IL126842A - Hybridization with artificial matching material - Google Patents

Hybridization with artificial matching material

Info

Publication number: IL126842A
Authority: IL; Israel
Prior art keywords: duplex; mismatch; oligonucleotide; target; nucleic acid
Prior art date: 1996-06-06

Application number

IL12684297A

Other languages

English (en)

Hebrew (he)

Other versions

IL126842A0 (en

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-06

Filing date

1997-06-05

Publication date

2004-03-28

1997-06-05 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1999-09-22 Publication of IL126842A0 publication Critical patent/IL126842A0/xx

2004-03-28 Publication of IL126842A publication Critical patent/IL126842A/en

Links

238000009396 hybridization Methods 0.000 title claims abstract description 68
238000000034 method Methods 0.000 claims abstract description 71
150000007523 nucleic acids Chemical class 0.000 claims abstract description 64
108091034117 Oligonucleotide Proteins 0.000 claims abstract description 62
108020004707 nucleic acids Proteins 0.000 claims abstract description 58
102000039446 nucleic acids Human genes 0.000 claims abstract description 58
230000008569 process Effects 0.000 claims abstract description 28
125000003729 nucleotide group Chemical group 0.000 claims description 39
239000002773 nucleotide Substances 0.000 claims description 36
230000000295 complement effect Effects 0.000 claims description 17
238000012544 monitoring process Methods 0.000 claims description 8
238000005406 washing Methods 0.000 claims description 8
238000012217 deletion Methods 0.000 claims description 6
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239000002777 nucleoside Substances 0.000 claims description 6
150000003833 nucleoside derivatives Chemical class 0.000 claims description 6
238000003780 insertion Methods 0.000 claims description 5
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239000000203 mixture Substances 0.000 claims description 2
239000000523 sample Substances 0.000 abstract description 88
108700028369 Alleles Proteins 0.000 abstract description 9
238000007899 nucleic acid hybridization Methods 0.000 abstract description 3
238000003203 nucleic acid sequencing method Methods 0.000 abstract 1
238000003752 polymerase chain reaction Methods 0.000 abstract 1
238000002844 melting Methods 0.000 description 15
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239000013615 primer Substances 0.000 description 14
108020005187 Oligonucleotide Probes Proteins 0.000 description 13
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101001100327 Homo sapiens RNA-binding protein 45 Proteins 0.000 description 10
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LOJNBPNACKZWAI-UHFFFAOYSA-N 3-nitro-1h-pyrrole Chemical compound [O-][N+](=O)C=1C=CNC=1 LOJNBPNACKZWAI-UHFFFAOYSA-N 0.000 description 8
238000006243 chemical reaction Methods 0.000 description 8
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 7
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238000003199 nucleic acid amplification method Methods 0.000 description 3
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
108020001019 DNA Primers Proteins 0.000 description 2
239000003155 DNA primer Substances 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 2
206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 2
238000002835 absorbance Methods 0.000 description 2
238000007844 allele-specific PCR Methods 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
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230000004048 modification Effects 0.000 description 2
238000010561 standard procedure Methods 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
OZFPSOBLQZPIAV-UHFFFAOYSA-N 5-nitro-1h-indole Chemical class [O-][N+](=O)C1=CC=C2NC=CC2=C1 OZFPSOBLQZPIAV-UHFFFAOYSA-N 0.000 description 1
208000035657 Abasia Diseases 0.000 description 1
101000775252 Arabidopsis thaliana NADPH-dependent oxidoreductase 2-alkenal reductase Proteins 0.000 description 1
102000053602 DNA Human genes 0.000 description 1
238000001712 DNA sequencing Methods 0.000 description 1
102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
101001041031 Homo sapiens Lariat debranching enzyme Proteins 0.000 description 1
102100021155 Lariat debranching enzyme Human genes 0.000 description 1
241000294754 Macroptilium atropurpureum Species 0.000 description 1
238000012408 PCR amplification Methods 0.000 description 1
241000700605 Viruses Species 0.000 description 1
230000003466 anti-cipated effect Effects 0.000 description 1
239000000427 antigen Substances 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
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210000000349 chromosome Anatomy 0.000 description 1
238000004590 computer program Methods 0.000 description 1
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238000007796 conventional method Methods 0.000 description 1
-1 cyano-substituted indoles Chemical class 0.000 description 1
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238000002405 diagnostic procedure Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
238000001917 fluorescence detection Methods 0.000 description 1
238000002073 fluorescence micrograph Methods 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000000329 molecular dynamics simulation Methods 0.000 description 1
230000035772 mutation Effects 0.000 description 1
229940127073 nucleoside analogue Drugs 0.000 description 1
238000002966 oligonucleotide array Methods 0.000 description 1
239000013612 plasmid Substances 0.000 description 1
230000001953 sensory effect Effects 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

IL12684297A 1996-06-06 1997-06-05 Hybridization with artificial matching material IL126842A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/659,605 US5780233A (en)	1996-06-06	1996-06-06	Artificial mismatch hybridization
PCT/US1997/009780 WO1997046711A1 (en)	1996-06-06	1997-06-05	Artificial mismatch hybridization

Publications (2)

Publication Number	Publication Date
IL126842A0 IL126842A0 (en)	1999-09-22
IL126842A true IL126842A (en)	2004-03-28

Family

ID=24646042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12684297A IL126842A (en)	1996-06-06	1997-06-05	Hybridization with artificial matching material

Country Status (11)

Country	Link
US (1)	US5780233A (de)
EP (1)	EP0970240B1 (de)
JP (1)	JP3816109B2 (de)
AT (1)	ATE266737T1 (de)
AU (1)	AU710204B2 (de)
CA (1)	CA2254111C (de)
DE (1)	DE69729122T2 (de)
DK (1)	DK0970240T3 (de)
IL (1)	IL126842A (de)
NZ (1)	NZ332753A (de)
WO (1)	WO1997046711A1 (de)

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ATE266737T1 (de)	2004-05-15
JP3816109B2 (ja)	2006-08-30
EP0970240A4 (de)	2001-07-11
DE69729122T2 (de)	2005-04-28
US5780233A (en)	1998-07-14
DE69729122D1 (de)	2004-06-17
JP2000511434A (ja)	2000-09-05
AU710204B2 (en)	1999-09-16
CA2254111C (en)	2008-02-12
NZ332753A (en)	1999-11-29
EP0970240A1 (de)	2000-01-12
IL126842A0 (en)	1999-09-22
EP0970240B1 (de)	2004-05-12
WO1997046711A1 (en)	1997-12-11
CA2254111A1 (en)	1997-12-11
DK0970240T3 (da)	2004-09-20
AU3302997A (en)	1998-01-05

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