IL117980A - Triazolone derivatives their preparation and pharmaceutical compositions containing them useful for the treatment of hyperlipidemia - Google Patents
Triazolone derivatives their preparation and pharmaceutical compositions containing them useful for the treatment of hyperlipidemiaInfo
- Publication number
- IL117980A IL117980A IL11798096A IL11798096A IL117980A IL 117980 A IL117980 A IL 117980A IL 11798096 A IL11798096 A IL 11798096A IL 11798096 A IL11798096 A IL 11798096A IL 117980 A IL117980 A IL 117980A
- Authority
- IL
- Israel
- Prior art keywords
- 6alkyl
- hyperlipidemia
- preparation
- treatment
- pharmaceutical compositions
- Prior art date
Links
- 208000031226 Hyperlipidaemia Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- FFSJPOPLSWBGQY-UHFFFAOYSA-N triazol-4-one Chemical class O=C1C=NN=N1 FFSJPOPLSWBGQY-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Seasonings (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95201010 | 1995-04-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL117980A0 IL117980A0 (en) | 1996-08-04 |
| IL117980A true IL117980A (en) | 2000-02-17 |
Family
ID=8220206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11798096A IL117980A (en) | 1995-04-20 | 1996-04-19 | Triazolone derivatives their preparation and pharmaceutical compositions containing them useful for the treatment of hyperlipidemia |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5922718A (fr) |
| EP (1) | EP0871626B1 (fr) |
| JP (1) | JP3782455B2 (fr) |
| KR (1) | KR100413219B1 (fr) |
| CN (1) | CN1076727C (fr) |
| AT (1) | ATE208386T1 (fr) |
| AU (1) | AU699313B2 (fr) |
| CA (1) | CA2217632A1 (fr) |
| CZ (1) | CZ291737B6 (fr) |
| DE (1) | DE69616825T2 (fr) |
| DK (1) | DK0871626T3 (fr) |
| ES (1) | ES2167555T3 (fr) |
| HU (1) | HUP9801056A3 (fr) |
| IL (1) | IL117980A (fr) |
| NO (1) | NO312415B1 (fr) |
| NZ (1) | NZ305869A (fr) |
| PL (1) | PL183737B1 (fr) |
| PT (1) | PT871626E (fr) |
| TW (1) | TW457240B (fr) |
| WO (1) | WO1996033193A1 (fr) |
| ZA (1) | ZA963152B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003213719A1 (en) | 2002-03-01 | 2003-09-16 | Regents Of The University Of Michigan | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| IL165383A0 (en) | 2002-06-21 | 2006-01-15 | Transform Pharmaceuticals Inc | Pharmaceutical compositions with improved dissolution |
| AU2004248302B2 (en) * | 2003-06-19 | 2009-07-30 | Merck Serono Sa | Use of prion conversion modulating agents |
| US20080057057A1 (en) * | 2004-03-18 | 2008-03-06 | Applied Research Systems Ars Holding N.V. | Anti-Lipid Rafts Antibodies |
| EP1742941A1 (fr) * | 2004-04-22 | 2007-01-17 | Transform Pharmaceuticals, Inc. | Nouvelles formes cristallines de saperconazole et procedes associes, compositions pharmaceutiques et procedes correspondants |
| EP1890767A2 (fr) * | 2005-05-27 | 2008-02-27 | Pfizer Products Inc. | Combinaison d'un antagoniste des recepteurs cannabinoides-1 et d'un inhibiteur des proteines microsomales de transfert de triglycerides pour traiter l'obesite ou maintenir une perte de poids |
| HK1221606A1 (zh) | 2013-06-07 | 2017-06-09 | 加州生物医学研究所 | 纤维化的小分子抑制剂 |
| EP3169343B1 (fr) | 2014-07-15 | 2020-03-25 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Polypeptides isolés de cd44 et utilisations associées |
| JP6706023B2 (ja) | 2014-12-10 | 2020-06-03 | ザ・スクリップス・リサーチ・インスティテュート | 線維症の小分子阻害剤 |
| BR112019021388B1 (pt) | 2017-04-11 | 2023-10-31 | Mitsui Chemicals Crop & Life Solutions, Inc | Compostos, agente de controle de pragas agrícolas e hortícolas, fungicida agrícola e hortícola e métodos para prevenção e/ou tratamento de uma doença de plantas |
| MX2022006861A (es) | 2019-12-04 | 2022-07-11 | Scripps Research Inst | Agonistas del receptor glp2 y metodos de uso. |
| KR20240032010A (ko) | 2021-06-09 | 2024-03-08 | 더 스크립스 리서치 인스티튜트 | 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3936470A (en) * | 1975-01-27 | 1976-02-03 | Janssen Pharmaceutica N.V. | 1,3-Dioxolan-2-ylmethylimidazoles |
| US4101665A (en) * | 1975-10-06 | 1978-07-18 | Janssen Pharmaceutica N.V. | 1-(2-Ar-4-aryloxymethyl-1,3-dioxolan-2-ylmethyl)imidazoles |
| US4218458A (en) * | 1978-06-23 | 1980-08-19 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4321272A (en) * | 1980-08-25 | 1982-03-23 | Syntex (U.S.A.) Inc. | Derivatives of substituted N-alkylimidazoles |
| DE3144318A1 (de) * | 1981-11-07 | 1983-05-19 | Bayer Ag, 5090 Leverkusen | 2-imidazolylmethyl-2-phenyl-1, 3-dioxolane, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
| US4619931A (en) * | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| CA1292472C (fr) * | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derives des ({4-¬4-(4-phenyl-1-piperazinyl)-phenoxymethyl|- 1,3-dioxolan-2-yl}methyl)-1h-imidazoles et 1h-1,2,4-triazoles |
| US4791111A (en) * | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| US4916134A (en) * | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
| NZ223799A (en) * | 1987-03-25 | 1989-12-21 | Janssen Pharmaceutica Nv | Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions |
| ES2141329T3 (es) * | 1994-01-24 | 2000-03-16 | Janssen Pharmaceutica Nv | Antifungicos azolicos solubles en agua. |
-
1996
- 1996-03-22 TW TW085103449A patent/TW457240B/zh not_active IP Right Cessation
- 1996-04-12 AT AT96910968T patent/ATE208386T1/de not_active IP Right Cessation
- 1996-04-12 CN CN96193235A patent/CN1076727C/zh not_active Expired - Fee Related
- 1996-04-12 DK DK96910968T patent/DK0871626T3/da active
- 1996-04-12 CZ CZ19973288A patent/CZ291737B6/cs not_active IP Right Cessation
- 1996-04-12 DE DE69616825T patent/DE69616825T2/de not_active Expired - Fee Related
- 1996-04-12 AU AU53998/96A patent/AU699313B2/en not_active Ceased
- 1996-04-12 US US08/930,847 patent/US5922718A/en not_active Expired - Fee Related
- 1996-04-12 PL PL96322872A patent/PL183737B1/pl not_active IP Right Cessation
- 1996-04-12 PT PT96910968T patent/PT871626E/pt unknown
- 1996-04-12 CA CA002217632A patent/CA2217632A1/fr not_active Abandoned
- 1996-04-12 ES ES96910968T patent/ES2167555T3/es not_active Expired - Lifetime
- 1996-04-12 NZ NZ305869A patent/NZ305869A/en unknown
- 1996-04-12 HU HU9801056A patent/HUP9801056A3/hu unknown
- 1996-04-12 KR KR1019970706751A patent/KR100413219B1/ko not_active Expired - Fee Related
- 1996-04-12 EP EP96910968A patent/EP0871626B1/fr not_active Expired - Lifetime
- 1996-04-12 WO PCT/EP1996/001585 patent/WO1996033193A1/fr not_active Ceased
- 1996-04-12 JP JP53146096A patent/JP3782455B2/ja not_active Expired - Fee Related
- 1996-04-19 ZA ZA9603152A patent/ZA963152B/xx unknown
- 1996-04-19 IL IL11798096A patent/IL117980A/xx not_active IP Right Cessation
-
1997
- 1997-10-10 NO NO19974690A patent/NO312415B1/no unknown
-
1999
- 1999-02-17 US US09/251,989 patent/US6197972B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1181079A (zh) | 1998-05-06 |
| NZ305869A (en) | 1998-08-26 |
| HK1012186A1 (en) | 1999-07-30 |
| CZ328897A3 (cs) | 1998-01-14 |
| EP0871626B1 (fr) | 2001-11-07 |
| PL183737B1 (pl) | 2002-07-31 |
| CZ291737B6 (cs) | 2003-05-14 |
| DE69616825D1 (en) | 2001-12-13 |
| AU699313B2 (en) | 1998-12-03 |
| IL117980A0 (en) | 1996-08-04 |
| JPH11503739A (ja) | 1999-03-30 |
| NO974690D0 (no) | 1997-10-10 |
| EP0871626A1 (fr) | 1998-10-21 |
| DE69616825T2 (de) | 2002-06-27 |
| CA2217632A1 (fr) | 1996-10-24 |
| WO1996033193A1 (fr) | 1996-10-24 |
| KR19980703346A (ko) | 1998-10-15 |
| ES2167555T3 (es) | 2002-05-16 |
| PT871626E (pt) | 2002-04-29 |
| CN1076727C (zh) | 2001-12-26 |
| HUP9801056A3 (en) | 1999-09-28 |
| HUP9801056A2 (hu) | 1999-06-28 |
| JP3782455B2 (ja) | 2006-06-07 |
| US6197972B1 (en) | 2001-03-06 |
| US5922718A (en) | 1999-07-13 |
| NO974690L (no) | 1997-10-10 |
| ZA963152B (en) | 1997-10-20 |
| PL322872A1 (en) | 1998-03-02 |
| TW457240B (en) | 2001-10-01 |
| ATE208386T1 (de) | 2001-11-15 |
| AU5399896A (en) | 1996-11-07 |
| NO312415B1 (no) | 2002-05-06 |
| KR100413219B1 (ko) | 2004-05-31 |
| DK0871626T3 (da) | 2002-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |