IL115592A - Stabilized pharmaceutical formulation comprising a growth hormone and leucine - Google Patents

Stabilized pharmaceutical formulation comprising a growth hormone and leucine

Info

Publication number: IL115592A
Authority: IL; Israel
Prior art keywords: growth hormone; leucine; pharmaceutical formulation; stabilized pharmaceutical; dissolved
Prior art date: 1994-10-13

Application number

IL11559295A

Other languages

English (en)

Other versions

IL115592A0 (en

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-13

Filing date

1995-10-12

Publication date

2000-07-26

1995-05-31 Priority claimed from US08/455,886 external-priority patent/US5654278A/en

1995-10-12 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1996-01-19 Publication of IL115592A0 publication Critical patent/IL115592A0/xx

2000-07-26 Publication of IL115592A publication Critical patent/IL115592A/xx

Links

102000018997 Growth Hormone Human genes 0.000 title abstract 2
108010051696 Growth Hormone Proteins 0.000 title abstract 2
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 title abstract 2
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 title abstract 2
239000000122 growth hormone Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
238000003776 cleavage reaction Methods 0.000 abstract 1
230000006240 deamidation Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

IL11559295A 1994-10-13 1995-10-12 Stabilized pharmaceutical formulation comprising a growth hormone and leucine IL115592A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32283894A	1994-10-13	1994-10-13
US08/455,886 US5654278A (en)	1994-10-13	1995-05-31	Composition and method comprising growth hormone and leucine

Publications (2)

Publication Number	Publication Date
IL115592A0 IL115592A0 (en)	1996-01-19
IL115592A true IL115592A (en)	2000-07-26

Family

ID=26983636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11559295A IL115592A (en)	1994-10-13	1995-10-12	Stabilized pharmaceutical formulation comprising a growth hormone and leucine

Country Status (8)

Country	Link
EP (1)	EP0785797B1 (de)
JP (1)	JP4064455B2 (de)
AT (1)	ATE213953T1 (de)
AU (1)	AU699369B2 (de)
DE (1)	DE69525757T2 (de)
ES (1)	ES2172594T3 (de)
IL (1)	IL115592A (de)
WO (1)	WO1996011704A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070179096A1 (en)	1996-04-24	2007-08-02	Novo Nordisk A/S	Pharmaceutical Formulation
AUPQ387599A0 (en)	1999-11-05	1999-12-02	Metabolic Pharmaceuticals Limited	Product and method for control of obesity
JP4711520B2 (ja)	2000-03-21	2011-06-29	日本ケミカルリサーチ株式会社	生理活性ペプチド含有粉末
CA2418960A1 (en)	2000-08-07	2002-02-14	Inhale Therapeutic Systems, Inc.	Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
PE20110543A1 (es) *	2008-08-15	2011-08-04	Ironwood Pharmaceuticals Inc	Formulacion solida oral que comprende linaclotida, cation de calcio y leucina
WO2011020054A1 (en) *	2009-08-13	2011-02-17	Ironwood Pharmaceuticals Inc.	Method for modulating the pharmacodynamic effect of orally administered guanylate cyclase receptor agonists
CA2811001A1 (en) *	2010-09-11	2012-03-15	Ironwood Pharmaceuticals, Inc.	Treatment of constipation-predominant irritable bowel syndrome

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5967228A (ja) *	1982-10-07	1984-04-16	Green Cross Corp:The	寒冷不溶性グロブリンの凍結乾燥方法
EP0303746B2 (de) *	1987-08-21	1998-12-02	Mallinckrodt Group Inc.	Stabilisierung von Wachstumshormonen
DE69232847T2 (de) *	1991-12-20	2003-09-11	Novo Nordisk A/S, Bagsvaerd	Stabilisierte pharmazeutische formulierung, die wachstumshormon und histidin enthält
SE9201073D0 (sv) *	1992-04-03	1992-04-03	Kabi Pharmacia Ab	Protein formulation

1995
- 1995-10-12 IL IL11559295A patent/IL115592A/xx not_active IP Right Cessation
- 1995-10-13 AT AT95933347T patent/ATE213953T1/de not_active IP Right Cessation
- 1995-10-13 WO PCT/DK1995/000410 patent/WO1996011704A1/en not_active Ceased
- 1995-10-13 JP JP51286396A patent/JP4064455B2/ja not_active Expired - Fee Related
- 1995-10-13 ES ES95933347T patent/ES2172594T3/es not_active Expired - Lifetime
- 1995-10-13 DE DE69525757T patent/DE69525757T2/de not_active Expired - Lifetime
- 1995-10-13 AU AU36054/95A patent/AU699369B2/en not_active Ceased
- 1995-10-13 EP EP95933347A patent/EP0785797B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH10507183A (ja)	1998-07-14
ES2172594T3 (es)	2002-10-01
IL115592A0 (en)	1996-01-19
DE69525757T2 (de)	2002-10-17
EP0785797B1 (de)	2002-03-06
EP0785797A1 (de)	1997-07-30
AU3605495A (en)	1996-05-06
JP4064455B2 (ja)	2008-03-19
ATE213953T1 (de)	2002-03-15
AU699369B2 (en)	1998-12-03
WO1996011704A1 (en)	1996-04-25
DE69525757D1 (de)	2002-04-11

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Legal Events

Date	Code	Title
2000-12-06	FF	Patent granted
2002-02-10	KB	Patent renewed
2006-08-01	MM9K	Patent not in force due to non-payment of renewal fees