IL127942A0 - 1,4-Di-substituted piperidines as muscarinic antagonists - Google Patents
1,4-Di-substituted piperidines as muscarinic antagonistsInfo
- Publication number
- IL127942A0 IL127942A0 IL12794297A IL12794297A IL127942A0 IL 127942 A0 IL127942 A0 IL 127942A0 IL 12794297 A IL12794297 A IL 12794297A IL 12794297 A IL12794297 A IL 12794297A IL 127942 A0 IL127942 A0 IL 127942A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- cycloalkyl
- heteroaryl
- aryl
- alkylheteroaryl
- Prior art date
Links
- -1 1,4-Di-substituted piperidines Chemical class 0.000 title abstract 5
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title abstract 2
- 239000003149 muscarinic antagonist Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 3
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67861896A | 1996-07-10 | 1996-07-10 | |
| PCT/US1997/011176 WO1998001425A1 (en) | 1996-07-10 | 1997-07-08 | 1,4-di-sustituted piperidines as muscarinic antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL127942A0 true IL127942A0 (en) | 1999-11-30 |
Family
ID=24723553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12794297A IL127942A0 (en) | 1996-07-10 | 1997-07-08 | 1,4-Di-substituted piperidines as muscarinic antagonists |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0912515B1 (de) |
| JP (1) | JP3068206B2 (de) |
| KR (1) | KR20000023599A (de) |
| AT (1) | ATE227708T1 (de) |
| AU (1) | AU728592B2 (de) |
| CA (1) | CA2259655C (de) |
| DE (1) | DE69717109T2 (de) |
| DK (1) | DK0912515T3 (de) |
| ES (1) | ES2182104T3 (de) |
| HU (1) | HUP9904622A3 (de) |
| IL (1) | IL127942A0 (de) |
| NZ (1) | NZ333513A (de) |
| PT (1) | PT912515E (de) |
| WO (1) | WO1998001425A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1600599A (en) * | 1998-02-27 | 1999-09-15 | Warner-Lambert Company | Heterocyclic substituted aniline calcium channel blockers |
| HK1039330B (en) * | 1999-05-04 | 2005-12-09 | Schering Corporation | Piperidine derivatives useful as ccr5 antagonists |
| US6635646B1 (en) | 1999-05-04 | 2003-10-21 | Schering Corporation | Pegylated interferon alfa-CCR5 antagonist combination HIV therapy |
| US6387930B1 (en) | 1999-05-04 | 2002-05-14 | Schering Corporation | Piperidine derivatives useful as CCR5 antagonists |
| AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| CN100374416C (zh) | 2000-04-28 | 2008-03-12 | 霍夫曼-拉罗奇有限公司 | 对(磺酰基)芳基和杂芳基类化合物 |
| US6640155B2 (en) | 2000-08-22 | 2003-10-28 | Lam Research Corporation | Chemical mechanical polishing apparatus and methods with central control of polishing pressure applied by polishing head |
| KR20040013090A (ko) | 2001-07-02 | 2004-02-11 | 아스트라제네카 아베 | 케모킨 수용체 활성의 조절자로서 유용한 피페리딘 유도체 |
| GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
| AR036366A1 (es) | 2001-08-29 | 2004-09-01 | Schering Corp | Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit |
| GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
| MXPA04005313A (es) | 2001-12-03 | 2004-09-13 | Hoffmann La Roche | Derivados de aminotetralin como antagonistas del receptor muscarinico. |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SI1514542T1 (sl) | 2002-06-14 | 2012-06-29 | Toyama Chemical Co Ltd | Farmacevtska sestava, vsebujoäśa takrin ali donepezil za izboljĺ anje moĺ˝ganske funkcije |
| SE0202838D0 (sv) * | 2002-09-24 | 2002-09-24 | Astrazeneca Ab | Chemical compounds |
| GB0223223D0 (en) * | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
| RU2224516C1 (ru) * | 2002-10-17 | 2004-02-27 | Государственное учреждение Институт токсикологии | Гидрохлорид 1-фенил-1-циклопентил-4-пиперидино-2-бутин-1-ола (пентифин), обладающий м4 холиноблокирующей активностью |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| US7820654B2 (en) | 2004-09-23 | 2010-10-26 | Dr. Reddy's Laboratories Ltd. | Pyrimidine compounds, process for their preparation and compositions containing them |
| WO2007011293A1 (en) | 2005-07-21 | 2007-01-25 | Astrazeneca Ab | Novel piperidine derivatives |
| CN101258142A (zh) | 2005-08-02 | 2008-09-03 | 莱西肯医药有限公司 | 作为蛋白激酶抑制剂的2-氨基芳基吡啶 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0711763B1 (de) * | 1993-07-28 | 2000-10-18 | Santen Pharmaceutical Co., Ltd. | 1,4-di(phenylalkyl)piperazinderivate |
| IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
-
1997
- 1997-07-08 EP EP97932321A patent/EP0912515B1/de not_active Expired - Lifetime
- 1997-07-08 PT PT97932321T patent/PT912515E/pt unknown
- 1997-07-08 DE DE69717109T patent/DE69717109T2/de not_active Expired - Fee Related
- 1997-07-08 DK DK97932321T patent/DK0912515T3/da active
- 1997-07-08 CA CA002259655A patent/CA2259655C/en not_active Expired - Fee Related
- 1997-07-08 ES ES97932321T patent/ES2182104T3/es not_active Expired - Lifetime
- 1997-07-08 WO PCT/US1997/011176 patent/WO1998001425A1/en not_active Ceased
- 1997-07-08 IL IL12794297A patent/IL127942A0/xx unknown
- 1997-07-08 AT AT97932321T patent/ATE227708T1/de not_active IP Right Cessation
- 1997-07-08 JP JP10505232A patent/JP3068206B2/ja not_active Expired - Fee Related
- 1997-07-08 AU AU35810/97A patent/AU728592B2/en not_active Ceased
- 1997-07-08 HU HU9904622A patent/HUP9904622A3/hu unknown
- 1997-07-08 NZ NZ333513A patent/NZ333513A/xx unknown
-
1999
- 1999-01-07 KR KR1019997000045A patent/KR20000023599A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2259655A1 (en) | 1998-01-15 |
| DE69717109T2 (de) | 2003-04-30 |
| HUP9904622A3 (en) | 2001-07-30 |
| ATE227708T1 (de) | 2002-11-15 |
| EP0912515B1 (de) | 2002-11-13 |
| HUP9904622A2 (hu) | 2000-06-28 |
| JPH11514671A (ja) | 1999-12-14 |
| PT912515E (pt) | 2003-03-31 |
| JP3068206B2 (ja) | 2000-07-24 |
| AU728592B2 (en) | 2001-01-11 |
| CA2259655C (en) | 2003-05-13 |
| EP0912515A1 (de) | 1999-05-06 |
| WO1998001425A1 (en) | 1998-01-15 |
| KR20000023599A (ko) | 2000-04-25 |
| DK0912515T3 (da) | 2003-03-10 |
| DE69717109D1 (de) | 2002-12-19 |
| AU3581097A (en) | 1998-02-02 |
| NZ333513A (en) | 2000-04-28 |
| ES2182104T3 (es) | 2003-03-01 |
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