IL125950A0 - Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy - Google Patents
Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapyInfo
- Publication number
- IL125950A0 IL125950A0 IL12595098A IL12595098A IL125950A0 IL 125950 A0 IL125950 A0 IL 125950A0 IL 12595098 A IL12595098 A IL 12595098A IL 12595098 A IL12595098 A IL 12595098A IL 125950 A0 IL125950 A0 IL 125950A0
- Authority
- IL
- Israel
- Prior art keywords
- administering
- methods
- receptor antagonists
- dopamine agonist
- ampa receptor
- Prior art date
Links
- 229940098747 AMPA receptor antagonist Drugs 0.000 title 1
- 239000000775 AMPA receptor antagonist Substances 0.000 title 1
- 208000012661 Dyskinesia Diseases 0.000 title 1
- 238000011292 agonist therapy Methods 0.000 title 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5809897P | 1997-09-05 | 1997-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL125950A0 true IL125950A0 (en) | 1999-04-11 |
Family
ID=22014669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12595098A IL125950A0 (en) | 1997-09-05 | 1998-08-27 | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6136812A (de) |
| EP (1) | EP0900568A3 (de) |
| JP (2) | JPH11158072A (de) |
| KR (1) | KR100440659B1 (de) |
| AU (1) | AU736254B2 (de) |
| CA (1) | CA2246839C (de) |
| HU (1) | HUP9802021A3 (de) |
| IL (1) | IL125950A0 (de) |
| NZ (1) | NZ331741A (de) |
| ZA (1) | ZA988139B (de) |
Families Citing this family (50)
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| US6627755B1 (en) * | 1997-06-09 | 2003-09-30 | Pfizer Inc | Quinazolin-4-one AMPA antagonists |
| US7671200B2 (en) * | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| DE60144277D1 (de) * | 2000-04-25 | 2011-05-05 | Icos Corp | Hemmer der menschlichen phosphatidyl-inositol-3-kinase delta |
| GB0017952D0 (en) * | 2000-07-22 | 2000-09-13 | Univ Manchester | Treatment of dyskinesia |
| WO2003022269A1 (en) * | 2001-09-12 | 2003-03-20 | Merck Patent Gmbh | Novel use of substituted aminomethyl chromans for the treatment of movement disorders and of adverse effects induced by drugs administered to treat extrapyramidal movement disorders |
| WO2003043961A2 (en) * | 2001-11-19 | 2003-05-30 | Iconix Pharmaceuticals, Inc. | Modulators of rho c activity |
| AU2002346471A1 (en) | 2001-11-20 | 2003-06-10 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
| ATE372341T1 (de) * | 2001-12-06 | 2007-09-15 | Merck & Co Inc | Inhibitoren von mitotischem kinesin |
| US7009049B2 (en) * | 2002-02-15 | 2006-03-07 | Cytokinetics, Inc. | Syntheses of quinazolinones |
| US7166595B2 (en) | 2002-05-09 | 2007-01-23 | Cytokinetics, Inc. | Compounds, methods and compositions |
| AU2003270015A1 (en) | 2002-05-09 | 2003-12-02 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2003103575A2 (en) | 2002-05-23 | 2003-12-18 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| CA2489367A1 (en) * | 2002-06-14 | 2003-12-24 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2004009036A2 (en) | 2002-07-23 | 2004-01-29 | Cytokinetics, Inc. | Compounds compositions and methods |
| JP4630665B2 (ja) * | 2002-09-13 | 2011-02-09 | モタック・ニューロサイエンス・リミテッド | 2,3−ベンゾジアゼピンによる基底核関連運動障害の治療 |
| WO2004034972A2 (en) | 2002-09-30 | 2004-04-29 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US20040242568A1 (en) * | 2003-03-25 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| MXPA06001601A (es) | 2003-08-13 | 2006-08-25 | Takeda Pharmaceutical | Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa. |
| JP2007510652A (ja) * | 2003-11-03 | 2007-04-26 | サイトキネティクス・インコーポレーテッド | ピリミジン−4−オン化合物、組成物、および方法 |
| EP1692112A4 (de) * | 2003-12-08 | 2008-09-24 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
| LT2612862T (lt) | 2004-05-13 | 2017-01-25 | Icos Corporation | Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės delta inhibitoriai |
| RU2007141401A (ru) * | 2005-04-08 | 2009-05-20 | ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) | Терапевтический агент для лечения дискинезии |
| AU2006244027A1 (en) * | 2005-05-11 | 2006-11-16 | Merck Sharp & Dohme Limited | 2,3-substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilloid-1 receptor (VR1) |
| NZ566799A (en) | 2005-09-14 | 2011-04-29 | Takeda Pharmaceutical | Dipeptidyl peptidase inhibitors for treating diabetes |
| WO2007035629A2 (en) | 2005-09-16 | 2007-03-29 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
| US20100152209A1 (en) * | 2005-11-04 | 2010-06-17 | Hydra Biosciences Inc. | Compounds for Modulating TRPV3 Function |
| EA200900330A1 (ru) | 2006-08-23 | 2009-08-28 | Ньюроджен Корпорейшн | Аналоги 2-феноксипиримидинона |
| US20080090845A1 (en) * | 2006-08-23 | 2008-04-17 | Neurogen Corporation | Haloalkyl-substituted pyrimidinone derivatives |
| CA2663436A1 (en) | 2006-10-04 | 2008-04-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| WO2008140750A1 (en) * | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| KR20170060179A (ko) | 2008-11-13 | 2017-05-31 | 길리아드 칼리스토가 엘엘씨 | 혈액 종양에 대한 요법 |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| US20110319416A1 (en) * | 2009-01-28 | 2011-12-29 | Emory University | Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions |
| AU2010229968A1 (en) | 2009-03-24 | 2011-10-13 | Gilead Calistoga Llc | Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| JP2012524126A (ja) | 2009-04-20 | 2012-10-11 | ギリアド カリストガ リミテッド ライアビリティ カンパニー | 固形腫瘍の治療方法 |
| CA2768843A1 (en) | 2009-07-21 | 2011-01-27 | Gilead Calistoga Llc | Treatment of liver disorders with pi3k inhibitors |
| ES2848273T3 (es) | 2012-03-05 | 2021-08-06 | Gilead Calistoga Llc | Formas polimórficas de (S)-2-(1-(9H-purin-6-ilamino)propilo)-5-fluoro-3-fenilquinazolina-4(3H)-ona |
| EP3083630B1 (de) | 2013-12-20 | 2019-08-21 | Gilead Calistoga LLC | Prozessverfahren für phosphatidylinositol-3-kinase-hemmer |
| JP2017500319A (ja) | 2013-12-20 | 2017-01-05 | ギリアード カリストガ エルエルシー | (s)−2−(1−(9h−プリン−6−イルアミノ)プロピル)−5−フルオロ−3−フェニルキナゾリン−4(3h)−オンの塩酸塩の多形形態 |
| US11021467B2 (en) | 2014-06-13 | 2021-06-01 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| US9957267B2 (en) | 2015-07-01 | 2018-05-01 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| WO2017112777A1 (en) | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| KR102736865B1 (ko) | 2017-06-21 | 2024-12-03 | 샤이 테라퓨틱스 엘엘씨 | 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물 |
| WO2019023278A1 (en) | 2017-07-25 | 2019-01-31 | Crinetics Pharmaceuticals, Inc. | MODULATORS OF SOMATOSTATIN AND USES THEREOF |
| JP7407461B2 (ja) | 2018-12-19 | 2024-01-04 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ras病、及び線維性疾患の処置のためのrasスーパーファミリーと相互作用する化合物 |
| EP4574822A3 (de) | 2020-01-29 | 2025-08-27 | Kamari Pharma Ltd. | Verbindungen und zusammensetzungen zur verwendung beim behandeln von hauterkrankungen |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4183931A (en) * | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
| US5395827A (en) * | 1986-04-09 | 1995-03-07 | Guilford Pharmaceuticals Inc. | ω-[2-(phosphonoalkyl)phenyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors |
| US5268378A (en) * | 1990-05-31 | 1993-12-07 | Merck Sharp & Dohme, Limited | Dioxo-tetrahydroquinoline derivatives |
| GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
| GB9026389D0 (en) * | 1990-12-05 | 1991-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| US5519019A (en) * | 1990-12-21 | 1996-05-21 | Gyogyszerkutato Intezet | N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same |
| US5639751A (en) * | 1990-12-21 | 1997-06-17 | Cyogyszerkutato Intezet Kft | N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders |
| US5521174A (en) * | 1990-12-21 | 1996-05-28 | Gyogyszerkutato Intezet Kv. | N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith |
| WO1992013535A1 (en) * | 1991-02-06 | 1992-08-20 | Research Corporation Technologies, Inc. | Anticonvulsant substituted quinazolones |
| CA2115442C (en) * | 1991-09-09 | 2003-09-23 | Christopher Franklin Bigge | Pharmaceutical preparation containing an uricosuric agent and an excitatory amino acid antagonist |
| DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
| PT101004B (pt) * | 1991-10-26 | 1999-10-29 | Schering Ag | Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem |
| GB9125515D0 (en) * | 1991-11-29 | 1992-01-29 | Merck Sharp & Dohme | Therapeutic agents |
| GB9125485D0 (en) * | 1991-11-29 | 1992-01-29 | Merck Sharp & Dohme | Therapeutic agents |
| GB9200781D0 (en) * | 1992-01-15 | 1992-03-11 | Merck Sharp & Dohme | Therapeutic agents |
| GB9206266D0 (en) * | 1992-03-23 | 1992-05-06 | Merck Sharp & Dohme | Therapeutic agents |
| GB9210393D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| DK0647137T3 (da) * | 1992-06-22 | 2008-12-08 | State Of Oregon Through Oregon | Glycinreceptorantagonister og anvendelse deraf |
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5356902A (en) * | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
| US5342946A (en) * | 1992-12-02 | 1994-08-30 | Guilford Pharmaceuticals Inc. | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors |
| US5364876A (en) * | 1992-12-02 | 1994-11-15 | Guilford Pharmaceuticals Inc. | Omega-[2-(alkyl)phenyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors |
| DK31093D0 (de) * | 1993-03-19 | 1993-03-19 | Novo Nordisk As | |
| ES2097652T3 (es) * | 1993-05-06 | 1997-04-01 | Novo Nordisk As | Compuestos de (1,2,4)triazolo(4,3-a)quinoxalina, su preparacion y uso. |
| US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
| DE69525738D1 (de) * | 1994-02-11 | 2002-04-11 | Novo Nordisk As | Heterocyclische verbindungen und ihre herstellung und verwendung |
| US5580877A (en) * | 1994-04-25 | 1996-12-03 | Merck Sharp & Dohme Ltd. | Pyrazolo-quinoline derivatives for treating cerebral ischemia |
| US5446051A (en) * | 1994-05-31 | 1995-08-29 | Eli Lilly And Company | Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists |
| WO1996008493A1 (en) * | 1994-09-16 | 1996-03-21 | Novo Nordisk A/S | [1,2,4]TRIAZOLO[4,3-a]QUINOXALINONE DERIVATIVES, THEIR PREPARATION AND USE |
| US5654303A (en) * | 1995-06-07 | 1997-08-05 | Warner-Lambert Company | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
| US5614508A (en) * | 1995-06-07 | 1997-03-25 | Warner-Lambert Company | Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists |
| BR9709085A (pt) * | 1996-05-15 | 1999-08-03 | Pfizer | Novas 2,3-dissubstituído-4(3H)-quinazolinonas |
-
1998
- 1998-08-27 IL IL12595098A patent/IL125950A0/xx unknown
- 1998-08-31 JP JP10245269A patent/JPH11158072A/ja active Pending
- 1998-09-04 NZ NZ331741A patent/NZ331741A/xx unknown
- 1998-09-04 US US09/148,974 patent/US6136812A/en not_active Expired - Fee Related
- 1998-09-04 AU AU83120/98A patent/AU736254B2/en not_active Ceased
- 1998-09-04 EP EP98307181A patent/EP0900568A3/de not_active Withdrawn
- 1998-09-04 HU HU9802021A patent/HUP9802021A3/hu unknown
- 1998-09-05 KR KR10-1998-0036653A patent/KR100440659B1/ko not_active Expired - Fee Related
- 1998-09-07 ZA ZA9808139A patent/ZA988139B/xx unknown
- 1998-09-08 CA CA002246839A patent/CA2246839C/en not_active Expired - Fee Related
-
2001
- 2001-05-02 JP JP2001134816A patent/JP2001316267A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR19990029570A (ko) | 1999-04-26 |
| AU8312098A (en) | 1999-03-18 |
| CA2246839A1 (en) | 1999-03-05 |
| EP0900568A2 (de) | 1999-03-10 |
| EP0900568A3 (de) | 2001-05-02 |
| AU736254B2 (en) | 2001-07-26 |
| US6136812A (en) | 2000-10-24 |
| HU9802021D0 (en) | 1998-10-28 |
| ZA988139B (en) | 2000-03-22 |
| JPH11158072A (ja) | 1999-06-15 |
| HUP9802021A2 (hu) | 1999-05-28 |
| NZ331741A (en) | 2000-08-25 |
| JP2001316267A (ja) | 2001-11-13 |
| HUP9802021A3 (en) | 2001-05-28 |
| CA2246839C (en) | 2002-11-12 |
| KR100440659B1 (ko) | 2004-12-17 |
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