IL130094A - Compounds 2 - imidazolinylaminobenzoxazole used as agonists of alpha-adrenoreceptor 2 - and pharmaceutical preparations containing them - Google Patents

Compounds 2 - imidazolinylaminobenzoxazole used as agonists of alpha-adrenoreceptor 2 - and pharmaceutical preparations containing them

Info

Publication number: IL130094A
Authority: IL; Israel
Prior art keywords: dosage range; compounds; usp; alpha; mmol
Prior art date: 1996-11-25

Application number

IL13009497A

Other languages

English (en)

Hebrew (he)

Other versions

IL130094A0 (en

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-25

Filing date

1997-11-21

Publication date

2001-09-13

1997-11-21 Application filed by Procter & Gamble filed Critical Procter & Gamble

2000-02-29 Publication of IL130094A0 publication Critical patent/IL130094A0/xx

2001-09-13 Publication of IL130094A publication Critical patent/IL130094A/en

Links

239000000556 agonist Substances 0.000 title description 14
102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 title description 11
108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 title description 11
WWGDPXQOBQLMRI-UHFFFAOYSA-N n-(4,5-dihydroimidazol-1-yl)-1,3-benzoxazol-2-amine Chemical class C1=NCCN1NC1=NC2=CC=CC=C2O1 WWGDPXQOBQLMRI-UHFFFAOYSA-N 0.000 title description 3
239000008194 pharmaceutical composition Substances 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 103
150000003839 salts Chemical class 0.000 claims abstract description 34
125000003342 alkenyl group Chemical group 0.000 claims abstract description 6
230000003287 optical effect Effects 0.000 claims abstract description 5
125000000355 1,3-benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims abstract 2
BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 claims description 4
125000004663 dialkyl amino group Chemical group 0.000 claims description 2
125000003282 alkyl amino group Chemical group 0.000 claims 1
-1 imidazolinylamino moiety Chemical group 0.000 abstract description 22
125000003545 alkoxy group Chemical group 0.000 abstract description 4
125000000217 alkyl group Chemical group 0.000 abstract description 4
150000002148 esters Chemical class 0.000 abstract description 4
239000001257 hydrogen Substances 0.000 abstract description 4
229910052739 hydrogen Inorganic materials 0.000 abstract description 4
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract description 3
150000001408 amides Chemical class 0.000 abstract description 3
125000004093 cyano group Chemical group *C#N 0.000 abstract description 2
125000000753 cycloalkyl group Chemical group 0.000 abstract description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract description 2
150000003573 thiols Chemical class 0.000 abstract description 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006559 (C1-C3) alkylamino group Chemical group 0.000 abstract 1
125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
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125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
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239000000018 receptor agonist Substances 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
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229960000888 rimantadine Drugs 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
229940047978 saccharin 30 mg Drugs 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
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230000020341 sensory perception of pain Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000004208 shellac Substances 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
230000008326 skin blood flow Effects 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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235000010262 sodium metabisulphite Nutrition 0.000 description 1
239000012453 solvate Substances 0.000 description 1
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KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
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229960000351 terfenadine Drugs 0.000 description 1
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229950010257 terpin Drugs 0.000 description 1
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
229960000278 theophylline Drugs 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
XFYDIVBRZNQMJC-UHFFFAOYSA-N tizanidine Chemical compound ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 XFYDIVBRZNQMJC-UHFFFAOYSA-N 0.000 description 1
229960000488 tizanidine Drugs 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
229960001017 tolmetin Drugs 0.000 description 1
UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
229940100613 topical solution Drugs 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
229960005294 triamcinolone Drugs 0.000 description 1
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 description 1
PKIDNTKRVKSLDB-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;hydrate Chemical compound O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PKIDNTKRVKSLDB-UHFFFAOYSA-K 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
238000010200 validation analysis Methods 0.000 description 1
238000007631 vascular surgery Methods 0.000 description 1
210000005166 vasculature Anatomy 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
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MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
229960005332 zileuton Drugs 0.000 description 1
229960000568 zipeprol Drugs 0.000 description 1
VSTNNAYSCJQCQI-UHFFFAOYSA-N zipeprol Chemical compound C=1C=CC=CC=1C(OC)CN(CC1)CCN1CC(O)C(OC)C1=CC=CC=C1 VSTNNAYSCJQCQI-UHFFFAOYSA-N 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL13009497A 1996-11-25 1997-11-21 Compounds 2 - imidazolinylaminobenzoxazole used as agonists of alpha-adrenoreceptor 2 - and pharmaceutical preparations containing them IL130094A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3178796P	1996-11-25	1996-11-25
PCT/US1997/020803 WO1998023611A1 (en)	1996-11-25	1997-11-21	2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists

Publications (2)

Publication Number	Publication Date
IL130094A0 IL130094A0 (en)	2000-02-29
IL130094A true IL130094A (en)	2001-09-13

Family

ID=21861392

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13009497A IL130094A (en)	1996-11-25	1997-11-21	Compounds 2 - imidazolinylaminobenzoxazole used as agonists of alpha-adrenoreceptor 2 - and pharmaceutical preparations containing them

Country Status (18)

Country	Link
US (1)	US6110952A (id)
EP (1)	EP0944622A1 (id)
JP (1)	JP2001506601A (id)
KR (1)	KR20000069128A (id)
AU (1)	AU736992B2 (id)
BR (1)	BR9713537A (id)
CA (1)	CA2272683A1 (id)
CO (1)	CO4910150A1 (id)
CZ (1)	CZ183699A3 (id)
HU (1)	HUP0002966A3 (id)
ID (1)	ID22060A (id)
IL (1)	IL130094A (id)
NO (1)	NO313755B1 (id)
PE (1)	PE16599A1 (id)
SK (1)	SK74999A3 (id)
TR (1)	TR199901486T2 (id)
WO (1)	WO1998023611A1 (id)
ZA (1)	ZA9710579B (id)

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KR20000069128A (ko) *	1996-11-25	2000-11-25	데이비드 엠 모이어	알파-2 아드레날린수용체 아고니스트로서 유용한 2-이미다졸리닐아미노벤즈옥사졸 화합물
WO2000051625A1 (en) *	1999-03-05	2000-09-08	The Trustees Of University Technology Corporation	Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
EP1799659A1 (en) *	2004-10-13	2007-06-27	PTC Therapeutics, Inc.	Compounds for nonsense suppression, and methods for their use
WO2007056457A2 (en)	2005-11-09	2007-05-18	Combinatorx, Incorporated	Methods, compositions, and kits for the treatment of medical conditions
US12246013B2 (en)	2008-08-01	2025-03-11	Eye Therapies Llc	Vasoconstriction compositions and methods of use
US20100028266A1 (en) *	2008-08-01	2010-02-04	Alpha Synergy Development. Inc.	Composition and methods for treating allergic response
US20100202979A1 (en) *	2008-08-01	2010-08-12	Gerald Horn	Compositions and methods for treatment of pulmonary diseases and conditions
US20100197694A1 (en) *	2008-08-01	2010-08-05	Gerald Horn	Compositions and methods for treatment of diseases and conditions with increased vascular permeability
US20100203165A1 (en)	2008-08-01	2010-08-12	Gerald Horn	Compositions and methods for treatment of disorders or conditions of the eye
US8952011B2 (en)	2008-08-01	2015-02-10	Eye Therapies Llc	Compositions and methods for the treatment of nasal conditions
US20110003823A1 (en) *	2008-08-01	2011-01-06	Alpha Synergy Development, Inc.	Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage
WO2010074753A1 (en)	2008-12-23	2010-07-01	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
US8987270B2 (en)	2009-07-27	2015-03-24	Eye Therapies Llc	Formulations of selective alpha-2 agonists and methods of use thereof
MX336578B (es) *	2011-07-25	2016-01-25	Allergan Inc	Derivados de n-(imidazolidin-2-ilideno)-heterociclopenta[b] pirididina como moduladores de receptores de alfa 2 adrenergicos.

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Publication number	Priority date	Publication date	Assignee	Title
BE795970A (fr) *	1972-02-29	1973-08-27	Pfizer	Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US3830804A (en) *	1972-11-20	1974-08-20	Eastman Kodak Co	Fluorescent(pyrimidinotriazolyl)-2-styrylbenzoxazoles
US4398028A (en) *	1977-01-14	1983-08-09	Sandoz Ltd.	Bicyclic heterocyclic amino derivatives
FR2521140A1 (fr) *	1982-02-05	1983-08-12	Synthelabo	Derives d'imidazolidine, leur preparation et leur application en therapeutique
US5091528A (en) *	1990-09-12	1992-02-25	Allergan, Inc.	6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
GB9110017D0 (en) *	1991-05-09	1991-07-03	Nat Res Dev	Spectroscopic investigation using organometallic compounds
ES2160700T3 (es) *	1994-01-24	2001-11-16	Allergan Sales Inc	Derivados aromaticos de 2-amino-imidazol como agonistas del adrenorreceptor alfa-2a.
EP0775134A4 (en) *	1994-08-04	1997-08-13	Synaptic Pharma Corp	NEW BENZIMIDAZOLE DERIVATIVES
KR100215541B1 (ko) *	1996-04-19	1999-08-16	박원훈	벤족사졸계 비선형 광학 유도체 및 이들로부터 얻어진고분자
KR20000069128A (ko) *	1996-11-25	2000-11-25	데이비드 엠 모이어	알파-2 아드레날린수용체 아고니스트로서 유용한 2-이미다졸리닐아미노벤즈옥사졸 화합물

1997
- 1997-11-21 KR KR1019997004616A patent/KR20000069128A/ko not_active Ceased
- 1997-11-21 CZ CZ991836A patent/CZ183699A3/cs unknown
- 1997-11-21 BR BR9713537A patent/BR9713537A/pt not_active Application Discontinuation
- 1997-11-21 EP EP97948291A patent/EP0944622A1/en not_active Withdrawn
- 1997-11-21 IL IL13009497A patent/IL130094A/en not_active IP Right Cessation
- 1997-11-21 WO PCT/US1997/020803 patent/WO1998023611A1/en not_active Ceased
- 1997-11-21 AU AU54382/98A patent/AU736992B2/en not_active Ceased
- 1997-11-21 JP JP52469598A patent/JP2001506601A/ja active Pending
- 1997-11-21 ID IDW990411A patent/ID22060A/id unknown
- 1997-11-21 US US09/308,792 patent/US6110952A/en not_active Expired - Fee Related
- 1997-11-21 CA CA002272683A patent/CA2272683A1/en not_active Abandoned
- 1997-11-21 TR TR1999/01486T patent/TR199901486T2/xx unknown
- 1997-11-21 SK SK749-99A patent/SK74999A3/sk unknown
- 1997-11-21 HU HU0002966A patent/HUP0002966A3/hu unknown
- 1997-11-24 CO CO97068611A patent/CO4910150A1/es unknown
- 1997-11-25 PE PE1997001065A patent/PE16599A1/es not_active Application Discontinuation
- 1997-11-25 ZA ZA9710579A patent/ZA9710579B/xx unknown
1999
- 1999-05-25 NO NO19992500A patent/NO313755B1/no unknown

Also Published As

Publication number	Publication date
CO4910150A1 (es)	2000-04-24
ID22060A (id)	1999-08-26
NO992500D0 (no)	1999-05-25
ZA9710579B (en)	1998-06-25
CA2272683A1 (en)	1998-06-04
CZ183699A3 (cs)	1999-09-15
PE16599A1 (es)	1999-03-12
NO992500L (no)	1999-07-26
AU736992B2 (en)	2001-08-09
KR20000069128A (ko)	2000-11-25
HUP0002966A3 (en)	2001-10-29
BR9713537A (pt)	2000-03-21
IL130094A0 (en)	2000-02-29
NO313755B1 (no)	2002-11-25
EP0944622A1 (en)	1999-09-29
WO1998023611A1 (en)	1998-06-04
JP2001506601A (ja)	2001-05-22
AU5438298A (en)	1998-06-22
US6110952A (en)	2000-08-29
HUP0002966A2 (hu)	2001-09-28
SK74999A3 (en)	2000-02-14
TR199901486T2 (xx)	1999-10-21

Legal Events

Date	Code	Title	Description
2004-01-04	KB	Patent renewed
2008-11-03	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
EP0944621B1 (en)	2004-09-01	2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists
US6117871A (en)	2000-09-12	6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists
US6225331B1 (en)	2001-05-01	Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists
US5965595A (en)	1999-10-12	2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US5916900A (en)	1999-06-29	7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
US5804587A (en)	1998-09-08	6-(2-imidazolinylamino) quinolines useful as alpha-2 adrenoceptor agonists
US6110952A (en)	2000-08-29	2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists
US5914342A (en)	1999-06-22	2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US6306877B1 (en)	2001-10-23	Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
US6172095B1 (en)	2001-01-09	Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
EP0944601B1 (en)	2003-02-12	Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
EP0975627A1 (en)	2000-02-02	5-(2-imidazolinylamino)benzimidazole compounds useful as alpha-2 adrenoceptor agonists
AU5433998A (en)	1998-06-22	2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonis ts
WO1998023612A1 (en)	1998-06-04	2-imidazolinylaminobenzothiazole compounds useful as alpha-2 adrenoceptor agonists