IL132546A0 - Bradykinin analogs as selective inhibitors of cell activation - Google Patents

Bradykinin analogs as selective inhibitors of cell activation

Info

Publication number: IL132546A0
Authority: IL; Israel
Prior art keywords: cell activation; selective inhibitors; bradykinin analogs; bradykinin; analogs
Prior art date: 1997-04-23

Application number

IL13254698A

Other languages

English (en)

Original Assignee

Univ Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-23

Filing date

1998-04-21

Publication date

2001-03-19

1998-04-21 Application filed by Univ Michigan filed Critical Univ Michigan

2001-03-19 Publication of IL132546A0 publication Critical patent/IL132546A0/xx

Links

229940124639 Selective inhibitor Drugs 0.000 title 1
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical class NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title 1
230000020411 cell activation Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/043—Kallidins; Bradykinins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Diabetes (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

IL13254698A 1997-04-23 1998-04-21 Bradykinin analogs as selective inhibitors of cell activation IL132546A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4608597P	1997-04-23	1997-04-23
PCT/US1998/008015 WO1998047522A1 (en)	1997-04-23	1998-04-21	Bradykinin analogs as selective inhibitors of cell activation

Publications (1)

Publication Number	Publication Date
IL132546A0 true IL132546A0 (en)	2001-03-19

Family

ID=21941533

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13254698A IL132546A0 (en)	1997-04-23	1998-04-21	Bradykinin analogs as selective inhibitors of cell activation

Country Status (5)

Country	Link
EP (1)	EP1019070A4 (de)
JP (1)	JP2001518119A (de)
CA (1)	CA2288027A1 (de)
IL (1)	IL132546A0 (de)
WO (1)	WO1998047522A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6544750B1 (en) *	1999-08-17	2003-04-08	Thromgen, Inc.	Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
US7879792B2 (en) *	2005-06-02	2011-02-01	The Regents Of The University Of Michigan	Synthetic peptide inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
US10299714B2 (en)	2010-12-02	2019-05-28	Becton, Dickinson And Company	Blood collection devices containing blood stabilization agent including variegin or analog thereof and/or a polysulfated disaccharide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4585757A (en) *	1984-07-27	1986-04-29	Texas Tech University Health Sciences Center	Hypotensive active peptides
ES2063912T3 (es) *	1989-01-24	1995-01-16	Aphton Corp	Composiciones inmunogenicas frente a peptidos de gastrina.
SE468516B (sv) *	1991-06-14	1993-02-01	Kabigen Ab	Nya polypeptider vilka kan utvinnas fraan tunntarmen och deras anvaendning
AU2548992A (en) *	1991-08-13	1993-03-16	Temple University - Of The Commonwealth System Of Higher Education	Modulation of blood pressure and inhibition of platelet activation with kininogen fragment
DE69627191T2 (de) *	1995-06-09	2004-01-08	The Regents Of The University Of Michigan, Ann Arbor	Bradikininanaloge als selektive thrombininhibitoren

1998
- 1998-04-21 JP JP54627498A patent/JP2001518119A/ja active Pending
- 1998-04-21 EP EP98919827A patent/EP1019070A4/de not_active Withdrawn
- 1998-04-21 WO PCT/US1998/008015 patent/WO1998047522A1/en not_active Ceased
- 1998-04-21 CA CA002288027A patent/CA2288027A1/en not_active Abandoned
- 1998-04-21 IL IL13254698A patent/IL132546A0/xx unknown

Also Published As

Publication number	Publication date
JP2001518119A (ja)	2001-10-09
WO1998047522A1 (en)	1998-10-29
EP1019070A4 (de)	2001-05-16
AU734935B2 (en)	2001-06-28
EP1019070A1 (de)	2000-07-19
CA2288027A1 (en)	1998-10-29
AU7252898A (en)	1998-11-13

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