IL123791A0 - Transgenic animals for xenotransplantation with reduced antibody-mediated rejection - Google Patents

Transgenic animals for xenotransplantation with reduced antibody-mediated rejection

Info

Publication number
IL123791A0
IL123791A0 IL12379196A IL12379196A IL123791A0 IL 123791 A0 IL123791 A0 IL 123791A0 IL 12379196 A IL12379196 A IL 12379196A IL 12379196 A IL12379196 A IL 12379196A IL 123791 A0 IL123791 A0 IL 123791A0
Authority
IL
Israel
Prior art keywords
xenotransplantation
transgenic animals
reduced antibody
mediated rejection
rejection
Prior art date
Application number
IL12379196A
Other languages
English (en)
Original Assignee
Nextran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nextran filed Critical Nextran
Publication of IL123791A0 publication Critical patent/IL123791A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biophysics (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL12379196A 1995-09-27 1996-09-23 Transgenic animals for xenotransplantation with reduced antibody-mediated rejection IL123791A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US446195P 1995-09-27 1995-09-27
US08/675,773 US6166288A (en) 1995-09-27 1996-07-03 Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
PCT/US1996/015255 WO1997012035A2 (en) 1995-09-27 1996-09-23 Transgenic animals for xenotransplantation with reduced antibody-mediated rejection

Publications (1)

Publication Number Publication Date
IL123791A0 true IL123791A0 (en) 1998-10-30

Family

ID=26673032

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12379196A IL123791A0 (en) 1995-09-27 1996-09-23 Transgenic animals for xenotransplantation with reduced antibody-mediated rejection

Country Status (10)

Country Link
US (1) US6166288A (de)
EP (1) EP0853665A2 (de)
JP (1) JP2001517924A (de)
CN (1) CN1278299A (de)
AU (1) AU727546B2 (de)
BR (1) BR9610843A (de)
CA (1) CA2233040A1 (de)
IL (1) IL123791A0 (de)
MX (1) MXPA98002434A (de)
WO (1) WO1997012035A2 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331658B1 (en) * 1993-04-20 2001-12-18 Integris Baptist Medical Center, Inc. Genetically engineered mammals for use as organ donors
US6231608B1 (en) * 1995-06-07 2001-05-15 Crosscart, Inc. Aldehyde and glycosidase-treated soft and bone tissue xenografts
EP0940467B1 (de) * 1996-05-17 2005-12-28 Nippon Meat Packers, Inc. Promotoren von komplementinhibitoren des schweines.
US6455037B1 (en) * 1996-11-01 2002-09-24 Mount Sinai School Of Medicine Of The City University Of New York Cells expressing an αgala nucleic acid and methods of xenotransplantation
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
CA2297105A1 (en) 1997-07-14 1999-01-28 Nippon Meat Packers, Inc. Transgenic mammals
CA2248971A1 (en) * 1997-10-31 1999-04-30 Kyowa Hakko Kogyo Co., Ltd. .beta.1, 3-n-acetylglucosaminyltransferase, dna encoding it and its use
US6383732B1 (en) * 1999-02-11 2002-05-07 Crosscart, Inc. Method of preparing xenograft heart valves
GB9807520D0 (en) * 1998-04-09 1998-06-10 Univ Wales Medicine Modified biological material
US6197294B1 (en) 1998-10-26 2001-03-06 Neurotech S.A. Cell surface molecule-induced macrophage activation
US6700037B2 (en) 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US6258998B1 (en) 1998-11-24 2001-07-10 Infigen, Inc. Method of cloning porcine animals
US6267786B1 (en) * 1999-02-11 2001-07-31 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
EP1197556A4 (de) * 1999-06-29 2003-01-22 Kyowa Hakko Kogyo Kk NüTZLICHE POLYPEPTIDE
US7414170B2 (en) 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
US7820878B2 (en) 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
AU2001261650A1 (en) * 2000-05-15 2001-11-26 Geron Corporation Ovine tissue for xenotransplantation
US7485769B2 (en) * 2000-08-25 2009-02-03 Nippon Meat Packers, Inc. Transgenic mammals
ATE502106T1 (de) 2000-12-22 2011-04-15 Kyowa Hakko Kirin Co Ltd Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
CA2438119C (en) * 2001-02-20 2014-12-16 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
US7126039B2 (en) 2001-03-21 2006-10-24 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
AU2002308533B2 (en) * 2001-04-30 2007-07-19 Rbc Biotechnology, Inc Modified organs and cells for xenotransplantation
US20050108780A1 (en) * 2002-01-24 2005-05-19 Erasmus University Intracellular antibodies for a retrovirus protein
US7547522B2 (en) 2002-08-14 2009-06-16 Immerge Biotherapeutics, Inc. Method to enrich for α(1,3)-galactosyltransferase null pig cells
EP1563084A4 (de) 2002-11-08 2006-03-01 Hematech Llc Transgene ungulaten mit reduzierter prionproteinaktivität und verwendungen davon
US7514593B2 (en) 2003-05-30 2009-04-07 The University Of North Carolina At Chapel Hill Animal model for chronic obstructive pulmonary disease and cystic fibrosis
US7368284B2 (en) * 2003-06-06 2008-05-06 University Of Pittsburgh Porcine CMP-N-Acetylneuraminic acid hydroxylase gene
EP2578676A1 (de) 2003-06-20 2013-04-10 Axiogenesis Ag Formgebung zu Gewebe in einem embryonischen Stammzellen (ES) System
AU2004259019B2 (en) 2003-07-21 2010-09-23 Lifecell Corporation Acellular tissue matrices made from galactose alpha-1,3-galactose-deficient tissue
US7420099B2 (en) 2004-04-22 2008-09-02 Kirin Holdings Kabushiki Kaisha Transgenic animals and uses thereof
US7732180B2 (en) * 2004-05-07 2010-06-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region
ES2770067T3 (es) 2004-05-11 2020-06-30 Ncardia Ag Descubrimiento de fármacos basado en células diferenciadas in vitro
CA2585098C (en) 2004-10-22 2018-12-18 Revivicor, Inc. Porcine genomic kappa and lambda light chain sequences
AU2006292827B2 (en) * 2005-08-09 2013-02-14 Revivicor, Inc. Transgenic ungulates expressing CTLA4-IG and uses thereof
EP2015707B1 (de) 2006-05-09 2019-01-23 LifeCell Corporation Verstärktes biologisches gewebe
US7663019B2 (en) * 2006-05-24 2010-02-16 North Carolina State University Transgenic snakes and methods of making
US8124831B2 (en) * 2006-07-06 2012-02-28 Duke University Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
DK3473260T3 (da) 2007-07-10 2020-12-21 Lifecell Corp Acellulære vævsmatrixs-sammensætninger til vævsreparation
WO2009069986A2 (en) * 2007-11-30 2009-06-04 Korea Research Institute Of Bioscience And Biotechnology Genetically-modified cell line for producing cloned miniature pigs for xenotransplantation and method for preparing the same.
AU2009256193B2 (en) 2008-06-06 2015-04-23 Lifecell Corporation Elastase treatment of tissue matrices
DK2348827T3 (en) 2008-10-27 2015-07-20 Revivicor Inc IMMUNICIPLY COMPROMATED PETS
AU2009316588B2 (en) 2008-11-21 2014-09-11 Stout Medical Group, L.P. Reinforced biologic material
US8986377B2 (en) 2009-07-21 2015-03-24 Lifecell Corporation Graft materials for surgical breast procedures
ES2644599T3 (es) 2009-09-02 2017-11-29 Lifecell Corporation Injertos vasculares procedentes de matrices de tejido acelular
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
US20110135706A1 (en) * 2009-12-03 2011-06-09 Lifecell Corporation Nerve treatment devices and methods
EP2536340B1 (de) 2010-02-19 2018-10-17 LifeCell Corporation Vorrichtungen zur behandlung der abdominalwand
AU2011232374B2 (en) 2010-03-25 2015-06-25 Lifecell Corporation Preparation of regenerative tissue scaffolds
AU2011276246B2 (en) 2010-07-08 2014-12-04 Lifecell Corporation Method for shaping tissue matrices
US20120040013A1 (en) 2010-08-10 2012-02-16 LifeCell Corporation. Regenerative Tissue Scaffolds
CA2807833C (en) 2010-08-26 2019-09-10 Lifecell Corporation Passive methods for anti-microbial biological meshes
US20120148542A1 (en) 2010-12-10 2012-06-14 Lifeline Scientific, Inc. Machine perfusion with complement inhibitors
EP2675901B1 (de) * 2011-02-14 2018-05-30 Revivicor, Inc. Genetisch modifizierte schweine für xenotransplantation von vaskularisierten xenotransplantaten und derivaten davon
US8637067B1 (en) 2011-03-10 2014-01-28 Lifecell Corporation Elastic tissue matrix derived hydrogel
BR112013026200A2 (pt) 2011-04-14 2019-08-27 Lifecell Corp método para preparar uma composição de matriz de tecido, e matriz de tecido
US10207025B2 (en) 2011-04-28 2019-02-19 Lifecell Corporation Method for enzymatic treatment of tissue products
KR102109309B1 (ko) 2011-04-28 2020-05-12 라이프셀 코포레이션 조직 생성물의 효소처리방법
US9238793B2 (en) 2011-04-28 2016-01-19 Lifecell Corporation Method for enzymatic treatment of tissue products
EP3622974A1 (de) 2011-11-10 2020-03-18 LifeCell Corporation Verfahren zur raumeliminierung durch gewebeannäherung
WO2013070670A1 (en) 2011-11-10 2013-05-16 Lifecell Corporation Device for tendon and ligament treatment
US9532863B2 (en) 2011-12-20 2017-01-03 Lifecell Corporation Sheet tissue products
CA2859657C (en) 2011-12-20 2021-03-02 Lifecell Corporation Acellular tissue matrix particles and flowable products comprising them
CA2861048C (en) 2012-01-24 2021-01-12 Lifecell Corporation Elongated tissue matrices
WO2013134009A1 (en) 2012-03-08 2013-09-12 Lifecell Corporation Enzyme-activated collagen and tissue matrices
CA2871635A1 (en) 2012-04-24 2013-10-31 Lifecell Corporation Functionalized tissue matrices comprising chelated metals
BR112014026090A8 (pt) 2012-04-24 2019-08-27 Lifecell Corp composição de matriz tecidual apta a fluir
WO2014008184A1 (en) 2012-07-05 2014-01-09 Lifecell Corporation Tissue-based drain manifolds
ES2836892T3 (es) 2012-07-06 2021-06-28 Lifecell Corp Matriz muscular descelularizada
EP3332816B1 (de) 2012-09-26 2020-11-04 LifeCell Corporation Verarbeitetes fettgewebe
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
CN108042849B (zh) 2013-02-06 2021-04-20 生命细胞公司 用于组织产物的局部改性的方法
CN103284797B (zh) * 2013-05-30 2016-06-29 美合实业（苏州）有限公司 一种内置消毒清洗装置的全科诊疗仪
DK3030272T3 (da) 2013-09-05 2019-09-09 Lifecell Corp Fremgangsmåde til enzymatisk behandling af vævsprodukter
ES2846758T3 (es) 2013-11-04 2021-07-29 Lifecell Corp Métodos para eliminar la alfa-galactosa
MX2016014504A (es) 2014-05-05 2017-05-23 Regeneron Pharma Animales c5 y c3 humanizados.
AU2015301688B2 (en) 2014-08-14 2019-10-10 Lifecell Corporation Tissue matrices and methods of treatment
US20170311579A1 (en) 2014-10-22 2017-11-02 Indiana University Research & Technology Corporation Triple transgenic pigs suitable for xenograft
CA3007417A1 (en) 2015-12-11 2017-06-15 Lifecell Corporation Methods and systems for stiffening of tissue for improved processing
CN108697828A (zh) 2016-02-11 2018-10-23 生命细胞公司 用于稳定包含胶原蛋白的组织产品防止酶降解的方法
WO2017210109A1 (en) 2016-06-03 2017-12-07 Lifecell Corporation Methods for localized modification of tissue products
ES2841427T3 (es) 2016-07-05 2021-07-08 Lifecell Corp Matrices de tejido que incorporan múltiples tipos de tejido
AU2017382173A1 (en) 2016-12-22 2019-06-06 Lifecell Corporation Devices and methods for tissue cryomilling
CA3047816A1 (en) 2016-12-23 2018-06-28 Lifecell Corporation Injectable polyurethanes and applications thereof
EP3558402A1 (de) 2016-12-23 2019-10-30 LifeCell Corporation Injizierbare hydrogele und anwendungen davon
CN111544652A (zh) 2017-01-30 2020-08-18 生命细胞公司 转谷氨酰胺酶处理的产品
US10940184B2 (en) 2017-01-30 2021-03-09 Lifecell Corporation Tissue matrix materials and enzymatic adhesives
AU2018212910A1 (en) 2017-01-30 2019-08-01 Lifecell Corporation Devices including muscle matrix and methods of production and use
CN107099513B (zh) * 2017-06-22 2020-07-14 北京邦卓生物科技有限公司 一种共表达ndv hn和ibdv vp2基因的hvt的构建及其应用
JP7502805B2 (ja) * 2019-03-21 2024-06-19 ザ ユーエイビー リサーチ ファウンデイション 補体媒介性溶解に対する細胞感受性を増加させる方法
CN114630579B (zh) 2019-11-05 2024-12-17 弗尔斯蒂血液研究所基金会股份有限公司 胎儿/新生儿同种免疫性血小板减少症的鼠模型
US11266129B2 (en) 2019-11-05 2022-03-08 Versiti Blood Research Institute Foundation, Inc. Murine model of fetal/neonatal alloimmune thrombocytopenia
WO2024261097A1 (en) 2023-06-20 2024-12-26 Institut National de la Santé et de la Recherche Médicale A new relevant non-human animal model of progressive metabolic dysfunction-associated steatotic liver disease (masld) and atherosclerosis development

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
MY107433A (en) * 1989-10-12 1995-12-30 Imutran Ltd Modiefied biological material.
US5324663A (en) * 1990-02-14 1994-06-28 The Regents Of The University Of Michigan Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures
JPH06506604A (ja) * 1991-07-15 1994-07-28 オクラホマ メディカル リサーチ ファウンデーション 自在なドナー細胞
WO1994006903A1 (en) * 1992-09-22 1994-03-31 Dnx Biotherapeutics, Inc. Delivery of proteins by intermembrane transfer for preaccommodation of xenogeneic organ transplants and other purposes
DE69431290D1 (de) * 1993-02-12 2002-10-10 Avant Immunotherapeutics Inc PULMONÄRE VERABREICHUNG DES LÖSLICHEN KOMPLEMENT-RECEPTORS TYP 1 sCR1
US5750176A (en) * 1994-03-09 1998-05-12 Abbott Laboratories Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
EP0755402B1 (de) * 1994-04-13 2008-05-14 Biotransplant, Inc Alpha(1,3)galactosyltransferase-negatives schwein
JPH10504707A (ja) * 1994-06-15 1998-05-12 アレクション・ファーマシューティカル・インク 異種移植片の超急性拒否反応を減少させる方法
AUPM772494A0 (en) * 1994-08-30 1994-09-22 Austin Research Institute, The Improvements in production of proteins in host cells
GB9421464D0 (en) * 1994-10-25 1994-12-07 Imutran Ltd Recombinant DNA

Also Published As

Publication number Publication date
EP0853665A2 (de) 1998-07-22
WO1997012035A3 (en) 1997-06-12
JP2001517924A (ja) 2001-10-09
AU727546B2 (en) 2000-12-14
CA2233040A1 (en) 1997-04-03
MXPA98002434A (es) 2005-04-29
BR9610843A (pt) 1999-07-13
US6166288A (en) 2000-12-26
AU7117096A (en) 1997-04-17
WO1997012035A2 (en) 1997-04-03
CN1278299A (zh) 2000-12-27

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