EP1019070A4 - Bradykinin analoge als selektive inhibitoren der zellaktivierung - Google Patents

Bradykinin analoge als selektive inhibitoren der zellaktivierung

Info

Publication number
EP1019070A4
EP1019070A4 EP98919827A EP98919827A EP1019070A4 EP 1019070 A4 EP1019070 A4 EP 1019070A4 EP 98919827 A EP98919827 A EP 98919827A EP 98919827 A EP98919827 A EP 98919827A EP 1019070 A4 EP1019070 A4 EP 1019070A4
Authority
EP
European Patent Office
Prior art keywords
bradykinine
cell activation
selective cell
activation inhibitors
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98919827A
Other languages
English (en)
French (fr)
Other versions
EP1019070A1 (de
Inventor
Alvin H Schmaier
Ahmed A K Hasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan (System)
University of Michigan-Ann Arbor
Original Assignee
University of Michigan (System)
University of Michigan-Ann Arbor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan (System), University of Michigan-Ann Arbor filed Critical University of Michigan (System)
Publication of EP1019070A1 publication Critical patent/EP1019070A1/de
Publication of EP1019070A4 publication Critical patent/EP1019070A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/043—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP98919827A 1997-04-23 1998-04-21 Bradykinin analoge als selektive inhibitoren der zellaktivierung Withdrawn EP1019070A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4608597P 1997-04-23 1997-04-23
US46085P 1997-04-23
PCT/US1998/008015 WO1998047522A1 (en) 1997-04-23 1998-04-21 Bradykinin analogs as selective inhibitors of cell activation

Publications (2)

Publication Number Publication Date
EP1019070A1 EP1019070A1 (de) 2000-07-19
EP1019070A4 true EP1019070A4 (de) 2001-05-16

Family

ID=21941533

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98919827A Withdrawn EP1019070A4 (de) 1997-04-23 1998-04-21 Bradykinin analoge als selektive inhibitoren der zellaktivierung

Country Status (5)

Country Link
EP (1) EP1019070A4 (de)
JP (1) JP2001518119A (de)
CA (1) CA2288027A1 (de)
IL (1) IL132546A0 (de)
WO (1) WO1998047522A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544750B1 (en) * 1999-08-17 2003-04-08 Thromgen, Inc. Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
US7879792B2 (en) * 2005-06-02 2011-02-01 The Regents Of The University Of Michigan Synthetic peptide inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
JP5937612B2 (ja) 2010-12-02 2016-06-22 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 血液安定剤を含む採血用デバイス

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585757A (en) * 1984-07-27 1986-04-29 Texas Tech University Health Sciences Center Hypotensive active peptides
US5489575A (en) * 1991-06-14 1996-02-06 Hans G. Boman Polypeptides and their use
WO1996041640A1 (en) * 1995-06-09 1996-12-27 The Regents Of The University Of Michigan Bradykinin analogs as selective thrombin inhibitors
US5607676A (en) * 1989-01-24 1997-03-04 Aphton Corporation Immunogenic compositions against gastrin peptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2548992A (en) * 1991-08-13 1993-03-16 Temple University - Of The Commonwealth System Of Higher Education Modulation of blood pressure and inhibition of platelet activation with kininogen fragment

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585757A (en) * 1984-07-27 1986-04-29 Texas Tech University Health Sciences Center Hypotensive active peptides
US5607676A (en) * 1989-01-24 1997-03-04 Aphton Corporation Immunogenic compositions against gastrin peptides
US5489575A (en) * 1991-06-14 1996-02-06 Hans G. Boman Polypeptides and their use
WO1996041640A1 (en) * 1995-06-09 1996-12-27 The Regents Of The University Of Michigan Bradykinin analogs as selective thrombin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9847522A1 *

Also Published As

Publication number Publication date
EP1019070A1 (de) 2000-07-19
AU734935B2 (en) 2001-06-28
JP2001518119A (ja) 2001-10-09
CA2288027A1 (en) 1998-10-29
WO1998047522A1 (en) 1998-10-29
AU7252898A (en) 1998-11-13
IL132546A0 (en) 2001-03-19

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