IL118518A - Preparations for the treatment of internal parasites containing the history of abramectin and cyclic precipitated peptides - Google Patents

Preparations for the treatment of internal parasites containing the history of abramectin and cyclic precipitated peptides

Info

Publication number: IL118518A
Authority: IL; Israel
Prior art keywords: spp; ivermectin; praziquantel; blb; bla
Prior art date: 1995-06-02

Application number

IL11851896A

Other languages

English (en)

Hebrew (he)

Other versions

IL118518A0 (en

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-02

Filing date

1996-05-31

Publication date

1998-12-27

1996-05-31 Application filed by Bayer Ag filed Critical Bayer Ag

1996-09-12 Publication of IL118518A0 publication Critical patent/IL118518A0/xx

1998-12-27 Publication of IL118518A publication Critical patent/IL118518A/en

Links

239000000203 mixture Substances 0.000 title claims abstract description 39
108010002156 Depsipeptides Proteins 0.000 title claims abstract description 26
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title claims description 9
150000002596 lactones Chemical class 0.000 claims abstract description 24
229960005362 epsiprantel Drugs 0.000 claims abstract description 14
LGUDKOQUWIHXOV-UHFFFAOYSA-N epsiprantel Chemical compound C1C(C2=CC=CC=C2CCC2)N2C(=O)CN1C(=O)C1CCCCC1 LGUDKOQUWIHXOV-UHFFFAOYSA-N 0.000 claims abstract description 14
FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 claims description 28
229960002957 praziquantel Drugs 0.000 claims description 28
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FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 claims description 16
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 9
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OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 description 4
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QLFZZSKTJWDQOS-YDBLARSUSA-N doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 description 3
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244000052769 pathogen Species 0.000 description 1
230000004796 pathophysiological change Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
229960005323 phenoxyethanol Drugs 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 description 1
235000010263 potassium metabisulphite Nutrition 0.000 description 1
239000004297 potassium metabisulphite Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
235000008476 powdered milk Nutrition 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
229960000996 pyrantel pamoate Drugs 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
235000003441 saturated fatty acids Nutrition 0.000 description 1
150000004671 saturated fatty acids Chemical class 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
238000006257 total synthesis reaction Methods 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000007762 w/o emulsion Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
210000002268 wool Anatomy 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL11851896A 1995-06-02 1996-05-31 Preparations for the treatment of internal parasites containing the history of abramectin and cyclic precipitated peptides IL118518A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19520275A DE19520275A1 (de)	1995-06-02	1995-06-02	Endoparasitizide Mittel

Publications (2)

Publication Number	Publication Date
IL118518A0 IL118518A0 (en)	1996-09-12
IL118518A true IL118518A (en)	1998-12-27

Family

ID=7763518

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11851896A IL118518A (en)	1995-06-02	1996-05-31	Preparations for the treatment of internal parasites containing the history of abramectin and cyclic precipitated peptides

Country Status (25)

Country	Link
US (1)	US6159932A (cs)
EP (1)	EP0828506B1 (cs)
JP (1)	JP4104653B2 (cs)
KR (1)	KR100434388B1 (cs)
CN (1)	CN1142790C (cs)
AR (1)	AR005640A1 (cs)
AT (1)	ATE213645T1 (cs)
AU (1)	AU703048B2 (cs)
BR (1)	BR9608961A (cs)
CA (1)	CA2222680C (cs)
CZ (1)	CZ287290B6 (cs)
DE (2)	DE19520275A1 (cs)
DK (1)	DK0828506T3 (cs)
ES (1)	ES2173284T3 (cs)
HU (1)	HU224961B1 (cs)
IL (1)	IL118518A (cs)
NO (1)	NO316608B1 (cs)
NZ (1)	NZ309073A (cs)
PL (1)	PL184848B1 (cs)
PT (1)	PT828506E (cs)
SK (1)	SK283884B6 (cs)
TR (1)	TR199701484T1 (cs)
TW (1)	TW469133B (cs)
WO (1)	WO1996038165A2 (cs)
ZA (1)	ZA964473B (cs)

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DE19545044A1 (de) *	1995-12-02	1997-06-05	Bayer Ag	Endoparasitizide Mittel
AU707949C (en) *	1996-07-30	2006-01-19	Merial, Inc.	Anthelmintic formulations
DE19654079A1 (de)	1996-12-23	1998-06-25	Bayer Ag	Endo-ekto-parasitizide Mittel
GB9825402D0 (en) †	1998-11-19	1999-01-13	Pfizer Ltd	Antiparasitic formulations
DE19921887A1 (de) *	1999-05-12	2000-11-16	Bayer Ag	Endoparasitizide Mittel
DE19962145A1 (de) *	1999-12-22	2001-06-28	Bayer Ag	Schädlingsbekämpfungsmittel/Depsipeptide
DE19962147A1 (de) *	1999-12-22	2001-06-28	Bayer Ag	Schädlingsbekämpfungsmittel / PF 1022-221
DE10008128A1 (de) *	2000-02-22	2001-08-23	Bayer Ag	Endoparasitizide Mittel
ES2258062T3 (es) *	2000-10-10	2006-08-16	Wyeth	Composicion antihelmintica.
US6893652B2 (en)	2001-08-27	2005-05-17	Wyeth	Endoparasiticidal gel composition
CA2464403A1 (en) *	2001-10-25	2003-05-01	Novartis Animal Health K.K.	Anthelmintic composition
US7001889B2 (en) *	2002-06-21	2006-02-21	Merial Limited	Anthelmintic oral homogeneous veterinary pastes
ITMI20031015A1 (it) *	2003-05-20	2004-11-21	Naxospharma S R L	Poli-(amminopirrolcarbossammidi) per uso nella profilassi e nel trattamento delle endoparassitosi animali e loro composizioni con ciclodestrine.
DE10358525A1 (de) *	2003-12-13	2005-07-07	Bayer Healthcare Ag	Endoparasitizide Mittel zur topischen Applikation
DE10359798A1 (de) *	2003-12-19	2005-07-21	Bayer Healthcare Ag	Cyclohexadepsipeptide zur Bekämpfung von Endoparasiten und ein Verfahren zu ihrer Herstellung
US20050226908A1 (en) *	2004-04-07	2005-10-13	Akzo Nobel N.V.	Efficacious composition of a benzimidazole, an avermectin and praziquantel and related methods of use
US20060147485A1 (en) *	2005-01-04	2006-07-06	Morten Pedersen	Oil-in-water formulation of avermectins
US20080125480A1 (en) *	2004-12-30	2008-05-29	Cheminova A/S	Oil-In-Water Formulation Of Avermectins
DE102005011779A1 (de) *	2005-03-11	2006-09-14	Bayer Healthcare Ag	Endoparasitizide Mittel
US20080027011A1 (en) *	2005-12-20	2008-01-31	Hassan Nached	Homogeneous paste and gel formulations
WO2012028556A1 (en) *	2010-08-31	2012-03-08	Bayer Animal Health Gmbh	Macrocyclic lactones and their use and their combinations with other active substances
ES2806256T3 (es)	2010-10-12	2021-02-17	Bayer Ip Gmbh	Productos masticables blandos no basados en almidón
ES2549045T3 (es)	2010-10-20	2015-10-22	Galderma S.A.	Método para tratar una infección por el virus del herpes usando un compuesto de lactona macrocíclica
CN104168886A (zh)	2012-03-13	2014-11-26	拜耳新西兰有限公司	长效组合物
NZ708741A (en)	2012-12-19	2019-11-29	Bayer Animal Health Gmbh	Tablets with improved acceptance and good storage stability
CA2981489A1 (en) *	2015-04-02	2016-10-06	Merial, Inc.	Anthelmintic combinations and methods of use thereof
CN107835818B (zh)	2015-05-20	2022-04-29	勃林格殷格翰动物保健美国公司	驱虫缩酚酸肽化合物
BR112018013369A2 (pt)	2015-12-28	2019-02-19	Merial, Inc.	compostos depsipeptídicos anti-helmínticos
CN107318861A (zh) *	2016-04-28	2017-11-07	江苏龙灯化学有限公司	一种杀虫组合物
EP3541789A1 (en)	2016-11-16	2019-09-25	Boehringer Ingelheim Animal Health USA Inc.	Anthelmintic depsipeptide compounds
MY194222A (en) *	2017-03-17	2022-11-22	Telluris Biotech India Private Ltd	A synergistic composition of a nematicide
US10857151B1 (en) *	2020-02-21	2020-12-08	Villya LLC	Treatment of female genital schistosomiasis
US20220047506A1 (en)	2020-08-12	2022-02-17	Villya LLC	Praziquantel Formulations
EP4208157A1 (en)	2020-09-04	2023-07-12	Elanco Us Inc.	Palatable formulations
WO2024158694A1 (en)	2023-01-23	2024-08-02	Villya LLC	Compositions and methods for improving the solubility of erectile dysfunction therapeutics

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SE434277B (sv) *	1976-04-19	1984-07-16	Merck & Co Inc	Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
JPS57139012A (en) *	1981-02-23	1982-08-27	Sankyo Co Ltd	Anthelmintic composition
ZA842571B (en) *	1983-04-07	1985-11-27	Merck & Co Inc	Novel synergistic antiparasitic combinations
NO176766C (no) *	1989-02-07	1995-05-24	Meiji Seika Kaisha	Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
GB9024924D0 (en) *	1990-11-16	1991-01-02	Beecham Group Plc	Novel compositions
NZ247278A (en) *	1991-02-12	1995-03-28	Ancare Distributors	Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
JPH0570366A (ja) *	1991-03-08	1993-03-23	Meiji Seika Kaisha Ltd	薬用組成物
NZ249588A (en) *	1992-03-17	1996-08-27	Fujisawa Pharmaceutical Co	Anthelmintic agent
DE4317458A1 (de) *	1992-06-11	1993-12-16	Bayer Ag	Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung
US5747448A (en) *	1993-02-19	1998-05-05	Meiji Seika Kaisha, Ltd.	Derivatives of cyclodepsipeptide PF 1022
BG61064B1 (bg) *	1993-08-12	1996-10-31	Илия Илиев	Лекарствено средство за обезпаразитяване на животни
DE4400464A1 (de) *	1994-01-11	1995-07-13	Bayer Ag	Endoparasitizide Mittel
DE4401389A1 (de) *	1994-01-19	1995-07-20	Bayer Ag	Verwendung von cyclischen Depsipeptiden mit 12 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 12 Ringatomen und Verfahren zu ihrer Herstellung

1995
- 1995-06-02 DE DE19520275A patent/DE19520275A1/de not_active Withdrawn
1996
- 1996-05-10 TW TW085105513A patent/TW469133B/zh not_active IP Right Cessation
- 1996-05-20 BR BR9608961A patent/BR9608961A/pt active IP Right Grant
- 1996-05-20 AU AU59004/96A patent/AU703048B2/en not_active Expired
- 1996-05-20 NZ NZ309073A patent/NZ309073A/xx not_active IP Right Cessation
- 1996-05-20 SK SK1599-97A patent/SK283884B6/sk not_active IP Right Cessation
- 1996-05-20 KR KR1019970708573A patent/KR100434388B1/ko not_active Expired - Lifetime
- 1996-05-20 JP JP53614696A patent/JP4104653B2/ja not_active Expired - Lifetime
- 1996-05-20 EP EP96916137A patent/EP0828506B1/de not_active Expired - Lifetime
- 1996-05-20 DE DE59608798T patent/DE59608798D1/de not_active Expired - Lifetime
- 1996-05-20 CA CA002222680A patent/CA2222680C/en not_active Expired - Lifetime
- 1996-05-20 AT AT96916137T patent/ATE213645T1/de active
- 1996-05-20 DK DK96916137T patent/DK0828506T3/da active
- 1996-05-20 WO PCT/EP1996/002170 patent/WO1996038165A2/de not_active Ceased
- 1996-05-20 ES ES96916137T patent/ES2173284T3/es not_active Expired - Lifetime
- 1996-05-20 PL PL96323595A patent/PL184848B1/pl unknown
- 1996-05-20 CZ CZ19973825A patent/CZ287290B6/cs not_active IP Right Cessation
- 1996-05-20 TR TR97/01484T patent/TR199701484T1/xx unknown
- 1996-05-20 US US08/952,356 patent/US6159932A/en not_active Expired - Lifetime
- 1996-05-20 CN CNB961956615A patent/CN1142790C/zh not_active Expired - Lifetime
- 1996-05-20 HU HU9900346A patent/HU224961B1/hu unknown
- 1996-05-20 PT PT96916137T patent/PT828506E/pt unknown
- 1996-05-31 ZA ZA9604473A patent/ZA964473B/xx unknown
- 1996-05-31 AR ARP960102860A patent/AR005640A1/es not_active Application Discontinuation
- 1996-05-31 IL IL11851896A patent/IL118518A/en not_active IP Right Cessation
1997
- 1997-12-01 NO NO19975516A patent/NO316608B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0828506A2 (de)	1998-03-18
DK0828506T3 (da)	2002-06-10
DE59608798D1 (de)	2002-04-04
CN1191489A (zh)	1998-08-26
CN1142790C (zh)	2004-03-24
CZ287290B6 (en)	2000-10-11
CZ382597A3 (cs)	1998-03-18
HU224961B1 (en)	2006-04-28
PT828506E (pt)	2002-08-30
SK283884B6 (sk)	2004-04-06
SK159997A3 (en)	1998-07-08
AR005640A1 (es)	1999-07-14
WO1996038165A3 (de)	1997-01-09
JPH11506438A (ja)	1999-06-08
ZA964473B (en)	1997-01-29
NO975516D0 (no)	1997-12-01
DE19520275A1 (de)	1996-12-05
WO1996038165A2 (de)	1996-12-05
CA2222680C (en)	2007-11-13
HUP9900346A2 (hu)	1999-06-28
NO316608B1 (no)	2004-03-08
TR199701484T1 (xx)	1998-03-21
KR100434388B1 (ko)	2004-08-25
US6159932A (en)	2000-12-12
HUP9900346A3 (en)	2000-04-28
TW469133B (en)	2001-12-21
ES2173284T3 (es)	2002-10-16
NO975516L (no)	1998-01-06
BR9608961A (pt)	1999-06-29
KR19990022094A (ko)	1999-03-25
IL118518A0 (en)	1996-09-12
JP4104653B2 (ja)	2008-06-18
AU703048B2 (en)	1999-03-11
PL184848B1 (pl)	2002-12-31
AU5900496A (en)	1996-12-18
CA2222680A1 (en)	1996-12-05
PL323595A1 (en)	1998-04-14
NZ309073A (en)	1998-12-23
EP0828506B1 (de)	2002-02-27
MX9709245A (es)	1998-03-31
ATE213645T1 (de)	2002-03-15

Legal Events

Date	Code	Title
1999-06-20	FF	Patent granted
2000-02-17	KB	Patent renewed
2002-07-25	KB	Patent renewed
2006-08-01	KB	Patent renewed
2010-11-30	KB	Patent renewed
2014-05-28	KB	Patent renewed
2016-12-29	EXP	Patent expired

Publication	Publication Date	Title
CA2222680C (en)	2007-11-13	Endoparasiticidal agents
HU218569B (hu)	2000-10-28	Eljárás ciklusos depszipeptidek szulfonilezésére, az így előállított új vegyületek és parazitaellenes szerkénti alkalmazásuk
EP0662326B1 (de)	2001-11-28	Endoparasitizide Mittel die Praziquantel und Epsiprantel enthalten
US5712295A (en)	1998-01-27	Agonists and antagonists of the nicotinic acetylcholine receptors of insects to control endoparasites
MXPA96006179A (en)	1998-01-01	Agonists and antagonists of the receptors of the nicotinic acid acetilcoline of insects for the control of endoparasi
CA2436832C (en)	2013-06-11	Crystal form of a cyclic depsipeptide having improved activity
IL150988A (en)	2011-06-30	Preparations against internal parasites
HUP0102476A2 (hu)	2001-10-28	Szubsztituált ciklooktadepszipeptidek
MXPA97009245A (en)	1998-10-15	Endoperasitician agents
MXPA00011972A (en)	2001-09-07	Substituted cyclooctadepsipeptides