IL127751A0 - Thrombin inhibitors - Google Patents

Thrombin inhibitors

Info

Publication number: IL127751A0
Authority: IL; Israel
Prior art keywords: thrombin inhibitors; thrombin; inhibitors
Prior art date: 1996-08-14

Application number

IL12775197A

Other languages

English (en)

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-14

Filing date

1997-07-29

Publication date

1999-10-28

1997-07-29 Application filed by Basf Ag filed Critical Basf Ag

1999-10-28 Publication of IL127751A0 publication Critical patent/IL127751A0/xx

Links

229940122388 Thrombin inhibitor Drugs 0.000 title 1
239000003868 thrombin inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)

IL12775197A 1996-08-14 1997-07-29 Thrombin inhibitors IL127751A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19632773A DE19632773A1 (de)	1996-08-14	1996-08-14	Neue Thrombininhibitoren
PCT/EP1997/004104 WO1998006741A1 (de)	1996-08-14	1997-07-29	Thrombininhibitoren

Publications (1)

Publication Number	Publication Date
IL127751A0 true IL127751A0 (en)	1999-10-28

Family

ID=7802624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12775197A IL127751A0 (en)	1996-08-14	1997-07-29	Thrombin inhibitors

Country Status (30)

Country	Link
US (1)	US6114358A (cs)
EP (1)	EP0956294B1 (cs)
JP (1)	JP4089981B2 (cs)
KR (1)	KR20000030002A (cs)
CN (1)	CN1228783A (cs)
AR (1)	AR009070A1 (cs)
AT (1)	ATE268781T1 (cs)
AU (1)	AU735364B2 (cs)
BG (1)	BG103096A (cs)
BR (1)	BR9711191A (cs)
CA (1)	CA2263220A1 (cs)
CO (1)	CO4900030A1 (cs)
CZ (1)	CZ299634B6 (cs)
DE (2)	DE19632773A1 (cs)
DK (1)	DK0956294T3 (cs)
ES (1)	ES2221062T3 (cs)
HR (1)	HRP970441B1 (cs)
HU (1)	HUP0001826A3 (cs)
ID (1)	ID17873A (cs)
IL (1)	IL127751A0 (cs)
MY (1)	MY132820A (cs)
NO (1)	NO990662D0 (cs)
NZ (1)	NZ333679A (cs)
PL (1)	PL188411B1 (cs)
PT (1)	PT956294E (cs)
RU (1)	RU2175328C2 (cs)
SK (1)	SK284915B6 (cs)
TR (1)	TR199900310T2 (cs)
WO (1)	WO1998006741A1 (cs)
ZA (1)	ZA977239B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9602263D0 (sv)	1996-06-07	1996-06-07	Astra Ab	New amino acid derivatives
SE9602646D0 (sv)	1996-07-04	1996-07-04	Astra Ab	Pharmaceutically-useful compounds
DE19632772A1 (de)	1996-08-14	1998-02-19	Basf Ag	Neue Benzamidine
DE19632773A1 (de) *	1996-08-14	1998-02-19	Basf Ag	Neue Thrombininhibitoren
AR013084A1 (es)	1997-06-19	2000-12-13	Astrazeneca Ab	Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv)	1997-12-05	1997-12-05	Astra Ab	New compounds
JP2002501081A (ja) *	1998-01-26	2002-01-15	ビーエーエスエフアクチェンゲゼルシャフト	トロンビンインヒビター
EP1049673A1 (de) *	1998-01-26	2000-11-08	Basf Aktiengesellschaft	Heterocyclische amidine als kallikrein protease inhibitoren
WO1999040088A1 (en) *	1998-02-09	1999-08-12	3-Dimensional Pharmaceuticals, Inc.	Heteroaryl amidines, methylamidines and guanidines as protease inhibitors, in particular as urokinase inhibitors
KR20010098982A (ko) *	1999-02-09	2001-11-08	3-디멘져널 파마슈티칼즈 인코오포레이티드	프로테아제 억제제로서의 헤테로아릴 아미딘, 메틸아미딘및 구아니딘
PL352824A1 (en) *	1999-04-09	2003-09-08	Abbott Gmbh & Co.Kg	Prodrugs of thrombin inhibitors
JP4489976B2 (ja)	1999-04-09	2010-06-23	ビーエーエスエフソシエタス・ヨーロピア	補体プロテアーゼの低分子インヒビター
WO2000061574A2 (de) *	1999-04-09	2000-10-19	Basf Aktiengesellschaft	Verfahren zur herstellung von thiophenyl-amidinen
AR023510A1 (es)	1999-04-21	2002-09-04	Astrazeneca Ab	Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
KR20010002891A (ko) *	1999-06-18	2001-01-15	성재갑	아릴 또는 헤테로아릴 그룹을 갖는 트롬빈 억제제 및 그 제조 방법
DE19933861A1 (de) *	1999-07-23	2001-01-25	Basf Ag	Verfahren zur Herstellung von 2-Aminomethyl-4-cyano-thiazol
DE10049937A1 (de) *	2000-10-06	2002-04-11	Knoll Ag	Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
DE10064797A1 (de) *	2000-12-22	2002-06-27	Knoll Ag	Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
FI122575B (fi)	2006-12-04	2012-03-30	Dieffenbacher Panelboard Oy	Laitteisto kuitujen, kuten lastujen sirottelemiseksi
CN102918034B (zh)	2010-03-30	2015-06-03	维颂公司	多取代芳族化合物作为凝血酶的抑制剂
LT2968297T (lt) *	2013-03-15	2019-01-10	Verseon Corporation	Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai
ES2791749T3 (es)	2013-03-15	2020-11-05	Verseon Corp	Halogenopirazoles como inhibidores de la trombina
CN103520160B (zh) *	2013-10-17	2015-04-22	广东药学院	三棱中肽类化合物的应用
CN106687445A (zh)	2014-09-17	2017-05-17	维颂公司	作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物
RU2017131562A (ru)	2015-02-27	2019-03-27	Версеон Корпорейшн	Замещенные пиразольные соединения как ингибиторы сериновых протеаз

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879313A (en) *	1988-07-20	1989-11-07	Mosanto Company	Novel platelet-aggregation inhibitors
US5332726A (en) *	1989-09-29	1994-07-26	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Antithrombotic peptides and pseudopeptides
GB9007751D0 (en) *	1990-04-05	1990-06-06	Ciba Geigy Ag	Novel platelet-aggregation inhibitors
EP0503203A1 (en) *	1991-03-15	1992-09-16	Merrell Dow Pharmaceuticals Inc.	Novel thrombin inhibitors
AU675981B2 (en) *	1992-12-02	1997-02-27	Bristol-Myers Squibb Company	Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
EP0648780A1 (en) *	1993-08-26	1995-04-19	Bristol-Myers Squibb Company	Heterocyclic thrombin inhibitors
IL112795A (en) *	1994-03-04	2001-01-28	Astrazeneca Ab	Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
DE4421052A1 (de) *	1994-06-17	1995-12-21	Basf Ag	Neue Thrombininhibitoren, ihre Herstellung und Verwendung
DE4443390A1 (de) *	1994-12-06	1996-06-13	Basf Ag	Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
US6030972A (en) *	1995-02-17	2000-02-29	Basf Aktiengesellschaft	Dipeptide amidines as thrombin inhibitors
DE19632772A1 (de) *	1996-08-14	1998-02-19	Basf Ag	Neue Benzamidine
DE19632773A1 (de) *	1996-08-14	1998-02-19	Basf Ag	Neue Thrombininhibitoren

1996
- 1996-08-14 DE DE19632773A patent/DE19632773A1/de not_active Withdrawn
1997
- 1997-07-29 BR BR9711191A patent/BR9711191A/pt not_active IP Right Cessation
- 1997-07-29 AU AU39417/97A patent/AU735364B2/en not_active Ceased
- 1997-07-29 NZ NZ333679A patent/NZ333679A/en unknown
- 1997-07-29 EP EP97936672A patent/EP0956294B1/de not_active Expired - Lifetime
- 1997-07-29 PT PT97936672T patent/PT956294E/pt unknown
- 1997-07-29 PL PL97331540A patent/PL188411B1/pl not_active IP Right Cessation
- 1997-07-29 TR TR1999/00310T patent/TR199900310T2/xx unknown
- 1997-07-29 AT AT97936672T patent/ATE268781T1/de not_active IP Right Cessation
- 1997-07-29 DK DK97936672T patent/DK0956294T3/da active
- 1997-07-29 CA CA002263220A patent/CA2263220A1/en not_active Abandoned
- 1997-07-29 WO PCT/EP1997/004104 patent/WO1998006741A1/de not_active Ceased
- 1997-07-29 RU RU99104925/04A patent/RU2175328C2/ru not_active IP Right Cessation
- 1997-07-29 JP JP50934098A patent/JP4089981B2/ja not_active Expired - Fee Related
- 1997-07-29 KR KR1019997001279A patent/KR20000030002A/ko not_active Withdrawn
- 1997-07-29 SK SK8-99A patent/SK284915B6/sk not_active IP Right Cessation
- 1997-07-29 CN CN97197391A patent/CN1228783A/zh active Pending
- 1997-07-29 ES ES97936672T patent/ES2221062T3/es not_active Expired - Lifetime
- 1997-07-29 HU HU0001826A patent/HUP0001826A3/hu unknown
- 1997-07-29 US US09/242,289 patent/US6114358A/en not_active Expired - Lifetime
- 1997-07-29 CZ CZ0048699A patent/CZ299634B6/cs not_active IP Right Cessation
- 1997-07-29 IL IL12775197A patent/IL127751A0/xx unknown
- 1997-07-29 DE DE59711714T patent/DE59711714D1/de not_active Expired - Fee Related
- 1997-08-11 HR HR970441A patent/HRP970441B1/xx not_active IP Right Cessation
- 1997-08-13 ZA ZA977239A patent/ZA977239B/xx unknown
- 1997-08-13 AR ARP970103680A patent/AR009070A1/es not_active Application Discontinuation
- 1997-08-13 MY MYPI97003700A patent/MY132820A/en unknown
- 1997-08-13 CO CO97046533A patent/CO4900030A1/es unknown
- 1997-08-14 ID IDP972839A patent/ID17873A/id unknown
1999
- 1999-01-19 BG BG103096A patent/BG103096A/xx unknown
- 1999-02-12 NO NO990662A patent/NO990662D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US6114358A (en)	2000-09-05
MY132820A (en)	2007-10-31
PT956294E (pt)	2004-10-29
ID17873A (id)	1998-02-05
HUP0001826A2 (hu)	2000-09-28
TR199900310T2 (xx)	1999-04-21
NZ333679A (en)	1999-09-29
NO990662L (no)	1999-02-12
SK284915B6 (sk)	2006-02-02
HUP0001826A3 (en)	2002-01-28
JP4089981B2 (ja)	2008-05-28
NO990662D0 (no)	1999-02-12
EP0956294B1 (de)	2004-06-09
CO4900030A1 (es)	2000-03-27
CN1228783A (zh)	1999-09-15
DK0956294T3 (da)	2004-10-11
BR9711191A (pt)	1999-08-17
JP2000516598A (ja)	2000-12-12
KR20000030002A (ko)	2000-05-25
WO1998006741A1 (de)	1998-02-19
ES2221062T3 (es)	2004-12-16
PL331540A1 (en)	1999-07-19
EP0956294A1 (de)	1999-11-17
DE19632773A1 (de)	1998-02-19
BG103096A (en)	1999-09-30
SK899A3 (en)	1999-06-11
CZ48699A3 (cs)	1999-05-12
AU3941797A (en)	1998-03-06
ZA977239B (en)	1999-02-15
CA2263220A1 (en)	1998-02-19
PL188411B1 (pl)	2005-01-31
HRP970441A2 (en)	1998-06-30
ATE268781T1 (de)	2004-06-15
HRP970441B1 (en)	2005-04-30
RU2175328C2 (ru)	2001-10-27
CZ299634B6 (cs)	2008-10-01
DE59711714D1 (de)	2004-07-15
AR009070A1 (es)	2000-03-08
AU735364B2 (en)	2001-07-05

Legal Events

Date	Code	Title	Description
2003-05-29	HP	Change in proprietorship

Publication	Publication Date	Title
HRP960075B1 (en)	2004-10-31	New thrombin inhibitors
PL331338A1 (en)	1999-07-05	Thiosulphonamidic metaloprotease inhibitors
AU3832895A (en)	1996-05-06	Thrombin inhibitors
HUP0001826A3 (en)	2002-01-28	Thrombin inhibitors
PL328307A1 (en)	1999-01-18	Serinic protease inhibitors
PL331803A1 (en)	1999-08-02	Bidonoric metaloprotease inhibitors
PL328875A1 (en)	1999-03-01	Serinic protease inhibitors
PL328223A1 (en)	1999-01-18	Aspartil protease inhibitors
IL136139A0 (en)	2001-05-20	Thrombin inhibitors
AU3396697A (en)	1998-04-14	Thrombin inhibitor
GB9613718D0 (en)	1996-08-28	Thrombin inhibitors
IL117437A0 (en)	1996-10-16	Novel thrombin inhibitors
IL121474A0 (en)	1998-02-08	Thrombin inhibitors
GB9624817D0 (en)	1997-01-15	Metalloproteinase inhibitors
ZA974779B (en)	1997-12-01	Thrombin inhibitors.
EP1027333A4 (en)	2000-11-08	THROMBIN INHIBITORS
GB9624319D0 (en)	1997-01-08	Thrombin inhibitors
GB9625311D0 (en)	1997-01-22	Thrombin inhibitors
GB9624278D0 (en)	1997-01-08	Thrombin inhibitors
GB9624292D0 (en)	1997-01-08	Thrombin inhibitors
GB9605163D0 (en)	1996-05-15	Thrombin inhibitors
SI0956294T1 (en)	2004-10-31	Thrombin inhibitors
GB9716872D0 (en)	1997-10-15	Thrombin Inhibitors
GB9704209D0 (en)	1997-04-16	Thrombin inhibitors
ZA968922B (en)	1997-05-28	Thrombin inhibitors