IL126659A - Fluorescent chelates as visual tissue specific imaging agents - Google Patents

Fluorescent chelates as visual tissue specific imaging agents

Info

Publication number
IL126659A
IL126659A IL12665997A IL12665997A IL126659A IL 126659 A IL126659 A IL 126659A IL 12665997 A IL12665997 A IL 12665997A IL 12665997 A IL12665997 A IL 12665997A IL 126659 A IL126659 A IL 126659A
Authority
IL
Israel
Prior art keywords
tissue specific
imaging agents
specific imaging
fluorescent chelates
chelates
Prior art date
Application number
IL12665997A
Other languages
English (en)
Other versions
IL126659A0 (en
Inventor
Garry E Kiefer
Darryl J Bornhop
Original Assignee
Dow Global Technologies Inc
Univ Texas Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Inc, Univ Texas Tech filed Critical Dow Global Technologies Inc
Publication of IL126659A0 publication Critical patent/IL126659A0/xx
Publication of IL126659A publication Critical patent/IL126659A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL12665997A 1996-04-19 1997-04-08 Fluorescent chelates as visual tissue specific imaging agents IL126659A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63514296A 1996-04-19 1996-04-19
US72833996A 1996-10-09 1996-10-09
PCT/US1997/005692 WO1997040055A1 (fr) 1996-04-19 1997-04-08 Chelates fluorescents utilises en tant qu'agents visuels destines a l'imagerie et specifiques de certains tissus

Publications (2)

Publication Number Publication Date
IL126659A0 IL126659A0 (en) 1999-08-17
IL126659A true IL126659A (en) 2003-05-29

Family

ID=27092308

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12665997A IL126659A (en) 1996-04-19 1997-04-08 Fluorescent chelates as visual tissue specific imaging agents

Country Status (11)

Country Link
US (1) US5928627A (fr)
EP (1) EP0898574B1 (fr)
KR (1) KR20000010533A (fr)
AT (1) ATE254129T1 (fr)
AU (1) AU719002B2 (fr)
CA (1) CA2251924C (fr)
DE (1) DE69726135T2 (fr)
IL (1) IL126659A (fr)
NO (1) NO984840L (fr)
TW (1) TW422841B (fr)
WO (1) WO1997040055A1 (fr)

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US7865230B1 (en) 1997-02-07 2011-01-04 Texas A&M University System Method and system for detecting sentinel lymph nodes
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
WO2000070528A2 (fr) * 1999-05-14 2000-11-23 Cytokinetics, Inc. Procede et appareil de bioinformatique cellulaire previsionnelle
WO2001027699A1 (fr) * 1999-10-14 2001-04-19 Meridian Chemical Technologies, Inc. Procede d'authentification d'un article
US6748259B1 (en) 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
US6686203B2 (en) * 2000-09-11 2004-02-03 William J. Calvo Histologic visualization of cyanoacrylate embolization
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
EP1429783A4 (fr) * 2001-09-04 2006-08-09 Univ Texas Tech Chelates d'imagerie multimodaux a usages multiples
DE60212424T2 (de) * 2001-10-22 2006-10-12 Dow Global Technologies, Inc., Midland Radiopharmazeutisches mittel zur behandlung von krebs im frühstadium
DE60207288T2 (de) * 2001-10-22 2006-05-18 Dow Global Technologies, Inc., Midland Gewebespezifische fluoreszierende chelate
AU2002367566B2 (en) 2001-11-20 2008-10-16 Duke University Interfacial biomaterials
US20020106811A1 (en) * 2002-04-14 2002-08-08 Jefferson Trent D. Method for authentication of an item
US8188116B2 (en) 2002-09-04 2012-05-29 Vanderbilt University Agents for therapy efficacy monitoring and deep tissue imaging
US7754884B2 (en) * 2005-01-03 2010-07-13 Vanderbilt University Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging
EP1654531A1 (fr) * 2003-06-20 2006-05-10 The Texas A & M University System Procede et systeme d'imagerie amelioree par contraste a fluorescence infrarouge proche avec zone d'exposition et zone de detection
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
GB2423988A (en) 2003-07-18 2006-09-13 Cytokinetics Inc Characterizing biological stimuli by response curves
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
EP1658282B1 (fr) * 2003-08-29 2010-10-27 Wallac Oy Nouveaux agents chelateurs, nouveaux chelates et leur utilisation
US8071626B2 (en) 2003-12-18 2011-12-06 Wallac Oy Chelating agents and highly luminescent and stable chelates and their use
CA2550074A1 (fr) * 2003-12-18 2005-06-30 Wallac Oy Nouveaux agents chelateurs, chelates hautement luminescents et stables et leur utilisation
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
US20060210479A1 (en) * 2004-08-10 2006-09-21 Dow Global Technologies Inc. Targeting chelants and chelates
US20060033752A1 (en) * 2004-08-13 2006-02-16 Gering David T Method and apparatus for displaying pixel data
JP5503149B2 (ja) 2006-03-10 2014-05-28 ノルディオン・（カナダ）・インコーポレイテッド 二官能性ポリアザ大環状キレート剤
US7570986B2 (en) * 2006-05-17 2009-08-04 The United States Of America As Represented By The Secretary Of Health And Human Services Teniae coli guided navigation and registration for virtual colonoscopy
US8140141B2 (en) * 2006-05-17 2012-03-20 University Of Utah Research Foundation Devices and methods for fluorescent inspection and/or removal of material in a sample
US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US7595699B1 (en) * 2008-03-04 2009-09-29 Freescale Semiconductor, Inc. Look loop circuit and method having improved lock time
GB0804190D0 (en) * 2008-03-06 2008-04-16 Ge Healthcare Ltd Ester imaging agents
WO2010075003A1 (fr) * 2008-12-16 2010-07-01 The University Of Akron Complexes d'ion lanthanide et procédé d'imagerie
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
WO2011133658A1 (fr) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions et procédés de ciblage et d'administration d'agents thérapeutiques dans des cellules
RU2435642C1 (ru) * 2010-05-18 2011-12-10 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ГОУ ВПО КубГУ) Способ получения материала на основе целлюлозы и его применение для определения тяжелых металлов
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
CA2956161A1 (fr) 2014-07-23 2016-01-28 Ohio State Innovation Foundation Methodes et compositions associees a des fragments d'anticorps qui se lient a la glycoproteine 72 associee aux tumeurs (tag 72)
EP3247988A4 (fr) 2015-01-23 2018-12-19 Vanderbilt University Interféromètre robuste et procédés de son utilisation
EP3408649B1 (fr) 2016-01-29 2023-06-14 Vanderbilt University Interférométrie à fonction de réponse en solution libre
JP6911855B2 (ja) * 2016-07-05 2021-07-28 コニカミノルタ株式会社 生体物質定量方法、画像処理装置、病理診断支援システム及びプログラム
ES2867895T3 (es) 2018-11-30 2021-10-21 Phytobiotics Futterzusatzstoffe Gmbh Sistema para el análisis de imágenes de excrementos de animales

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SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents
US5645818A (en) * 1989-03-24 1997-07-08 Guerbet S.A. Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
CA2042075C (fr) * 1991-05-08 2001-01-23 Branko Palcic Systeme d'imagerie endoscopique
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
WO1994026754A1 (fr) * 1993-05-06 1994-11-24 The Dow Chemical Company Acides bicyclopolyazamacrocyclophosphoniques, leurs complexes et conjugues, destines a etre utilises en tant qu'agents de contraste, et leurs procedes de preparation
EP0570575B1 (fr) * 1991-12-10 1997-12-10 The Dow Chemical Company Acides bicycloazamacrocyclophosphoniques, conjugues, agents de contraste et leur preparation
US5312922A (en) * 1992-04-06 1994-05-17 Nordion International Inc. Europium and terbium chelators for time-resolved fluorometric assays
US5462725A (en) * 1993-05-06 1995-10-31 The Dow Chemical Company 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
WO1994026755A1 (fr) * 1993-05-06 1994-11-24 The Dow Chemical Company Complexes d'acides bicyclopolyazamacrocyclophosphoniques, conjugues de ces derniers, procede de preparation associe et d'utilisation en tant que produits radiopharmaceutiques
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US5457186A (en) * 1993-10-13 1995-10-10 Wallac Oy Luminescent lanthanide chelates with decreased non-radiative energy loss
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence

Also Published As

Publication number Publication date
DE69726135D1 (de) 2003-12-18
NO984840D0 (no) 1998-10-16
EP0898574A1 (fr) 1999-03-03
ATE254129T1 (de) 2003-11-15
US5928627A (en) 1999-07-27
KR20000010533A (ko) 2000-02-15
CA2251924A1 (fr) 1997-10-30
NO984840L (no) 1998-12-16
TW422841B (en) 2001-02-21
AU719002B2 (en) 2000-05-04
WO1997040055A1 (fr) 1997-10-30
AU2660697A (en) 1997-11-12
EP0898574B1 (fr) 2003-11-12
DE69726135T2 (de) 2004-08-26
IL126659A0 (en) 1999-08-17
CA2251924C (fr) 2006-05-30

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees