IL123185A - Process for the manufacture of a pharmaceutical solid composition comprising enalapril sodium - Google Patents

Process for the manufacture of a pharmaceutical solid composition comprising enalapril sodium

Info

Publication number
IL123185A
IL123185A IL12318596A IL12318596A IL123185A IL 123185 A IL123185 A IL 123185A IL 12318596 A IL12318596 A IL 12318596A IL 12318596 A IL12318596 A IL 12318596A IL 123185 A IL123185 A IL 123185A
Authority
IL
Israel
Prior art keywords
sodium
enalapril
maleate
water
mixing
Prior art date
Application number
IL12318596A
Other languages
English (en)
Other versions
IL123185A0 (en
Original Assignee
Sherman Bernard Charles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24034300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL123185(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sherman Bernard Charles filed Critical Sherman Bernard Charles
Publication of IL123185A0 publication Critical patent/IL123185A0/xx
Publication of IL123185A publication Critical patent/IL123185A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL12318596A 1995-08-04 1996-07-30 Process for the manufacture of a pharmaceutical solid composition comprising enalapril sodium IL123185A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/511,297 US5573780A (en) 1995-08-04 1995-08-04 Stable solid formulation of enalapril salt and process for preparation thereof
PCT/CA1996/000513 WO1997005881A1 (en) 1995-08-04 1996-07-30 Stable solid formulation of enalapril salt and process for preparation thereof

Publications (2)

Publication Number Publication Date
IL123185A0 IL123185A0 (en) 1998-09-24
IL123185A true IL123185A (en) 2001-08-08

Family

ID=24034300

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12318596A IL123185A (en) 1995-08-04 1996-07-30 Process for the manufacture of a pharmaceutical solid composition comprising enalapril sodium

Country Status (14)

Country Link
US (2) US5573780A (de)
EP (4) EP0841930B1 (de)
JP (1) JP3290994B2 (de)
AT (1) ATE288271T1 (de)
AU (1) AU697696C (de)
BR (1) BR9609964A (de)
CA (1) CA2166001C (de)
DE (4) DE05076813T1 (de)
DK (1) DK0841930T3 (de)
ES (4) ES2223315T1 (de)
IL (1) IL123185A (de)
NZ (1) NZ313576A (de)
RU (1) RU2161970C2 (de)
WO (1) WO1997005881A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573780A (en) * 1995-08-04 1996-11-12 Apotex Usa Inc. Stable solid formulation of enalapril salt and process for preparation thereof
RU2140261C1 (ru) * 1997-04-03 1999-10-27 Открытое акционерное общество "АЙ СИ ЭН Лексредства" Твердая лекарственная форма на основе малеата эналаприла
ES2125198B1 (es) * 1997-05-13 1999-11-16 Vita Invest Sa Asociacion a dosis fija de un inhibidor de la enzima convertidora de angiotensina y de un antagonista de los canales de calcio, procedimiento para su preparacion y su utilizacion para el tratamiento de enfermees cardiovasculares.
US6296871B1 (en) * 1998-04-12 2001-10-02 Ranbaxy Laboratories Limited Stable solid pharmaceutical compositions containing enalapril maleate
US6153223A (en) * 1998-06-05 2000-11-28 Watson Pharmaceuticals, Inc. Stabilized pharmaceutical compositions
NZ333206A (en) * 1998-12-08 2000-07-28 Bernard Charles Sherman Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor
US6637359B1 (en) * 1998-12-15 2003-10-28 Maritrans Inc. System and method for internally fitting a new inner hull to an existing outer hull to form a rebuilt double hull vessel
US6555551B1 (en) 1999-08-31 2003-04-29 Mutual Pharmaceutical Co., Inc. Stable formulations of ACE inhibitors, and methods for preparation thereof
US20040157911A1 (en) * 1999-08-31 2004-08-12 Spiridon Spireas Storage-stable and bio-stable formulations of ace inhibitors, and methods for preparation thereof
US20030225124A1 (en) * 1999-08-31 2003-12-04 Spiridon Spireas Stable formulations of ACE inhibitors, and methods for preparation thereof
US6764694B1 (en) * 1999-08-31 2004-07-20 Mutual Pharmaceutical Co., Inc. Stable formulations of ACE inhibitors, and methods for preparation thereof
RU2169005C1 (ru) * 2000-09-08 2001-06-20 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Фармацевтическая композиция с антигипертензивным действием и способ ее получения
UA78542C2 (en) * 2002-01-15 2007-04-10 Actavis Group Hf Formulations of quinapril and other ace inhibitors
RU2203052C1 (ru) * 2002-02-15 2003-04-27 Нестерук Владимир Викторович Твердая лекарственная форма эналаприла
US20030215526A1 (en) * 2002-03-08 2003-11-20 Scott Stofik Stable formulations of angiotensin converting enzyme (ACE) inhibitors
RU2207869C1 (ru) * 2002-04-04 2003-07-10 Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Фармацевтическая твердая композиция на основе эналаприла малеата и способ ее получения
HRP20140476T1 (hr) 2005-11-17 2014-07-18 Silverstone Pharma Est. Stabilni oblik amorfnih soli perindoprila, postupak njihove pripreme, posebno industrijske pripreme i njihova uporaba u lijeäśenju hipertenzije
EA027787B1 (ru) 2010-06-23 2017-09-29 Крка, Товарна Здравил, Д.Д., Ново Место Пероральные лекарственные формы, содержащие лерканидипин и эналаприл и их фармацевтически приемлемые соли
WO2012085249A2 (en) 2010-12-24 2012-06-28 Krka, D.D., Novo Mesto Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts
CN109350733A (zh) * 2018-06-08 2019-02-19 山东理工职业学院 一种马来酸依那普利片剂的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2576214B1 (fr) * 1985-01-18 1987-02-20 Synthelabo Compositions pharmaceutiques a base de diltiazem et d'un antihypertenseur
US4743450A (en) * 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
DE4112014A1 (de) * 1991-04-12 1992-10-15 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung
SI9111842A (sl) * 1991-11-25 1998-04-30 Krka Stabilna formulacija soli enalaprila, postopek za njeno pripravo in njena uporaba
WO1994001093A1 (en) * 1992-07-09 1994-01-20 Merck & Co., Inc. Controlled porosity osmotic enalapril pump
US5573780A (en) * 1995-08-04 1996-11-12 Apotex Usa Inc. Stable solid formulation of enalapril salt and process for preparation thereof

Also Published As

Publication number Publication date
EP0841930A1 (de) 1998-05-20
AU697696C (en) 2006-04-06
RU2161970C2 (ru) 2001-01-20
DE04078149T1 (de) 2005-12-29
ES2264912T1 (es) 2007-02-01
EP0841930B1 (de) 2005-02-02
CA2166001C (en) 2005-12-27
CA2166001A1 (en) 1996-12-05
US5690962A (en) 1997-11-25
ES2223315T1 (es) 2005-03-01
AU697696B2 (en) 1998-10-15
IL123185A0 (en) 1998-09-24
DK0841930T3 (da) 2005-04-25
DE69616072D1 (de) 2001-11-22
ES2245275T1 (es) 2006-01-01
BR9609964A (pt) 1999-02-02
DE69616072T2 (de) 2009-09-10
NZ313576A (en) 1999-05-28
WO1997005881A1 (en) 1997-02-20
US5573780A (en) 1996-11-12
JP3290994B2 (ja) 2002-06-10
ATE288271T1 (de) 2005-02-15
ES2236741T3 (es) 2005-07-16
EP1442746A1 (de) 2004-08-04
EP1527780A1 (de) 2005-05-04
DE05076813T1 (de) 2006-11-30
AU6608496A (en) 1997-03-05
JPH10511103A (ja) 1998-10-27
EP1637142A2 (de) 2006-03-22
DE04076118T1 (de) 2005-02-10
EP1637142A3 (de) 2008-04-02

Similar Documents

Publication Publication Date Title
AU697696C (en) Stable solid formulation of enalapril salt and process for preparation thereof
KR100348842B1 (ko) 염기성물질로안정화된약제학적조성물
US5256699A (en) Dispersible tablet formulation of diclofenac acid free base
US5562921A (en) Stable solid pharmaceutical compositions containing enalapril maleate
HU229134B1 (en) Process of forming a compressed solid oral dosage form comprising valsartan
AU626924B2 (en) Dispersable formulation of diclofenac in free acid form
US5292520A (en) Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer
US3865935A (en) Tableting of erythromycin base
EP0159852A2 (de) Direkt verpressbare Arzneigemische
KR910011241A (ko) 정제로 직접 압착 가능한 약제학적 분말 조성물을 제조하기 위한 분무 건조법
JP3170139B2 (ja) 発泡性錠剤
EP0952823B1 (de) Stabilisierte pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung
IE75887B1 (en) High-content ibuprofen lysinate pharmaceutical formulation
JP3687025B2 (ja) 安定なマレイン酸エナラプリル錠剤
HK1088545A (en) Stable solid formulation of enalapril salt and process for preparation thereof
HK1077505A (en) Stable solid formulation of enalapril salt and process for preparation thereof
Bansal et al. Effect of formulation and process variables on the dissolution profile of naproxen sodium from tablets
EP1178793B1 (de) Enalaprilmaleat enthaltende, stabile, feste arzneimittel
CA2330904C (en) Fosinopril sodium tablet formulation
JP2702325B2 (ja) 顆粒状カルシウム組成物及びそれからなる錠剤
CA2343949A1 (en) Benazepril hydrochloride tablet formulations
US3655742A (en) Process for producing magnesium probenecid tetrahydrate
CA2413578C (en) Use of dicalcium phosphate anhydride powder
JPH11228400A (ja) 医薬組成物

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees