IL119207A - Neuroprotective phenols for the treatment of tinnitus - Google Patents

Neuroprotective phenols for the treatment of tinnitus

Info

Publication number: IL119207A
Authority: IL; Israel
Prior art keywords: compound; use according; tinnitus; gallons; hydroxy
Prior art date: 1995-09-15

Application number

IL11920796A

Other languages

English (en)

Hebrew (he)

Other versions

IL119207A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-15

Filing date

1996-09-05

Publication date

2004-05-12

1996-09-05 Application filed by Pfizer filed Critical Pfizer

1996-12-05 Publication of IL119207A0 publication Critical patent/IL119207A0/xx

2004-05-12 Publication of IL119207A publication Critical patent/IL119207A/en

Links

208000009205 Tinnitus Diseases 0.000 title claims abstract description 25
231100000886 tinnitus Toxicity 0.000 title claims abstract description 25
238000011282 treatment Methods 0.000 title claims abstract description 15
230000000324 neuroprotective effect Effects 0.000 title description 6
150000002989 phenols Chemical class 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 48
150000003839 salts Chemical class 0.000 claims abstract description 21
BDERNNFJNOPAEC-UHFFFAOYSA-N 1-propanol Substances CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 12
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 11
239000003814 drug Substances 0.000 claims description 11
229940044613 1-propanol Drugs 0.000 claims description 9
229910052739 hydrogen Inorganic materials 0.000 claims description 8
239000001257 hydrogen Substances 0.000 claims description 8
MGSHXMOLUWTMGP-UHFFFAOYSA-N 3'-carboxy-alpha-chromanol Chemical group C1=CC=C2C(O)CCOC2=C1 MGSHXMOLUWTMGP-UHFFFAOYSA-N 0.000 claims description 6
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
LKGCPYOBWLSCTK-UHFFFAOYSA-N methanesulfonic acid;trihydrate Chemical compound O.O.O.CS(O)(=O)=O LKGCPYOBWLSCTK-UHFFFAOYSA-N 0.000 claims description 5
238000002360 preparation method Methods 0.000 claims description 5
150000003892 tartrate salts Chemical class 0.000 claims description 5
125000000217 alkyl group Chemical group 0.000 claims description 4
229910052799 carbon Inorganic materials 0.000 claims description 4
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
229940095064 tartrate Drugs 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 3
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229910052717 sulfur Inorganic materials 0.000 claims description 2
SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 3
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QEMSVZNTSXPFJA-HNAYVOBHSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol Chemical compound C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 QEMSVZNTSXPFJA-HNAYVOBHSA-N 0.000 claims 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Plant Substances (AREA)

IL11920796A 1995-09-15 1996-09-05 Neuroprotective phenols for the treatment of tinnitus IL119207A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US385595P	1995-09-15	1995-09-15

Publications (2)

Publication Number	Publication Date
IL119207A0 IL119207A0 (en)	1996-12-05
IL119207A true IL119207A (en)	2004-05-12

Family

ID=21707919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11920796A IL119207A (en)	1995-09-15	1996-09-05	Neuroprotective phenols for the treatment of tinnitus

Country Status (17)

Country	Link
US (1)	US5716961A (de)
EP (1)	EP0768086B1 (de)
JP (1)	JP3038155B2 (de)
KR (1)	KR970014765A (de)
CN (1)	CN1104892C (de)
AT (1)	ATE224714T1 (de)
AU (1)	AU697679B2 (de)
CA (1)	CA2185512C (de)
DE (1)	DE69623899T2 (de)
DK (1)	DK0768086T3 (de)
ES (1)	ES2181853T3 (de)
IL (1)	IL119207A (de)
MY (1)	MY119375A (de)
NZ (1)	NZ299376A (de)
PT (1)	PT768086E (de)
TW (1)	TW450807B (de)
ZA (1)	ZA967746B (de)

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GB9804885D0 (en)	1998-03-06	1998-04-29	Merck Sharp & Dohme	Therapeutic combination
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
FR2787028B1 (fr) *	1998-12-15	2002-10-18	Aventis Pharma Sa	Utilisation du riluzole dans le traitement des traumatismes acoustiques
ID30355A (id) *	1999-04-07	2001-11-22	Pfizer Prod Inc	Penggunaan inhibitor-inhibitor cyp2d6 dalam terapi kombinasi
US6586446B1 (en)	1999-10-15	2003-07-01	Bristol-Myers Squibb Company	Bicyclic and tricyclic amines as modulators of chemokine receptor activity
US6784200B2 (en) *	2000-10-13	2004-08-31	Bristol-Myers Squibb Pharma Company	Bicyclic and tricyclic amines as modulators of chemokine receptor activity
YU27801A (sh) *	2000-04-28	2003-04-30	Pfizer Products Inc.	Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera
DE10048969A1 (de) *	2000-08-23	2002-03-14	Mueller Schwefe Gerhard	Verwendung von Flupirtin zur Tinnitusbehandlung
IL145584A0 (en)	2000-10-02	2002-06-30	Pfizer Prod Inc	Nmda nr2b antagonists for treatment
UA73619C2 (en) *	2000-12-13	2005-08-15	Pfizer Prod Inc	Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment
SE0100344D0 (sv) *	2001-02-05	2001-02-05	Jan Nordmark	New Use
ES2185606T3 (es) *	2001-03-21	2003-05-01	Sanol Arznei Schwarz Gmbh	Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma.
US6743921B2 (en) *	2002-01-24	2004-06-01	Dsm Catalytica Pharmaceuticals, Inc.	Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
US7589110B2 (en) *	2002-09-06	2009-09-15	Durect Corporation	Delivery of modulators of glutamate-mediated neurotransmission to the inner ear
US7785653B2 (en) *	2003-09-22	2010-08-31	Innovational Holdings Llc	Method and apparatus for loading a beneficial agent into an expandable medical device
US9072662B2 (en)	2004-03-29	2015-07-07	Auris Medical Ag	Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US8268866B2 (en)	2004-03-29	2012-09-18	Matthieu Guitton	Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US20060063802A1 (en)	2004-03-29	2006-03-23	Matthieu Guitton	Methods for the treatment of tinnitus induced by cochlear excitotoxicity
KR101271263B1 (ko)	2005-09-28	2013-06-07	아우리스 메디칼 아게	내이 장애 치료용 약학 조성물
WO2009033069A1 (en) *	2007-09-07	2009-03-12	Xenoport, Inc.	Simple pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
US20090082464A1 (en) *	2007-09-07	2009-03-26	Bernd Jandeleit	Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
TW200932734A (en) *	2007-10-15	2009-08-01	Xenoport Inc	Internally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
US8454877B2 (en) *	2009-04-03	2013-06-04	Pelican Products, Inc.	Method and apparatus for molding an article
WO2011145062A1 (en)	2010-05-21	2011-11-24	Link Research & Grants Corporation	Treatment of tinnitus and related auditory dysfunctions
US20130230586A1 (en)	2010-10-02	2013-09-05	Link Research & Grants Corporation	Treatment of Tinnitus and Related Auditory Dysfunctions
US8648198B2 (en)	2011-01-19	2014-02-11	Cold Spring Harbor Laboratory	Phenylethanolamine-based NMDA receptor antagonists
US8920855B1 (en)	2012-10-30	2014-12-30	Setem Hemth, Inc	Methods of topically treating tinnitus and related disorders

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SK279476B6 (sk) *	1989-05-17	1998-11-04	Pfizer	Deriváty 2-piperidino a 2-pyrolidino-1-alkanolov a
EP0584192A1 (de) *	1991-04-18	1994-03-02	Pfizer Inc.	Prodrug-ester von phenolischen 2-piperidino-1-alkanolen
EP0542689B1 (de) *	1991-11-15	1998-09-23	Phafag Aktiengesellschaft	Verwendung von 1-(aminoalkyl)-3-Quinoxalin-2-on Derivaten zur Herstellung von neuroprotektiven Mitteln
GB9400680D0 (en) *	1994-01-14	1994-03-09	Sandoz Ltd	Improvements in or relating to organic compounds

1996
- 1996-06-11 TW TW085107025A patent/TW450807B/zh not_active IP Right Cessation
- 1996-08-27 AT AT96306198T patent/ATE224714T1/de not_active IP Right Cessation
- 1996-08-27 EP EP96306198A patent/EP0768086B1/de not_active Expired - Lifetime
- 1996-08-27 PT PT96306198T patent/PT768086E/pt unknown
- 1996-08-27 DE DE69623899T patent/DE69623899T2/de not_active Expired - Fee Related
- 1996-08-27 DK DK96306198T patent/DK0768086T3/da active
- 1996-08-27 ES ES96306198T patent/ES2181853T3/es not_active Expired - Lifetime
- 1996-09-05 IL IL11920796A patent/IL119207A/en not_active IP Right Cessation
- 1996-09-09 US US08/709,996 patent/US5716961A/en not_active Expired - Fee Related
- 1996-09-12 JP JP8262343A patent/JP3038155B2/ja not_active Expired - Fee Related
- 1996-09-13 NZ NZ299376A patent/NZ299376A/en unknown
- 1996-09-13 CN CN96112326A patent/CN1104892C/zh not_active Expired - Fee Related
- 1996-09-13 AU AU65635/96A patent/AU697679B2/en not_active Ceased
- 1996-09-13 MY MYPI96003783A patent/MY119375A/en unknown
- 1996-09-13 ZA ZA9607746A patent/ZA967746B/xx unknown
- 1996-09-13 CA CA002185512A patent/CA2185512C/en not_active Expired - Fee Related
- 1996-09-14 KR KR1019960039978A patent/KR970014765A/ko not_active Ceased

Also Published As

Publication number	Publication date
US5716961A (en)	1998-02-10
JPH09124482A (ja)	1997-05-13
NZ299376A (en)	2000-07-28
AU697679B2 (en)	1998-10-15
DE69623899T2 (de)	2003-01-23
TW450807B (en)	2001-08-21
CA2185512A1 (en)	1997-03-16
ES2181853T3 (es)	2003-03-01
JP3038155B2 (ja)	2000-05-08
KR970014765A (ko)	1997-04-28
DK0768086T3 (da)	2002-10-14
CN1104892C (zh)	2003-04-09
MY119375A (en)	2005-05-31
EP0768086B1 (de)	2002-09-25
CA2185512C (en)	2000-08-08
ATE224714T1 (de)	2002-10-15
EP0768086A1 (de)	1997-04-16
PT768086E (pt)	2003-01-31
ZA967746B (en)	1998-03-13
DE69623899D1 (de)	2002-10-31
AU6563596A (en)	1997-03-20
IL119207A0 (en)	1996-12-05
MX9603819A (es)	1997-07-31
CN1149454A (zh)	1997-05-14

Legal Events

Date	Code	Title
2004-09-27	FF	Patent granted
2004-11-10	KB	Patent renewed
2007-07-24	MM9K	Patent not in force due to non-payment of renewal fees

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