dermatological treatment preparations
AR243493A1 (es) * 1987-06-16 1993-08-31 Merrell Dow Pharma Procedimiento para preparar (e)-2-(p-fluorfenetil)-3-fluoralilamina y sus sales farmaceuticamente aceptables, util como inhibidor de mao-b irreversible y activado por enzimas.
DK0522956T3 (da) * 1991-07-08 1997-07-28 Sanofi Sa Fremstilling af 2-(2-thienyl)ethylamin og syntese af thieno 3,2-c pyridinderivater deraf.
US5164511A (en) * 1991-09-26 1992-11-17 Cornell Research Foundation, Inc. Thioimideazoles useful as intermediates for preparing thiazine
KR950701518A (ko) * 1992-05-27 1995-04-28 스티븐 엘. 네스비트 알쯔하이머 질환의 치료에 있어서 (E)-2-(p-플로오로펜에틸)-3-플루오로알릴아민의 용도(Use of (E)-2-(p-fluorophenethyl)-3-fluoroallylamine in the treatmet of Alzheimer's disease)

Also Published As

Publication number Publication date
NZ330234A (en) 1999-03-29
CA2275136A1 (en) 1996-04-04
AU3634395A (en) 1996-04-19
EP0872465A3 (en) 1999-12-22
IL126277A0 (en) 1999-05-09
EP0872465A2 (en) 1998-10-21
US5599986A (en) 1997-02-04
FI971282A7 (fi) 1997-03-26
WO1996010003A1 (en) 1996-04-04
DK0784604T3 (da) 2000-07-10
KR970706236A (ko) 1997-11-03
EP0784604B1 (en) 1999-11-17
DE69513414D1 (de) 1999-12-23
FI971282L (fi) 1997-03-26
MX9702198A (es) 1997-06-28
NZ293812A (en) 1998-06-26
CA2275137A1 (en) 1996-04-04
EP0875499A3 (en) 1999-12-22
EP0875499A2 (en) 1998-11-04
ES2140708T3 (es) 2000-03-01
AU697344B2 (en) 1998-10-01
FI971282A0 (fi) 1997-03-26
NZ330233A (en) 1999-03-29
NO971433L (no) 1997-03-25
JPH10506891A (ja) 1998-07-07
ATE186717T1 (de) 1999-12-15
NO971433D0 (no) 1997-03-25
CN1159179A (zh) 1997-09-10
HUT77742A (hu) 1998-07-28
IL115421A0 (en) 1995-12-31
DE69513414T2 (de) 2000-05-18
CA2199009A1 (en) 1996-04-04
EP0784604A1 (en) 1997-07-23

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees